Photobiological implications of folate depletion and repletion in cultured human keratinocytes

Journal of Photochemistry and Photobiology B: Biology

Volumn 99, Issue 1, 2010, Pages 49-61

  Williams, Joshua D ^a   Jacobson, Myron K ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Cancer; DNA damage; Folate; Keratinocytes; Skin biology; Solar simulated light

Indexed keywords

FOLIC ACID; URACIL;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DNA METABOLISM; FOLIC ACID DEFICIENCY; GENOMIC INSTABILITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIOBIOLOGY; SKIN; SKIN CARCINOGENESIS; ULTRAVIOLET RADIATION;

CELL LINE; COMET ASSAY; DNA DAMAGE; FOLIC ACID; FOLIC ACID DEFICIENCY; GENOMIC INSTABILITY; HUMANS; KERATINOCYTES; S PHASE; TETRAHYDROFOLATES; ULTRAVIOLET RAYS; URACIL;

EID: 77952242528     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jphotobiol.2010.02.003     Document Type: Article

References (59)

1. Lucock M. Folic acid: nutritional biochemistry, molecular biology and role in disease processes. Mol. Genet. Metab. 2000, 71(1-2):121-138.
2. Lucock M., Yates Z. Folic acid fortification: a double-edged sword. Curr. Opin. Clin. Nutr. Metab. Care 2009, 12(6):555-564.
3. Eichholzer M., Tonz O., Zimmermann R. Folic acid: a public-health challenge. Lancet 2006, 367(9519):1352-1361.
4. Bonaa K.H., et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. New Engl. J. Med. 2006, 354(15):1578-1588.
5. Gisondi P., et al. Folic acid in general medicine and dermatology. J. Dermatol. Treat. 2007, 18(3):138-146.
6. Ulrey C.L., et al. The impact of metabolism on DNA methylation. Hum. Mol. Genet. 2005, 14(1):139-147.
7. Kompis I.M., Islam K., Then R.L. DNA and RNA synthesis: antifolates. Chem. Rev. 2005, 105(2):593-620.
8. Jang H., Mason J.B., Choi S.W. Genetic and epigenetic interactions between folate and aging in carcinogenesis. J. Nutr. 2005, 135(12):967S-2971S.
9. Branda R.F., Blickensderfer D.B. Folate deficiency increases genetic damage caused by alkylating agents and gamma-irradiation in Chinese hamster ovary cells. Cancer Res. 1993, 53(22):5401-5408.
10. Jablonski N.G., Chaplin G. The evolution of human skin coloration. J. Hum. Evol. 2000, 39(1):57-106.
11. Tam T.T., et al. Photodegradation of 5-methyltetrahydrofolate in the presence of Uroporphyrin. J. Photochem. Photobiol. B 2009, 94(3):201-204.
12. Steindal A.H., et al. Photodegradation of 5-methyltetrahydrofolate: biophysical aspects. Photochem. Photobiol. 2006, 82(6):1651-1655.
13. Steindal A.H., et al. 5-Methyltetrahydrofolate is photosensitive in the presence of riboflavin. Photochem. Photobiol. Sci. 2008, 7(7):814-818.
14. Off M.K., et al. Ultraviolet photodegradation of folic acid. J. Photochem. Photobiol. B 2005, 80(1):47-55.
15. Duthie S.J., Hawdon A. DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro. FASEB J. 1998, 12(14):1491-1497.
16. James S.J., Basnakian A.G., Miller B.J. In vitro folate deficiency induces deoxynucleotide pool imbalance apoptosis, and mutagenesis in Chinese hamster ovary cells. Cancer Res. 1994, 54(19):5075-5080.
17. Melnyk S., et al. Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells. Cancer Lett. 1999, 146(1):35-44.
18. Linhart H.G., et al. Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations. Gastroenterology 2009, 136(1):227-235. e3.
19. Crott J.W., et al. Moderate folate depletion modulates the expression of selected genes involved in cell cycle intracellular signaling and folate uptake in human colonic epithelial cell lines. J. Nutr. Biochem. 2008, 19(5):328-335.
20. Crott J.W., et al. The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. Cancer Epidemiol. Biomarkers Prev. 2001, 10(10):1089-1096.
21. Beetstra S., et al. Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei. Mutat. Res. 2005, 578(1-2):317-326.
22. Kim Y.I., et al. Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am. J. Clin. Nutr. 1997, 65(1):46-52.
23. Halsted C.H., et al. Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc. Natl. Acad. Sci. USA 2002, 99(15):10072-10077.
24. Duthie S.J., et al. Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells. Nutr. Cancer 2000, 37(2):245-251.
25. Katula K.S., Heinloth A.N., Paules R.S. Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J. Nutr. Biochem. 2007, 18(8):541-552.
26. Higgins J.R., et al. The relationship between increased folate catabolism and the increased requirement for folate in pregnancy. Bjog 2000, 107(9):1149-1154.
27. Stover P.J. Physiology of folate and vitamin B12 in health and disease. Nutr. Rev. 2004, 62(6 Pt 2):S3-12. (discussion S13).
28. Suh J.R., et al. Purification and properties of a folate-catabolizing enzyme. J. Biol. Chem. 2000, 275(45):35646-35655.
29. Anguera M.C., et al. Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation. J. Biol. Chem. 2003, 278(32):29856-29862.
30. Suh J.R., Herbig A.K., Stover P.J. New perspectives on folate catabolism. Annu. Rev. Nutr. 2001, 21:255-282.
31. Kim Y.I., et al. Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in persons with colorectal polyps. Am. J. Clin. Nutr. 1998, 68(4):866-872.
32. Wondrak G.T., et al. Identification of alpha-dicarbonyl scavengers for cellular protection against carbonyl stress. Biochem. Pharmacol. 2002, 63(3):361-373.
33. Wondrak G.T., et al. Proteins of the extracellular matrix are sensitizers of photo-oxidative stress in human skin cells. J. Invest. Dermatol. 2003, 121(3):578-586.
34. Gilchrest B.A., Yaar M. Ageing and photoageing of the skin: observations at the cellular and molecular level. Brit. J. Dermatol. 1992, 127(41):25-30.
35. Jacobson E.L., Shieh W.M., Huang A.C. Mapping the role of NAD metabolism in prevention and treatment of carcinogenesis. Mol. Cell. Biochem. 1999, 193(1-2):69-74.
36. Boukamp P., et al. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell. Biol. 1988, 106(3):761-771.
37. Lehman T.A., et al. p53 mutations in human immortalized epithelial cell lines. Carcinogenesis 1993, 14(5):833-839.
38. Benavente C.A., Jacobson E.L. Niacin restriction upregulates NADPH oxidase and reactive oxygen species (ROS) in human keratinocytes. Free Radical Biol. Med. 2008, 44(4):527-557.
39. Patring J.D., et al. Development of a simplified method for the determination of folates in baker's yeast by HPLC with ultraviolet and fluorescence detection. J. Agric. Food Chem. 2005, 53(7):2406-2411.
40. Garbis S.D., et al. Determination of folates in human plasma using hydrophilic interaction chromatography-tandem mass spectrometry. Anal. Chem. 2001, 73(22):5358-5364.
41. Smith D.E., et al. Quantitative determination of erythrocyte folate vitamer distribution by liquid chromatography-tandem mass spectrometry. Clin. Chem. Lab. Med. 2006, 44(4):450-459.
42. van den Berg H., Finglas P.M., Bates C. FLAIR intercomparisons on serum and red cell folate. Int. J. Vitam. Nutr. Res. 1994, 64(4):288-293.
43. Singh N.P., et al. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell. Res. 1988, 175(1):184-191.
44. Courtemanche C., et al. Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison. FASEB J. 2004, 18(1):209-211.
45. Tourriere H., Pasero P. Maintenance of fork integrity at damaged DNA and natural pause sites. DNA Repair (Amst) 2007, 6(7):900-913.
46. Dianov G.L., et al. Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation. Mol. Gen. Genet. 1991, 225(3):448-452.
47. Bonassi S., et al. Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens. European Study Group on Cytogenetic Biomarkers and Health. Cancer Res. 2000, 60(6):1619-1625.
48. Narbutt J., et al. Suberythemal ultraviolet B radiation alters the expression of cell cycle-related proteins in the epidermis of human subjects without leading to photoprotection. Brit. J. Dermatol. 2009, 161(4):890-896.
49. Weisfelner M.E., Gottlieb A.B. The role of apoptosis in human epidermal keratinocytes. J. Drugs Dermatol. 2003, 2(4):385-391.
50. Chaturvedi V., et al. Abnormal NF-kappaB signaling pathway with enhanced susceptibility to apoptosis in immortalized keratinocytes. J. Dermatol. Sci. 2001, 26(1):67-78.
51. Magal S.S., et al. Induction of apoptosis in human keratinocytes containing mutated p53 alleles and its inhibition by both the E6 and E7 oncoproteins. Int. J. Cancer 1998, 75(1):96-104.
52. Wondrak G.T., Jacobson M.K., Jacobson E.L. Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection. Photochem. Photobiol. Sci. 2006, 5(2):215-237.
53. Ebbing M., et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA 2009, 302(19):2119-2126.
54. Cole B.F., et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 2007, 297(21):2351-2359.
55. Ravanat J.L., Douki T., Cadet J. Direct and indirect effects of UV radiation on DNA and its components. J. Photochem. Photobiol. B 2001, 63(1-3):88-102.
56. Vink A.A., Roza L. Biological consequences of cyclobutane pyrimidine dimers. J. Photochem. Photobiol. B 2001, 65(2-3):101-104.
57. Brash D.E., et al. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc. Natl. Acad. Sci. USA 1991, 88(22):10124-10128.
58. Li L.S., et al. DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets. Brit. J. Pharmacol. 2009, 158(3):679-692.
59. Offer T., et al. 5-Methyltetrahydrofolate inhibits photosensitization reactions and strand breaks in DNA. FASEB J. 2007, 21(9):2101-2107.