Polymorphism C1114G of Gene Encoding the Cardiac Regulator of G-Protein Signaling 2 May Be Associated with Number of Episodes of Neurally Mediated Syncope

Archives of Medical Research

Volumn 40, Issue 3, 2009, Pages 191-195

  Lelonek, Malgorzata ^a   Pietrucha, Tadeusz ^a   Matyjaszczyk, Monika ^a   Goch, Jan Henryk ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Gene polymorphism; RGS2; Syncope; Tilting

Indexed keywords

GENOMIC DNA; GLYCERYL TRINITRATE; RGS2 PROTEIN;

ADULT; ARTICLE; BLOOD CELL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC TRAIT; GENOTYPE; HEART RATE; HETEROZYGOTE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NEURALLY MEDIATED SYNCOPE; REGRESSION ANALYSIS; SYNCOPE; SYSTOLIC BLOOD PRESSURE; TILTING; VASOCONSTRICTION;

ADULT; FEMALE; GENOTYPE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RGS PROTEINS; SYNCOPE; TILT-TABLE TEST;

EID: 67349145974     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2009.02.005     Document Type: Article

References (29)

1. Newton J.L., Kenny R., Lawson J., Frearson R., and Donaldson P. Prevalence of familial history in vasovagal syncope and haemodynamic response to head up tilt in first degree relatives. Clin Auton Res 13 (2003) 22-26
2. Marquez M.F., Urias K.I., Hermosillo A.G., et al. Familial vasovagal syncope. Europace 7 (2005) 472-474
3. Newton J.L., Kerr S., Pairman J., et al. Familial neurocardiogenic (vasovagal) syncope. Am J Med Genet A 133 (2005) 176-179
4. Camfield P.R., and Camfield C. Syncope in childhood: a case control clinical study of the family tendency to faint. Can J Neurol Sci 17 (1990) 306-308
5. Marquez M.F., Hernandez-Pacheco G., Hermosillo A.G., Gomez J.R., Cardenas M., and Vargas-Alarcon G. The Arg389Gly β1-adrenergic receptor gene polymorphism and susceptibility to faint during head-up tilt test. Europace 9 (2007) 585-588
6. Lelonek M., Pietrucha T., Stanczyk A., and Goch J.H. Vasovagal syncope patients and the C825T GNB3 polymorphism. Anadolu Kardiyol Derg 7 Suppl.1 (2007) 206-208
7. Lelonek M., Pietrucha T., Matyjaszczyk M., and Goch J.H. Mutation T/C,Ile 131 of the gene encoding the alfa subunit of the human Gs protein and predisposition to vasovagal syncope. Circ J 72 (2008) 558-562
8. Riddle E.L., Schwartzman R.A., Bond M., and Insel P.A. Multi-tasking RGS proteins in the heart: the next therapeutic target?. Circ Res 96 (2005) 401-411
9. Wieland T., and Mittmann C. Regulators of G-protein signaling: multifunctional proteins with signaling the cardiovascular system. Pharmacol Ther 97 (2003) 95-115
10. Bourne H.R. How receptors talk to trimeric G proteins. Curr Opin Cell Biol 9 (1997) 134-142
11. Kehrl J.H., and Sinnarajah S. RGS2: a multifunctional regulator of G-protein signaling. Int J Biochem Cell Biol 34 (2002) 432-438
12. Salim S., Sinnarajah S., Kehrl J., and Dessauer C.W. Identification of RGS2 and type V adenylyl cyclase interaction sites. J Biol Chem 278 (2003) 15842-15849
13. Semplicini A., Lenzini L., Sartori M., et al. Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotension II. J Hypertens 24 (2006) 1115-1124
14. Quan K.J., Carlson M.D., and Thames M.C. Mechanisms of heart rate and arterial blood pressure control: implications for the pathophysiology of neurocardiogenic syncope. Pacing Clin Electrophysiol 20 (1997) 764-774
15. Del Rosso A., Bartoli P., Bartoletti A., et al. Shortened head-up tilt testing potentiated with sublingual nitroglycerin in patients with unexplained syncope. Am Heart J 135 (1998) 564-570
16. Brignole M., Alboni P., Benditt D., et al. Guidelines on management (diagnosis and treatment) of syncope-update 2004. Executive summary. Eur Heart J 25 (2004) 2054-2072
17. Li Y., Hashim S., and Anand-Srivastava M.B. Angiotensin II-evoked enhanced expression of RGS2 attenuates Gi-mediated adenylyl cyclase signaling in A10 cells. Cardiovasc Res 66 (2005) 503-511
18. Gu S., Anton A., Salim S., Blumer K.J., Dessauer C.W., and Heximer S.P. Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins. Mol Pharmacol 73 (2008) 1-11
19. Roy A.A., Baragli A., Bernstein L.S., Hepler J.R., Hebert T.E., and Chidiac P. RGS2 interacts with Gs and adenylyl cyclase in living cells. Cell Signal 18 (2006) 336-348
20. Salim S., and Dessauer C.W. Analysis of the interaction between RGS2 and adenylyl cyclase. Methods Enzymol 390 (2004) 83-99
21. Tang K.M., Wang G., Ping L., et al. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med 9 (2003) 2506-2512
22. Heximer S.P., Knutsen R.H., Sun X., et al. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest 111 (2003) 445-452
23. Yang J., Kamide K., Kokubo Y., et al. Genetic variation of regulator of G-protein signaling 2 in hypertensive patients and in the general population. J Hypertens 23 (2005) 1497-1505
24. Grant S.L., Lasségue B., Griendling K.K., Ushio-Fukai M., Lyons P.R., and Alexander R.W. Specific regulation of RGS2 messenger RNA by angiotensin II in cultured vascular smooth muscle cells. Mol Pharmacol 57 (2000) 460-467
25. Sun X., Kaltenbronn K.M., Steinberg T.H., and Blumer K.J. RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling. Mol Pharmacol 67 (2005) 631-639
26. Gross V., Tank J., Obst M., et al. Autonomic nervous system and blood pressure regulation in RGS2-deficient mice. Am J Physiol Regul Integr Comp Physiol 288 (2005) R1134-R1142
27. Lelonek M., Pietrucha T., Matyjaszczyk M., and Goch J.H. C825T G-protein β3 subunit gene polymorphism, tilt test results and point score in syncopal patients. Clin Auton Res 18 (2008) 158-161
28. Newton J.L., Donaldson P., Parry S., et al. Angiotensin converting enzyme insertion/deletion polymorphisms in vasovagal syncope. Europace 7 (2005) 396-399
29. Sartori M., Ceolotto G., Dorigatti F., et al. RGS2 C1114G polymorphism and body weight gain in hypertensive patients. Metabolism 57 (2008) 421-427