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Volumn 85, Issue 1, 2010, Pages 1-8

Effects of saccharomyces cerevisiae mec1, tel1, and mre11 mutations on spontaneous and methylmethane sulfonate-induced genome instability

Author keywords

Loss of heterozygosity; Mec1(atr) tel1(atm); Methylmethane sulfonate; Saccharomyces cerevisiae; Spontaneous mutation

Indexed keywords

FUNGAL DNA; MESYLIC ACID METHYL ESTER; MRE11 PROTEIN; PROTEIN MEC1; PROTEIN TEL1; SACCHAROMYCES CEREVISIAE PROTEIN; UNCLASSIFIED DRUG; DEOXYRIBONUCLEASE; EXODEOXYRIBONUCLEASE; MEC1 PROTEIN, S CEREVISIAE; MRE11 PROTEIN, S CEREVISIAE; MUTAGENIC AGENT; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TEL1 PROTEIN, S CEREVISIAE;

EID: 77952759691     PISSN: 13417568     EISSN: None     Source Type: Journal    
DOI: 10.1266/ggs.85.1     Document Type: Article
Times cited : (3)

References (35)
  • 1
    • 0027476083 scopus 로고
    • Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae
    • Ajimura, M., Leem, S. H., and Ogawa, H. (1993) Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae. Genetics 133, 51-66.
    • (1993) Genetics , vol.133 , pp. 51-66
    • Ajimura, M.1    Leem, S.H.2    Ogawa, H.3
  • 2
    • 0032721091 scopus 로고    scopus 로고
    • The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae
    • Bressan, D. A., Baxter, B. K., and Petrini, J. H. (1999) The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae. Mol. Cell. Biol. 19, 7681-7687.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 7681-7687
    • Bressan, D.A.1    Baxter, B.K.2    Petrini, J.H.3
  • 3
    • 47749141560 scopus 로고    scopus 로고
    • ATR: An essential regulator of genome integrity
    • Cimprich, K. A., and Cortez, D. (2008) ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 9, 616-627.
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 4
    • 0035989348 scopus 로고    scopus 로고
    • Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes
    • Craven, R. J., Greenwell, P. W., Dominska, M., and Petes, T. D. (2002) Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics 161, 493-507.
    • (2002) Genetics , vol.161 , pp. 493-507
    • Craven, R.J.1    Greenwell, P.W.2    Dominska, M.3    Petes, T.D.4
  • 5
    • 5644232838 scopus 로고    scopus 로고
    • Loss of heterozygosity and DNA damage repair in Saccharomyces cerevisiae
    • Daigaku, Y., Endo, K., Watanabe, E., Ono, T., and Yamamoto, K. (2004) Loss of heterozygosity and DNA damage repair in Saccharomyces cerevisiae. Mutat. Res. 556, 183-191.
    • (2004) Mutat. Res , vol.556 , pp. 183-191
    • Daigaku, Y.1    Endo, K.2    Watanabe, E.3    Ono, T.4    Yamamoto, K.5
  • 6
    • 33747334306 scopus 로고    scopus 로고
    • Loss of heterozygosity in yeast can occur by ultraviolet irradiation during the S phase of the cell cycle
    • Daigaku, Y., Mashiko, S., Mishiba, K., Yamamura, S., Ui, A., Enomoto, T., and Yamamoto, K. (2006) Loss of heterozygosity in yeast can occur by ultraviolet irradiation during the S phase of the cell cycle. Mutat. Res. 600, 177-183
    • (2006) Mutat. Res , vol.600 , pp. 177-183
    • Daigaku, Y.1    Mashiko, S.2    Mishiba, K.3    Yamamura, S.4    Ui, A.5    Enomoto, T.6    Yamamoto, K.7
  • 7
    • 0029808466 scopus 로고    scopus 로고
    • Cell cycle checkpoints: Preventing an identity crisis
    • Elledge, S. J. (1996) Cell cycle checkpoints: Preventing an identity crisis. Science 274, 1664-1672.
    • (1996) Science , vol.274 , pp. 1664-1672
    • Elledge, S.J.1
  • 8
    • 56349166602 scopus 로고    scopus 로고
    • UV but not X rays stimulate homologous recombination between sister chromatids and homologs in a Saccharomyces cerevisiae mec1 (ATR) hypomorphic mutant
    • Fasullo, M., and Sun, M. (2008) UV but not X rays stimulate homologous recombination between sister chromatids and homologs in a Saccharomyces cerevisiae mec1 (ATR) hypomorphic mutant. Mutat. Res. 648, 73-81
    • (2008) Mutat. Res , vol.648 , pp. 73-81
    • Fasullo, M.1    Sun, M.2
  • 9
    • 0029088371 scopus 로고
    • TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene
    • Greenwell, P. W., Kronmal, S. L., Porter, S. E., Gassenhuber, J., Obermaier, B., and Petes, T. D. (1995) TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82, 823-829.
    • (1995) Cell , vol.82 , pp. 823-829
    • Greenwell, P.W.1    Kronmal, S.L.2    Porter, S.E.3    Gassenhuber, J.4    Obermaier, B.5    Petes, T.D.6
  • 10
    • 0034854142 scopus 로고    scopus 로고
    • Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex
    • Grenon, M., Gilbert, C., and Lowndes, N. F. (2001) Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex. Nat. Cell Biol. 3, 844-847.
    • (2001) Nat. Cell Biol , vol.3 , pp. 844-847
    • Grenon, M.1    Gilbert, C.2    Lowndes, N.F.3
  • 11
    • 33745924670 scopus 로고    scopus 로고
    • Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation
    • Grenon, M., Magill, C. P., Lowndes, N. F., and Jackson, S. P. (2006) Double-strand breaks trigger MRX- and Mec1- dependent, but Tel1-independent, checkpoint activation. FEMS Yeast Res. 6, 836-847.
    • (2006) FEMS Yeast Res , vol.6 , pp. 836-847
    • Grenon, M.1    Magill, C.P.2    Lowndes, N.F.3    Jackson, S.P.4
  • 12
    • 0034528820 scopus 로고    scopus 로고
    • Spontaneous loss of heterozygosity in diploid Saccharomyces cerevisiae cells
    • Hiraoka, M., Watanabe, K., Umezu, K., and Maki, H. (2000) Spontaneous loss of heterozygosity in diploid Saccharomyces cerevisiae cells. Genetics 156, 1531-1548.
    • (2000) Genetics , vol.156 , pp. 1531-1548
    • Hiraoka, M.1    Watanabe, K.2    Umezu, K.3    Maki, H.4
  • 13
    • 30344463835 scopus 로고    scopus 로고
    • ATM- and cell cycledependent regulation of ATR in response to DNA double- strand breaks
    • Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C., Lukas, J., and Jackson, S. P. (2006) ATM- and cell cycledependent regulation of ATR in response to DNA double- strand breaks. Nat. Cell Biol. 8, 37-45.
    • (2006) Nat. Cell Biol , vol.8 , pp. 37-45
    • Jazayeri, A.1    Falck, J.2    Lukas, C.3    Bartek, J.4    Smith, G.C.5    Lukas, J.6    Jackson, S.P.7
  • 14
    • 0028914077 scopus 로고
    • Interaction of Mre11 and Rad50: Two proteins required for DNA repair and meiosis- specific double-strand break formation in Saccharomyces cerevisiae
    • Johzuka, K., and Ogawa, H. (1995) Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis- specific double-strand break formation in Saccharomyces cerevisiae. Genetics 139, 1521-1532.
    • (1995) Genetics , vol.139 , pp. 1521-1532
    • Johzuka, K.1    Ogawa, H.2
  • 15
    • 0027971222 scopus 로고
    • An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae
    • Kato, R., and Ogawa, H. (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res. 22, 3104-3112.
    • (1994) Nucleic Acids Res , vol.22 , pp. 3104-3112
    • Kato, R.1    Ogawa, H.2
  • 16
    • 0034733693 scopus 로고    scopus 로고
    • Damage-induced recombination in the yeast Saccharomyces cerevisiae
    • Kupiec, M. (2000) Damage-induced recombination in the yeast Saccharomyces cerevisiae. Mutat. Res. 451, 91-105
    • (2000) Mutat. Res , vol.451 , pp. 91-105
    • Kupiec, M.1
  • 17
    • 52449114574 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer
    • Lavin, M. F. (2008) Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat. Rev. Mol. Cell Biol. 9, 759-769.
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 759-769
    • Lavin, M.F.1
  • 18
    • 0029150855 scopus 로고
    • TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1
    • Morrow, D. M., Tagle, D. A., Shiloh, Y., Collins, F. S., and Hieter, P. (1995) TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82, 831-840.
    • (1995) Cell , vol.82 , pp. 831-840
    • Morrow, D.M.1    Tagle, D.A.2    Shiloh, Y.3    Collins, F.S.4    Hieter, P.5
  • 19
    • 7644232348 scopus 로고    scopus 로고
    • Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway
    • Nakada, D., Hirano, Y., and Sugimoto, K. (2004) Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway. Mol. Cell. Biol. 24, 10016-10025.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 10016-10025
    • Nakada, D.1    Hirano, Y.2    Sugimoto, K.3
  • 21
    • 0008158443 scopus 로고
    • Radiosensitivity in ataxia-telangiectasia: A new explanation
    • Painter, R. B., and Young, B. R. (1980) Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc. Natl. Acad. Sci. USA 77, 7315-7317.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 7315-7317
    • Painter, R.B.1    Young, B.R.2
  • 22
    • 0036861699 scopus 로고    scopus 로고
    • The Roles of REV3 and RAD57 In Double-strand-break-repair-induced mutagenesis of Saccharomyces cerevisiae
    • Rattray, A. J., Shafer, B. K., McGill, C. B., and Strathern, J. N. (2002) The roles of REV3 and RAD57 in double-strand-break-repair-induced mutagenesis of Saccharomyces cerevisiae. Genetics 162, 1063-1077.
    • (2002) Genetics , vol.162 , pp. 1063-1077
    • Rattray, A.J.1    Shafer, B.K.2    McGill, C.B.3    Strathern, J.N.4
  • 23
    • 57349104059 scopus 로고    scopus 로고
    • 1-Nitropyrene efficiently induces mitotic recombination in Saccharomyces cerevisiae
    • Rhenimi, L. R., Abu-Nasr, N. F., and Yamamoto, K. (2008) 1-Nitropyrene efficiently induces mitotic recombination in Saccharomyces cerevisiae. J. Radiat. Res. 49, 615-622.
    • (2008) J. Radiat. Res , vol.49 , pp. 615-622
    • Rhenimi, L.R.1    Abu-Nasr, N.F.2    Yamamoto, K.3
  • 24
    • 0030593033 scopus 로고    scopus 로고
    • Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways
    • Sanchez, Y., Desany, B. A., Jones, W. J., Liu, Q., Wang, B., and Elledge, S. J. (1996) Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271, 357-360.
    • (1996) Science , vol.271 , pp. 357-360
    • Sanchez, Y.1    Desany, B.A.2    Jones, W.J.3    Liu, Q.4    Wang, B.5    Elledge, S.J.6
  • 25
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh, Y. (2003) ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 3, 155-168.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 27
    • 3242889151 scopus 로고    scopus 로고
    • Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis
    • Taylor, A. M., Groom, A., and Byrd, P. J. (2004) Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis. DNA Repair 3, 1219-1225.
    • (2004) DNA Repair , vol.3 , pp. 1219-1225
    • Taylor, A.M.1    Groom, A.2    Byrd, P.J.3
  • 28
    • 34248389364 scopus 로고    scopus 로고
    • Rad50 is involved in MMS-induced recombination between homologous chromosomes in mitotic cells
    • Tomizawa, Y., Ui, A., Onoda, F., Ogiwara, H., Tada, S., Enomoto, T., and Seki, M. (2007) Rad50 is involved in MMS-induced recombination between homologous chromosomes in mitotic cells. Genes Genet. Syst. 82, 157-160.
    • (2007) Genes Genet. Syst , vol.82 , pp. 157-160
    • Tomizawa, Y.1    Ui, A.2    Onoda, F.3    Ogiwara, H.4    Tada, S.5    Enomoto, T.6    Seki, M.7
  • 29
    • 0034964498 scopus 로고    scopus 로고
    • A DNA damage response pathway controlled by Tel1 and the Mre11 complex
    • Usui, T., Ogawa, H., and Petrini, J. H. (2001) A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol. Cell 7, 1255-1266.
    • (2001) Mol. Cell , vol.7 , pp. 1255-1266
    • Usui, T.1    Ogawa, H.2    Petrini, J.H.3
  • 30
    • 0142136826 scopus 로고    scopus 로고
    • Requirement of the MRN complex for ATM activation by DNA damage
    • Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., and Shiloh, Y. (2003) Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 22, 5612-5621.
    • (2003) EMBO J , vol.22 , pp. 5612-5621
    • Uziel, T.1    Lerenthal, Y.2    Moyal, L.3    Andegeko, Y.4    Mittelman, L.5    Shiloh, Y.6
  • 31
    • 0028676232 scopus 로고
    • New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae
    • Wach, A., Brachat, A., Pohlmann, R., and Philippsen, P. (1994) New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10, 1793-1808.
    • (1994) Yeast , vol.10 , pp. 1793-1808
    • Wach, A.1    Brachat, A.2    Pohlmann, R.3    Philippsen, P.4
  • 32
    • 0030840519 scopus 로고    scopus 로고
    • Heterologous HIS3 marker and GFP reporter modules for PCR-targeting in Saccharomyces cerevisiae
    • Wach, A., Brachat, A., Alberti-Segui, C., Rebischung, C., and Philippsen, P. (1997) Heterologous HIS3 marker and GFP reporter modules for PCR-targeting in Saccharomyces cerevisiae. Yeast 13, 1065-1075.
    • (1997) Yeast , vol.13 , pp. 1065-1075
    • Wach, A.1    Brachat, A.2    Alberti-Segui, C.3    Rebischung, C.4    Philippsen, P.5
  • 33
    • 0028353634 scopus 로고
    • Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
    • Weinert, T. A., Kiser, G. L., and Hartwell, L. H. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8, 652-665.
    • (1994) Genes Dev , vol.8 , pp. 652-665
    • Weinert, T.A.1    Kiser, G.L.2    Hartwell, L.H.3
  • 34
    • 54849438701 scopus 로고    scopus 로고
    • Phenyl hydroquinone, an Ames test- negative carcinogen, induces Hog1-dependent stress response signaling
    • Yamamoto, A., Nunoshiba, T., Umezu, K., Enomoto, T., and Yamamoto, K. (2008) Phenyl hydroquinone, an Ames test- negative carcinogen, induces Hog1-dependent stress response signaling. FEBS J. 275, 5733-5744.
    • (2008) FEBS J , vol.275 , pp. 5733-5744
    • Yamamoto, A.1    Nunoshiba, T.2    Umezu, K.3    Enomoto, T.4    Yamamoto, K.5
  • 35
    • 0032161269 scopus 로고    scopus 로고
    • A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
    • Zhao, X., Muller, E. G., and Rothstein, R. (1998) A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol. Cell 2, 329-340.
    • (1998) Mol. Cell , vol.2 , pp. 329-340
    • Zhao, X.1    Muller, E.G.2    Rothstein, R.3


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