Insertion of an NPVY sequence into the cytosolic domain of the erythropoietin receptor selectively affects erythropoietin-mediated signalling and function

Biochemical Journal

Volumn 427, Issue 2, 2010, Pages 305-312

  Liron, Tamar ^a   Nahari, Tal ^a   Souroujon, Miriam C ^b   Neumann, Drorit ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b OPEN UNIVERSITY OF ISRAEL   (Israel)

Author keywords

Apoptosis; Erythropoietin; NPXY motif; Phosphorylation; Signal transduction

Indexed keywords

APOPTOSIS; CELL SURFACE EXPRESSION; CELL SURFACE RECEPTORS; CELL SURFACES; CYTOSOLIC DOMAINS; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTORS; ETOPOSIDE; EXTRACELLULAR- SIGNAL-REGULATED KINASE 1/2; IN-CELL; INDUCED APOPTOSIS; INTRACELLULAR DOMAIN; INTRACELLULAR LEVELS; JANUS KINASE 2; MEDIATED SIGNALLING; PROGENITOR CELL; SIGNAL TRANSDUCERS; WILD TYPES;

BACTERIOPHAGES; CELL DEATH; CELL MEMBRANES; CELL PROLIFERATION; CHEMICAL ACTIVATION; ENZYME ACTIVITY; PHOSPHORYLATION;

SIGNAL TRANSDUCTION;

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; ETOPOSIDE; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; STAT5 PROTEIN;

APOPTOSIS; ARTICLE; CELL MATURATION; CELL PROLIFERATION; CELL PROTECTION; CELL SURFACE; CONTROLLED STUDY; CYTOSOL; GENE INSERTION SEQUENCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; METABOLISM; MOUSE; MUTATION; PHOSPHORYLATION; UPREGULATION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL PROLIFERATION; CYTOSOL; ERYTHROPOIETIN; HUMANS; MICE; MUTATION; PHOSPHORYLATION; RECEPTORS, ERYTHROPOIETIN; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 77952769868     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091951     Document Type: Article

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