Synthesis and ligand based 3D-QSAR of 2,3-bis-benzylidenesuccinaldehyde derivatives as new class potent fptase inhibitor, and prediction of active molecules

Bulletin of the Korean Chemical Society

Volumn 31, Issue 5, 2010, Pages 1355-1360

  Soung, Min Gyu ^a   Kim, Jong Han ^b   Kwon, Byoung Mog ^c   Sung, Nack Do ^a  

^a Chungnam National University   (South Korea)

^b Unigen Inc   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

2,3 Bis benzylidenesuccinaldehydes; 3D QSAR; CoMFA; CoMSIA; FPTase inhibition activity

Indexed keywords

3D-QSAR; ACTIVE COMPOUNDS; ACTIVE MOLECULES; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE-MOLECULAR-SIMILARITY-INDICES ANALYSIS; CONTOUR MAP; DESCRIPTORS; GRAPHICAL ANALYSIS; INHIBITION ACTIVITY; INHIBITOR DESIGN; INHIBITORY ACTIVITY; PROGRESSIVE SCRAMBLING; STATISTICAL QUALITY; STERIC FACTOR; STRONG CORRELATION;

CHELATION; DIMERS; SYNTHESIS (CHEMICAL); THREE DIMENSIONAL;

ENZYME INHIBITION;

EID: 77952643433     PISSN: 02532964     EISSN: 12295949     Source Type: Journal    
DOI: 10.5012/bkcs.2010.31.5.1355     Document Type: Article

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