Lunasin peptide purified from Solanum nigrum L. protects DNA from oxidative damage by suppressing the generation of hydroxyl radical via blocking fenton reaction

Cancer Letters

Volumn 293, Issue 1, 2010, Pages 58-64

  Jeong, Jin Boo ^a   De Lumen, Ben O ^b   Jeong, Hyung Jin ^a  

^a Andong National University   (South Korea)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Carcinogenesis; Chemoprevention; DNA oxidation; Lunasin peptide; Solanum nigrum L.

Indexed keywords

FERROUS ION; HISTONE H2AX; HYDROXYL RADICAL; LUNASIN; SOLANUM NIGRUM EXTRACT; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA DAMAGE; DRUG PURIFICATION; FENTON REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IRON CHELATION; OXIDATIVE STRESS; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; DNA; DNA DAMAGE; FERROUS COMPOUNDS; FREE RADICAL SCAVENGERS; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; IRON CHELATING AGENTS; IRON-BINDING PROTEINS; MICE; NIH 3T3 CELLS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PLANT EXTRACTS; PLANT PROTEINS; SEEDS; SOLANUM NIGRUM;

SOLANUM NIGRUM;

EID: 77952430321     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.12.019     Document Type: Article

References (29)

1. Shureiqi I., Reddy P., Brenner D.E. Chemoprevention: general perspective. Oncol. Hematol. 2000, 33:157-167.
2. Dizdaroglu M. Chemical determination of free radical induced damage to DNA. Free Radic. Biol. Med. 1991, 10:225-242.
3. Genestra M. Oxyl radicals, redox-sensitive signaling cascades and antioxidants. Cell. Signal. 2007, 19:1807-1819.
4. Halliwell B., Gutteridge M.C. Free Radicals in Biology and Medicine 1989, Clarendon Press, Oxford.
5. Guo H., Kouzuma Y., Yonekura M. Structures and properties of antioxidative peptides derived from royal jelly protein. Food Chem. 2009, 1:238-245.
6. Chen H.M., Muramoto K., Yamauchi F. Structural analysis of antioxidative peptides from soybean β-conglycinin. J. Agric. Food Chem. 1995, 43:574-578.
7. Suetsuna K., Ukeda H., Ochi H. Isolation and characterization of free radical scavenging activities peptides derived from casein. J. Nutri. Biochem. 2000, 11:128-131.
8. Tsuge N., Eikawa Y., Nomura Y., Yamamoto M., Sugisawa K. Antioxidative activity of peptides prepared by enzymatic hydrolysis of egg-white albumin. Nippon Nogei Kagaku Kaishi 1991, 65:1635-1641. (in Japanese).
9. Park P.J., Jung W.K., Nam K.S., Shahidi F., Kim S.K. Purification and characterization of antioxidative peptides from protein hydrolysate of lecithin-free egg yolk. J. Am. Oil Chem. Soc. 2001, 78:651-656.
10. Kim S.K., Kim Y.T., Byun H.G., Nam K.S., Joo D.S., Shahidi F. Isolation and characterization of antioxidative peptides from gelatin hydrolysate of Alaska pollack skin. J. Agric. Food Chem. 2001, 49:1984-1989.
11. Galvez A.F., Chen N., Macasieb J., de Lumen B.O. Chemopreventive property of a soybean peptide (lunasin) that binds to deacetylated histones and inhibits acetylation. Cancer Res. 2001, 61:7473-7478.
12. Jeong H.J., Lam Y., de Lumen B.O. Barley lunasin suppresses ras-induced colony formation and histone acetylation in mammalian cells. J. Agric. Food Chem. 2002, 50:5903-5908.
13. Jeong H.J., Jeong J.B., Kim D.S., Park J.H., Lee J.B., Kweon D.H., Chung G.Y., Seo E.W., de Lumen B.O. The cancer preventive peptide lunasin from wheat inhibits core histone acetylation. Cancer Lett. 2007, 255:42-48.
14. Jeong J.B., Jeong H.J., Park J.H., Lee S.H., Lee J.R., Lee H.K., Chung G.Y., Choi J.D., de Lumen B.O. Cancer-preventive peptide lunasin from Solanum nigrum L. inhibits acetylation of core histone H3 and H4 and phosphorylation of retinoblastoma protein (RB). J. Agric. Food Chem. 2007, 55:10707-10713.
15. Ruoslahti E., Pierschbacher M.D. Arg-Gly-Asp: a versatile cell recognition signal. Cell 1986, 44:517-518.
16. Akiyama S.K., Olden K., Yamada K.M. Fibronectin and integrins in invasion and metastasis. Cancer Metastas. Rev. 1986, 14:173-189.
17. Revilleza M.J., Galvez A.F., Krenz D.C., de Lumen B.O. An 8 kDa methionine-rich protein from soybean (Glycine max) cotyledon: identification, purification, and N-terminal sequence. J. Agric. Food Chem. 1996, 44:930-2935.
18. de Lumen B.O. Lunasin: a cancer preventive soy peptide. Nutr. Rev. 2005, 63:16-21.
19. Lam Y., Galvez A.F., de Lumen B.O. Lunasin suppresses E1A-mediated transformation of mammalian cells but does not inhibit growth of immortalized and established cancer cell line. Nutr. Cancer 2003, 47:88-94.
20. Smirnoff N., Cumbes Q.J. Hydroxyl radical scavenging activity of compatible solutes. Phytochemistry 1989, 28:1057-1060.
21. Hus B., Coupar I.M., Ng K. Antioxidant activity of hot water extract from the fruit of the Doum palm. Hyphaene thebaica. Food Chem. 2006, 98:317-328.
22. Jung Y., Surh Y. Oxidative DNA damage and cytotoxicity induced by copper-stimulated redox cycling of salsolinol, a neurotoxic tetrahydroisoquinoline alkaloid. Free Radic. Biol. Med. 2001, 30:1407-1417.
23. Lloyd R.V., Hanna P.M., Mason R.P. The origin of the hydroxyl radical oxygen in the Fenton reaction. Free Radic. Biol. Med. 1997, 22:885-888.
24. Cai L., Koropatnick J., George Cherian M. Metallothionein protects DNA from copper-induced but not iron-induced cleavage in vitro. Chem.-Biol. Interact. 1995, 96:143-155.
25. Jeong H.J., Park J.H., Yi L., de Lumen B.O. Characterization of lunasin isolated from soybean. J. Agric. Food Chem. 2003, 51:7901-7906.
26. Leonard S.S., Keil D., Mehlman T., Proper S., Shi X., Harris G.K. Essiac Tea: Scavenging of reactive oxygen species and effects on DNA damage. J. Ethnopharmacol. 2006, 103:288-296.
27. Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine, 139. J. Biol. Chem. 1988, 273:5858-5868.
28. Hussain S.P., Hofseth L.J., Harris C.C. Radical causes of cancer. Nat. Rev. Cancer 1984, 3:276-285.
29. Sakanaka S., Tachibana Y., Okada Y. Preparation and antioxidant properties of extracts of Japanese persimmon leaf tea (kakinoha-cha). Food Chem. 2005, 89:569-575.