Induction and progression of cholangiofibrosis in rat liver injured by oral administration of furan

Toxicologic Pathology

Volumn 38, Issue 2, 2010, Pages 213-229

  Hickling, K C ^a   Hitchcock, J M ^b   Chipman, J K ^c   Hammond, T G ^a   Evans, J G ^a  

^a ASTRAZENECA   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Cholangiofibrosis; Furan; Rat

Indexed keywords

FURAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT CARCINOMA; BILE DUCT DISEASE; CHOLANGIOFIBROSIS; CONTROLLED STUDY; EPITHELIUM CELL; FIBROBLAST; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER INJURY; LIVER PARENCHYMA; MALE; MESENCHYME CELL; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; BILE DUCTS; CARCINOGENS; CELL PROLIFERATION; DISEASE PROGRESSION; DRUG-INDUCED LIVER INJURY; EPITHELIAL CELLS; FURANS; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS; RODENTIA; ZEA MAYS;

EID: 77952497141     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623309357945     Document Type: Article

References (60)

1. Alison, M. (1998). Liver stem cells: a two compartment system. Curr Opin Cell Biol 10, 710-715
2. Alison, M., Golding, M., Elnasir, L., Nagy, P., Thorgeirsson, S., and Sarraf, C. (1997). Wholesale hepatocytic differentiation in the rat from ductular oval cells, the progeny of biliary stem cells. J Hepatol 26, 343-352
3. Barker, T. H., Pallero, M. A., MacEwen, M. W., Tilden, S. G., Woods, A., Murphy-Ullrich, J. E., & Hagood, J. S. (2004). Thrombospondin- 1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and Src activation. J. of Bio Chem 279, 23510-23516
4. Bannasch, P. (1996). Pathogenesis of hepatocellular carcinoma: sequential cellular, molecular, and metabolic changes. Prog Liver Dis 14, 161-197
5. Bannasch, P., and Reiss, W. (1971). Histogenesis and cytogenesis of cholangiocellular tumors in nitrosomorpholine-intoxicated rats. A contribution to the morphogenesis of polycystic disease of the liver. Zeitschrift fur Krebsforschung und Klinische Onkologie - Cancer Research & Clinical Oncology 76, 193-215.
6. Beaulieu, J. F. (1997). Extracellular matrix components and integrins in relationship to human intestinal epithelial cell differentiation. Prog Histochem Cytochem 31, 1-78.
7. Beaulieu, J. F., and Vachon, P. H. (1994). Reciprocal expression of laminin A- chain isoforms along the crypt-villus axis in the human small intestine. Gastroenterology 106, 829-839
8. Benyon, R. C., and Arthur, M. J. (1998). Mechanisms of hepatic fibrosis. JPediatr Gastroenterol Nutr 27, 75-85.
9. Bhunchet, E., and Wake, K. (1992). Role of mesenchymal cell populations in porcine serum-induced rat liver fibrosis. Hepatology 16, 452-473
10. Bucala, R., Spiegel, L. A., Chesney, J., Hogan, M., and Cerami, A. (1994). Circulating fibrocytes define a new leGBRocyte subpopulation that mediates tissue repair. Molecular Medicine 1, 71-81.
11. Cassiman, D., Libbrecht, L., Desmet, V., Denef, C., and Roskams, T. (2002). Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. J Hepatol 36, 200-209
12. De Maio, A., Vega, V. L., and Contreras, J. E. (2002). Gap junctions, homeostasis, and injury. J Cell Physiol 191, 269-282
13. Dunsford, H. A., and Sell, S. (1989). Production of monoclonal antibodies to preneoplastic liver cell populations induced by chemical carcinogens in rats and to transplantable Morris hepatomas. Cancer Res 49, 4887-4893
14. Erickson, A. C., and Bacellos-Hoff, M. H. (2003). The not-so innocent bystander: the microenvironment as a therapaeutic target in cancer. Expert Opin Ther Targets 7, 71-88.
15. Evans, J. G. (1983). Studies on the Pathogenesis of Cholangiofibrosis and Its Significance as a Preneoplastic Lesion. The Royal Veterinary College, University of London.
16. Farber, E. (1956). Similarities in the sequence of early histological changes induced in the livers of rats by ethionine, 2-acetylaminofluorine and 3-methyl-4-dimethylaminoazobenzene. Cancer Res 16, 142-148
17. Goldsworthy, T. L., Hanigan, M. H., and Pitot, H. C. (1986). Models of hepato carcinogenesis in the rat - contrasts and comparisons. Crit Rev Toxicol 17, 61-89.
18. Hagios, C., Lochter, A., and Bissell, M. J. (1998). Tissue architecture: the ultimate regulator of epithelial function? Philosophical Transactions of the Royal Society of London - Series B: Biological Sciences 353, 857-870
19. Hickling, K. C., Hitchcock, J. M., Oreffo, V., Mally, A., Hammond, T. G., Evans, J. G., and Chipman J. K. (2010). Evidence ofoxidative stress and associated DNA damage, increased proliferative drive and altered gene expression in rat liver produced by the cholangiocarcinogenic agent furan. Toxicol Pathol.
20. Hitchcock, J. M. (2003). Toward a Molecular Characterisation ofFuran Induced Cholangiocarcinoma in the Rat. School of Biosciences, University of Birmingham, GBR.
21. Hoppo, T., Fujii, H., Hirose, T., Yasuchika, K., Azuma, H., Baba, S., Naito, M., Machimoto, T., & Ikai, I. (2004). Thy1-Positive Mesenchymal Cells Promote the Maturation of CD49f-Positive Hepatic Progenitor Cells in the Mouse Fetal Liver. Hepatology 39, 1362-1370
22. Jamison, K. C., Larson, J. L., Butterworth, B. E., Harden, R., Skinner, B. L., and Wolf, D. C. (1996). A non-bile duct origin for intestinal crypt-like ducts with periductular fibrosis induced in livers of F344 rats by chloroform inhalation. Carcinogenesis 17, 675-682
23. Jankowski, J. A., Wright, N. A., Meltzer, S. J., Triadafilopoulos, G., Geboes, K., Casson, A. G., Kerr, D., and Young, L. S. (1999). Molecular evolution of the metaplasia-dysplasia-adenocarcinoma sequence in the esophagus. Am JPathol 154, 965-973
24. Jhandier, M. N., Kruglov, E. A., Lavoie, E. G., Sevigny, J., and Dranoff, J. A. (2005). Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2. JBiol Chem 7, 22986-22992
25. Kalluri, R., and Zeisberg, M. (2006). Fibroblasts in cancer. Nat Rev Cancer 6, 392-401.
26. Kim, T.-H., Mars, W. M., Stolz, D. B., Petersen, B. E., & Michalopoulos, G. K. (1997). Extracellular matrix remodeling at the early stages of liver regeneration in the rat. Hepatology 26, 896-904.
27. Knittel, T., Kobold, D., Piscaglia, F., Saile, B., Neubauer, K., Mehde, M., Timpl, R., and Ramadori, G. (1999). Localisation of liver myofibroblasts and hepatic stellate cells in normal and diseased livers: Distinct roles of (myo-) fibrobast subpoulations in hepatic tissue repair. Histochemistry and Cell Biology 112, 387-KU.
28. Koumas, L., Smith, T. J., Feldon, S., Blumberg, N., and Phipps, R. P. (2003). Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes. Am J Pathol 163, 1291-1300.
29. Maronpot, R. R., Giles, H. D., Dykes, D. J., and Irwin, R. D. (1991). Furan- induced hepatic cholangiocarcinomas in Fischer 344 rats. Toxicol Pathol 19, 561-570
30. Martinez-Hernandez, A., and Amenta, P. S. (1993). The hepatic extracellular matrix I. Components and distribution in normal liver. Virchows Archiv A. Pathological Anatomy and Histopathology 423, 1-11.
31. Michalopoulos, G. K., and De Frances, M. C. (1997). Liver regeneration. Science 4, 60-66.
32. Miller, K. D. (2002). Immunohistochemical techniques. In Theory and Practice of Histological Techniques (J. D. Bancroft and M. Gamble, eds.), p. 421. Churchill Livingstone, London.
33. Mueller, M. M., and Fusenig, N. E. (2004). Friends or foes - bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 4, 839-849
34. Neubauer, K., Knittel, T., Aurisch, S., Fellmer, P., and Ramadori, G. (1996). Glial fibrillary acidic protein - a cell type specific marker for Ito cells in vivo and in vitro. J Hepatol 24, 719-730
35. Nieto, N., and Cederbaum, A. I. (2003). Increased Sp1-dependent transactivation of the LAMgamma 1 promoter in hepatic stellate cells co-cultured with HepG2 cells overexpressing cytochrome P450 2E1. J Bio Chem 278, 15360-15372
36. Nieto, N., Friedman, S. L., Greenwel, P., and Cederbaum, A. I. (1999). CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells. Hepatology 30, 987-996
37. Paku, S., Nagy, P., Kopper, L., and Thorgeirsson, S. S. (2004). 2-acetylaminofluorene dose-dependent differentiation of rat oval cells into hepatocytes confocal and electron microscopic studies. Hepatology 39, 1353-1361
38. Paku, S., Schnur, J., Nagy, P., and Thorgeirsson, S. S. (2001). Origin and structural evolution of the early proliferating oval cells in rat liver. Am JPath 158, 1313-1323
39. Phan, S. H. (2003). Fibroblast phenotypes in pulmonary fibrosis. A. Journal of Respiratory Cell & Molecular Biology 29, S87-S92.
40. Powell, D. W., Mifflin, R. C., Valentich, J. D., Crowe, S. E., Saada, J. I., & West, A. B. (1999). Myofibroblasts. I. Paracrine cells important in health and disease. AJP-Cell Physiology 277, C1-19.
41. Radaeva, S., Ferreira-Gonzalez, A., and Sirica, A. E. (1999). Overexpression of C-NEU and C-MET during rat liver cholangiocarcinogenesis: a link between biliary intestinal metaplasia and mucin-producing cholangiocar- cinoma. Hepatology 29, 1453-1462
42. Ramadori, G. & Saile, B. (2002). Mesenchymal cells in the liver-One cell type or two? Liver 22, 283-294
43. Ren, P., Silberg, D. G., and Sirica, A. E. (2000). Expression of an intestine- specific transcription factor (CDX1) in intestinal metaplasia and in subsequently developed intestinal type of cholangiocarcinoma in rat liver. Am J Pathol 156, 621-627
44. Sato, M., SuzGBRi, S., and Senoo, H. (2003). Hepatic stellate cells: Unique characteristics in cell biology and phenotype. Cell Structure & Function 28, 105-112
45. Scharfinann, R. (1999). (2000). Control of early development of the pancreas in rodents and humans: Implications of signals from the mesenchyme. Diabetologia 43, 1083-1092
46. Sell, S. (1997). Electron microscopical identification of putative liver stem cell and intermediate hepatocytes following periportal necrosis induced in rats by allyl alcohol. Stem cells 15, 378-385
47. Sell, S. (2001). Heterogeneity and plasticity of hepatocyte lineage cells. Hepatology 33, 738-750
48. Simon-Assmann, P., Kedinger, M., De Arcangelis, A., Rousseau, V., and Simo, P. (1995). Extracellular matrix components in intestinal development. Experientia 51, 883-900.
49. Simon-Assmann, P., Lefebvre, O., Bellissent-Waydelich, J. O., Orian- Rousseau, V., and De Arcangelis, A. (1998). The laminins: Role in intestinal morphogenesis and differentiation. Ann NY Acad Sci 859, 46-64.
50. Sirica, A. E., Cole, S. L., and Williams, T. (1994). A unique rat model of bile ductular hyperplasia in which liver is almost totally replaced with well- differentiated bile ductules. Am J Pathol 144, 1257-1268
51. Sirica, A. E., Radaeva, S., and Caran, N. (1997). Neu overexpression in the furan rat model of cholangiocarcinogenesis compared with biliary ductal cell hyperplasia. Am J Pathol 151, 1685-1694
52. Tatematsu, M., Kaku, T., Medline, A., and Farber, E. (1985). Intestinal metaplasia as a common option of oval cells in relation to cholangio- fibrosis in liver of rats exposed to 2-acetylaminofluorene. Lab Invest 52, 354-362
53. Thomson, M. D., and Monga, S. P. (2007). WNT/beta-catenin signaling in liver health and disease. Hepatology 45, 1298-1305.
54. Tisty, T. D., and Hein, P. W. (2001). Know thy neighbor: Stromal cells can contribute oncogenic signals. Curr Opin Genet Dev 11, 54-59.
55. Trudgill, N. J., Suvarna, S. K., Royds, J. A., and Riley, S. A. (2003). Cell cycle regulation in patients with intestinal metaplasia at the gastro-oesophageal junction. Mol Pathol 56, 313-317
56. Wells, R. G., Kruglov, E., & Dranoff, J. A. (2004). Autocrine release of TGF-b by portal fibroblasts regulates cell growth. FEBS Letters 559, 107-110
57. Vogelstein, B., and Kinzler, K. W. (1993). The multistep nature of cancer. Trends in Genetics 9, 138-141
58. Yin, L., Lynch, D., and Sell, S. (1999). Participation of different cell types in the restitutive response of the rat liver to periportal injury induced by allyl alcohol. J Hepatol 31, 497-507.
59. Yuasa, Y. (2003). Control of gut differentiation and intestinal-type gastric carcinogenesis. Nat Rev Cancer 3, 592-600.
60. Zhou, Y., Hagood, J. S., & Murphy-Ullrich, J. E. (2004). Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuli. A. Journal of Path 165, 659-669