Polycomb group proteins as epigenetic mediators of neuroprotection in ischemic tolerance

Science Signaling

Volumn 3, Issue 111, 2010, Pages

  Stapels, Martha ^a   Piper, Chelsea ^b   Yang, Tao ^b   Li, Minghua ^b   Stowel, Cheri ^b,c   Xiong, Zhi Gang ^b   Saugstad, Julie ^b   Simon, Roger P ^b   Geromanos, Scott ^a   Langridge, James ^a   Lan, Jing Quan ^b   Zhou, An ^b  

^a WATERS CORPORATION   (United States)

^b LEGACY RESEARCH   (United States)

^c DEVERS EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR PROTEIN; POLYCOMB GROUP PROTEIN; POTASSIUM CHANNEL; BMI1 PROTEIN, MOUSE; KCNA5 PROTEIN, MOUSE; KCNAB2 PROTEIN, MOUSE; NEUROPROTECTIVE AGENT; ONCOPROTEIN; POTASSIUM CHANNEL KV1.5; REPRESSOR PROTEIN; SHAKER POTASSIUM CHANNEL; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN NERVE CELL; CONTROLLED STUDY; EPIGENETICS; ISCHEMIC PRECONDITIONING; MALE; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEOMICS; ANIMAL; C57BL MOUSE; DRUG ANTAGONISM; GENETIC EPIGENESIS; GENETICS; IN VITRO STUDY; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; BRAIN ISCHEMIA; EPIGENESIS, GENETIC; KV1.5 POTASSIUM CHANNEL; MALE; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; PROTEOMICS; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; SIGNAL TRANSDUCTION;

EID: 77952579908     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000502     Document Type: Article

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40. Acknowledgments: We thank A. White for helping with processing of mouse brain samples, S. Crawford for administrative assistance, an, anngacy Good Samaritan Foundation (A. Z.), and by a Legacy Research RAC grant (A. Z.). C. S. was supported by Discoveries in Sight of Legacy Research. Author contributions: A. Z. designed the entire project and most experiments; Z. G. X. designed electrophysiology experiments; J. L. directed the development of mass spectrometry tools; M. S., C. P., T. Y., M. L., C. S., J. Q. L., and J. A. S. performed the experiments; A. Z., M. S., Z. G. X., J. A. S., C. S., and S. G. analyzed the data; A. Z., R. P. S., Z. G. X., and J. A. S. interpreted results; and A. Z. and R. P. S. wrote the manuscript (M. S., Z. G. X., and J. A. S. wrote portions of Materials and Methods and C. P. assisted in figure preparation). None of the material has been published or is under consideration elsewhere, including the Internet. The MCAO and intracerebroventricular injection protocols used in this study were approved by the Institutional Animal Care and Use Committee of Legacy Research. All animal experiments were conducted in accordance with the NIH Guide for the Care and Use of Laboratory Animals.