Application of egg yolk antibodies as replacement for antibiotics in poultry

World's Poultry Science Journal

Volumn 66, Issue 1, 2010, Pages 27-37

  Yegani, M ^a   Korver, D R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Antibody responses; Antigens; Egg yolk antibodies; Feed; IgY; Infectious diseases; Poultry

Indexed keywords

ANIMALIA; BACTERIA (MICROORGANISMS); GALLUS GALLUS;

EID: 77952511468     PISSN: 00439339     EISSN: 17434777     Source Type: Journal    
DOI: 10.1017/S0043933910000048     Document Type: Review

References (76)

1. ABDEL-MONEIM, A.S. and ABDEL-GAWAD, M.M.A. (2006) Genetic variations in maternal transfer and immune responsiveness to infectious bursal disease virus. Veterinary Microbiology 114: 16-24.
2. AKITA, E.M. and NAKAI, S. (1992) Immunoglobulins from egg yolk: Isolation and purification. Journal of Food Science 57: 629-634.
3. AMARAL, J.A., TINO DE FRANCO, M., CARNEIRO-SAMPAIO, M.M. and CARBONARE, S. (2002) Anti-enteropahtogenic Escherichia coli immunoglobulin Y isolated from eggs laid by immunized Leghorn chickens. Research in Veterinary Science 72: 229-234.
4. BEDFORD, M. (2000) Removal of antibiotic growth promoters from poultry diets: implications and strategies to minimize subsequent problems. World's Poultry Science Journal 56: 347-365.
5. BOX, P.G., STEDMAN, R.A. and SINGLETON, L. (1969) Newcastle disease. I. The use of egg yolk derived antibody for passive immunization of chickens. Journal of Comparative Pathology 79: 495-506.
6. CARLANDER, D., KOLLBERG, H., WEJAKER, P.E. and LARSSON, A. (2000) Peroral immunotherapy with yolk antibodies for the prevention and treatment of enteric infections. Immunology Research 21: 1-6.
7. CARLANDER, D., STALBERG, J. and LARSSON, A. (1999) Chicken antibodies: A clinical chemistry perspective. Upsala Journal of Medical Sciences 104: 179-189.
8. CARLANDER, D., WILHELMSON, M. and LARSSON, A. (2001) Limited day to day variation of IgY levels in eggs from individual laying hens. Food and Agricultural Immunology 13: 87-92.
9. CARLANDER, D., WILHELMSON, M. and LARSSON, A. (2003) Immunoglobulin Y levels in egg yolk from three chicken genotypes. Food and Agricultural Immunology 15: 35-40.
10. CASADEVALL, A. and SCHARFF, M.D. (1994) Serum therapy revisited: animal models of infection and development of passive antibody therapy. Antimicrobial Agents and Chemotherapy 38: 1695-1702.
11. CHANG H.M., OU-YANG, R.F., CHEN, Y.T. and CHEN, C.C. (1999) Productivity and some properties of immunoglobulin specific against Streptococcus mutants serotype c in chicken egg yolk (IgY). Journal of Agricultural and Food Chemistry 47: 61-66.
12. COATES, M.E., DAVIES, M.K. and KON, S.K. (1955) The effect of antibiotics on the intestine of the chick. British Journal of Nutrition 9: 110-119.
13. COLLETT, S.R. (2004) Controlling gastrointestinal disease to improve absorptive membrane integrity and optimize digestion efficiency, in: TUCKER, L.A. & TAYLOR-PICKARD, J.A. (Eds) Interfacing Immunity, Gut Health and Performance, pp. 77-91 (Nottingham, Nottingham University Press).
14. CRAY, C. and VILLAR, D. (2008) Cross-reactivity of anti-chicken IgY antibody with immunoglobulins of exotic avian species. Veterinary Clinical Pathology 37: 328-331.
15. DEMEULENAER, B. and HUYGHEBAERT, A. (2001) Isolation and Purification of Chicken Egg Yolk Immunoglobulins: A Review. Food and Agricultural Immunology 13: 275-288.
16. ERHARD, M.H., SCHMIDT, P., ZINSMEISTER, P., HOFMANN, A. and MÜNSTER. U. et al. (2000) Adjuvant effects of various lipopeptides and interferon on the humoral immune response of chickens. Poultry Science 79: 1264-1270.
17. ETERRADOSSI, N., TOQUIN, D., ABBASSI, H., RIVALLAN, G., COTTEE, J.P. and GUITTET, M. (1997) Passive protection of specific pathogen free chicks against infectious bursal disease by in-ovo injection of semi-purified egg-yolk antiviral immunoglobulins. Journal of Veterinary Medicine B44: 371-383.
18. FULTON, R.M., NERSESSIAN, B.N. and REED, W.M. (2002) Prevention of Salmonella enteritidis infection in commercial ducklings by oral chicken egg-derived antibody alone or in combination with probiotics. Poultry Science 81: 34-40.
19. GAST, R.K., PORTER JR, R.E. and HOLT, P.S. (1997) Assessing the sensitivity of egg yolk antibody testing for detecting Salmonella enteritidis infections in laying hens. Poultry Science 76: 798-801.
20. GHARAIBEH, S., MAHMOUD, K. and AL-NATOUR, M. (2008) Field evaluation of maternal antibody transfer to a group of pathogens in meat-type chickens. Poultry Science 87: 1550-1555.
21. GIRARD, F., BATISSON, I., MARTINE, G., BRETON, C., HAREL, J. and FAIRBROTHER, J.M. (2006) Use of virulence factor-specific egg yolk-derived immunoglobulins as a promising alternative to antibiotics for prevention of attaching and effacing Escherichia coli infections. FEMS Immunology and Medical Microbiology 46: 340-350.
22. GOTTSTEIN, B. and HEMMELER, E. (1985) Egg yolk immunoglobulin Y as an alternative antibody in the serology of echinococcosis. Zeitschrift for Parasitenkunde 71: 273-276.
23. GORBACH, S.L. (2001) Antimicrobial use in animal feed-time to stop. New England Journal of Medicine 345: 1202-1203.
24. GRAHAM, J.P., BOLAND, J.J. and SIRBERGELD, E. (2007) Growth promoting antibiotics in food animal production: An Economic Analysis. Public Health Reports 122: 79-87.
25. GURTLER, M., METHNER, U., KOBILKE, H. and FEHLHABER, K. (2004) Effect of orally administered egg yolk antibodies on Salmonella enteritidis contamination of hen's eggs. Journal of Veterinary Medicine B Infectious Disease Veterinary Public Health 51: 129-134.
26. HAGAN, J.C., ASHTON, N.J., BRADBURY, J.M. and MORGAN, K.L. (2004) Evaluation of an egg yolk enzyme-linked immunosorbent assay antibody test and its use to assess the prevalence of Mycoplasma synoviae in UK laying hens. Avian Pathology 33: 93-97.
27. HAMAL, K.R., BURGESS, S.C., PEVZNER, I.Y. and ERF, G.F. (2006) Maternal antibody transfer from dams to their egg yolks, egg whites, and chicks in meat lines of chickens. Poultry Science 85: 1364-1372.
28. HATTA, H., OZEKI, M. and TSUDA, K. (1997) Egg yolk antibody Ig Y and its application, in: YAMAMOTO, T., JUNEJA, L.R., HATTA, H. & KIM, M. (Eds) Hen Eggs: Their Basic and Applied Science, pp. 151-178 (Florida, CRC Press).
29. HOLT, P.S., STONE, H.D., GAST, R.K. and GREENE, C.R. (2000) Application of the agar gel precipitin test to detect antibodies to Salmonella enterica serovar enteritidis in serum and egg yolks from infected hens. Poultry Science 79: 1246-1250.
30. KARIYAWASAM, S., WILKIE, B.N. and GYLES, C.L. (2004) Resistance of broiler chickens to Escherichia coli respiratory tract infection induced by passively transferred egg-yolk antibodies. Veterinary Microbiology 98: 273-284.
31. KARLSSON, M., KOLLBERG, H. and LARSSON, A. (2004) Chicken IgY: utilizing the evolutionary advantage. World's Poultry Science Journal 60: 341-348.
32. KITAGUCHI, K., MINOURA, M., NORITAKE, M., MIZUTANI, M., KINOSHITA, K., HORIO, F. and MURAI, A. (2008) Determination of immunoglobulin Y concentration in yolk extract prepared by water dilution method: Comparisons among three strains of chickens. The Journal of Poultry Science 45: 82-87.
33. KO, K.Y. and AHN, D.U. (2007) Preparation of immunoglobulin Y from egg yolk using ammonium sulfate precipitation and Ion exchange chromatography. Poultry Science 86: 400-407.
34. KWEON, C.H., KWON, B.J., WOO, S.R., KIM, J.M., WOO, G.H., SON, D.H., HUR, W. and LEE, Y. S. (2000) Immunoprophylactic effect of chicken egg yolk immunoglobulin (Ig Y) against porcine epidemic diarrhea virus (PEDV) in piglets. Journal of Veterinary Medical Sciences 62: 961-964.
35. LARSSON, A., BALOW, R.M., LINDAHL, T.L. and FORSBERG, P.O. (1993) Chicken antibodies: taking advantage of evolution--a review. Poultry Science 72: 1807-1812.
36. LEE, E.N., SUNWOO, H.H., MENNINEN, K. and SIM, J.S. (2002) In vitro studies of chicken egg yolk antibody (IgY) against Salmonella enteritidis and Salmonella typhimurium. Poultry Science 81: 632-641.
37. LEE, S.B., MINE, Y. and STEVENSO, R.M. (2000) Effects of hen egg yolk immunoglobulin in passive protection of rainbow trout against Yersinia ruckeri. Journal of Agricultural and Food Chemistry 48: 110-115.
38. LESLIE, G.A. and CLEM, L.W. (1969) Phylogeny of immunoglobulin structure and function. III. Immunoglobulins of the chicken. The Journal of Experimental Medicine 130: 1337-1352.
39. LESLIE, G.A., WILSON, H.R. and CLEM, L.W. (1971a) Studies on the secretory immunologic system of fowl. I. Presence of immunoglobulins in chicken secretions. Journal of Immunology 106: 1441-1446.
40. LESLIE, G.A., CRANDALL, R.B. and CRANDALL, C.A. (1971b) Studies on the secretory immunologic system of fowl. II. Immunoglobulin-producing cells associated with mucous membranes. Immunology 21: 983-987.
41. LEVESQUE, S., MARTINEZ, G. and FAIRBROTHER, J.M. (2007) Improvement of adjuvant systems to obtain a cost-effective production of high levels of specific IgY. Poultry Science 86: 630-635.
42. LI, X., NAKANO, T., SUNWOO, H.H., PAEK, B.H., CHAE, H.S. and SIM, J.S. (1998) Effects of egg and yolk weights on yolk antibody (IgY) production in laying chickens. Poultry Science 77: 266-270.
43. LOEKEN, M.R. and ROTH, T.F. (1983) Analysis of maternal IgG subpopulations which are transported into the chicken oocyte. Immunology 49: 21-28.
44. MALIK, M.W., AYUB, N. and QURESHI, I.Z. (2006) Passive immunization using purified IgYs against infectious bursal disease of chickens in Pakistan. Journal of Veterinary Science 7: 43-46.
45. MALMARUGAN, S., RAMAN, M., JAISREE, S. and ELANTHALIR, P. (2005) Egg immunoglobulins -an alternative source of antibody for diagnosis of infectious bursal disease. Veterinarski Arhiv 75: 49-56.
46. MILES, R.D., BUTCHER, G.D., HENRY, P.R. and LITTELL, R.C. (2006) Effect of antibiotic growth promoters on broiler performance, intestinal growth parameters, and quantitative morphology. Poultry Science 85: 476-485.
47. NILSSON, E., LARSSON, A., OLESEN, H.V., WEJAKER, P. and KOLLBERG, H. (2008) Good effect of IgY against Pseudomonas aeruginosa infections in cystic fibrosis patients. Pediatric Pulmonology 43: 892-899.
48. NILSSON, E. and LARSSON, A. (2007) Stability of chicken IgY antibodies freeze-dried in the presence of lactose, sucrose and threalose. The Journal of Poultry Science 44: 58-62.
49. O'FARRELLY, C., BRANTON, D. and WANKE, C.A. (1992) Oral ingestion of egg yolk immunoglobulin from hens immunized with an enterotoxigenic Escherichia coli strain prevents diarrhea in rabbits challenged with the same strain. Infection and Immunity 60: 2593-2597.
50. OPITZ, H.M., El-BEGEARMI, M., FLEGG, P. and BEANE, D. (1993) Effectiveness of five feed additives in chicks infected with Salmonella enteritidis phage type 13a. Journal of Applied Poultry Research 2: 147-153.
51. OWUSU-ASIEDU, A., NYACHOTI, C.M., BAIDOO, S.K., MARQUARDT, R.R. and YANG, X. (2003) Response of early-weaned pigs to an enterotoxigenic Escherichia coli (K88) challenge when fed diets containing spray-dried porcine plasma or pea protein isolate plus egg yolk antibody. Journal of Animal Science 81: 1781-1789. (Pubitemid 38572490)
52. ÖZPINAR, H., ERHARD, M.H., AYTUG, N., ÖZPINAR, A., BAKLACI, C. et al. (1996) Dose-dependent effects of specific egg-yolk antibodies on diarrhea of newborn calves. Preventive Veterinary Medicine 27: 67-73.
53. PIELA, T.H., GULKA, C.M., YATES, V.J. and CHANG, P.W. (1984) Use of egg yolk in serological tests (ELISA and HI) to detect antibody to Newcastle disease, infectious bronchitis, and Mycoplasma gallisepticum. Avian Diseases 28: 877-883.
54. REILLY, R.M., DOMINGO, R. and SANDHU, J. (1997) Oral delivery of antibodies. Future pharmacokinetic trends. Clinical Pharmacokinetics 32: 313-323.
55. ROSE, M.E., ORLANS, E. and BUTTRESS, N. (1974) Immunoglobulin classes on the hen's egg: their segregation in yolk and white. European Journal of Immunology 4: 521-523.
56. ROSE, M.E. and ORLANS, E. (1981) Immunoglobulins in the egg, embryo and young chick. Developmental and Comparative Immunology 5: 15-20.
57. SARKER, S.A., CASSWALL, T.H., JUNEJA, L.R., HOQ, E., HOSSAIN, I., FUCHS, G.J. and HAMMARSTROM, L. (2001) Randomized, placebo-controlled, clinical trial of hyperimmunized chicken egg yolk immunoglobulin in children with rotavirus diarrhea. Journal of Pediatric Gastroenterology and Nutrition 32: 19-25.
58. SCHADE, R., STAAK, C., HENDRIKSEN, C., ERHARS, M., HUGL, H. et al. (1996) The production of avian (egg yolk) antibodies: IgY. ATLA 24: 925-934.
59. SHIMIZU, M., NAGASHIMA, H., HASHIMOTO, K. and SUZUKI, T. (1994) Egg yolk antibody (IgY) stability in aqueous solution with high sugar concentrations. Journal of Food Science 59: 763-765.
60. SHIN, J.H., YANG, M., NAM, S.W., KIM, J.T., MYUNG, N.H., BANG, W.G. and Roe, I.H. (2002) Use of egg yolk-derived immunoglobulin as an alternative to antibiotic treatment for control of Helicobacter pylori infection. Clinical and Diagnostic Laboratory Immunology 9: 1061-1066.
61. STEDMAN, R.A., SINGLETON, L. and BOX, P.G. (1969) Purification of Newcastle disease virus antibody from the egg yolk of the hen. Journal of Comparative Pathology 79: 507-516.
62. SUGITA-KONISHI, Y., SHIBATA, K., YUN, S.S., HARA-KUDO, Y., YAMAGUCHI, K. and KUMAGAI, S. (1996) Immune functions of immunoglobulin Y isolated from egg yolk of hens immunized with various infectious bacteria. Bioscience, Biotechnology and Biochemistry 60: 886-888.
63. SUNWOO, H.H., LEE, E.N., MENNINEN, K., SURESH, M.R. and SIM, J.S. (2002) Growth inhibitory effect of chicken egg yolk antibody (IgY) on Escherichia coli O157: H7. Journal of Food Science 67: 1486-1494.
64. SUNWOO, H.H., NAKANO, T., DIXON, W.T. and SIM, J.S. (1996) Immune responses in chickens against lipopolysaccharide of Escherichia coli and Salmonella typhimurium. Poultry Science 75: 342-345.
65. TELLEZ, G., PETRONE, V.M., ESCORCIA, M., MORISHITA, T.Y., COBB, C.W., VILLASENOR, L. and PROMSOPONE, B. ( 2001) Evaluation of avian-specific probiotic and Salmonella enteritidis-, Salmonella typhimurium-, and Salmonella Heidelberg-specific antibodies on cecal colonization and organ invasion of Salmonella enteritidis in broilers. Journal of Food Protection 64: 287-291. (Pubitemid 32203145)
66. THOMAS, E., BOUMA, A., VAN EERDEN, E., LANDMAN, W.J.M., VAN KNAPEN, F., STEGEMAN, A. and BERGWERFF, A.A. (2006) Detection of egg yolk antibodies reflecting Salmonella enteritidis infections using a surface plasmon resonance biosensor. Journal of Immunological Methods 315: 68-74.
67. TSUBOKURA, K., BERNDTSON, E., BOGSTEDT, A., KAIJSER, B., KIM, M., OZEKI, M. and L. HAMMARSTROM, L. (1997) Oral administration of antibodies as prophylaxis and therapy in Campylobacter jejuni-infected chickens. Clinical and Experimental Immunology 108: 451-455.
68. WILKIE, D.C. (2006) Non-antibiotic approaches to control pathogens in the gastrointestinal tract of the broiler chicken. Ph.D. Thesis, University of Saskatchewan.
69. WILKIE, D.C., VAN KESSEL, A.G., DUMONNCEAUX, T.J. and DREW, M.D. (2006) The effect of henegg antibodies on Clostridium perfringens colonization in the gastrointestinal tract of broiler chickens. Preventive Veterinary Medicine 74: 279-292.
70. WILLS, F.K. and LUGINBUHL, R.E. (1963) The use of egg yolk for passive immunization of chickens against Newcastle disease. Avian Diseases. 7: 5-12.
71. WORLD HEALTH ORGANIZATION (1997) The medical impact of antimicrobial use in food animals. Proceedings of WHO meeting, Berlin. pp. 1-21.
72. YOKOYAMA, H., HASHI, T., UMEDA, K., ICATLO JR, F.C., KUROKI, M., IKEMORI, Y. and KODAMA, Y. (1997) Effect of oral egg antibody in experimental F18+ Escherichia coli infection in weaned pigs. Journal of Veterinary Medical Science 59: 917-921.
73. YOKOYAMA, H., PERALTA, R.C., DIAZ, R., SENDO, S., IKEMORI, Y. and KODAMA, Y. (1992) Passive protective effect of chicken egg yolk immunoglobulins against experimental enterotoxigenic Escherichia coli infection in neonatal piglets. Infection and Immunity 60: 998-1007.
74. YOKOYAMA, H., PERALTA, R.C., UMEDA, K., HASHI, T., ICATLO JR, F.C., KUROKI, M., IKEMORI, Y. and KODOMA, Y. (1998) Prevention of fatal salmonellosis in neonatal calves, using orally administered chicken egg yolk Salmonella-specific antibodies. American Journal of Veterinary Research 59: 416-420.
75. YOUNG, C.A., SILVERSIDES, F.G. and JONES, S.R.M. (2007) Chicken-derived IgY recognizes developing and mature stages of Loma salmonae (Microsporidia) in Pacific salmon, Oncorhynchus spp. Aquaculture 273: 398-404.
76. ZHEN, Y.H., JIN, L.J., GUO, J., LI, X.Y., LU, Y.N., CHEN, J. and XU, Y.P. (2008) Characterization of specific egg yolk immunoglobulin (IgY) against mastitis-causing Escherichia coli. Veterinary Microbiology 130: 126-133.