메뉴 건너뛰기




Volumn 298, Issue 6, 2010, Pages

Mechanotransduction by GEF-H1 as a novel mechanism of ventilator-induced vascular endothelial permeability

Author keywords

Actin; Cyclic stretch; Endothelium; GEF; Mechanical forces; Microtubules; Rho

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR H1; NOCODAZOLE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA; THROMBIN RECEPTOR ACTIVATING PEPTIDE 6; UNCLASSIFIED DRUG;

EID: 77952761852     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00263.2009     Document Type: Article
Times cited : (91)

References (73)
  • 1
    • 0343893748 scopus 로고    scopus 로고
    • Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome
    • The Acute Respiratory Distress Syndrome Network
    • The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342: 1301-1308, 2000.
    • (2000) N Engl J Med , vol.342 , pp. 1301-1308
  • 4
    • 42749091991 scopus 로고    scopus 로고
    • Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: Is altered GEF-H1 activity a crucial determinant of disease pathogenesis?
    • Birkenfeld J, Nalbant P, Yoon SH, Bokoch GM. Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis? Trends Cell Biol 18: 210-219, 2008.
    • (2008) Trends Cell Biol , vol.18 , pp. 210-219
    • Birkenfeld, J.1    Nalbant, P.2    Yoon, S.H.3    Bokoch, G.M.4
  • 7
    • 21844466715 scopus 로고    scopus 로고
    • ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability
    • DOI 10.1016/j.febslet.2005.06.018, PII S0014579305007477
    • Birukova AA, Adyshev D, Gorshkov B, Birukov KG, Verin AD. ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability. FEBS Lett 579: 4031-4037, 2005. (Pubitemid 40961907)
    • (2005) FEBS Letters , vol.579 , Issue.18 , pp. 4031-4037
    • Birukova, A.A.1    Adyshev, D.2    Gorshkov, B.3    Birukov, K.G.4    Verin, A.D.5
  • 11
  • 12
    • 58149356253 scopus 로고    scopus 로고
    • Paxillin is involved in the differential regulation of endothelial barrier by HGF and VEGF
    • Birukova AA, Cokic I, Moldobaeva N, Birukov KG. Paxillin is involved in the differential regulation of endothelial barrier by HGF and VEGF. Am J Respir Cell Mol Biol 40: 99-107, 2009.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 99-107
    • Birukova, A.A.1    Cokic, I.2    Moldobaeva, N.3    Birukov, K.G.4
  • 14
    • 71049174151 scopus 로고    scopus 로고
    • Lung endothelial barrier protection by iloprost in the 2-hit models of ventilator-induced lung injury (VILI) involves inhibition of Rho signaling
    • Birukova AA, Fu P, Xing J, Cokic I, Birukov KG. Lung endothelial barrier protection by iloprost in the 2-hit models of ventilator-induced lung injury (VILI) involves inhibition of Rho signaling. Transl Res 155: 44-54, 2010.
    • (2010) Transl Res , vol.155 , pp. 44-54
    • Birukova, A.A.1    Fu, P.2    Xing, J.3    Cokic, I.4    Birukov, K.G.5
  • 16
    • 34247618164 scopus 로고    scopus 로고
    • Tiam1 and betaPIX mediate Rac-dependent endothelial barrier protective response to oxidized phospholipids
    • DOI 10.1002/jcp.20966
    • Birukova AA, Malyukova I, Mikaelyan A, Fu P, Birukov KG. Tiam1 and betaPIX mediate Rac-dependent endothelial barrier protective response to oxidized phospholipids. J Cell Physiol 211: 608-617, 2007. (Pubitemid 46683029)
    • (2007) Journal of Cellular Physiology , vol.211 , Issue.3 , pp. 608-617
    • Birukova, A.A.1    Malyukova, I.2    Mikaelyan, A.3    Fu, P.4    Birukov, K.G.5
  • 17
    • 56149112369 scopus 로고    scopus 로고
    • Magnitude-dependent effects of cyclic stretch on HGF- and VEGF-induced pulmonary endothelial remodeling and barrier regulation
    • Birukova AA, Moldobaeva N, Xing J, Birukov KG. Magnitude-dependent effects of cyclic stretch on HGF- and VEGF-induced pulmonary endothelial remodeling and barrier regulation. Am J Physiol Lung Cell Mol Physiol 295: L612-L623, 2008.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295
    • Birukova, A.A.1    Moldobaeva, N.2    Xing, J.3    Birukov, K.G.4
  • 18
    • 0347989369 scopus 로고    scopus 로고
    • Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction
    • DOI 10.1016/j.mvr.2003.09.007
    • Birukova AA, Smurova K, Birukov KG, Kaibuchi K, Garcia JGN, Verin AD. Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res 67: 64-77, 2004. (Pubitemid 38050225)
    • (2004) Microvascular Research , vol.67 , Issue.1 , pp. 64-77
    • Birukova, A.A.1    Smurova, K.2    Birukov, K.G.3    Kaibuchi, K.4    Garcia, J.G.N.5    Verin, A.D.6
  • 20
    • 34250177621 scopus 로고    scopus 로고
    • Prostaglandins PGE2 and PGI2 promote endothelial barrier enhancement via PKA- And Epac1/Rap1-dependent Rac activation
    • Birukova AA, Zagranichnaya T, Alekseeva E, Fu P, Chen W, Jacobson JR, Birukov KG. Prostaglandins PGE2 and PGI2 promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation. Exp Cell Res 313: 2504-2520, 2007.
    • (2007) Exp Cell Res , vol.313 , pp. 2504-2520
    • Birukova, A.A.1    Zagranichnaya, T.2    Alekseeva, E.3    Fu, P.4    Chen, W.5    Jacobson, J.R.6    Birukov, K.G.7
  • 21
    • 0038554077 scopus 로고    scopus 로고
    • Biology of the p21-activated kinases
    • Bokoch GM. Biology of the p21-activated kinases. Annu Rev Biochem 72: 743-781, 2003.
    • (2003) Annu Rev Biochem , vol.72 , pp. 743-781
    • Bokoch, G.M.1
  • 22
    • 19444362954 scopus 로고    scopus 로고
    • PAK4 mediates morphological changes through the regulation of GEF-H1
    • Callow MG, Zozulya S, Gishizky ML, Jallal B, Smeal T. PAK4 mediates morphological changes through the regulation of GEF-H1. J Cell Sci 118: 1861-1872, 2005.
    • (2005) J Cell Sci , vol.118 , pp. 1861-1872
    • Callow, M.G.1    Zozulya, S.2    Gishizky, M.L.3    Jallal, B.4    Smeal, T.5
  • 23
    • 0033781864 scopus 로고    scopus 로고
    • Invited review: Mechanisms of ventilator-induced lung injury: A perspective
    • Dos Santos CC, Slutsky AS. Invited review: mechanisms of ventilator-induced lung injury: a perspective. J Appl Physiol 89: 1645-1655, 2000.
    • (2000) J Appl Physiol , vol.89 , pp. 1645-1655
    • Dos Santos, C.C.1    Slutsky, A.S.2
  • 24
    • 0034807581 scopus 로고    scopus 로고
    • Cytoskeletal regulation of pulmonary vascular permeability
    • Dudek SM, Garcia JG. Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 91: 1487-1500, 2001.
    • (2001) J Appl Physiol , vol.91 , pp. 1487-1500
    • Dudek, S.M.1    Garcia, J.G.2
  • 25
    • 0030462929 scopus 로고    scopus 로고
    • Microtubule disruption induces the formation of actin stress fibers and focal adhesions in cultured cells: Possible involvement of the rho signal cascade
    • Enomoto T. Microtubule disruption induces the formation of actin stress fibers and focal adhesions in cultured cells: possible involvement of the rho signal cascade. Cell Struct Funct 21: 317-326, 1996. (Pubitemid 27068315)
    • (1996) Cell Structure and Function , vol.21 , Issue.5 , pp. 317-326
    • Enomoto, T.1
  • 26
    • 0034660145 scopus 로고    scopus 로고
    • Cyclic amp blocks bacterial lipopolysaccharide-induced myosin light chain phosphorylation in endothelial cells through inhibition of Rho/Rho kinase signaling
    • Essler M, Staddon JM, Weber PC, Aepfelbacher M. Cyclic AMP blocks bacterial lipopolysaccharide-induced myosin light chain phosphorylation in endothelial cells through inhibition of Rho/Rho kinase signaling. J Immunol 164: 6543-6549, 2000. (Pubitemid 30408840)
    • (2000) Journal of Immunology , vol.164 , Issue.12 , pp. 6543-6549
    • Essler, M.1    Staddon, J.M.2    Weber, P.C.3    Aepfelbacher, M.4
  • 28
    • 0035150402 scopus 로고    scopus 로고
    • Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells
    • DOI 10.1016/S0165-6147(00)01596-0, PII S0165614700015960
    • Fukata Y, Amano M, Kaibuchi K. Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol Sci 22: 32-39, 2001. (Pubitemid 32126284)
    • (2001) Trends in Pharmacological Sciences , vol.22 , Issue.1 , pp. 32-39
    • Fukata, Y.1    Kaibuchi, K.2    Amano, M.3    Kaibuchi, K.4
  • 32
    • 2442480438 scopus 로고    scopus 로고
    • Intracellular glutathione in stretch-induced cytokine release from alveolar type-2 like cells
    • DOI 10.1111/j.1440-1843.2003.00527.x
    • Jafari B, Ouyang B, Li LF, Hales CA, Quinn DA. Intracellular glutathione in stretch-induced cytokine release from alveolar type-2 like cells. Respirology 9: 43-53, 2004. (Pubitemid 38647769)
    • (2004) Respirology , vol.9 , Issue.1 , pp. 43-53
    • Jafari, B.1    Ouyang, B.2    Li, L.-F.3    Hales, C.A.4    Quinn, D.A.5
  • 34
    • 66449091744 scopus 로고    scopus 로고
    • GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: Role in the regulation of tubular paracellular permeability
    • Kakiashvili E, Speight P, Waheed F, Seth R, Lodyga M, Tanimura S, Kohno M, Rotstein OD, Kapus A, Szaszi K. GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability. J Biol Chem 284: 11454-11466, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 11454-11466
    • Kakiashvili, E.1    Speight, P.2    Waheed, F.3    Seth, R.4    Lodyga, M.5    Tanimura, S.6    Kohno, M.7    Rotstein, O.D.8    Kapus, A.9    Szaszi, K.10
  • 35
    • 33846847701 scopus 로고    scopus 로고
    • Rap1: A key regulator in cell-cell junction formation
    • DOI 10.1242/jcs.03306
    • Kooistra MR, Dube N, Bos JL. Rap1: a key regulator in cell-cell junction formation. J Cell Sci 120: 17-22, 2007. (Pubitemid 46206645)
    • (2007) Journal of Cell Science , vol.120 , Issue.1 , pp. 17-22
    • Kooistra, M.R.H.1    Dube, N.2    Bos, J.L.3
  • 36
    • 0036228955 scopus 로고    scopus 로고
    • Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton
    • DOI 10.1038/ncb773
    • Krendel M, Zenke FT, Bokoch GM. Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. Nat Cell Biol 4: 294-301, 2002. (Pubitemid 34308855)
    • (2002) Nature Cell Biology , vol.4 , Issue.4 , pp. 294-301
    • Krendel, M.1    Zenke, F.T.2    Bokoch, G.M.3
  • 37
    • 0030477840 scopus 로고    scopus 로고
    • Mechanisms of increased endothelial permeability
    • Lum H, Malik AB. Mechanisms of increased endothelial permeability. Can J Physiol Pharmacol 74: 787-800, 1996.
    • (1996) Can J Physiol Pharmacol , vol.74 , pp. 787-800
    • Lum, H.1    Malik, A.B.2
  • 40
    • 5644287793 scopus 로고    scopus 로고
    • In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: Mechanistic insights
    • McVerry BJ, Garcia JG. In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. Cell Signal 17: 131-139, 2005.
    • (2005) Cell Signal , vol.17 , pp. 131-139
    • McVerry, B.J.1    Garcia, J.G.2
  • 41
    • 33644839612 scopus 로고    scopus 로고
    • Signaling mechanisms regulating endothelial permeability
    • Mehta D, Malik AB. Signaling mechanisms regulating endothelial permeability. Physiol Rev 86: 279-367, 2006.
    • (2006) Physiol Rev , vol.86 , pp. 279-367
    • Mehta, D.1    Malik, A.B.2
  • 44
    • 34548820709 scopus 로고    scopus 로고
    • Re-evaluation of Evans Blue dye as a marker of albumin clearance in murine models of acute lung injury
    • DOI 10.1016/j.trsl.2007.03.013, PII S1931524407000977
    • Moitra J, Sammani S, Garcia JG. Re-evaluation of Evans Blue dye as a marker of albumin clearance in murine models of acute lung injury. Transl Res 150: 253-265, 2007. (Pubitemid 47444609)
    • (2007) Translational Research , vol.150 , Issue.4 , pp. 253-265
    • Moitra, J.1    Sammani, S.2    Garcia, J.G.N.3
  • 45
    • 0032581274 scopus 로고    scopus 로고
    • Pp125(FAK) is required for stretch dependent morphological response of endothelial cells
    • Naruse K, Yamada T, Sai XR, Hamaguchi M, Sokabe M. Pp125FAK is required for stretch dependent morphological response of endothelial cells. Oncogene 17: 455-463, 1998. (Pubitemid 28395910)
    • (1998) Oncogene , vol.17 , Issue.4 , pp. 455-463
    • Naruse, K.1    Yamada, T.2    Sai, X.-R.3    Hamaguchi, M.4    Sokabe, M.5
  • 46
    • 0033791649 scopus 로고    scopus 로고
    • Structural insights into microtubule function
    • Nogales E. Structural insights into microtubule function. Annu Rev Biochem 69: 277-302, 2000.
    • (2000) Annu Rev Biochem , vol.69 , pp. 277-302
    • Nogales, E.1
  • 48
    • 0034907213 scopus 로고    scopus 로고
    • MDia mediates Rho-regulated formation and orientation of stable microtubules
    • Palazzo AF, Cook TA, Alberts AS, Gundersen GG. mDia mediates Rho-regulated formation and orientation of stable microtubules. Nat Cell Biol 3: 723-729, 2001.
    • (2001) Nat Cell Biol , vol.3 , pp. 723-729
    • Palazzo, A.F.1    Cook, T.A.2    Alberts, A.S.3    Gundersen, G.G.4
  • 49
    • 0842331443 scopus 로고    scopus 로고
    • Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling
    • Palazzo AF, Eng CH, Schlaepfer DD, Marcantonio EE, Gundersen GG. Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling. Science 303: 836-839, 2004.
    • (2004) Science , vol.303 , pp. 836-839
    • Palazzo, A.F.1    Eng, C.H.2    Schlaepfer, D.D.3    Marcantonio, E.E.4    Gundersen, G.G.5
  • 52
    • 0023293040 scopus 로고
    • Microtubules containing acetylated alpha-tubulin in mammalian cells in culture
    • Piperno G, LeDizet M, Chang XJ. Microtubules containing acetylated alpha-tubulin in mammalian cells in culture. J Cell Biol 104: 289-302, 1987.
    • (1987) J Cell Biol , vol.104 , pp. 289-302
    • Piperno, G.1    LeDizet, M.2    Chang, X.J.3
  • 53
    • 0037369208 scopus 로고    scopus 로고
    • External mechanical strain regulates membrane targeting of Rho GTPases by controlling the state of microtubule polymerization
    • Putnam AJ, Cunningham JJ, Pillemer BB, Mooney DJ. External mechanical strain regulates membrane targeting of Rho GTPases by controlling the state of microtubule polymerization. Am J Physiol Cell Physiol 284: C627-C639, 2003.
    • (2003) Am J Physiol Cell Physiol , vol.284
    • Putnam, A.J.1    Cunningham, J.J.2    Pillemer, B.B.3    Mooney, D.J.4
  • 54
    • 0032567341 scopus 로고    scopus 로고
    • Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases
    • DOI 10.1074/jbc.273.52.34954
    • Ren Y, Li R, Zheng Y, Busch H. Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. J Biol Chem 273: 34954-34960, 1998. (Pubitemid 29028193)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.52 , pp. 34954-34960
    • Ren, Y.1    Li, R.2    Zheng, Y.3    Busch, H.4
  • 55
    • 0035844869 scopus 로고    scopus 로고
    • Focal contacts as mechanosensors: Externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism
    • DOI 10.1083/jcb.153.6.1175
    • Riveline D, Zamir E, Balaban NQ, Schwarz US, Ishizaki T, Narumiya S, Kam Z, Geiger B, Bershadsky AD. Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol 153: 1175-1186, 2001. (Pubitemid 34289257)
    • (2001) Journal of Cell Biology , vol.153 , Issue.6 , pp. 1175-1185
    • Riveline, D.1    Zamir, E.2    Balaban, N.Q.3    Schwarz, U.S.4    Ishizaki, T.5    Narumiya, S.6    Kam, Z.7    Geiger, B.8    Bershadsky, A.D.9
  • 57
    • 50849083158 scopus 로고    scopus 로고
    • Cell adhesion receptors in mechanotransduction
    • Schwartz MA, Desimone DW. Cell adhesion receptors in mechanotransduction. Curr Opin Cell Biol 20: 551-556, 2008.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 551-556
    • Schwartz, M.A.1    Desimone, D.W.2
  • 58
    • 13544264582 scopus 로고    scopus 로고
    • Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells
    • DOI 10.1016/j.yexcr.2004.11.001
    • Shikata Y, Rios A, Kawkitinarong K, DePaola N, Garcia JG, Birukov KG. Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells. Exp Cell Res 304: 40-49, 2005. (Pubitemid 40222075)
    • (2005) Experimental Cell Research , vol.304 , Issue.1 , pp. 40-49
    • Shikata, Y.1    Rios, A.2    Kawkitinarong, K.3    Depaola, N.4    Garcia, J.G.N.5    Birukov, K.G.6
  • 59
    • 65449115660 scopus 로고    scopus 로고
    • Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids
    • Singleton PA, Chatchavalvanich S, Fu P, Xing J, Birukova AA, Fortune JA, Klibanov AM, Garcia JG, Birukov KG. Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids. Circ Res 104: 978-986, 2009.
    • (2009) Circ Res , vol.104 , pp. 978-986
    • Singleton, P.A.1    Chatchavalvanich, S.2    Fu, P.3    Xing, J.4    Birukova, A.A.5    Fortune, J.A.6    Klibanov, A.M.7    Garcia, J.G.8    Birukov, K.G.9
  • 60
    • 16544387521 scopus 로고    scopus 로고
    • Phosphatase 2A is involved in endothelial cell microtubule remodeling and barrier regulation
    • Tar K, Birukova AA, Csortos C, Bako E, Garcia JG, Verin AD. Phosphatase 2A is involved in endothelial cell microtubule remodeling and barrier regulation. J Cell Biochem 92: 534-546, 2004.
    • (2004) J Cell Biochem , vol.92 , pp. 534-546
    • Tar, K.1    Birukova, A.A.2    Csortos, C.3    Bako, E.4    Garcia, J.G.5    Verin, A.D.6
  • 62
    • 17644401347 scopus 로고    scopus 로고
    • Cross-linked small polyethylenimines: While still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo
    • DOI 10.1007/s11095-004-1874-y
    • Thomas M, Ge Q, Lu JJ, Chen J, Klibanov AM. Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo. Pharm Res 22: 373-380, 2005. (Pubitemid 40558495)
    • (2005) Pharmaceutical Research , vol.22 , Issue.3 , pp. 373-380
    • Thomas, M.1    Ge, Q.2    Lu, J.J.3    Chen, J.4    Klibanov, A.M.5
  • 63
    • 0033061238 scopus 로고    scopus 로고
    • Alveolar epithelial surface area-volume relationship in isolated rat lungs
    • Tschumperlin DJ, Margulies SS. Alveolar epithelial surface area-volume relationship in isolated rat lungs. J Appl Physiol 86: 2026-2033, 1999.
    • (1999) J Appl Physiol , vol.86 , pp. 2026-2033
    • Tschumperlin, D.J.1    Margulies, S.S.2
  • 65
    • 0034682993 scopus 로고    scopus 로고
    • Activation of RhoA by thrombin in endothelial hyperpermeability: Role of Rho kinase and protein tyrosine kinases
    • van Nieuw Amerongen GP, van Delft S, Vermeer MA, Collard JG, van Hinsbergh VW. Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases. Circ Res 87: 335-340, 2000.
    • (2000) Circ Res , vol.87 , pp. 335-340
    • Van Nieuw Amerongen, G.P.1    Van Delft, S.2    Vermeer, M.A.3    Collard, J.G.4    Van Hinsbergh, V.W.5
  • 67
    • 0031717365 scopus 로고    scopus 로고
    • Regulation of the actin cytoskeleton by thrombin in human endothelial cells: Role of Rho proteins in endothelial barrier function
    • Vouret-Craviari V, Boquet P, Pouyssegur J, Van Obberghen-Schilling E. Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function. Mol Biol Cell 9: 2639-2653, 1998. (Pubitemid 28425899)
    • (1998) Molecular Biology of the Cell , vol.9 , Issue.9 , pp. 2639-2653
    • Vouret-Craviari, V.1    Boquet, P.2    Pouyssegur, J.3    Van Obberghen-Schilling, E.4
  • 68
    • 33751256003 scopus 로고    scopus 로고
    • P120-Catenin and p190RhoGAP Regulate Cell-Cell Adhesion by Coordinating Antagonism between Rac and Rho
    • DOI 10.1016/j.cell.2006.09.046, PII S0092867406014073
    • Wildenberg GA, Dohn MR, Carnahan RH, Davis MA, Lobdell NA, Settleman J, Reynolds AB. p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Cell 127: 1027-1039, 2006. (Pubitemid 44792253)
    • (2006) Cell , vol.127 , Issue.5 , pp. 1027-1039
    • Wildenberg, G.A.1    Dohn, M.R.2    Carnahan, R.H.3    Davis, M.A.4    Lobdell, N.A.5    Settleman, J.6    Reynolds, A.B.7
  • 69
    • 28044432798 scopus 로고    scopus 로고
    • 2 production in human patellar tendon fibroblasts
    • DOI 10.1016/j.gene.2005.08.006, PII S0378111905005044
    • Yang G, Im HJ, Wang JH. Repetitive mechanical stretching modulates IL-1beta induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts. Gene 363: 166-172, 2005. (Pubitemid 41691905)
    • (2005) Gene , vol.363 , Issue.1-2 , pp. 166-172
    • Yang, G.1    Im, H.-J.2    Wang, J.H.-C.3
  • 70
    • 0030590084 scopus 로고    scopus 로고
    • Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase (pp125(FAK)), morphological changes and migration of endothelial cells
    • DOI 10.1006/bbrc.1996.1057
    • Yano Y, Saito Y, Narumiya S, Sumpio BE. Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase (pp125FAK), morphological changes and migration of endothelial cells. Biochem Biophys Res Commun 224: 508-515, 1996. (Pubitemid 26268217)
    • (1996) Biochemical and Biophysical Research Communications , vol.224 , Issue.2 , pp. 508-515
    • Yano, Y.1    Saito, Y.2    Narumiya, S.3    Sumpio, B.E.4
  • 71
    • 0346874411 scopus 로고    scopus 로고
    • Quantification of Stretch-Induced Cytoskeletal Remodeling in Vascular Endothelial Cells by Image Processing
    • Yoshigi M, Clark EB, Yost HJ. Quantification of stretch-induced cytoskeletal remodeling in vascular endothelial cells by image processing. Cytometry A 55: 109-118, 2003. (Pubitemid 37522513)
    • (2003) Cytometry Part a , vol.55 , Issue.2 , pp. 109-118
    • Yoshigi, M.1    Clark, E.B.2    Yost, H.J.3
  • 72
    • 2442483847 scopus 로고    scopus 로고
    • P21-activated Kinase 1 Phosphorylates and Regulates 14-3-3 Binding to GEF-H1, a Microtubule-localized Rho Exchange Factor
    • DOI 10.1074/jbc.M400084200
    • Zenke FT, Krendel M, DerMardirossian C, King CC, Bohl BP, Bokoch GM. p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. J Biol Chem 279: 18392-18400, 2004. (Pubitemid 38623255)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.18 , pp. 18392-18400
    • Zenke, F.T.1    Krendel, M.2    Dermardirossian, C.3    King, C.C.4    Bohl, B.P.5    Bokoch, G.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.