Paracrine Interactions of Melanocytes in Pigmentary Disorders

The Pigmentary System: Physiology and Pathophysiology: Second Edition

Volumn , Issue , 2007, Pages 421-444

  Imokawa, Genji ^a  

^a Skin Bio Assess Institute   (Japan)

Author keywords

Eicosanoids; Endothelin 1 growth related oncogene; Paracrine cytokines; Paracrine interactions

Indexed keywords

EID: 77952240344     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470987100.ch21     Document Type: Chapter

References (86)

1. Amiel, J., T. Attie, D. Jan, A. Pelet, P. Edery, C. Bidaud, D. Lacombe, P. Tam, J. Simeoni, E. Flori, C. Nihoul-Fekete, A. Munnich, and S. Lyonnet. Heterozygous endothelin receptor B (EDNRB) mutations in isolated Hirschsprung disease. Hum. Mol. Genet. 5:255-257, 1996.
2. Anisowicz, A., D. Zajchowski, G. Stenman, and R. Sager. Functional diversity of GRO gene expression in human fibroblasts and mammary epithelial cells. Proc. Natl. Acad. Sci. USA 85:9645-9649, 1988.
3. Arai, H., K. Nakao, K. Takaya, K. Hosoda, Y. Ogawa, S. Nakanishi, and H. Immura. The human endothelin B receptor gene. Structural organization and chromosomal assignment. J. Biol. Chem. 268: 3463-3470, 1993.
4. Barker, D., E. Wright, K. Nguyen, L. Cannon, P. Fain, D. Goldgar, D. T. Bishop, J. Carey, B. Baty, and J. Kivlin. Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17. Science 236:1100-1102, 1987.
5. Benedict, P. H., G. Szabo, T. B. Fitzpatrick, and S. L. Sinesi. Melanotic macules in Albright's syndrome and in neurofibromatosis. JAMA 205:618-626, 1968.
6. Bernstein, A., L. Forrester, A. D. Reith, P. Dubreuil, and R. Rottapel. The murine W/c-kit and steel loci and the control of hematopoiesis. Semin. Hematol. 28:138-142, 1991.
7. Besmer, P., K. Manova, R. Duttlinger, E. J. Huang, A. Packer, C. Gyssler, and R. Bachvarova. The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melano-genesis. Development 119:125-137, 1993.
8. Brenner, B. M., J. L. Troy, and B. J. Ballermann. Endothelium-dependent vascular responses. Mediators and mechanisms. J. Clin. Invest. 84:1373-1378, 1989.
9. Castor, C. W., J. W. Miller, and D. A. Walz. Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor. Proc. Natl. Acad. Sci. USA 80:765-769, 1983.
10. Cawthorn, R. M., R. Weiss, G. Xu, D. Viskochil, M. Culver, J. Stevens, M. Robertson, D. Dunn, R. Gesteland, and P. O'Conell. A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure and point mutations. Cell 62:193-201, 1990.
11. Costa, J. J., G. D. Demetri, T. J. Harrist, A. M. Dvorak, D. F. Hayes, E. A. Merica, D. M. Menchaca, A. J. Gringeri, L. B. Schwartz, and S. J. Galli. Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo. J. Exp. Med. 183:2681-2686, 1996.
12. Eisinger, M., and O. Marko. Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin. Proc. Natl. Acad. Sci. USA 79:2018-2022, 1982.
13. Ezoe, K., S. A. Holmes, L. Ho, C. P. Bennett, J. L. Bolognia, L. Brueton, J. Burn, R. Falabella, E. M. Gatto, N. Ishii, C. Moss, M. R. Pittelkow, E. Thompson, K. A. Ward, and R. A. Spritz. Novel mutations and deletions of the KIT (steel factor receptor) gene in human piebaldism. Am. J. Hum. Genet. 56: 58-66, 1995.
14. Frenk, E., and A. Marazzi. Neurofibromatosis of von Recklinghausen: quantitative study of the epidermal keratinocyte and melanocyte populations. J. Invest. Dermatol. 83:23-25, 1984.
15. Galli, S. J., K. M. Zsebo, and E. N. Geissler. The kit ligand, stem cell factor. Adv. Immunol. 55:1-96, 1993.
16. Giebel, L. B., and R. A. Spritz. Mutation of the KIT (mast/stem-cell growth factor receptor) protooncogene in human piebaldism. Proc. Natl. Acad. Sci. USA 88:8696-8699, 1991.
17. Grichnik, J. M., J. Crawford, F. Jimenez, J. Kurtzberg, M. Buchanan, S. Blackwell, R. E. Clark, and M. G. Hitchcock. Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients. J. Am. Acad. Dermatol. 33:577-583, 1995.
18. Griesser, J., D. Kaufmann, I. Eisenbarth, C. Bauerle, and W. Krone. Ras-GTP regulation is not altered in cultured melanocytes with reduced levels of neurofibromin derived from patients with neurofibromatosis 1 (NF1). Boil. Chem. Hoppe Seyler 376:91-101, 1995.
19. Hachiya, A., A. Kobayashi, A. Ohuchi, Y. Takema, and G. Imokawa. The paracrine role of stem cell factor/c-kit signaling in the activation of human melanocytes in ultraviolet B-induced pigmentation. J. Invest. Dermatol. 116:578-586, 2001.
20. Hachiya, A., T. Kobayashi, Y. Takema, and G. Imokawa. Biochemical characterization of endothelin-converting enzyme-1alpha in cultured skin-derived cells and its postulated role in the stimulation of melanogenesis in human epidermis. J. Biol. Chem. 277:5395-5403, 2002.
21. Hachiya, A., A. Kobayashi, Y. Yoshida, T. Kitahara, Y. Takema, and G. Imokawa. Biphasic expression of two paracrine melanogenic cytokines, stem cell factor and endothelin-1, in ultraviolet B-induced human melanosis. submitted, 2004.
22. Halaban, R., and G. Moellmann. White mutants in mice shedding light on humans. J. Invest. Dermatol. 100:176S-185S, 1993.
23. Hann S. K., and J. J. Nordlund. Vitiligo. Oxford: Blackwell Science, 2000.
24. Hattori, H., M. Kawashima, Y. Ichikawa, and G. Imokawa. The epidermal stem cell factor is over-expressed in lentigo senilis: implication for the mechanism of hyperpigmentation. J. Invest. Dermatol. 122:1256-1265, 2004.
25. Heenan, P. J. Tumors of the fibrous tissue involving the skin. In: Lever's Histopathology of the Skin, 8th edn, W. F. Lever and G. Schaumbur-Lever (eds). Philadelphia, PA: J. B. Lippincott, 1997, p. 847.
26. Imokawa, G., and M. Kawai. Differential hypermelanosis induced by allergic contact dermatitis. J. Invest. Dermatol. 789:540-546, 1987.
27. Imokawa, G., M. Kawai, Y. Mishima, and I. Motegi. Differential analysis of experimental hypermelanosis induced by UVB, PUVA and allergic contact dermatitis using brownish guinea pig model. Arch. Dermatol. Res. 278:352-362, 1986.
28. Imokawa, G., Y. Yada, and M. Miyagishi. Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes. J. Biol. Chem. 267:24675-24680, 1992 a.
29. Imokawa, G., Y. Yada, and M. Okuda. Allergic contact dermatitis releases soluble factors that stimulate melanogenesis through activation of protein kinase C-related signal-transduction pathway. J. Invest. Dermatol. 99:482-488, 1992 b.
30. Imokawa, G., M. Miyagishi, and Y. Yada. Endothelin-1 as a new melanogen: coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis. J. Invest. Dermatol. 105: 32-37, 1995.
31. Imokawa, G., Y. Yada, N. Morisaki, and M. Kimura. Characterization of keratinocyte-and fibroblast-derived mitogens for human melanocyte-their roles in stimulated cutaneous pigmentation. In: Melanogenesis and Malignant Melanoma, Y. Hori, V. J. Hearing, and J. Nakayama (eds). Amsterdam, The Netherlands: Elsevier Science, 1996 a, pp. 35-38.
32. Imokawa, G., Y. Yada, and M. Kimura. Signaling mechanisms of endothelin-induced mitogenesis in human melanocytes. Biochem. J. 314:305-312, 1996 b.
33. Imokawa, G., Y. Yada, N. Morisaki, and M. Kimura. Granulocyte/macrophage-colony-stimulatory factor is an intrinsic keratinocyte-derived growth factor for human melanocytes in UVA-induced melanosis. Biochem. J. 313:625-631, 1996 c.
34. Imokawa, G., T. Kobayashi, M. Miyagishi, K. Higashi, and Y. Yada. The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanisms of mitogenesis and melanogenesis. Pigment Cell Res. 10:218-228, 1997.
35. Imokawa, G., Y. Yada, and K. Higuchi. Purification and characterization of an allergy-induced melanogenic stimulating factor in brownish guinea pig skin. J. Biol. Chem. 273:1605-1612, 1998 a.
36. Imokawa, G., Y. Yada, N. Morisaki, and M. Kimura. Biological characterization of human fibroblast-derived mitogenic factors for human melanocytes. Biochem. J. 330:1235-1239, 1998 b.
37. Imokawa, G., T. Kobayashi, and M. Miyagishi. Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes: cross-talk via trans-activation of the tyrosine kinase c-kit receptor. J. Biol. Chem. 275:33321-33328, 2000.
38. Inoue, A., M. Yanagisawa, S. Kimura, Y. Kasuya, T. Miyauchi, K. Goto, and T. Masaki. The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression. Proc. Natl. Acad. Sci. USA 86:2863-2867, 1989.
39. Kadono, S., I. Manaka, M. Kawashima, T. Kobayashi, and G. Imokawa. The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis. J. Invest. Dermatol. 116:571-577, 2001.
40. Kang, S., and A. J. Sorber. Disturbances of melanin pigmentation. In: Dermatology, 3rd edn, vol. 2, S. L. Moschella and H. J. Hurley (eds). Philadelphia: W. B. Saunders, 1992, pp. 1446-1447.
41. Kitamura, R., K. Tsukamoto, K. Harada, A. Shimizu, S. Shimada, T. Kobayashi, and G. Imokawa. Mechanisms underlying the dysfunction of melanocytes in vitiligo epidermis: role of SCF/KIT protein interactions and its downstream effector, MITF-M. J. Pathol. 202:463-475, 2004.
42. Kojima, T., M. A. Cromie, G. J. Fisher, J. J. Voorhees, and J. T. Elder. GRO-alpha mRNA is selectively overexpressed in psoriatic epidermis and is reduced by cyclosporin A in vivo, but not in cultured keratinocytes. J. Invest. Dermatol. 101:767-772, 1993.
43. Kunisada, T., S. Z. Lu, H. Yoshida, S. Nishikawa, S. Nishikawa, M. Mizoguchi, S. Hayashi, L. Tyrrell, D. A. Williams, X. Wang, and B. J. Longley. Murine cutaneous mastocytosis and epidermal melanocytosis induced by keratinocyte expression of transgenic stem cell factor. J. Exp. Med. 187:1565-1573, 1998.
44. Laporte, S., J. B. Denault, P. D'Orléans-Juste, and R. Leduc. Presence of furin mRNA in cultured bovine endothelial cells and possible involvement of furin in the processing of the endothelin precursor. J. Cardiovasc. Pharmacol. 22:S7-S10, 1993.
45. Lin, R. Y. Multiple dermatofibromas and systemic lupus erythematosus. Cutis 32:45-49, 1986.
46. Longley, B. J., G. S. Morganroth, L. Tyrrell, T. G. Ding, D. M. Anderson, D. E. Williams, and R. Halaban. Altered metabolism of mast-cell growth factor (c-kit ligand) in cutaneous mastocytosis. N. Engl. J. Med. 328:1302-1307, 1993.
47. Luster, A. D., J. C. Unkeless, and J. V. Ravetch. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 315:672-676, 1985.
48. Manaka, I., S. Kadono, M. Kawashima, T. Kobayashi, and G. Imokawa. The mechanim of hyperpigmentation in seborrhoeic keratosis involves the high expression of endothelin-converting enzyme-1 a and TNFα, which stimulate secretion of endothelin-1. Br. J. Dermatol. 145:895-903, 2001.
49. Maresca, V., M. Roccella, F. Roccella, E. Camera, G. Del Porto, S. Passi, P. Grammatico, and M. Picardo. Increased sensitivity to per-oxidative agents as a possible pathogenic factor of melanocyte damage in vitiligo. J. Invest. Dermatol. 109:310-313, 1997.
50. Matsui, Y., K. M. Zsebo, and B. L. M. Hogan. Embryonic expression of a hematopoietic growth factor encoded by the Sl locus and the ligand for c-kit. Nature 347:667-669, 1990.
51. Matsumoto, K., H. Tajima, and T. Nakamura. Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth. Biochem. Biophys. Res. Commun. 176:45-51, 1991.
52. Moretti, S., A. Spallanzani, L. Amato, G. Hautmann, I. Gallerani, M. Fabiani, and P. Fabbri. New insights into the pathogenesis of vitiligo: imbalance of epidermal cytokines at sites of lesions. Pigment Cell Res. 15:87-92, 2002.
53. Moscher, D. B., T. B. Fitzpatrick, Y. Hori, et al. Disorders of pigmentation. In: Dermatology in General Medicine, vol. 1, T. B. Fitzpatrick, A. Z. Eisen, K. Wolff, I. M. Freedberg, and K. F. Austen (eds). New York: McGraw-Hill, 1993, pp. 967-969.
54. Moser, B., C. Schumacher, V. von Tscharner, I. Clark-Lewis, and M. Baggiolline. Neutrophil-activating peptide 2 and gro/melanoma growth-stimulatory activity interact with neutrophil-activating peptide 1/interleukin 8 receptors on human neutrophils. J. Biol. Chem. 266:10666-10671, 1991.
55. Newman, D. M., and J. B. Walter. Multiple dermatofibromas in patients with systemic lupus erythematosus on immunosuppressive therapy. N. Engl. J. Med. 289:842-843, 1973.
56. Nishikawa, S., M. Kusakabe, K. Yoshinaga, M. Ogawa, S. Hayashi, T. Kunisada, T. Era, T. Sakakura, and S.-I. Nishikawa. In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development. EMBO J. 10:2111-2118, 1991.
57. Nordlund, J. J., and J. P. Ortonne. Vitiligo vulgaris. In: The Pigmentary System. Physiology and Pathophysiology, J. J. Nordlund, R. E. Boissy, V. J. Hearing, R. A. King, and J. P. Ortonne (eds). New York: Oxford University Press, 1998, 513-551.
58. Nurnberger, M., and I. Moll. Semiquantitative aspects of mast cells in normal skin and in neurofibromas of neurofibromatosis type 1 and 5. Dermatology 188:296-299, 1994.
59. Okazaki, M., K. Yoshimura, Y. Suzuki, G. Uchid, Y. Kitano, K. Harii, and G. Imokawa. The mechanism of epidermal hyperpigmentation in café-au-lait macules of neurofibromatosis type-1 (von Recklinghausen's disease) may be associated with dermal fibroblast-derived stem cell factor and hepatocyte growth factor. Br. J. Dermatol. 148:689-697, 2003.
60. Okura, M., H. Maeda, S. Nishikawa, and M. Mizoguchi. Effects of monoclonal anti-c-kit antibody (ACK2) on melanocytes in newborn mice. J. Invest. Dermatol. 105:322-328, 1995.
61. Orr-Urtreger, A., A. Avivi, Y. Zimmer, D. Givol, Y. Yarden, and P. Lonai. Developmental expression of c-kit, a proto-oncogene encoded by the W locus. Development 109:911-923, 1990.
62. Passi, S., M. Grandinetti, F. Maggio, A. Stancato, and C. De Luca. Epidermal oxidative stress in vitiligo. Pigment Cell Res. 11:81-85, 1998.
63. Puffenberger, E. G., K. Hosoda, S. S. Washington, K. Nakao, D. deWit, M. Yanagisawa, and A. Chakravart. A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell 79:1257-1266, 1994.
64. Resink, T. J., T. Scott-Burden, and E. R. Buhler. Enhanced responsiveness to angiotensin II in vascular smooth muscle cells from spontaneously hypertensive rats is not associated with alterations in protein kinase C. Biochem. Biophys. Res. Commun. 158:279-286, 1989.
65. Reynolds, E. E., L. L. Mok, and S. Kurokawa. Phorbol ester dissociates endothelin-stimulated phosphoinositide hydrolysis and arachi-donic acid release in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 161:1252-1259, 1989.
66. Richmond, A., D. H. Lawson, D. W. Nixon, S. Stevens, and R. K. Chawla. Extraction of a melanoma growth-stimulatory activity from culture medium conditioned by the Hs0294 human melanoma cell line. Cancer Res. 43:2106-2112, 1983.
67. Sakamoto, A., M. Yanagisawa, T. Sawamura, T. Enoki, T. Ohtani, T. Sakurai, K. Nakao, T. Toyo-Oka, and T. Masaki. Distinct subdomains of human endothelin receptor determine their selectivity to endothelin A selective antagonist and endothelin B selective agonist. J. Biol. Chem. 268:8547-8553, 1993.
68. Sakurai, T., M. Yanagisawa, Y. Takuwa, H. Miyazaki, S. Kimura, K. Goto, and T. Masaki. Cloning of a cDNA encoding a nonisopeptide-selective subtype of the endothelin receptor. Nature 348:732-735, 1990.
69. Schallreuter, K. U., J. M. Wood, and J. Berger. Low catalase levels in the epidermis of patients with vitiligo. J. Invest. Dermatol. 97: 1081-1085, 1991.
70. Shishido, E., S. Kadono, I. Manaka, M. Kawashima, and G. Imokawa. The mechanism of epidermal hyperpigmentation in dermatofibroma is associated with stem cell factor and hepatocyte growth factor expression. J. Invest. Dermatol. 117:627-633, 2001.
71. Spritz, R. A., L. B. Giebel, and S. A. Holmes. Dominant negative and loss of function mutations of the c-kit (mast/stem-cell growth factor receptor) protooncogene in human piebaldism. Am. J. Hum. Genet. 50:261-269, 1992.
72. Teraki, E., S. Tajima, I. Manaka, M. Kawashima, M. Miyagishi, and G. Imokawa. Role of endothelin-1 in hyperpigmentation in sebor-rhoeic keratosis. Br. J. Dermatol. 135:918-923, 1996.
73. Tobin, D. J., N. N. Swanson, M. R. Pittelkow, E. M. Peters, and K. U. Schallreuter. Melanocytes are not absent in lesional skin of long duration vitiligo. J. Pathol. 191:407-416, 2000.
74. Tsuboi, R., C. Sato, C. Shi, T. Nakamura, T. Sakurai, and H. Ogawa. Endothelin-1 acts as an autocrine growth factor for normal ker-atinocytes. J. Cell Physiol. 159:213-220, 1994.
75. van den Wijngaard, R., A. Wankowicz-Kalinska, S. Pals, J. Weening, and P. Das. Autoimmune melanocyte destruction in vitiligo. Lab. Invest. 81:1061-1067, 2001.
76. Venner, T. J., D. N. Sauder, C. Feliciani, and R. C. Mckenzie. Interleukin-8 and melanoma growth-stimulating activity (GRO) are induced by ultraviolet B radiation in human keratinocyte cell lines. Exp. Dermatol. 4:138-145, 1995.
77. Viskochil, D., A. M. Buchberg, G. Xu, R. M. Cawthorn, J. Stevens, R. K. Wokff, M. Culver, J. C. Carey, N. G. Copeland, and N. A. Jenkins. Deletions or translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell 62:187-192, 1990.
78. Wallance, M. R., D. A. Marchuk, L. B. Anderson, R. Letcher, H. M. Odeh, A. M. Saulino, J. W. Fountain, A. Brereton, J. Nicholson, and A. L. Mitchell. Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. Science 249:181-186, 1990.
79. Walz, A., P. Peveri, H. Aschauer, and M. Baggioline. Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes. Biochem. Biophys. Res. Commun. 149: 755-761, 1987.
80. Wankowicz-Kalinska, A., C. Le Poole, R. van der Wijngaard, W. J. Storkus, and P. K. Das. Melanocyte-specific immune response in melanoma and vitiligo: two faces of the same coin? Pigment Cell Res. 16:254-260, 2003.
81. Watanabe, H., H. Miyazaki, M. Kondoh, Y. Masuda, S. Kimura, M. Yanagisawa, T. Masaki, and K. Murakami. Two distinct types of endothelin receptors are present on chick cardiac membranes. Biochem. Biophys. Res. Commun. 161:1252-1259, 1989.
82. Wen, D. Z., A. Rowland, and R. Derynck. Expression and secretion of gro/MGSA by stimulated human endothelial cells. EMBO J. 8:1761-1766, 1989.
83. Williams, D. E., P. de Vries, A. E. Namen, M. B. Widmer, and S. D. Lyman. The steel factor. Dev. Biol. 151:368-376, 1992.
84. Yada, Y., K. Higuchi, and G. Imokawa. Effects of endothelins on signal transduction and proliferation in human melanocytes. J. Biol. Chem. 266:18352-18357, 1991.
85. Yanagisawa, M., H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto, and T. Masaki. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332:411-415, 1988.
86. Yoshida, H., S. Hayashi, L. D. Shultz, K. Yamamura, S., Nishikawa, S.-I. Nishikawa, and T. Kunisada. Neural and skin cell specific expression pattern conferred by steel factor regulatory sequence in transgenic mice. Dev. Dyn. 207:222-232, 1996.