-
1
-
-
34250322596
-
Evolution at the system level: The natural history of protein interaction networks
-
Stumpf MP, Kelly WP, Thorne T, Wiuf C. Evolution at the system level: the natural history of protein interaction networks. Trends Ecol Evol 2007;22(7):366-373.
-
(2007)
Trends Ecol Evol
, vol.22
, Issue.7
, pp. 366-373
-
-
Stumpf, M.P.1
Kelly, W.P.2
Thorne, T.3
Wiuf, C.4
-
2
-
-
3042721988
-
Back to the biology in Systems Biology: What can we learn from biomolecular networks?
-
Huang S. Back to the biology in Systems Biology: what can we learn from biomolecular networks? Brief Funct Genomic Proteomic 2004;2(4):279-297.
-
(2004)
Brief Funct Genomic Proteomic
, vol.2
, Issue.4
, pp. 279-297
-
-
Huang, S.1
-
3
-
-
34248211750
-
The art and practice of Systems Biology in medicine: Mapping patterns of relationships
-
van der Greef J, Martin S, Juhasz P, et al. The art and practice of Systems Biology in medicine: mapping patterns of relationships. J Proteome Res 2007;6(4):1540-1559.
-
(2007)
J Proteome Res
, vol.6
, Issue.4
, pp. 1540-1559
-
-
Van Der Greef, J.1
Martin, S.2
Juhasz, P.3
-
4
-
-
34547969327
-
Adjoint systems for models of cell signaling pathways and their application to parameter fitting
-
Fujarewicz K, Kimmel M, Lipniacki T, Swierniak A. Adjoint systems for models of cell signaling pathways and their application to parameter fitting. IEEE/ACM transactions on computational biology and bioinformatics/IEEE, ACM 2007;4(3):322-335.
-
(2007)
IEEE/ACM Transactions on Computational Biology and Bioinformatics/IEEE, ACM
, vol.4
, Issue.3
, pp. 322-335
-
-
Fujarewicz, K.1
Kimmel, M.2
Lipniacki, T.3
Swierniak, A.4
-
5
-
-
34447625052
-
Cancer Systems Biology: Exploring cancer-associated genes on cellular networks
-
Wang E, Lenferink A, O'Connor-McCourt M. Cancer Systems Biology: exploring cancer-associated genes on cellular networks. Cell Mol Life Sci 2007;64(14):1752-1762.
-
(2007)
Cell Mol Life Sci
, vol.64
, Issue.14
, pp. 1752-1762
-
-
Wang, E.1
Lenferink, A.2
O'Connor-McCourt, M.3
-
6
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. In: Cell; 2000:57-70.
-
(2000)
Cell
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
7
-
-
0034471876
-
Genes that regulate metastasis and angiogenesis
-
Webb CP, Vande Woude GF. Genes that regulate metastasis and angiogenesis. J Neurooncol 2000;50(1-2):71-87.
-
(2000)
J Neurooncol
, vol.50
, Issue.1-2
, pp. 71-87
-
-
Webb, C.P.1
Vande Woude, G.F.2
-
8
-
-
0034956456
-
Cancer development and progression: A non-adaptive process driven by genetic drift
-
Aranda-Anzaldo A. Cancer development and progression: a non-adaptive process driven by genetic drift. Acta Biotheor 2001;49(2):89-108.
-
(2001)
Acta Biotheor
, vol.49
, Issue.2
, pp. 89-108
-
-
Aranda-Anzaldo, A.1
-
9
-
-
34248547564
-
Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma
-
Balakrishnan A, Bleeker FE, Lamba S, et al. Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma. Cancer Res 2007;67(8):3545-50.
-
(2007)
Cancer Res
, vol.67
, Issue.8
, pp. 3545-3550
-
-
Balakrishnan, A.1
Bleeker, F.E.2
Lamba, S.3
-
10
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
Sjoblom T, Jones S, Wood LD, et al. The consensus coding sequences of human breast and colorectal cancers. Science 2006;314(5797):268-274.
-
(2006)
Science
, vol.314
, Issue.5797
, pp. 268-274
-
-
Sjoblom, T.1
Jones, S.2
Wood, L.D.3
-
11
-
-
34250829110
-
Perspectives on the failure of pharmaceutical and medical device industries to fully protect public health interests
-
Maron BJ, Hauser RG. Perspectives on the failure of pharmaceutical and medical device industries to fully protect public health interests. Am J Cardiol 2007;100(1):147-151.
-
(2007)
Am J Cardiol
, vol.100
, Issue.1
, pp. 147-151
-
-
Maron, B.J.1
Hauser, R.G.2
-
12
-
-
34347330024
-
Implementing the U. S. FDA guidance onpharmacogenomic data submissions
-
Goodsaid F, Frueh FW. Implementing the U. S. FDA guidance onpharmacogenomic data submissions. Environ Mol Mutagen 2007;48(5):354-358.
-
(2007)
Environ Mol Mutagen
, vol.48
, Issue.5
, pp. 354-358
-
-
Goodsaid, F.1
Frueh, F.W.2
-
13
-
-
33845524213
-
Challenges of drug discovery for personalized medicine
-
Jain KK. Challenges of drug discovery for personalized medicine. Curr Opin Mol Ther 2006;8(6):487-492.
-
(2006)
Curr Opin Mol Ther
, vol.8
, Issue.6
, pp. 487-492
-
-
Jain, K.K.1
-
14
-
-
34250835590
-
Management updates for women with a BRCA1 or BRCA2 mutation
-
Nusbaum R, Isaacs C. Management updates for women with a BRCA1 or BRCA2 mutation. Mol Diagn Ther 2007;11(3):133-44.
-
(2007)
Mol Diagn Ther
, vol.11
, Issue.3
, pp. 133-144
-
-
Nusbaum, R.1
Isaacs, C.2
-
15
-
-
33947320272
-
Individualized drug therapy
-
Daly AK. Individualized drug therapy. Curr Opin Drug Discov Devel 2007;10(1):29-36.
-
(2007)
Curr Opin Drug Discov Devel
, vol.10
, Issue.1
, pp. 29-36
-
-
Daly, A.K.1
-
16
-
-
29544447266
-
The AmpliChip CYP450 genotyping test: Integrating a new clinical tool
-
deLeon J, Susce MT, Murray-Carmichael E. The AmpliChip CYP450 genotyping test: Integrating a new clinical tool. Mol Diagn Ther 2006;10(3):135-151.
-
(2006)
Mol Diagn Ther
, vol.10
, Issue.3
, pp. 135-151
-
-
DeLeon, J.1
Susce, M.T.2
Murray-Carmichael, E.3
-
17
-
-
34147111853
-
Impact of pharmacogenomics on clinical practice in oncology
-
Marsh S. Impact of pharmacogenomics on clinical practice in oncology. Mol Diagn Ther 2007;11(2):79-82.
-
(2007)
Mol Diagn Ther
, vol.11
, Issue.2
, pp. 79-82
-
-
Marsh, S.1
-
18
-
-
34247391164
-
Role of tumor markers in patients with solid cancers: A critical review
-
Duffy MJ. Role of tumor markers in patients with solid cancers: A critical review. Eur J Intern Med 2007;18(3):175-184.
-
(2007)
Eur J Intern Med
, vol.18
, Issue.3
, pp. 175-184
-
-
Duffy, M.J.1
-
19
-
-
34347258849
-
Prostate-specific antigen in the early detection of prostate cancer
-
Thompson IM, Ankerst DP. Prostate-specific antigen in the early detection of prostate cancer. Cmaj 2007;176(13):1853-1858.
-
(2007)
Cmaj
, vol.176
, Issue.13
, pp. 1853-1858
-
-
Thompson, I.M.1
Ankerst, D.P.2
-
20
-
-
18144411357
-
Translation research: From accurate diagnosis to appropriate treatment
-
Webb CP, Pass HI. Translation research: from accurate diagnosis to appropriate treatment. J Transl Med 2004;2(1):35.
-
(2004)
J Transl Med
, vol.2
, Issue.1
, pp. 35
-
-
Webb, C.P.1
Pass, H.I.2
-
21
-
-
26444506232
-
Asbestos exposure, pleural mesothelioma, and serum osteopontin levels
-
Pass HI, Lott D, Lonardo F, et al. Asbestos exposure, pleural mesothelioma, and serum osteopontin levels. N Engl J Med 2005;353(15):1564-1573.
-
(2005)
N Engl J Med
, vol.353
, Issue.15
, pp. 1564-1573
-
-
Pass, H.I.1
Lott, D.2
Lonardo, F.3
-
22
-
-
34250217011
-
Expression genomics in breast cancer research: Microarrays at the crossroads of biology and medicine
-
Miller LD, Liu ET. Expression genomics in breast cancer research: microarrays at the crossroads of biology and medicine. Breast Cancer Res 2007;9(2):206.
-
(2007)
Breast Cancer Res
, vol.9
, Issue.2
, pp. 206
-
-
Miller, L.D.1
Liu, E.T.2
-
24
-
-
33748503420
-
Evaluation of DNA microarray results with quantitative gene expression platforms
-
Canales RD, Luo Y, Willey JC, et al. Evaluation of DNA microarray results with quantitative gene expression platforms. Nat Biotechnol 2006;24(9):1115-1122.
-
(2006)
Nat Biotechnol
, vol.24
, Issue.9
, pp. 1115-1122
-
-
Canales, R.D.1
Luo, Y.2
Willey, J.C.3
-
25
-
-
34249072202
-
Molecular concepts analyzes links tumors, pathways, mechanisms, and drugs
-
Rhodes DR, Kalyana-Sundaram S, Tomlins SA, et al. Molecular concepts analyzes links tumors, pathways, mechanisms, and drugs. Neoplasia 2007;9(5):443-454.
-
(2007)
Neoplasia
, vol.9
, Issue.5
, pp. 443-454
-
-
Rhodes, D.R.1
Kalyana-Sundaram, S.2
Tomlins, S.A.3
-
26
-
-
34249275704
-
EGFR and HER-2 antagonists in breast cancer
-
O'Donovan N, Crown J. EGFR and HER-2 antagonists in breast cancer. Anticancer Res 2007;27(3 A):1285-1294.
-
(2007)
Anticancer Res
, vol.27
, Issue.3 A
, pp. 1285-1294
-
-
O'Donovan, N.1
Crown, J.2
-
27
-
-
33846400585
-
HER-2 (c-erbB-2) test update: Present status and problems
-
Tsuda H. HER-2 (c-erbB-2) test update: present status and problems. Breast Cancer 2006;13(3):236-248.
-
(2006)
Breast Cancer
, vol.13
, Issue.3
, pp. 236-248
-
-
Tsuda, H.1
-
28
-
-
33846847772
-
Resistance to targeted therapy in chronic myelogenous leukemia
-
Hochhaus A, Erben P, Ernst T, Mueller MC. Resistance to targeted therapy in chronic myelogenous leukemia. Semin Hematol 2007;44(1 Suppl 1):S15-24.
-
(2007)
Semin Hematol
, vol.44
, Issue.1
, pp. S15-S24
-
-
Hochhaus, A.1
Erben, P.2
Ernst, T.3
Mueller, M.C.4
-
29
-
-
33847718214
-
The EGF receptor family: Spearheadingamerger of signaling and therapeutics
-
Bublil EM, Yarden Y. The EGF receptor family: spearheadingamerger of signaling and therapeutics. Curr Opin Cell Biol 2007;19(2):124-134.
-
(2007)
Curr Opin Cell Biol
, vol.19
, Issue.2
, pp. 124-134
-
-
Bublil, E.M.1
Yarden, Y.2
-
30
-
-
33748282569
-
Computational exploration of the activated pathways associated with DNA damage response in breast cancer
-
Wen L, Li W, Sobel M, Feng JA. Computational exploration of the activated pathways associated with DNA damage response in breast cancer. Proteins 2006;65(1):103-110.
-
(2006)
Proteins
, vol.65
, Issue.1
, pp. 103-110
-
-
Wen, L.1
Li, W.2
Sobel, M.3
Feng, J.A.4
-
32
-
-
34548388340
-
A multidimensional analyzes of genes mutated in breast and colorectal cancers
-
Lin J, Gan CM, Zhang X, et al. A multidimensional analyzes of genes mutated in breast and colorectal cancers. Genome Res 2007;17(9):1304-1318.
-
(2007)
Genome Res
, vol.17
, Issue.9
, pp. 1304-1318
-
-
Lin, J.1
Gan, C.M.2
Zhang, X.3
-
33
-
-
33847628809
-
Definitions and validation criteria for biomarkers and surrogate endpoints: Development and testing of a quantitative hierarchical levels of evidence schema
-
Lassere MN, Johnson KR, Boers M, et al. Definitions and validation criteria for biomarkers and surrogate endpoints: development and testing of a quantitative hierarchical levels of evidence schema. J Rheumatol 2007;34(3):607-615.
-
(2007)
J Rheumatol
, vol.34
, Issue.3
, pp. 607-615
-
-
Lassere, M.N.1
Johnson, K.R.2
Boers, M.3
-
34
-
-
33645959506
-
Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies
-
Burczynski ME, Dorner AJ. Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies. Pharmacogenomics 2006;7(2):187-202.
-
(2006)
Pharmacogenomics
, vol.7
, Issue.2
, pp. 187-202
-
-
Burczynski, M.E.1
Dorner, A.J.2
-
35
-
-
1842458410
-
Development and use of biomarkers in oncology drug development
-
Floyd E, McShane TM. Development and use of biomarkers in oncology drug development. Toxicol Pathol 2004;32 Suppl 1:106-115.
-
(2004)
Toxicol Pathol
, vol.32
, pp. 106-115
-
-
Floyd, E.1
McShane, T.M.2
-
36
-
-
14344251403
-
New science-based endpoints to accelerate oncology drug development
-
Kelloff GJ, Sigman CC. New science-based endpoints to accelerate oncology drug development. Eur J Cancer 2005;41(4):491-501.
-
(2005)
Eur J Cancer
, vol.41
, Issue.4
, pp. 491-501
-
-
Kelloff, G.J.1
Sigman, C.C.2
-
37
-
-
33750286135
-
The multifaceted circulating endothelial cell in cancer: Towards marker and target identification
-
Bertolini F, Shaked Y, Mancuso P, Kerbel RS. The multifaceted circulating endothelial cell in cancer: towards marker and target identification. Nat Rev Cancer 2006;6(11):835-845.
-
(2006)
Nat Rev Cancer
, vol.6
, Issue.11
, pp. 835-845
-
-
Bertolini, F.1
Shaked, Y.2
Mancuso, P.3
Kerbel, R.S.4
-
38
-
-
34247216006
-
Promoting, improving and accelerating the drug development and approval processes
-
Graul AI. Promoting, improving and accelerating the drug development and approval processes. Drug news & perspectives 2007;20(1):45-55.
-
(2007)
Drug News & Perspectives
, vol.20
, Issue.1
, pp. 45-55
-
-
Graul, A.I.1
-
39
-
-
34249853738
-
Computational and experimental approaches for modeling gene regulatory networks
-
Goutsias J, Lee NH. Computational and experimental approaches for modeling gene regulatory networks. Curr Pharm Des 2007;13(14):1415-1436.
-
(2007)
Curr Pharm Des
, vol.13
, Issue.14
, pp. 1415-1436
-
-
Goutsias, J.1
Lee, N.H.2
-
40
-
-
33947278433
-
Discovery of cancer biomarkers through the use of mouse models
-
Kuick R, Misek DE, Monsma DJ, et al. Discovery of cancer biomarkers through the use of mouse models. Cancer Lett 2007;249(1):40-48.
-
(2007)
Cancer Lett
, vol.249
, Issue.1
, pp. 40-48
-
-
Kuick, R.1
Misek, D.E.2
Monsma, D.J.3
-
41
-
-
1542437962
-
Genetic testing coverage and reimbursement: A provider's dilemma
-
Logue LJ. Genetic testing coverage and reimbursement: a provider's dilemma. Clin Leadersh Manag Rev 2003;17(6):346-350.
-
(2003)
Clin Leadersh Manag Rev
, vol.17
, Issue.6
, pp. 346-350
-
-
Logue, L.J.1
-
42
-
-
3342964433
-
Beyond fast track for drug approvals
-
Roberts TG, Jr., Chabner BA. Beyond fast track for drug approvals. N Engl J Med 2004;351(5):501-555.
-
(2004)
N Engl J Med
, vol.351
, Issue.5
, pp. 501-555
-
-
Roberts, T.G.1
Chabner, B.A.2
-
43
-
-
0036402924
-
Delivery of high-quality biomarker assays
-
Swanson BN. Delivery of high-quality biomarker assays. Dis Markers 2002;18(2):47-56.
-
(2002)
Dis Markers
, vol.18
, Issue.2
, pp. 47-56
-
-
Swanson, B.N.1
-
44
-
-
33845199056
-
Cancer cell-based genomic and small molecule screens
-
Caldwell JS. Cancer cell-based genomic and small molecule screens. Adv Cancer Res 2007;96:145-173.
-
(2007)
Adv Cancer Res
, vol.96
, pp. 145-173
-
-
Caldwell, J.S.1
-
45
-
-
33750460197
-
Developing gene expression signatures of pathway deregulationin tumors
-
Watters JW, Roberts CJ. Developing gene expression signatures of pathway deregulationin tumors. Mol Cancer Ther 2006;5(10):2444-2449.
-
(2006)
Mol Cancer Ther
, vol.5
, Issue.10
, pp. 2444-2449
-
-
Watters, J.W.1
Roberts, C.J.2
-
46
-
-
33644871485
-
Evolution of resistance to cancer therapy
-
Michor F, Nowak MA, Iwasa Y. Evolution of resistance to cancer therapy. Curr Pharm Des 2006;12(3):261-271.
-
(2006)
Curr Pharm Des
, vol.12
, Issue.3
, pp. 261-271
-
-
Michor, F.1
Nowak, M.A.2
Iwasa, Y.3
-
47
-
-
34147184365
-
Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel
-
Sarkaria JN, Yang L, Grogan PT, et al. Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel. Mol Cancer Ther 2007;6(3):1167-1174.
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.3
, pp. 1167-1174
-
-
Sarkaria, J.N.1
Yang, L.2
Grogan, P.T.3
-
48
-
-
33947498978
-
Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer
-
Sequist LV, Bell DW, Lynch TJ, Haber DA. Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J Clin Oncol 2007;25(5):587-595.
-
(2007)
J Clin Oncol
, vol.25
, Issue.5
, pp. 587-595
-
-
Sequist, L.V.1
Bell, D.W.2
Lynch, T.J.3
Haber, D.A.4
-
49
-
-
33745458519
-
Albumin-bound paclitaxel: A next-generation taxane
-
Gradishar WJ. Albumin-bound paclitaxel: a next-generation taxane. Expert Opin Pharmacother 2006;7(8):1041-1053.
-
(2006)
Expert Opin Pharmacother
, vol.7
, Issue.8
, pp. 1041-1053
-
-
Gradishar, W.J.1
-
50
-
-
34548398070
-
Current status of excision repair cross complementing-group 1 (ERCC1) in cancer
-
Gossage L, Madhusudan S. Current status of excision repair cross complementing-group 1 (ERCC1) in cancer. Cancer Treat Rev 2007;33(6):565-577.
-
(2007)
Cancer Treat Rev
, vol.33
, Issue.6
, pp. 565-577
-
-
Gossage, L.1
Madhusudan, S.2
-
52
-
-
35549013373
-
Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling
-
Shtiegman K, Kochupurakkal BS, Zwang Y, et al. Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling. Oncogene 2007;26(49):6968-6978.
-
(2007)
Oncogene
, vol.26
, Issue.49
, pp. 6968-6978
-
-
Shtiegman, K.1
Kochupurakkal, B.S.2
Zwang, Y.3
-
53
-
-
33746961739
-
Mechanisms of disease: Oncogene addiction-A rationale for molecular targeting in cancer therapy
-
Weinstein IB, Joe AK. Mechanisms of disease: Oncogene addiction-a rationale for molecular targeting in cancer therapy. Nat Clin Pract Oncol 2006;3(8):448-457.
-
(2006)
Nat Clin Pract Oncol
, vol.3
, Issue.8
, pp. 448-457
-
-
Weinstein, I.B.1
Joe, A.K.2
-
54
-
-
33751016673
-
Neoplastic stem cells: A novel therapeutic target in clinical oncology
-
Schulenburg A, Ulrich-Pur H, Thurnher D, et al. Neoplastic stem cells: a novel therapeutic target in clinical oncology. Cancer 2006;107(10):2512-2520.
-
(2006)
Cancer
, vol.107
, Issue.10
, pp. 2512-2520
-
-
Schulenburg, A.1
Ulrich-Pur, H.2
Thurnher, D.3
-
55
-
-
3042721988
-
Back to the biology in Systems Biology: What can we learn from biomolecular networks?
-
Huang S. Back to the biology in Systems Biology: what can we learn from biomolecular networks? Briefings in functional genomics & proteomics 2004;2(4):279-297.
-
(2004)
Briefings in Functional Genomics & Proteomics
, vol.2
, Issue.4
, pp. 279-297
-
-
Huang, S.1
-
56
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
New York, NY
-
Sjoblom T, Jones S, Wood LD, et al. The consensus coding sequences of human breast and colorectal cancers. Science (New York, NY 2006;314(5797):268-274.
-
(2006)
Science
, vol.314
, Issue.5797
, pp. 268-274
-
-
Sjoblom, T.1
Jones, S.2
Wood, L.D.3
-
57
-
-
34249072202
-
Molecular concepts analyzes links tumors, pathways, mechanisms, and drugs
-
New York, NY
-
Rhodes DR, Kalyana-Sundaram S, Tomlins SA, et al. Molecular concepts analyzes links tumors, pathways, mechanisms, and drugs. Neoplasia (New York, NY 2007;9(5):443-454.
-
(2007)
Neoplasia
, vol.9
, Issue.5
, pp. 443-454
-
-
Rhodes, D.R.1
Kalyana-Sundaram, S.2
Tomlins, S.A.3
-
59
-
-
33746961739
-
Mechanisms of disease: Oncogene addiction-A rationale for molecular targeting in cancer therapy
-
Weinstein IB, Joe AK. Mechanisms of disease: Oncogene addiction-a rationale for molecular targeting in cancer therapy. Nature clinical practice 2006;3(8):448-457.
-
(2006)
Nature Clinical Practice
, vol.3
, Issue.8
, pp. 448-457
-
-
Weinstein, I.B.1
Joe, A.K.2
-
60
-
-
84919980604
-
-
www.fda.gov/cber/gdlns/iche15term.htm
-
-
-
-
61
-
-
84919980603
-
-
www.fda.gov/bbs/topics/news/2006/NEW01337.html
-
-
-
-
62
-
-
84919980602
-
-
www.fda.gov/cdrh/oivd/guidance/1610.html
-
-
-
-
63
-
-
84919980601
-
-
www.xbtransmed.com
-
-
-
-
64
-
-
84919980600
-
-
www.genego.com
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