Cancer development and progression: A non-adaptive process driven by genetic drift

Acta Biotheoretica

Volumn 49, Issue 2, 2001, Pages 89-108

  Aranda Anzaldo, Armando ^a  

^a UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MÉXICO   (Mexico)

Author keywords

Ageing; Chemotherapy; Clonal selection; Development; Evolution; Fitness; Oncogenes; p53; Somatic mutation; Tumour suppressors

Indexed keywords

PROTEIN P53;

ANIMAL; ARTICLE; CELL DIVISION; CELL SURVIVAL; CELL TRANSFORMATION; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC SELECTION; GENETICS; HUMAN; MUTATION; ONCOGENE; PHYSIOLOGY; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL DIVISION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE FREQUENCY; GENES, TUMOR SUPPRESSOR; HUMANS; MUTATION; ONCOGENES; SELECTION (GENETICS); TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0034956456     PISSN: 00015342     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010215424196     Document Type: Article

References (85)

1. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
2. On the role of chromatin higher-order structure and mechanical interactions in the regulation of gene expression
3. Higher-order structure in the cell nucleus and embryonic development
4. A role for the nucleotype in the pathogenesis of primary hepatocellular carcinoma
5. The gene as the unit of selection: A case of evolutive delusion
6. p53 is a rate-limiting factor in the repair of higher-order DNA structure
7. High frequency developmental abnormalities in p53-deficient mice
8. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
9. Aneuploidy and cancer: Vintage wine in a new bottle?
10. Molecular themes in oncogenesis
11. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
12. The units of selection revisited: The modules of selection
13. Cancer: A biological approach
14. Mutations of mitotic checkpoint genes in human cancers
15. Mutation selection and the natural history of cancer
16. The future of naturalistic philosophy of science
17. How does increased fitness evolve?
18. Evolution of senescence: Alzheimer's disease and evolution
19. Killer in search of a motive?
20. Chromosome aberrations in liver cells in relation to the somatic mutation theory of ageing
21. Genetic stability: The key to longevity?
22. Human telomeres are attached to the nuclear matrix
23. Telomeres and senescence: Ending the debate
24. Epidemiology of cancer
25. Comparative rates of spontaneous mutation
26. Retroviruses as carcinogens and pathogens: Expectations and reality
27. Oncogenes and cancer
28. A genetic model for colorectal tumorigenesis
29. Cancer progression
30. Auto-organisation, développement et théories de l'evolution
31. What is cancer?
32. Pathobiology of cancer
33. Selecting and maintaining a diverse T-cell repertoire
34. Creation of human tumour cells with defined genetic elements
35. Tumour suppressors: A developing role for p53?
36. The moulding of senescence by natural selection
37. Telomeres shorten during ageing of human fibroblasts
38. The future of ageing
39. p53 mutations in human cancers
40. Dominant transformation by mutated ras genes in vitro requires more than 100 times higher expression than is observed in cancers
41. Genetic pathways in colorectal and other cancers
42. Molecular determinants of dysplasia in colorectal lesions
43. Gatekeepers and caretakers
44. Cellular oncogenes and multistep carcinogenesis
45. Worrying about p53
46. Genetic instability in colorectal cancers
47. Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells
48. Aneuploidy vs. gene mutation hypothesis of cancer: Recent study claims mutation but is found to support aneuploidy
49. Mutator phenotype may be required for multistage carcinogenesis
50. Transient expression of a mutator phenotype in cancer cells
51. Mitotic misregulation and human ageing
52. Tumor suppressor genes
53. Diabetes mellitus
54. The clonal evolution of tumor cell populations
55. New tumor suppressor found twice
56. Molecular portraits of human breast tumours
57. Cellular harmonic information transfer through a tissue tensegrity-matrix system
58. How aneuploidy affects metabolic control and causes cancer
59. Specificity and functional significance of DNA interaction with the nuclear matrix: New approaches to clarify old questions
60. Conditional mutator phenotypes in hMSH2-deficient tumor cell lines
61. Spontaneous mutation and parental age in humans
62. Knockout mouse fault lines
63. Evolution of high mutation rates in experimental populations of E. coli
64. Detection of both mutant and wild-type p53 proteins in normal skin fibroblasts and demostration of a shared 'second hit' on p53 in diverse tumors from a cancer-prone family with Li-Fraumeni syndrome
65. Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog
66. High resolution analysis of interphase chromosme domains
67. Lessons from hereditary colorectal cancer
68. The theory of evolution today
69. Molecular mechanisms of carcinogenesis