CD11chi dendritic cells regulate the re-establishment of vascular quiescence and stabilization after immune stimulation of lymph nodes

Journal of Immunology

Volumn 184, Issue 8, 2010, Pages 4247-4257

  Tzeng, Te Chen ^a,b   Chyou, Susan ^a   Tian, Sha ^a   Webster, Brian ^a,c   Carpenter, April C ^a,d   Guaiquil, Victor H ^a   Lu, Theresa T ^a,b  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P 15095; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; VASCULAR CELL ADHESION MOLECULE 1; HLA ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; CHIMERA; CONTROLLED STUDY; DENDRITIC CELL; DOWN REGULATION; ENDOTHELIUM CELL; IMMUNOREGULATION; IMMUNOSTIMULATION; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; UPREGULATION; VASCULAR ENDOTHELIUM; VENULE; WILD TYPE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL MOTION; CYTOLOGY; FIBROBLAST; IMMUNOLOGY; LYMPH VESSEL; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT; TRANSGENIC MOUSE; TUMOR CELL LINE; VASCULARIZATION;

ANIMALS; ANTIGENS, CD11C; B-LYMPHOCYTES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DENDRITIC CELLS; ENDOTHELIUM, VASCULAR; FIBROBLASTS; HISTOCOMPATIBILITY ANTIGENS CLASS II; LYMPH NODES; LYMPHATIC VESSELS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEIN TRANSPORT; T-LYMPHOCYTES; UP-REGULATION;

EID: 77952747811     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902914     Document Type: Article

References (47)

1. von Andrian, U. H., and T. R. Mempel. 2003. Homing and cellular traffic in lymph nodes. Nat. Rev. Immunol. 3: 867-878.
2. Guarda, G., M. Hons, S. F. Soriano, A. Y. Huang, R. Polley, A. Martín-Fontecha, J. V. Stein, R. N. Germain, A. Lanzavecchia, and F. Sallusto. 2007. L-selectinnegative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. Nat. Immunol. 8: 743-752.
3. Martín-Fontecha, A., L. L. Thomsen, S. Brett, C. Gerard, M. Lipp, A. Lanzavecchia, and F. Sallusto. 2004. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat. Immunol. 5: 1260-1265.
4. Martín-Fontecha, A., D. Baumjohann, G. Guarda, A. Reboldi, M. Hons, A. Lanzavecchia, and F. Sallusto. 2008. CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming. J. Exp. Med. 205: 2561-2574.
5. Soderberg, K. A., G. W. Payne, A. Sato, R. Medzhitov, S. S. Segal, and A. Iwasaki. 2005. Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc. Natl. Acad. Sci. U.S.A. 102: 16315-16320.
6. Webster, B., E. H. Ekland, L. M. Agle, S. Chyou, R. Ruggieri, and T. T. Lu. 2006. Regulation of lymph node vascular growth by dendritic cells. J. Exp. Med. 203: 1903-1913.
7. Anderson, N. D., A. O. Anderson, and R. G. Wyllie. 1975. Microvascular changes in lymph nodes draining skin allografts. Am. J. Pathol. 81: 131-160.
8. Gaengel, K., G. Genové, A. Armulik, and C. Betsholtz. 2009. Endothelial-mural cell signaling in vascular development and angiogenesis. Arterioscler. Thromb. Vasc. Biol. 29: 630-638.
9. Hellström, M., H. Gerhardt, M. Kalén, X. Li, U. Eriksson, H. Wolburg, and C. Betsholtz. 2001. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J. Cell Biol. 153: 543-553. (Pubitemid 34280141)
10. Jain, R. K. 2003. Molecular regulation of vessel maturation. Nat. Med. 9: 685-693.
11. Liao, S., and N. H. Ruddle. 2006. Synchrony of high endothelial venules and lymphatic vessels revealed by immunization. J. Immunol. 177: 3369-3379. (Pubitemid 44277857)
12. Herman, P. G., I. Yamamoto, and H. Z. Mellins. 1972. Blood microcirculation in the lymph node during the primary immune response. J. Exp. Med. 136: 697-714.
13. Chyou, S., E. H. Ekland, A. C. Carpenter, T.-C. J. Tzeng, S. Tian, M. Michaud, J. A. Madri, and T. T. Lu. 2008. Fibroblast-type reticular stromal cells regulate the lymph node vasculature. J. Immunol. 181: 3887-3896.
14. Angeli, V., F. Ginhoux, J. Llodrà, L. Quemeneur, P. S. Frenette, M. Skobe, R. Jessberger, M. Merad, and G. J. Randolph. 2006. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 24: 203-215. (Pubitemid 43214589)
15. Uchimura, K., and S. D. Rosen. 2006. Sulfated L-selectin ligands as a therapeutic target in chronic inflammation. Trends Immunol. 27: 559-565. (Pubitemid 44708834)
16. Bajénoff, M., J. G. Egen, L. Y. Koo, J. P. Laugier, F. Brau, N. Glaichenhaus, and R. N. Germain. 2006. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25: 989-1001. (Pubitemid 44914055)
17. Cyster, J. G. 2005. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 23: 127-159.
18. Link, A., T. K. Vogt, S. Favre, M. R. Britschgi, H. Acha-Orbea, B. Hinz, J. G. Cyster, and S. A. Luther. 2007. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat. Immunol. 8: 1255-1265.
19. Gretz, J. E., A. O. Anderson, and S. Shaw. 1997. Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex. Immunol. Rev. 156: 11-24.
20. Lämmermann, T., and M. Sixt. 2008. The microanatomy of T-cell responses. Immunol. Rev. 221: 26-43.
21. Junt, T., E. Scandella, and B. Ludewig. 2008. Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence. Nat. Rev. Immunol. 8: 764-775.
22. Jung, S., D. Unutmaz, P. Wong, G. Sano, K. De los Santos, T. Sparwasser, S. Wu, S. Vuthoori, K. Ko, F. Zavala, et al. 2002. In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 17: 211-220.
23. Sapoznikov, A., Y. Pewzner-Jung, V. Kalchenko, R. Krauthgamer, I. Shachar, and S. Jung. 2008. Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches. Nat. Immunol. 9: 388-395.
24. Darrasse-Jèze, G., S. Deroubaix, H. Mouquet, G. D. Victora, T. Eisenreich, K. H. Yao, R. F. Masilamani, M. L. Dustin, A. Rudensky, K. Liu, and M. C. Nussenzweig. 2009. Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J. Exp. Med. 206: 1853-1862.
25. Berger, A. C., X. Q. Wang, A. Zalatoris, J. Cenna, and J. C. Watson. 2004. A murine model of ex vivo angiogenesis using aortic disks grown in fibrin clot. Microvasc. Res. 68: 179-187.
26. Sixt, M., N. Kanazawa, M. Selg, T. Samson, G. Roos, D. P. Reinhardt, R. Pabst, M. B. Lutz, and L. Sorokin. 2005. The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node. Immunity 22: 19-29. (Pubitemid 40143448)
27. Luther, S. A., H. L. Tang, P. L. Hyman, A. G. Farr, and J. G. Cyster. 2000. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc. Natl. Acad. Sci. USA 97: 12694-12699.
28. Nicosia, R. F., and A. Ottinetti. 1990. Modulation of microvascular growth and morphogenesis by reconstituted basement membrane gel in three-dimensional cultures of rat aorta: a comparative study of angiogenesis in matrigel, collagen, fibrin, and plasma clot. In Vitro Cell. Dev. Biol. 26: 119-128.
29. Hebel, K., K. Griewank, A. Inamine, H. D. Chang, B. Müller-Hilke, S. Fillatreau, R. A. Manz, A. Radbruch, and S. Jung. 2006. Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11c (high) dendritic cells. Eur. J. Immunol. 36: 2912-2919.
30. Allan, R. S., J. Waithman, S. Bedoui, C. M. Jones, J. A. Villadangos, Y. Zhan, A. M. Lew, K. Shortman, W. R. Heath, and F. R. Carbone. 2006. Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming. Immunity 25: 153-162.
31. López-Bravo, M., and C. Ardavín. 2008. In vivo induction of immune responses to pathogens by conventional dendritic cells. Immunity 29: 343-351.
32. Shortman, K., and S. H. Naik. 2007. Steady-state and inflammatory dendriticcell development. Nat. Rev. Immunol. 7: 19-30.
33. Itano, A. A., and M. K. Jenkins. 2003. Antigen presentation to naive CD4 T cells in the lymph node. Nat. Immunol. 4: 733-739.
34. Steinman, R. M. 2008. Dendritic cells in vivo: a key target for a new vaccine science. Immunity 29: 319-324.
35. Plaks, V., T. Birnberg, T. Berkutzki, S. Sela, A. BenYashar, V. Kalchenko, G. Mor, E. Keshet, N. Dekel, M. Neeman, and S. Jung. 2008. Uterine DCs are crucial for decidua formation during embryo implantation in mice. J. Clin. Invest. 118: 3954-3965.
36. Park, S. K., W. S. Yang, S. K. Lee, H. Ahn, J. S. Park, O. Hwang, and J. D. Lee. 2000. TGF-beta(1) down-regulates inflammatory cytokine-induced VCAM-1 expression in cultured human glomerular endothelial cells. Nephrol. Dial. Transplant. 15: 596-604.
37. Gamble, J. R., and M. A. Vadas. 1991. Endothelial cell adhesiveness for human T lymphocytes is inhibited by transforming growth factor-beta 1. J. Immunol. 146: 1149-1154.
38. Kabashima, K., T. A. Banks, K. M. Ansel, T. T. Lu, C. F. Ware, and J. G. Cyster. 2005. Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity 22: 439-450. (Pubitemid 40545110)
39. Asselin-Paturel, C., G. Brizard, J. J. Pin, F. Brière, and G. Trinchieri. 2003. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J. Immunol. 171: 6466-6477. (Pubitemid 37532075)
40. Garside, P., E. Ingulli, R. R. Merica, J. G. Johnson, R. J. Noelle, and M. K. Jenkins. 1998. Visualization of specific B and T lymphocyte interactions in the lymph node. Science 281: 96-99. (Pubitemid 28354051)
41. Okada, T., M. J. Miller, I. Parker, M. F. Krummel, M. Neighbors, S. B. Hartley, A. O'Garra, M. D. Cahalan, and J. G. Cyster. 2005. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol. 3: e150. (Pubitemid 41032214)
42. Gorelik, L., K. Gilbride, M. Dobles, S. L. Kalled, D. Zandman, and M. L. Scott. 2003. Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells. J. Exp. Med. 198: 937-945.
43. Pape, K. A., A. Khoruts, A. Mondino, and M. K. Jenkins. 1997. Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells. J. Immunol. 159: 591-598.
44. Kojima, M., S. Nakamura, Y. Morishita, H. Itoh, K. Yoshida, Y. Ohno, T. Oyama, S. Asano, T. Joshita, S. Mori, et al. 2000. Reactive follicular hyperplasia in the lymph node lesions from systemic lupus erythematosus patients: a clinicopathological and immunohistological study of 21 cases. Pathol. Int. 50: 304-312.
45. Ruan, J., E. Hyjek, P. Kermani, P. J. Christos, A. T. Hooper, M. Coleman, B. Hempstead, J. P. Leonard, A. Chadburn, and S. Rafii. 2006. Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkin's lymphoma. Clin. Cancer Res. 12: 5622-5631.
46. Lenz, G., G. Wright, S. S. Dave, W. Xiao, J. Powell, H. Zhao, W. Xu, B. Tan, N. Goldschmidt, J. Iqbal, et al; Lymphoma/Leukemia Molecular Profiling Project. 2008. Stromal gene signatures in large-B-cell lymphomas. N. Engl. J. Med. 359: 2313-2323.
47. Saria, A., and J. M. Lundberg. 1983. Evans blue fluorescence: quantitative and morphological evaluation of vascular permeability in animal tissues. J. Neurosci. Methods 8: 41-49. (Pubitemid 13083017)