Diastereoisomeric analogues of gramicidin S: Structure, biological activity and interaction with lipid bilayers

Biochemical Journal

Volumn 349, Issue 3, 2000, Pages 747-755

  Jelokhani Niaraki, Masood ^a   Kondejewski, Leslie H ^a   Farmer, Susan W ^b   Hancock, Robert E W ^b   Kay, Cyril M ^a   Hodges, Robert S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Antimicrobial cyclic peptides; CD spectroscopy; Peptide phospholipid vesicle interaction; Structure function relationships; sheet turn conformation

Indexed keywords

AMINO ACID; CYCLOPEPTIDE; DRUG ANALOG; GRAMICIDIN S; LEUCINE; LYSINE; PHOSPHOLIPID; PROLINE; TRIFLUOROETHANOL; TYROSINE; VALINE;

AMINO ACID SUBSTITUTION; ANTIMICROBIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CELL VACUOLE; CIRCULAR DICHROISM; DIASTEREOISOMER; DRUG ACTIVITY; DRUG COMPARISON; DRUG INTERACTION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIPID BILAYER; MICELLE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 0034254229     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3490747     Document Type: Article

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