Sustained hypercapnia induces cerebral microvascular degeneration in the immature brain through induction of nitrative stress

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 298, Issue 6, 2010, Pages

  Honoré, Jean Claude ^a,b   Kooli, Amna ^a,c   Hou, Xin ^a   Hamel, David ^a,b   Rivera, José Carlos ^a,b   Picard, Émilie ^a,b   Hardy, Pierre ^a,b   Tremblay, Sophie ^a   Varma, Daya R ^c   Jankov, Robert P ^d   Mancini, Joseph A ^a   Balazy, Michael ^e   Chemtob, Sylvain ^a,b,c  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Brain microvasculature; Cell death; Reactive nitrogen species; Trans fatty acids

Indexed keywords

3 NITROTYROSINE; 5,10,15,20 TETRAKIS(4 SULFONATOPHENYL)PORPHYRINATO IRON; CARBON DIOXIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; IRON DERIVATIVE; LIPID; N(G) NITROARGININE METHYL ESTER; NITRATE; NITRITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD VESSEL; BRAIN DEGENERATION; BRAIN GROWTH; BRAIN MICROVASCULAR DEGENERATION; CELL CULTURE; CONTROLLED STUDY; DRUG EFFICACY; ENDOTHELIUM CELL; EX VIVO STUDY; HYPERCAPNIA; IMMUNOREACTIVITY; IN VITRO STUDY; NEWBORN; NITRATION; NITRATIVE STRESS; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TREATMENT OUTCOME;

ANIMALS; ANIMALS, NEWBORN; BRAIN; HYPERCAPNIA; NEURODEGENERATIVE DISEASES; NITRATES; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; NITROARGININE; OXYGEN; RATS; RATS, SPRAGUE-DAWLEY; TYROSINE;

EID: 77952697146     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00807.2009     Document Type: Article

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