Genetic insight into syncopal tilted population with severe clinical presentation

Autonomic Neuroscience: Basic and Clinical

Volumn 147, Issue 1-2, 2009, Pages 97-100

  Lelonek, Malgorzata ^a   Pietrucha, Tadeusz ^a   Matyjaszczyk, Monika ^a   Goch, Jan Henryk ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

G proteins; Gene polymorphism; Malignant syncope; Tilting

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN BETA 3 SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; RGS2 PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; FRACTURE; GENE FREQUENCY; GENETIC ANALYSIS; GENOTYPE; HUMAN; INJURY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; POPULATION RESEARCH; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SYNCOPE; TILTING;

ADULT; AUTONOMIC NERVOUS SYSTEM DISEASES; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENOTYPE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GTP-BINDING PROTEINS; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MALE; MIDDLE AGED; MUTATION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; RGS PROTEINS; SIGNAL TRANSDUCTION; SYNCOPE, VASOVAGAL; YOUNG ADULT;

EID: 64649098040     PISSN: 15660702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autneu.2009.01.011     Document Type: Article

References (24)

1. Brignole M., Alboni P., Benditt D., Bergfeldt L., Blanc J.J., Bloch Thomsen P.E., et al. Guidelines on management (diagnosis and treatment) of syncope-update 2004. Executive summary. Eur. Heart J. 25 (2004) 2054-2072
2. Camfield P.R., and Camfield C. Syncope in childhood: a case control clinical study of the family tendency to faint. Can. J. Neurol. Sci. 17 (1990) 306-308
3. Del Rosso A., Bartoli P., Bartoletti A., Brandinelli-Geri A., Bonechi F., Maioli M., et al. Shortened head-up tilt testing potentiated with sublingual nitroglycerin in patients with unexplained syncope. Am. Heart J. 135 (1998) 564-570
4. Hernandez-Pacheco G., Serrano H., Marquez M.F., Hermosillo A.G., Perez-Vielma N., Sotomayor A., et al. Genetic study of the vasovagal syncope associated to the Arg389Gly polymorphism of the beta1 adrenergic receptor. Arch. Cardiol. Mex. 78 (2008) 134-138
5. Jia H., Hingorani A.D., Sharma P., Hopper R., Dickerson C., Trutwein D., et al. Association of the Gsα gene with essential hypertension and response to B-blockade. Hypertension (1999) 34:8-14
6. Lelonek M., Pietrucha T., Stanczyk A., and Goch J.H. Vasovagal syncope patients and the C825T GNB3 polymorphism. Anadolu Kardiyol. Derg. 7 Suppl.1 (2007) 206-208
7. Lelonek M., Pietrucha T., Matyjaszczyk M., and Goch J.H. Mutation T/C,Ile 131 of the gene encoding the alfa subunit of the human Gs protein and predisposition to vasovagal syncope. Circ. J. 72 (2008) 558-562
8. Lelonek M., Pietrucha T., Matyjaszczyk M., and Goch J.H. C825T G-protein β3 subunit gene polymorphism, tilt test results and point score in syncopal patients. Clin. Auton. Res. 18 (2008) 158-161
9. Marquez M.F., Urias K.I., Hermosillo A.G., Jardon J.L., Iturralde P., Colin L., et al. Familial vasovagal syncope. Europace 7 (2005) 472-474
10. Marquez M.F., Hernandez-Pacheco G., Hermosillo A.G., Gomez J.R., Cardenas M., and Vargas-Alarcon G. The Arg389Gly B1-adrenergic receptor gene polymorphism and susceptibility to faint during head-up tilt test. Europace 9 (2007) 585-588
11. Newton J.L., Kenny R., Lawson J., Frearson R., and Donaldson P. Prevalence of familial history in vasovagal syncope and haemodynamic response to head up tilt in first degree relatives. Clin. Auton. Res. 13 (2003) 22-26
12. Newton J.L., Kerr S., Pairman J., McLaren A., Norton M., Kenny R.A., et al. Familial neurocardiogenic (vasovagal) syncope. Am. J. Med. Genet. A 133 (2005) 176-179
13. Quan K.J., Carlson M.D., and Thames M.C. Mechanisms of heart rate and arterial blood pressure control: implications for the pathophysiology of neurocardiogenic syncope. Pacing Clin. Electrophysiol. 20 (1997) 764-774
14. Rosskopf D., Busch S., Manthey I., and Siffert W. G protein B3 gene. Structure, promoter, and additional polymorphisms. Hypertension 36 (2000) 33-41
15. Rosskopf D., Koch K., Habich C.h., Geerdes J., Ludwig A., Wilhelms S., et al. Iteraction of Gβ3s, a splice variant of the G-protein Gβ3, with Gγ and Gα-proteins. Cell Signal 15 (2003) 479-688
16. Roy A.A., Baragli A., Bernstein L.S., Hepler J.R., Hebert T.E., and Chidiac P. RGS2 interacts with Gs and adenylyl cyclase in living cells. Cell Signal 18 (2006) 336-348
17. Semplicini A., Lenzini L., Sartori M., Papparella I., Calo L.A., Pagnin E., et al. Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II. J. Hypertens. 24 (2006) 1115-1124
18. Siffert W., Rosskopf D., Moritz A., Wieland T., Kaldenberg-Stasch G., Kettler N., et al. Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension. J. Clin. Invest. 96 (1995) 759-766
19. Siffert W., Rosskopf D., Siffert G., Busch S., Moritz A., Erbel R., et al. Association of a human G-protein beta3 subunit variant with hypertension. Nat. Genet. 18 (1998) 45-48
20. Siffert W., Forster P., Jöckel K.H., Mvere D.A., Brinkmann B., Naber C.h., et al. Worldwide ethnic distribution of the G protein B3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J. Am. Soc. Nephrol. 10 (1999) 1921-1930
21. Strickberger S.A., Benson W., Biaggioni I., Callans D.J., Vohen M.I., Ellenbogen K., et al. AHA/ACCF scientific statement on the evaluation of syncope. Circulation 113 (2006) 316-327
22. Tabara Y., Kohara K., and Miki T. Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hypotension. J Hypertens 20 (2002) 651-656
23. Tang K.M., Wang G., Ping L., Karas R.H., Aronovitz M., Heximer S.P., et al. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat. Med. 9 (2003) 1506-1512
24. Wieland T., and Mittmann C. Regulators of G-protein signaling: multifunctional proteins with signaling the cardiovascular system. Pharmacol. Ther. 97 (2003) 95-115