Increased origin activity in transformed versus normal cells: Identification of novel protein players involved in DNA replication and cellular transformation

Nucleic Acids Research

Volumn 38, Issue 7, 2010, Pages 2314-2331

  di Paola, Domenic ^a,b   Rampakakis, Emmanouil ^a,b   Chan, Man Kid ^a,b   Arvanitis, Dina N ^a,b   Zannis Hadjopoulos, Maria ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN 6; DNA; PROTEIN ANTIBODY; REPLICATION LICENSING FACTOR CDT1; CDC6 PROTEIN, HUMAN; CDT1 PROTEIN, HUMAN; CELL CYCLE PROTEIN; NUCLEAR PROTEIN; ORIGIN RECOGNITION COMPLEX;

ANTIGEN BINDING; ARTICLE; CELL ACTIVITY; CELL SPECIFICITY; CELL TRANSFORMATION; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME REPLICATION; CONTROLLED STUDY; DNA REPLICATION; ELECTROPHORETIC MOBILITY; GENE LOCUS; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; CELL LINE; COPY NUMBER VARIATION; DNA REPLICATION ORIGIN; GENETICS; HUMAN GENOME; METABOLISM; PLASMID;

CELL CYCLE PROTEINS; CELL LINE; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; CLONING, MOLECULAR; DNA; DNA COPY NUMBER VARIATIONS; DNA REPLICATION; GENETIC LOCI; GENOME, HUMAN; HUMANS; MASS SPECTROMETRY; NUCLEAR PROTEINS; ORIGIN RECOGNITION COMPLEX; PLASMIDS; REPLICATION ORIGIN;

EID: 77952301361     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkp1192     Document Type: Article

References (63)

1. Jacob, F., Brenner, S. and Cuzin, F. (1963) On the regulation of DNA replication in bacteria. Cold Spring Harbor Symp. Quant. Biol., 28, 329-348.
2. Edenberg, H.J. and Huberman, J.A. (1975) Eukaryotic chromosome replication. Annu. Rev. Genet., 9, 245-284.
3. Hand, R. (1978) Eucaryotic DNA: organization of the genome for replication. Cell, 15, 317-325.
4. Zannis-Hadjopoulos, M. and Price, G.B. (1999) Eukaryotic DNA replication. J. Cell. Biochem., Supplements 32/33, 1-14.
5. Machida, Y.J., Hamlin, J.L. and Dutta, A. (2005) Right place, right time, and only once: replication initiation in metazoans. Cell, 123, 13-24.
6. Teer, J.K. and Dutta, A. (2006) Regulation of S phase. Results Probl. Cell Differ., 42, 31-63.
7. Martin, R. (1981) The transformation of cell growth and transmogrification of DNA synthesis by simian virus 40. Adv. Cancer Res., 34, 1-68.
8. Anglana, M., Apiou, F., Bensimon, A. and Debatisse, M. (2003) Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing. Cell, 114, 385-394.
9. Zannis-Hadjopoulos, M. and Price, G. (1998) Regulatory parameters of DNA replication. Crit. Rev. Eukary. Gene Exp., 8, 81-106.
10. Tao, L., Nielsen, T., Friedlander, P., Zannis-Hadjopoulos, M. and Price, G. (1997) Differential DNA replication origin activities in human normal skin fibroblast and HeLa cell lines. J. Mol. Biol., 273, 509-518.
11. Tao, L., Dong, Z., Leffak, M., Zannis-Hadjopoulos, M. and Price, G. (2000) Major DNA replication initiation sites in the c-myc locus in human cells. J. Cell. Biochem., 78, 442-457.
12. Tao, L., Dong, Z., Zannis-Hadjopoulos, M. and Price, G.B. (2001) Immortalization of human WI38 cells is associated with differential activation of the c-myc origins. J. Cell. Biochem., 82, 522-534.
13. Di Paola, D., Price, G.B. and Zannis-Hadjopoulos, M. (2006) Differentially active origins of DNA replication in tumor versus normal cells. Cancer Res., 66, 5094-5103.
14. Martin, R.G. and Oppenheim, A. (1977) Initiation points for DNA replication in nontransformed and simian virus 40-transformed Chinese hamster lung cells. Cell, 11, 859-869.
15. Oppenheim, A. and Martin, R.G. (1978) Initiation points for DNA replication in nontransformed and simian virus 40-transformed BALB/c 3T3 cells. J. Virol., 25, 450-452.
16. Collins, J., Glock, M. and Chu, A. (1982) Nuclease S1 sensitive sites in potential deoxyribonucleic acid of cold-and temperature-sensitive mammalian cells. Biochemistry, 21, 3414-3419.
17. Itoh-Lindstrom, Y. and Leffak, M. (1994) Alteration of in vitro DNA synthesis in the alpha globin locus of embryo fibroblasts due to in vivo activity of Rous Sarcoma Virus. Nucleic Acids Res., 22, 498-508.
18. Kennedy, B.K., Barbie, D.A., Classon, M., Dyson, N. and Harlow, E. (2000) Nuclear organization of DNA replication in primary mammalian cells. Genes Dev., 14, 2855-2868.
19. Dimitrova, D.S. and Berezney, R. (2002) The spatio-temporal organization of DNA replication sites is identical in primary, immortalized and transformed mammalian cells. J. Cell Sci., 115, 4037-4051.
20. Panning, M.M. and Gilbert, D.M. (2005) Spatio-temporal organization of DNA replication in murine embryonic stem, primary, and immortalized cells. J. Cell. Biochem., 95, 74-82.
21. Conti, C., Sacca, B., Herrick, J., Lalou, C., Pommier, Y. and Bensimon, A. (2007) Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells. Mol. Biol. Cell, 18, 3059-3067.
22. de Campos Vidal, B., Russo, J. and Mello, M.L. (1998) DNA content and chromatin texture of benzo[a]pyrene-transformed human breast epithelial cells as assessed by image analysis. Exp. Cell Res., 244, 77-82.
23. Mello, M.L., Russo, P., Russo, J. and Vidal, B.C. (2007) 17-beta-estradiol affects nuclear image properties in MCF-10F human breast epithelial cells with tumorigenesis. Oncol. Rep., 18, 1475-1481.
24. Amiel, A., Litmanovitch, T., Lishner, M., Mor, A., Gaber, E., Tangi, I., Fejgin, M. and Avivi, L. (1998) Temporal differences in replication timing of homologous loci in malignant cells derived from CML and lymphoma patients. Genes Chromosomes Cancer, 22, 225-231.
25. McNairn, A.J. and Gilbert, D.M. (2005) Overexpression of ORC subunits and increased ORC-chromatin association in transformed mammalian cells. J. Cell. Biochem., 96, 879-887.
26. Lau, E. and Jiang, W. (2006) Is there a pre-RC checkpoint that cancer cells lack? Cell Cycle, 5, 1602-1606.
27. Lau, E., Tsuji, T., Guo, L., Lu, S.H. and Jiang, W. (2007) The role of pre-replicative complex (pre-RC) components in oncogenesis. FASEB J., 21, 3786-3794.
28. Dutta, A. (2007) Chaotic license for genetic instability and cancer. Nat Genet, 39, 10-11.
29. Hu, L., Xu, X. and Valenzuela, M.S. (2004) Identification of novel initiation sites for human DNA replication around ARSH1, a previously characterized yeast replicator. Biochem. Biophys. Res. Commun., 313, 1058-1064.
30. Hu, L., Xu, X. and Valenzuela, M.S. (2004) Initiation sites for human DNA replication at a putative ribulose-5-phosphate 3-epimerase gene. Biochem. Biophys. Res. Commun., 320, 648-655.
31. Kumar, S., Giacca, M., Norio, G., Biamonti, G., Riva, S. and Falaschi, A. (1996) Utilization of the same DNA replication origin by human cells of different derivation. Nucleic Acids Res., 24, 3289-3294.
32. Nielsen, T., Bell, D., Lamoureux, C., Zannis-Hadjopoulos, M. and Price, G.B. (1994) A reproducible method for identification of human genomic DNA autonomously replicating sequences. Mol. Gen. Genet., 242, 280-288.
33. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
34. Matheos, D., Novac, O., Price, G.B. and Zannis-Hadjopoulos, M. (2003) Analysis of the DNA replication competence of the xrs-5 mutant cells defective in Ku86. J. Cell Sci., 116, 111-124.
35. Tatsumi, Y., Tsurimoto, T., Shirahige, K., Yoshikawa, H. and Obuse, C. (2000) Association of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structures. J. Biol. Chem., 275, 5904-5910.
36. Sibani, S., Price, G.B. and Zannis-Hadjopoulos, M. (2005) Decreased origin usage and initiation of DNA replication in haploinsufficient HCT116 Ku80+/- cells. J. Cell Sci., 118, 3247-3261.
37. Price, G.B., Allarakhia, M., Cossons, N., Nielsen, T., Diaz-Perez, M., Friedlander, P., Tao, L. and Zannis-Hadjopoulos, M. (2003) Identification of a cis-element that determines autonomous DNA replication in eukaryotic cells. J. Biol. Chem., 278, 19649-19659.
38. Giacca, M., Zentilin, L., Norio, P., Diviacco, S., Dimitrova, D., Contreas, G., Biamonti, G., Perini, G., Weighardt, F., Riva, S. et al. (1994) Fine mapping of a replication origin of human DNA. Proc. Natl Acad. Sci. USA, 91, 7119-7123.
39. DePamphilis, M. (1993) How transcription factor regulate origins of DNA replication in eukaryotic cells. Trends Cell. Biol., 3, 161-167.
40. DePamphilis, M.L. (1997) The search for origins of DNA replication. Methods, 13, 211-219.
41. Wang, J., Lindner, S.E., Leight, E.R. and Sugden, B. (2006) Essential elements of a licensed, mammalian plasmid origin of DNA synthesis. Mol. Cell. Biol., 26, 1124-1134.
42. Lebofsky, R., Heilig, R., Sonnleitner, M., Weissenbach, J. and Bensimon, A. (2006) DNA replication origin interference increases the spacing between initiation events in human cells. Mol. Biol. Cell, 17, 5337-5345.
43. Bartkova, J., Horejsi, Z., Koed, K., Kramer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J.M., Lukas, C. et al. (2005) DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature, 434, 864-870.
44. Gorgoulis, V.G., Vassiliou, L.V., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., Ditullio, R.A. Jr, Kastrinakis, N.G., Levy, B. et al. (2005) Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature, 434, 907-913.
45. Bartek, J., Bartkova, J. and Lukas. (2007) DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene, 26, 7773-7779.
46. Bandura, J.L. and Calvi, B.R. (2002) Duplication of the genome in normal and cancer cell cycles. Cancer Biol. Ther., 1, 8-13.
47. Abdurashidova, G., Danailov, M.B., Ochem, A., Triolo, G., Djeliova, V., Radulescu, S., Vindigni, A., Riva, S. and Falaschi, A. (2003) Localization of proteins bound to a replication origin of human DNA along the cell cycle. EMBO J., 22, 4294-4303.
48. Ghosh, M., Kemp, M., Liu, G., Ritzi, M., Schepers, A. and Leffak, M. (2006) Differential binding of replication proteins across the human c-myc replicator. Mol. Cell. Biol., 26, 5270-5283.
49. Liontos, M., Koutsami, M., Sideridou, M., Evangelou, K., Kletsas, D., Levy, B., Kotsinas, A., Nahum, O., Zoumpourlis, V., Kouloukoussa, M. et al. (2007) Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res., 67, 10899-10909.
50. Rampakakis, E., Di Paola, D. and Zannis-Hadjopoulos, M. (2008) Ku is involved in cell growth, DNA replication and G1-S transition. J. Cell Sci., 121, 590-600.
51. Guan, J., DiBiase, S. and Iliakis, G. (2000) The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication. Nucleic Acids Res., 28, 1183-1192.
52. An, J., Yang, D.Y., Xu, Q.Z., Zhang, S.M., Huo, Y.Y., Shang, Z.F., Wang, Y., Wu, D.C. and Zhou, P.K. (2008) DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein. Mol. Cancer, 7, 32.
53. Minopoli, G., Stante, M., Napolitano, F., Telese, F., Aloia, L., De Felice, M., Di Lauro, R., Pacelli, R., Brunetti, A., Zambrano, N. et al. (2007) Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage. J. Biol. Chem., 282, 831-835.
54. Yang, Z., Cool, B.H., Martin, G.M. and Hu, Q. (2006) A dominant role for FE65 (APBB1) in nuclear signaling. J. Biol. Chem., 281, 4207-4214.
55. Ono, Y., Furuta, T., Ohmoto, T., Akiyama, K. and Seki, S. (1994) Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease. Mutat. Res., 315, 55-63.
56. Bobola, M.S., Blank, A., Berger, M.S., Stevens, B.A. and Silber, J.R. (2001) Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas. Clin. Cancer Res., 7, 3510-3518.
57. Chen, Y., Schnetz, M.P., Irarrazabal, C.E., Shen, R.F., Williams, C.K., Burg, M.B. and Ferraris, J.D. (2007) Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: functional effects of Hsp90 and PARP-1. Am. J. Physiol. Renal Physiol., 292, F981-F992.
58. Dellaire, G., Makarov, E.M., Cowger, J.J., Longman, D., Sutherland, H.G., Luhrmann, R., Torchia, J. and Bickmore, W.A. (2002) Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. Mol. Cell. Biol., 22, 5141-5156.
59. Jin, Y.J. and Burakoff, S.J. (1993) The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin. Proc. Natl Acad. Sci. USA, 90, 7769-7773.
60. Yang, W.M., Yao, Y.L. and Seto, E. (2001) The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1. EMBO J., 20, 4814-4825.
61. Yang,S., Du,J., Wang,Z., Yuan,W., Qiao,Y., Zhang,M., Zhang,J., Gao,S., Yin,J., Sun,B. et al. (2007) BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells. BMC Cancer, 7, 211.
62. Ogawa, K., Utsunomiya, T., Mimori, K., Tanaka, Y., Tanaka, F., Inoue, H., Murayama, S. and Mori, M. (2004) Clinical significance of elongation factor-1 delta mRNA expression in oesophageal carcinoma. Br. J. Cancer, 91, 282-286.
63. Lei, Y.X., Chen, K. and Wu, Z.L. (2002) Blocking the translation elongation factor-1 delta with its antisense mRNA results in a significant reversal of its oncogenic potential. Teratog. Carcinog. Mutagen., 22, 377-383.