Hypochlorite modification of sphingomyelin generates chlorinated lipid species that induce apoptosis and proteome alterations in dopaminergic PC12 neurons in vitro

Free Radical Biology and Medicine

Volumn 48, Issue 12, 2010, Pages 1588-1600

  Nusshold, Christoph ^a   Kollroser, Manfred ^a   Köfeler, Harald ^a   Rechberger, Gerald ^b   Reicher, Helga ^a   Üllen, Andreas ^a   Bernhart, Eva ^a   Waltl, Sabine ^a   Kratzer, Ingrid ^a   Hermetter, Albin ^c   Hackl, Hubert ^d   Trajanoski, Zlatko ^d   Hrzenjak, Andelko ^a   Malle, Ernst ^a   Sattler, Wolfgang ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

^c GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^d GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

2D DIGE; Chlorinative stress; Chlorohydrins; Free radicals; Glycolysis; Lipotoxicity; MPO H2O2 chloride system; Proteomics

Indexed keywords

HYPOCHLORITE; HYPOCHLOROUS ACID; MYELOPEROXIDASE; PROTEOME; REACTIVE OXYGEN METABOLITE; SPHINGOMYELIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; FEMALE; GLYCOLYSIS; IN VITRO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MODIFICATION; PROTEOMICS; RAT; TANDEM MASS SPECTROMETRY; UNINDEXED SEQUENCE;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRAIN CHEMISTRY; CELL LINE; DOPAMINE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FOURIER ANALYSIS; HALOGENATION; HYPOCHLOROUS ACID; IMAGE PROCESSING, COMPUTER-ASSISTED; LIPIDS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; NEURONS; OXIDANTS; OXIDATIVE STRESS; PROTEOME; RATS; REACTIVE OXYGEN SPECIES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPHINGOMYELINS;

EID: 77952671496     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.02.037     Document Type: Article

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