메뉴 건너뛰기




Volumn 6, Issue 5, 2010, Pages 733-739

Prognostic markers in gliomas

Author keywords

1p19q codeletion; Diffuse gliomas; Isocitrate dehydrogenase 1; Isocitrate dehydrogenase 2; O6 methylguanine DNA methyltransferase; Predictive and prognostic marker

Indexed keywords

ALPHA INTERNEXIN; ARGININE; BIOCHEMICAL MARKER; CARMUSTINE; CYSTEINE; EPIDERMAL GROWTH FACTOR RECEPTOR; GLYCINE; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE ISOENZYME; LEUCINE; LOMUSTINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROCARBAZINE; PROTEIN P53; SERINE; TEMOZOLOMIDE; UNCLASSIFIED DRUG; VALINE; VINCRISTINE;

EID: 77952471455     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.10.25     Document Type: Review
Times cited : (16)

References (57)
  • 1
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352 (10), 987-996 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , Issue.10 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    Van Den Bent, M.J.3
  • 2
    • 34547122001 scopus 로고    scopus 로고
    • The 2007 WHO classification of tumours of the central nervous system
    • Louis DN, Ohgaki H, Wiestler OD et al.: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114 (2), 97-109 (2007).
    • (2007) Acta Neuropathol. , vol.114 , Issue.2 , pp. 97-109
    • Louis, D.N.1    Ohgaki, H.2    Wiestler, O.D.3
  • 4
    • 70350449411 scopus 로고    scopus 로고
    • Advances in the genetics of glioblastoma: Are we reaching critical mass?
    • Purow B, Schiff D: Advances in the genetics of glioblastoma: are we reaching critical mass? Nat. Rev. Neurol. 5 (8), 419-426 (2009).
    • (2009) Nat. Rev. Neurol. , vol.5 , Issue.8 , pp. 419-426
    • Purow, B.1    Schiff, D.2
  • 5
    • 63849133291 scopus 로고    scopus 로고
    • Oligodendrogliomas: Molecular biology and treatment
    • Bromberg JE, van den Bent MJ: Oligodendrogliomas: molecular biology and treatment. Oncologist 14 (2), 155-163 (2009).
    • (2009) Oncologist , vol.14 , Issue.2 , pp. 155-163
    • Bromberg, J.E.1    Van Den Bent, M.J.2
  • 6
    • 33750563258 scopus 로고    scopus 로고
    • A t (1;19) (q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma
    • • Demonstrates that the 1p19q codeletion is owing to a reciprocal translocation between chromosomes 1 and 19
    • Jenkins RB, Blair H, Ballman KV al et.: A t (1;19) (q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma. Cancer Res. 66 (20), 9852-9861 (2006). • Demonstrates that the 1p19q codeletion is owing to a reciprocal translocation between chromosomes 1 and 19.
    • (2006) Cancer Res. , vol.66 , Issue.20 , pp. 9852-9861
    • Jenkins, R.B.1    Blair, H.2    Ballman, K.V.3
  • 7
    • 0028006633 scopus 로고
    • Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p
    • Reifenberger J, Reifenberger G, Liu L, James CD, Wechsler W, Collins VP: Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. Am. J. Pathol. 145 (5), 1175-1190 (1994).
    • (1994) Am. J. Pathol. , vol.145 , Issue.5 , pp. 1175-1190
    • Reifenberger, J.1    Reifenberger, G.2    Liu, L.3    James, C.D.4    Wechsler, W.5    Collins, V.P.6
  • 8
    • 0032494479 scopus 로고    scopus 로고
    • Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas
    • Cairncross JG, Ueki K, Zlatescu MC et al.: Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J. Natl Cancer Inst. 90 (19), 1473-1479 (1998).
    • (1998) J. Natl. Cancer Inst. , vol.90 , Issue.19 , pp. 1473-1479
    • Cairncross, J.G.1    Ueki, K.2    Zlatescu, M.C.3
  • 9
    • 0034307067 scopus 로고    scopus 로고
    • Allelic loss of chromosome 1p and radiotherapy plus chemotherapy in patients with oligodendrogliomas
    • Bauman GS, Ino Y, Ueki K et al.: Allelic loss of chromosome 1p and radiotherapy plus chemotherapy in patients with oligodendrogliomas. Int. J. Radiat. Oncol Biol. Phys. 48 (3), 825-830 (2000).
    • (2000) Int. J. Radiat. Oncol. Biol. Phys. , vol.48 , Issue.3 , pp. 825-830
    • Bauman, G.S.1    Ino, Y.2    Ueki, K.3
  • 10
    • 33745575716 scopus 로고    scopus 로고
    • Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402
    • Cairncross G, Berkey B, Shaw E et al.: Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402. J. Clin. Oncol. 24 (18), 2707-2714 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 , pp. 2707-2714
    • Cairncross, G.1    Berkey, B.2    Shaw, E.3
  • 11
    • 12144290789 scopus 로고    scopus 로고
    • Prognostic value of 1p, 19q, 9p, 10q, and EGFR-FISH analyses in recurrent oligodendrogliomas
    • Fallon KB, Palmer CA, Roth KA et al.: Prognostic value of 1p, 19q, 9p, 10q, and EGFR-FISH analyses in recurrent oligodendrogliomas. J. Neuropathol. Exp. Neurol. 63 (4), 314-322 (2004).
    • (2004) J. Neuropathol. Exp. Neurol. , vol.63 , Issue.4 , pp. 314-322
    • Fallon, K.B.1    Palmer, C.A.2    Roth, K.A.3
  • 12
    • 39749102303 scopus 로고    scopus 로고
    • Genetic markers predictive of chemosensitivity and outcome in gliomatosis cerebri
    • Kaloshi G, Everhard S, Laigle-Donadey F et al.: Genetic markers predictive of chemosensitivity and outcome in gliomatosis cerebri. Neurology 70 (8), 590-595 (2008).
    • (2008) Neurology , vol.70 , Issue.8 , pp. 590-595
    • Kaloshi, G.1    Everhard, S.2    Laigle-Donadey, F.3
  • 13
    • 33745532038 scopus 로고    scopus 로고
    • Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: A randomized European Organisation for Research and Treatment of Cancer Phase III trial
    • van den Bent MJ, Carpentier AF, Brandes AA et al.: Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer Phase III trial. J. Clin. Oncol. 24 (18), 2715-2722 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 , pp. 2715-2722
    • Van Den Bent, M.J.1    Carpentier, A.F.2    Brandes, A.A.3
  • 14
    • 37249021342 scopus 로고    scopus 로고
    • Combined 1p/19q loss in oligodendroglial tumors: Predictive or prognostic biomarker?
    • Weller M, Berger H, Hartmann C et al.: Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker? Clin. Cancer Res. 13 (23), 6933-6937 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , Issue.23 , pp. 6933-6937
    • Weller, M.1    Berger, H.2    Hartmann, C.3
  • 15
    • 34249938331 scopus 로고    scopus 로고
    • Dynamic history of low-grade gliomas before and after temozolomide treatment
    • Ricard D, Kaloshi G, Amiel-Benouaich A et al.: Dynamic history of low-grade gliomas before and after temozolomide treatment. Ann. Neurol. 61 (5), 484-490 (2007).
    • (2007) Ann. Neurol. , vol.61 , Issue.5 , pp. 484-490
    • Ricard, D.1    Kaloshi, G.2    Amiel-Benouaich, A.3
  • 16
    • 74049107766 scopus 로고    scopus 로고
    • Diagnostic and prognostic markers in gliomas
    • Ducray F, El Hallani S, Idbaih A: Diagnostic and prognostic markers in gliomas. Curr. Opin. Oncol. 21 (6), 537-542 (2009).
    • (2009) Curr. Opin. Oncol. , vol.21 , Issue.6 , pp. 537-542
    • Ducray, F.1    Hallani, S.E.2    Idbaih, A.3
  • 17
    • 41149167213 scopus 로고    scopus 로고
    • 1p36 is a preferential target of chromosome 1 deletions in astrocytic tumours and homozygously deleted in a subset of glioblastomas
    • Ichimura K, Vogazianou AP, Liu L et al.: 1p36 is a preferential target of chromosome 1 deletions in astrocytic tumours and homozygously deleted in a subset of glioblastomas. Oncogene 27 (14), 2097-2108 (2008).
    • (2008) Oncogene , vol.27 , Issue.14 , pp. 2097-2108
    • Ichimura, K.1    Vogazianou, A.P.2    Liu, L.3
  • 18
    • 24644519817 scopus 로고    scopus 로고
    • Two types of chromosome 1p losses with opposite signifcance in gliomas
    • Idbaih A, Marie Y, Pierron G et al.: Two types of chromosome 1p losses with opposite signifcance in gliomas. Ann. Neurol. 58 (3), 483-487 (2005).
    • (2005) Ann. Neurol. , vol.58 , Issue.3 , pp. 483-487
    • Idbaih, A.1    Marie, Y.2    Pierron, G.3
  • 19
    • 33749471311 scopus 로고    scopus 로고
    • Identification of der (1;19) (q10;p10) in five oligodendrogliomas suggests mechanism of concurrent 1p and 19q loss
    • Griffn CA, Burger P, Morsberger L et al.: Identification of der (1;19) (q10;p10) in five oligodendrogliomas suggests mechanism of concurrent 1p and 19q loss. J. Neuropathol. Exp. Neurol. 65 (10), 988-994 (2006).
    • (2006) J. Neuropathol. Exp. Neurol. , vol.65 , Issue.10 , pp. 988-994
    • Griffn, C.A.1    Burger, P.2    Morsberger, L.3
  • 20
    • 58149462265 scopus 로고    scopus 로고
    • NOTCH2 is neither rearranged nor mutated in t (1;19) positive oligodendrogliomas
    • Benetkiewicz M, Idbaih A, Cousin PY et al.: NOTCH2 is neither rearranged nor mutated in t (1;19) positive oligodendrogliomas. PLoS ONE 4 (1), E4107 (2009).
    • (2009) PLoS ONE , vol.4 , Issue.1
    • Benetkiewicz, M.1    Idbaih, A.2    Cousin, P.Y.3
  • 21
    • 54049094870 scopus 로고    scopus 로고
    • Gene amplification is a poor prognostic factor in anaplastic oligodendrogliomas
    • Idbaih A, Criniere E, Marie Y et al.: Gene amplification is a poor prognostic factor in anaplastic oligodendrogliomas. Neuro. Oncol. 10 (4), 540-547 (2008).
    • (2008) Neuro. Oncol. , vol.10 , Issue.4 , pp. 540-547
    • Idbaih, A.1    Criniere, E.2    Marie, Y.3
  • 22
    • 40349089779 scopus 로고    scopus 로고
    • BAC array CGH distinguishes mutually exclusive alterations that define clinicogenetic subtypes of gliomas
    • Idbaih A, Marie Y, Lucchesi C et al.: BAC array CGH distinguishes mutually exclusive alterations that define clinicogenetic subtypes of gliomas. Int. J. Cancer 122 (8), 1778-1786 (2008).
    • (2008) Int. J. Cancer , vol.122 , Issue.8 , pp. 1778-1786
    • Idbaih, A.1    Marie, Y.2    Lucchesi, C.3
  • 23
    • 33750580929 scopus 로고    scopus 로고
    • 6-methylguanine DNA methyltransferase promoter methylation status, 1p and 19q deletions, and response to temozolomide in anaplastic and recurrent oligodendroglioma: A prospective GICNO study
    • 6-methylguanine DNA methyltransferase promoter methylation status, 1p and 19q deletions, and response to temozolomide in anaplastic and recurrent oligodendroglioma: a prospective GICNO study. J. Clin. Oncol. 24 (29), 4746-4753 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.29 , pp. 4746-4753
    • Brandes, A.A.1    Tosoni, A.2    Cavallo, G.3
  • 24
    • 11144349554 scopus 로고    scopus 로고
    • Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors
    • Mollemann M, Wolter M, Felsberg J, Collins VP, Reifenberger G: Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors. Int. J. Cancer 113 (3), 379-385 (2005).
    • (2005) Int. J. Cancer , vol.113 , Issue.3 , pp. 379-385
    • Mollemann, M.1    Wolter, M.2    Felsberg, J.3    Collins, V.P.4    Reifenberger, G.5
  • 25
    • 44949118621 scopus 로고    scopus 로고
    • Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile
    • Ducray F, Idbaih A, de Reynies A et al.: Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile. Mol. Cancer 7, 41 (2008).
    • (2008) Mol. Cancer , vol.7 , Issue.41
    • Ducray, F.1    Idbaih, A.2    De Reynies, A.3
  • 26
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    • Phillips HS, Kharbanda S, Chen R et al.: Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9 (3), 157-173 (2006).
    • (2006) Cancer Cell. , vol.9 , Issue.3 , pp. 157-173
    • Phillips, H.S.1    Kharbanda, S.2    Chen, R.3
  • 27
    • 60549115792 scopus 로고    scopus 로고
    • α-internexin expression identifes 1p19q codeleted gliomas
    • • Demonstrates that INA expression appears to be a simple and reliable marker of 1p19q codeletion
    • Ducray F, Criniere E, Idbaih A et al.: α-internexin expression identifes 1p19q codeleted gliomas. Neurology 72 (2), 156-161 (2009). • Demonstrates that INA expression appears to be a simple and reliable marker of 1p19q codeletion.
    • (2009) Neurology , vol.72 , Issue.2 , pp. 156-161
    • Ducray, F.1    Criniere, E.2    Idbaih, A.3
  • 28
    • 71949083197 scopus 로고    scopus 로고
    • Role of MGMT in tumor development, progression, diagnosis, treatment and prognosis
    • Sharma S, Salehi F, Scheithauer BW, Rotondo F, Syro LV, Kovacs K: Role of MGMT in tumor development, progression, diagnosis, treatment and prognosis. Anticancer Res. 29 (10), 3759-3768 (2009).
    • (2009) Anticancer Res. , vol.29 , Issue.10 , pp. 3759-3768
    • Sharma, S.1    Salehi, F.2    Scheithauer, B.W.3    Rotondo, F.4    Syro, L.V.5    Kovacs, K.6
  • 29
    • 63449086968 scopus 로고    scopus 로고
    • Epigenetic mechanisms in glioblastoma multiforme
    • Nagarajan RP, Costello JF: Epigenetic mechanisms in glioblastoma multiforme. Semin. Cancer Biol. 19 (3), 188-197 (2009).
    • (2009) Semin. Cancer Biol. , vol.19 , Issue.3 , pp. 188-197
    • Nagarajan, R.P.1    Costello, J.F.2
  • 30
    • 0034626988 scopus 로고    scopus 로고
    • Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
    • Esteller M, Garcia-Foncillas J, Andion E et al.: Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N. Engl. J. Med. 343 (19), 1350-1354 (2000).
    • (2000) N. Engl. J. Med. , vol.343 , Issue.19 , pp. 1350-1354
    • Esteller, M.1    Garcia-Foncillas, J.2    Andion, E.3
  • 31
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised Phase III study: 5-year analysis of the EORTC-NCIC trial
    • •• Demonstrates that MGMT promoter methylation is an independent factor of favorable outcome for patients included in the European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada 26981/22981 trial evaluating the effect of concomitant and adjuvant temozolomide versus radiotherapy alone in glioblastoma patients
    • Stupp R, Hegi ME, Mason WP et al.: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised Phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 10 (5), 459-466 (2009). •• Demonstrates that MGMT promoter methylation is an independent factor of favorable outcome for patients included in the European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada 26981/22981 trial evaluating the effect of concomitant and adjuvant temozolomide versus radiotherapy alone in glioblastoma patients.
    • (2009) Lancet Oncol. , vol.10 , Issue.5 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3
  • 32
    • 33749075532 scopus 로고    scopus 로고
    • Phase II trial of lomustine plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03
    • Herrlinger U, Rieger J, Koch D et al.: Phase II trial of lomustine plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03. J. Clin. Oncol. 24 (27), 4412-4417 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.27 , pp. 4412-4417
    • Herrlinger, U.1    Rieger, J.2    Koch, D.3
  • 33
    • 77952526135 scopus 로고    scopus 로고
    • Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide
    • Epub ahead of print
    • Weiler M, Hartmann C, Wiewrodt D et al.: Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide. Int. J. Radiat. Oncol. Biol. Phys. (2009) (Epub ahead of print).
    • (2009) Int. J. Radiat. Oncol. Biol. Phys.
    • Weiler, M.1    Hartmann, C.2    Wiewrodt, D.3
  • 34
    • 33846009775 scopus 로고    scopus 로고
    • MGMT methylation: A marker of response to temozolomide in low-grade gliomas
    • Everhard S, Kaloshi G, Criniere E et al.: MGMT methylation: a marker of response to temozolomide in low-grade gliomas. Ann. Neurol. 60 (6), 740-743 (2006).
    • (2006) Ann. Neurol. , vol.60 , Issue.6 , pp. 740-743
    • Everhard, S.1    Kaloshi, G.2    Criniere, E.3
  • 35
    • 73349121355 scopus 로고    scopus 로고
    • MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: A report from EORTC Brain Tumor Group study 26951
    • van den Bent MJ, Dubbink HJ, Sanson M et al.: MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group study 26951. J. Clin. Oncol. 27 (35), 5881-5886 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.35 , pp. 5881-5886
    • Van Den Bent, M.J.1    Dubbink, H.J.2    Sanson, M.3
  • 36
    • 73349134695 scopus 로고    scopus 로고
    • NOA-04 randomized Phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide
    • Wick W, Hartmann C, Engel C et al.: NOA-04 randomized Phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. J. Clin. Oncol. 27 (35), 5874-5880 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.35 , pp. 5874-5880
    • Wick, W.1    Hartmann, C.2    Engel, C.3
  • 37
    • 51249098488 scopus 로고    scopus 로고
    • 6-methylguanine-methyltransferase (MGMT) immunohistochemistry in glioblastoma multiforme: Observer variability and lack of association with patient survival impede its use as clinical biomarker
    • 6-methylguanine-methyltransferase (MGMT) immunohistochemistry in glioblastoma multiforme: observer variability and lack of association with patient survival impede its use as clinical biomarker. Brain Pathol. 18 (4), 520-532 (2008).
    • (2008) Brain Pathol. , vol.18 , Issue.4 , pp. 520-532
    • Preusser, M.1    Janzer, R.C.2    Felsberg, J.3
  • 38
    • 68949149010 scopus 로고    scopus 로고
    • Identifcation of regions correlating MGMT promoter methylation and gene expression in glioblastomas
    • Everhard S, Tost J, El Abdalaoui H et al.: Identifcation of regions correlating MGMT promoter methylation and gene expression in glioblastomas. Neuro. Oncol. 11 (4), 348-356 (2009).
    • (2009) Neuro. Oncol. , vol.11 , Issue.4 , pp. 348-356
    • Everhard, S.1    Tost, J.2    Abdalaoui, H.E.3
  • 39
    • 63449115574 scopus 로고    scopus 로고
    • MGMT analysis at DNA, RNA and protein levels in glioblastoma tissue
    • • Compares different techniques to determine MGMT methylation status
    • Preusser M: MGMT analysis at DNA, RNA and protein levels in glioblastoma tissue. Histol. Histopathol. 24 (4), 511-518 (2009). • Compares different techniques to determine MGMT methylation status.
    • (2009) Histol. Histopathol. , vol.24 , Issue.4 , pp. 511-518
    • Preusser, M.1
  • 40
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • •• Reports the sequencing of more than 20, 000 genes in 22 glioblastomas and IDH1 mutations identified for the first time
    • Parsons DW, Jones S, Zhang X et al.: An integrated genomic analysis of human glioblastoma multiforme. Science 321 (5897), 1807-1812 (2008). •• Reports the sequencing of more than 20, 000 genes in 22 glioblastomas and IDH1 mutations identified for the first time.
    • (2008) Science , vol.321 , Issue.5897 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 41
    • 67449099808 scopus 로고    scopus 로고
    • Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
    • Kang MR, Kim MS, Oh JE et al.: Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers. Int. J. Cancer 125 (2), 353-355 (2009).
    • (2009) Int. J. Cancer , vol.125 , Issue.2 , pp. 353-355
    • Kang, M.R.1    Kim, M.S.2    Oh, J.E.3
  • 42
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • • Demonstrates that IDH1 mutations are specifc to diffuse gliomas and result in a reduction of IDH1 enzymatic activity
    • Yan H, Parsons DW, Jin G et al.: IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360 (8), 765-773 (2009). • Demonstrates that IDH1 mutations are specifc to diffuse gliomas and result in a reduction of IDH1 enzymatic activity.
    • (2009) N. Engl. J. Med. , vol.360 , Issue.8 , pp. 765-773
    • Yan, H.1    Parsons, D.W.2    Jin, G.3
  • 43
    • 70249097408 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas
    • • This study, based on 404 gliomas, demonstrated that IDH1 mutations are tightly related to genomic profile but are also strong and independent prognostic markers in grade II-IV gliomas
    • Sanson M, Marie Y, Paris S et al.: Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas. J. Clin. Oncol. 27 (25), 4150-4154 (2009). • This study, based on 404 gliomas, demonstrated that IDH1 mutations are tightly related to genomic profile but are also strong and independent prognostic markers in grade II-IV gliomas.
    • (2009) J. Clin. Oncol. , vol.27 , Issue.25 , pp. 4150-4154
    • Sanson, M.1    Marie, Y.2    Paris, S.3
  • 44
    • 70349653793 scopus 로고    scopus 로고
    • IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas
    • Nobusawa S, Watanabe T, Kleihues P, Ohgaki H: IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas. Clin. Cancer Res. 15 (19), 6002-6007 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.19 , pp. 6002-6007
    • Nobusawa, S.1    Watanabe, T.2    Kleihues, P.3    Ohgaki, H.4
  • 45
    • 65349150503 scopus 로고    scopus 로고
    • IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
    • Watanabe T, Nobusawa S, Kleihues P, Ohgaki H: IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am. J. Pathol. 174 (4), 1149-1153 (2009).
    • (2009) Am. J. Pathol. , vol.174 , Issue.4 , pp. 1149-1153
    • Watanabe, T.1    Nobusawa, S.2    Kleihues, P.3    Ohgaki, H.4
  • 47
    • 58349111311 scopus 로고    scopus 로고
    • 132)) occur frequently in high-grade gliomas but not in other solid tumors
    • 132)) occur frequently in high-grade gliomas but not in other solid tumors. Hum. Mutat. 30 (1), 7-11 (2009).
    • (2009) Hum. Mutat. , vol.30 , Issue.1 , pp. 7-11
    • Bleeker, F.E.1    Lamba, S.2    Leenstra, S.3
  • 48
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis ER, Ding L, Dooling DJ et al.: Recurring mutations found by sequencing an acute myeloid leukemia genome. N. Engl. J. Med. 361 (11), 1058-1066 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.11 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 50
    • 68349116524 scopus 로고    scopus 로고
    • IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas
    • Ichimura K, Pearson DM, Kocialkowski S et al.: IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas. Neuro. Oncol. 11 (4), 341-347 (2009).
    • (2009) Neuro. Oncol. , vol.11 , Issue.4 , pp. 341-347
    • Ichimura, K.1    Pearson, D.M.2    Kocialkowski, S.3
  • 51
    • 64849098267 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1 α
    • • IDH1 mutation results in the inactivation of enzymatic activity and HIF-α pathway activation, which may contribute to tumorigenesis
    • Zhao S, Lin Y, Xu W et al.: Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1 α. Science 324 (5924), 261-265 (2009). • IDH1 mutation results in the inactivation of enzymatic activity and HIF-α pathway activation, which may contribute to tumorigenesis.
    • (2009) Science , vol.324 , Issue.5924 , pp. 261-265
    • Zhao, S.1    Lin, Y.2    Xu, W.3
  • 52
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • •• Reports that mutations in the IDH1 gene result in a gain of enzyme function leading to the production of 2-hydroxyglutarate, which may contribute to gliomagenesis
    • Dang L, White DW, Gross S et al.: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462 (7274), 739-744 (2009). •• Reports that mutations in the IDH1 gene result in a gain of enzyme function leading to the production of 2-hydroxyglutarate, which may contribute to gliomagenesis.
    • (2009) Nature , vol.462 , Issue.7274 , pp. 739-744
    • Dang, L.1    White, D.W.2    Gross, S.3
  • 53
    • 57349166553 scopus 로고    scopus 로고
    • Hydroxyglutaric aciduria and malignant brain tumor: A case report and literature review
    • Aghili M, Zahedi F, Rafiee E: Hydroxyglutaric aciduria and malignant brain tumor: a case report and literature review. J. Neurooncol. 91 (2), 233-236 (2009).
    • (2009) J. Neurooncol. , vol.91 , Issue.2 , pp. 233-236
    • Aghili, M.1    Zahedi, F.2    Rafiee, E.3
  • 54
    • 0038810144 scopus 로고    scopus 로고
    • D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats
    • Latini A, Scussiato K, Rosa RB et al.: D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats. Eur. J. Neurosci. 17 (10), 2017-2022 (2003).
    • (2003) Eur. J. Neurosci. , vol.17 , Issue.10 , pp. 2017-2022
    • Latini, A.1    Scussiato, K.2    Rosa, R.B.3
  • 55
    • 77952468297 scopus 로고    scopus 로고
    • 132H mutation-specific IDH1 antibody binding in brain tumors
    • Epub ahead of print
    • 132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathol. (2009) (Epub ahead of print).
    • (2009) Brain Pathol.
    • Capper, D.1    Weissert, S.2    Balss, J.3
  • 57
    • 34249889900 scopus 로고    scopus 로고
    • Mechanisms of disease: Genetic predictors of response to treatment in brain tumors
    • Collins VP: Mechanisms of disease: genetic predictors of response to treatment in brain tumors. Nat. Clin. Pract. Oncol. 4 (6), 362-374 (2007).
    • (2007) Nat. Clin. Pract. Oncol. , vol.4 , Issue.6 , pp. 362-374
    • Collins, V.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.