Evidence of oxidative stress and associated DNA damage, increased proliferative drive, and altered gene expression in rat liver produced by the cholangiocarcinogenic agent Furan

Toxicologic Pathology

Volumn 38, Issue 2, 2010, Pages 230-243

  Hickling, K C ^a   Hitchcock, J M ^b   Oreffo, V ^a   Mally, A ^c   Hammond, T G ^a   Evans, J G ^a   Chipman, J K ^d  

^a ASTRAZENECA   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Animal model cholangiofibrosis; DNA damage; Liver; Oxidative stress

Indexed keywords

CONNEXIN 32; CYTOCHROME P450 2E1; DNA; FURAN; OXYGEN RADICAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT CARCINOMA; BILE DUCT DISEASE; CELL CYCLE REGULATION; CHOLANGIOFIBROSIS; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION REGULATION; GENE MUTATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER NECROSIS; LIVER PARENCHYMA; MALE; METAPLASIA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BILE DUCTS; CARCINOGENICITY TESTS; CARCINOGENS; CELL PROLIFERATION; CYTOCHROME P-450 CYP2E1; DEOXYGUANOSINE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FURANS; GENE EXPRESSION; HEPATOCYTES; LIVER; LIVER CIRRHOSIS; MALE; METAPLASIA; OXIDATIVE STRESS; RATS;

ANIMALIA; RATTUS;

EID: 77952538111     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623309357946     Document Type: Article

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