1-Nitropyrene efficiently induces mitotic recombination in Saccharomyces cerevisiae

Journal of Radiation Research

Volumn 49, Issue 6, 2008, Pages 615-622

  Rhenimi, Lalla Rajaa ^a   Abu Nasr, Naglaa Fathi ^a   Yamamoto, Kazuo ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Mutagenesis; Nitropyrene; Nitroreductase; Recombinogenic; S. cerevisiae

Indexed keywords

CYTOLOGY; GENES; MAMMALS;

CARCINOGENICS; DIESEL EXHAUSTS; DIPLOID CELLS; GENE-CONVERSION; INDUCED MUTATIONS; MITOTIC RECOMBINATION; NITROPYRENE; NITROREDUCTASES; RECOMBINOGENIC; S.CEREVISIAE;

YEAST;

BACTERIA (MICROORGANISMS); MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 57349104059     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.08031     Document Type: Article

References (30)

1. Rosenkranz, H. S., McCoy, E. C., Sanders, D. R., Butler, M., Kiriazides, D. K. and Mermelstein, R. (1980) Nitropyrenes: isolation, identificaton, and reduction of mutagenic impurities in carbon black and toners. Science 209: 1039-1043.
2. Gibson, T. L. (1983) Sources of direct-acting nitroarene mutagens in airborne particulate matter. Mutat. Res. 122: 115-121.
3. Schuetzle, D. (1983) Sampling of vehicle emissions for chemical analysis and biological testing. Environ. Health Perspect. 47: 65-80.
4. McGregor, W. G., Maher, V. M. and McCormick, J. J. (1994) Kinds and locations of mutations induced in the hypoxanthine-guanine phosphoribosyltransferase gene of human T-lymphocytes by 1-nitrosopyrene, including those caused by V(D)J recombinase. Cancer Res. 54: 4207-4213.
5. Rosenkranz, H. S. and Mermelstein, R. (1983) Mutagenicity and genotoxicity of nitroarenes. All nitro-containing chemicals were not created equal. Mutat. Res. 114: 217-267.
6. Hirose, M., Lee, M. S., Wang, C. Y. and King, C. M. (1984) Induction of rat mammary gland tumors by 1-nitropyrene, a recently recognized environmental mutagen. Cancer Res. 44: 1158-1162.
7. Wislocki, P. G., Bagan, E. S., Lu, A. Y., Dooley, K. L., Fu, P. P., Han-Hsu, H., Beland, F. A. and Kadlubar, F. F. (1986) Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay. Carcinogenesis 7: 1317-1322.
8. Thornton-Manning, J. R., Smith, B. A., Beland, F. A. and Heflich, R. H. (1991) S9-mediated metabolism of 1-nitropyrene to a mutagen in Chinese hamster ovary cells by ring-oxidation under aerobic conditions and by nitroreduction under anaerobic conditions. Carcinogenesis 12: 2317-2323.
9. Yang, J. L., Maher, V. M. and McCormick, J. J. (1988) Kinds and spectrum of mutations induced by 1-nitrosopyrene adducts during plasmid replication in human cells. Mol. Cell. Biol. 8: 3364-3372.
10. Newton, R. K., Mittelstaedt, R. A., Manjanatha, M. G. and Heflich, R. H. (1992) DNA sequence analysis of 1-nitrosopyrene-induced mutations in the hprt gene of Chinese hamster ovary cells. Carcinogenesis 13: 819-825.
11. Stanton, C. A., Garner, R. C. and Martin, C. N. (1988) The mutagenicity and DNA base sequence changes induced by 1-nitroso- and 1-nitropyrene in the cI gene of lambda prophage. Carcinogenesis 9: 1153-1157.
12. Fifer, E. K., Howard, P. C., Heflich, R. H. and Beland, F. A. (1986) Synthesis and mutagenicity of 1-nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide, microsomal metabolites of 1-nitropyrene. Mutagenesis 1: 433-438.
13. Heflich, R. H., Thornton-Manning, J. R., Kinouchi, T. and Beland, F. A. (1990) Mutagenicity of oxidized microsomal metabolites of 1-nitropyrene in Chinese hamster ovary cells. Mutagenesis 5: 151-157.
14. Kim, H. J., Kim, T. H., Lee, S. Y., Lee, D. H., Kim, S. I., Pfeifer, G. P., Kim, S. K. and Lee, C. S. (2005) DNA sequence analysis of 1-nitropyrene-4,5-oxide and 1-nitropyrene-9,10-oxide induced mutations in the hprt gene of Chinese hamster ovary cells. Mol. Cells 19: 114-123.
15. Bai, F., Nakanishi, Y., Takayama, K., Pei, X. H., Tokiwa, H. and Hara, N. (1998) Ki-ras mutation and cell proliferation of lung lesions induced by 1-nitropyrene in A/J mice. Mol. Carcinog. 22: 258-264.
16. Bai, F., Nakanishi, Y., Takayama, K., Pei, X. H., Inoue, K., Harada, T., Izumi, M. and Hara, N. (2003) Codon 64 of K-ras gene mutation pattern in hepatocellular carcinomas induced by bleomycin and 1-nitropyrene in A/J mice. Teratog. Carcinog. Mutagen. Suppl. 1: 161-170.
17. Wilcox, P. and Parry, J. M. (1981) The genetic activity of dinitropyrenes in yeast: unusual dose response curves for induced mitotic gene conversion. Carcinogenesis 2: 1201-1205.
18. McCoy, E. C., Anders, M., Rosenkranz, H. S. and Mermelstein, R. (1983) Apparent absence of recombinogenic activity of nitropyrenes for yeast. Mutat. Res. 116: 119-127.
19. Ohnishi, G., Endo, K., Doi, A., Fujita, A., Daigaku, Y., Nunoshiba, T. and Yamamoto, K. (2004) Spontaneous mutagenesis in haploid and diploid Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 325: 928-933.
20. Daigaku, Y., Endo, K., Watanabe, E., Ono, T. and Yamamoto, K. (2004) Loss of heterozygosity and DNA damage repair in Saccharomyces cerevisiae. Mutat. Res. 556: 183-191.
21. Daigaku, Y., Mashiko, S., Mishiba, K., Yamamura, S., Ui, A., Enomoto, T. and Yamamoto, K. (2006) Loss of heterozygosity in yeast can occur by ultraviolet irradiation during the S phase of the cell cycle. Mutat. Res. 600: 177-183.
22. Endo, K., Tago, Y., Daigaku, Y. and Yamamoto, K. (2007) Error-free RAD52 pathway and error-prone REV3 pathway determines spontaneous mutagenesis in Saccharomyces cerevisiae. Genes Genet. Syst. 82 : 35-42.
23. McCoy, E. C., Anders, M., McCartney, M., Howard, P. C., Beland, F. A. and Rosenkranz, H. S. (1984) The recombinogenic inactivity of 1-nitropyrene for yeast is due to a deficiency in a functional nitroreductase. Mutat. Res. 139: 115-118.
24. Mermelstein, R., Kiriazides, D. K., Butler, M., McCoy, E. C. and Rosenkranz, H. S. (1981) The extraordinary mutagenicity of nitropyrenes in bacteria. Mutat. Res. 89: 187-196.
25. Watanabe, M., Nishino, T., Takio, K., Sofuni, T. and Nohmi, T. (1998) Purification and characterization of wild-type and mutant classical nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J. Biol. Chem. 273: 23922-22928.
26. de Oliveira, I. M., Henriques, J. A. and Bonatto, D. (2007) In silico identification of a new group of specific bacterial and fungal nitroreductases-like proteins. Biochem. Biophys. Res. Commun. 355: 919-925.
27. Nachtman, J. P. and Wolff, S. (1982) Activity of nitropolynuclear aromatic hydrocarbons in the sister chromatid exchange assay with and without metabolic activation. Environ. Mutagen. 4: 1-5.
28. Murakami, Y., Hayashi, K., Hirohashi, S. and Sekiya, T. (1991) Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas. Cancer Res. 51: 5520-5525.
29. Oda, T., Tsuda, H., Scarpa, A., Sakamoto, M. and Hirohashi, S. (1992) p53 gene mutation spectrum in hepatocellular carcinoma. Cancer Res. 52: 6358-6364.
30. Hoffmann, W. (1985) Molecular characterization of the CAN1 locus in Saccharomyces cerevisiae. A transmembrane protein without N-terminal hydrophobic signal sequence. J. Biol. Chem. 260: 11831-11837.