Lack of association between genetic polymorphisms affecting sympathetic activity and tilt-induced vasovagal syncope

Autonomic Neuroscience: Basic and Clinical

Volumn 155, Issue 1-2, 2010, Pages 98-103

  Sorrentino, Sandro ^a   Forleo, Cinzia ^a   Iacoviello, Massimo ^a   Guida, Pietro ^a   D'Andria, Valentina ^a   Favale, Stefano ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Genetic polymorphisms; Italian study; Sympathetic nervous system; Tilt table testing; Vasovagal syncope

Indexed keywords

ALPHA 1A ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; DOPAMINE BETA MONOOXYGENASE; G PROTEIN BETA3 SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HEAD TILTING; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SYMPATHETIC TONE; SYNCOPE;

ADOLESCENT; ADULT; AGED; FEMALE; G-PROTEIN-COUPLED RECEPTOR KINASE 3; GENETIC PREDISPOSITION TO DISEASE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTURE; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, BETA-1; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SYMPATHETIC NERVOUS SYSTEM; SYNCOPE, VASOVAGAL; TILT-TABLE TEST; YOUNG ADULT;

EID: 77952545758     PISSN: 15660702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autneu.2010.01.002     Document Type: Article

References (41)

1. Abboud F.M. Neurocardiogenic syncope. N. Engl. J. Med. 328 (1993) 1117-1120
2. Brand E., Herrmann S.M., Nicaud V., Ruidavets J.B., Evans A., Arveiler D., Luc G., Plouin P.F., Tiret L., and Cambien F. The 825C/T polymorphism of the G-protein subunit ß3 is not related to hypertension. Hypertension 33 (1999) 1175-1178
3. Brignole M., Alboni P., Benditt D.G., Bergfeldt L., Blanc J.J., Thomsen P.E., van Dijk J.G., Fitzpatrick A., Hohnloser S., Janousek J., Kapoor W., Kenny R.A., Kulakowski P., Masotti G., Moya A., Raviele A., Sutton R., Theodorakis G., Ungar A., and Wieling W. Task force on syncope, European Society of Cardiology. Guidelines on management (diagnosis and treatment) of syncope - update, Executive summary. Eur. Heart. J. 25 (2004) 2054-2072
4. Brodde O.E., Bruck H., Leineweber K., and Seyfarth T. Presence, distribution and physiological function of adrenergic and muscarinic receptor subtypes in the human heart. Basic. Res. Cardiol. 96 (2001) 528-538
5. Brodde O.E., Bruck H., and Leineweber K. Cardiac adrenoceptors: physiological and pathophysiological relevance. J. Pharmacol. Sci. 100 (2006) 323-337
6. Deinum J., Steenbergen-Spanjers G.C.H., Jansen M., Boomsma F., Lenders J.V.M., van Ittersum J., and Wevers R.A. DBH gene variants that cause low plasma dopamine ß hydroxylase with or without a severe orthostatic syndrome. J. Med. Genet. 41 (2004) e38
7. Forleo C., Resta N., Sorrentino S., Guida P., Manghisi A., De Luca V., Romito R., Iacoviello M., De Tommasi E., Troisi F., Rizzon B., Guanti G., Rizzon P., and Pitzalis M.V. Association of beta-adrenergic receptor polymorphisms and progression to heart failure in patients with idiopathic dilated cardiomyopathy. Am. J. Med. 117 (2004) 451-458
8. Fortin J., Habenbacher W., Heller A., Hacker A., Grullenberger R., Innerhofer J., Passath H., Wagner C., Haitchi G., Flotzinger D., Pacher R., and Wach P. Non-invasive beat-to-beat cardiac output monitoring by an improved method of transthoracic bioimpedance measurement. Comput. Biol. Med. 36 (2006) 1185-1203
9. Gerra G., Garofano L., Zaimovic A., Moi G., Branchi B., Bussandri M., Brambilla F., and Donnini C. Association of the serotonin transporter promoter polymorphism with smoking behavior among adolescents. Am. J. Med. Genet. B Neuropsychiatr. Genet. 135B (2005) 73-78
10. Gratze G., Fortin J., Holler A., Grasenick K., Pfurtscheller G., Wach P., Schönegger J., Kotanko P., and Skrabal F. A software package for non-invasive, real-time beat-to-beat monitoring of stroke volume, blood pressure, total peripheral resistance and for assessment of autonomic function. Comput. Biol. Med. 28 (1998) 121-142
11. Haworth C.M.A., Butcher L.M., Docherty S.J., Wardle J., and Plomin R. No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins. BMC Med. Genet. 27 (2008) 9-12
12. Heils A., Teufel A., Petri S., Stober G., Riederer P., Bengel D., and Lesch K.P. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 66 (1996) 2621-2624
13. Hess C., Reif A., Strobel A., Boreatti-Hummer A., Heine M., Lesch K.P., and Jacob C.P. A functional dopamine-beta-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders. J. Neural. Transm. 116 (2009) 121-130
14. Hsu J.W., Wang Y.C., Lin C.C., Bai Y.M., Chen J.Y., Chiu H.J., Tsai S.J., and Hong C.J. No evidence for association of alpha 1a adrenoceptor gene polymorphism and clozapine-induced urinary incontinence. Neuropsychobiology 42 (2000) 62-65
15. Iacoviello M., Forleo C., Sorrentino S., Romito R., De Tommasi E., Lucarelli K., Guida P., and Pitzalis M.V. Alpha- and beta-adrenergic receptor polymorphisms in hypertensive and normotensive offspring. J. Cardiovasc. Med. (Hagerstown) 7 (2006) 316-321
16. Iacoviello M., Guida P., Forleo C., Sorrentino S., D'Alonzo L., and Favale S. Impaired arterial baroreflex function before nitrate-induced vasovagal syncope during head-up tilt test. Europace 10 (2008) 1170-1175
17. Kemper C.M., O'connor D.T., and Westlund K.N. Immunocytochemical localization of dopamine-ß-hydroxylase in neurons of the human brain stem. Neuroscience 23 (1987) 981-989
18. Kirstein S.I., and Insel P.A. Autonomic nervous system pharmacogenomics: a progress report. Pharmacol. Rev. 56 (2004) 31-52
19. Lelonek M., Pietrucha T., Matyjaszczyk M., and Goch J.H. Mutation T/C, Ile 131 of the gene encoding the alfa subunit of the human Gs protein and predisposition to vasovagal syncope. Circ. J. 72 (2008) 558-562
20. Lelonek M., Pietrucha T., Matyjaszczyk M., and Goch J.H. A novel approach to syncopal patients: association analysis of polymorphisms in G-protein genes and tilt outcome. Europace 11 (2009) 89-93
21. Lelonek M., Pietrucha T., Matyjaszczyk M., and Goch J.A. Polymorphism C1114G of gene encoding the cardiac regulator of G-protein signaling 2 may be associated with number of episodes of neurally mediated syncope. Arch. Med. Res. 40 (2009) 191-195
22. Lelonek M., Pietrucha T., Matyjaszczyk M., and Goch J.A. Genetic insight into syncopal tilted population with severe clinical presentation. Auton. Neurosci. 147 (2009) 97-100
23. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Müller C.R., Hamer D.H., and Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1531
24. Levin M.C., Marullo S., Muntaner O., Andersson B., and Magnusson Y. The myocardium-protective Gly-49 variant of the beta 1-adrenergic receptor exhibits constitutive activity and increased desensitization and down-regulation. J. Biol. Chem. 277 (2002) 30429-30435
25. Màrquez M.F., Urias K.I., Hermosillo A.G., Jardòn J.L., Iturralde P., Colìn L., Nava S., and Càrdenas M. Familial vasovagal syncope. Europace 7 (2005) 472-474
26. 1-adrenergic receptor gene polymorphism and susceptibility to faint during head-up tilt test. Europace 9 (2007) 585-588
27. Mason D.A., Moore J.D., Green S.A., and Liggett S.B. A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. J. Biol. Chem. 274 (1999) 12670-12674
28. Mathias C.J., Deguchi K., Bleasdale-Barr K., and Kimber J.R. Frequency of family history in vasovagal syncope. Lancet 352 (1998) 33-34
29. Newton J.L., Kerr S., Pairman J., McLaren A., Norton M., Kenny R.A., and Morris C.M. Familial neurocardiogenic (vasovagal) syncope. Am. J. Med. Genet. 133A (2005) 176-179
30. Newton J.L., Donaldson P., Parry S., Kenny R.A., Smith J., Gibson A.M., and Morris C. Angiotensin converting enzyme insertion/deletion polymorphisms in vasovagal syncope. Europace 7 (2005) 396-399
31. Olde Nordkamp L.R.A., Wieling W., Zwinderman A.H., Wilde A.A., and van Dijk N. Genetic aspects of vasovagal syncope: a systematic review of current evidence Europace. 11 (2009) 414-420
32. Rathz D.A., Brown K.M., Kramer L.A., and Liggett S.B. Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking. J. Cardiovasc. Pharmacol. 39 (2002) 155-160
33. Ross O.A., Heckman M.G., Soto A.I., Diehl N.N., Haugarvoll K., Vilariño-Güell K., Aasly J.O., Sando S., Gibson J.M., Lynch T., Krygowska-Wajs A., Opala G., Barcikowska M., Czyzewski K., Ryan U.J., Wszolek Z.K., and Farrer M.J. Dopamine β-hydroxylase -1021C>T association and Parkinson's disease. Parkinsonism Relat. Disord. 14 (2008) 544-547
34. Saadjian A.H., Gerolami V., Giorgi R., Mercier L., Berge-Lefranc J.L., Paganelli F., Ibrahim Z., By Y., Guéant J.L., Lévy S., and Guieu R.P. Head-up tilt induced syncope and adenosine A2A receptor gene polymorphism. Eur. Heart J. 30 (2009) 1510-1515
35. 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy. Br. J. Pharmacol. 118 (1996) 1403-1408
36. Siffert W., Rosskopf D., Siffert G., Busch S., Moritz A., Erbel R., Sharma A.M., Ritz E., Wichmann H.E., Jakobs K.H., and Horsthemke B. Association of a human G-protein beta3 subunit variant with hypertension. Nat. Genet. 18 (1998) 45-48
37. Snapir A., Koshenvuo J., Toikka J., Orho-Melander M., Hinkka S., and Saraste M. Effects of common polymorphisms in the alpha1A-, alpha2B-, beta1- and beta2-adrenoreceptors on haemodynamic responses to adrenaline. Clin. Sci. (Lond.) 104 (2003) 509-520
38. Sorrentino S., Forleo C., Iacoviello M., Guida P., D'Andria V., and Favale S. Endothelin system polymorphisms in tilt test-induced vasovagal syncope. Clin. Auton. Res. 19 (2009) 123-129
39. Xie H.G., Kim R.B., Stein C.M., Gainer J.V., Brown N.J., and Wood A.J. Alpha1A-adrenergic receptor polymorphism: association with ethnicity but not essential hypertension. Pharmacogenetics 9 (1999) 651-656
40. Weinshilboum R.M. Serum dopamine beta-hydroxylase. Pharmacol. Rev. 30 (1978) 133-166
41. Zabetian C.P., Anderson G.M., Buxbaum S.G., Elston R.C., Ichinose H., Nagatsu T., Kim K.S., Kim C.H., Malison R.T., Gelernter J., and Cubells J.F. A quantitative-trait analysis of human plasma-dopamine ß-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus. Am. J. Hum. Genet. 68 (2001) 515-522