A quantitative co-localization analysis of large unspliced tenascin-C L and laminin-5/γ2-chain in basement membranes of oral squamous cell carcinoma by confocal laser scanning microscopy

Journal of Oral Pathology and Medicine

Volumn 36, Issue 1, 2007, Pages 6-11

  Franz, Marcus ^a   Hansen, Torsten ^a   Borsi, Laura ^b   Geier, Christiane ^a   Hyckel, Peter ^a   Schleier, Peter ^a   Richter, Petra ^a   Altendorf Hofmann, Annelore ^a   Kosmehl, Hartwig ^c   Berndt, Alexander ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF GENOA   (Italy)

^c HELIOS KLINIKUM ERFURT   (Germany)

Author keywords

Basement membrane; Co localization; Laminin 5; Malignancy grading; Oral squamous cell carcinoma; Tenascin CL

Indexed keywords

KALININ; TENASCIN;

ARTICLE; CANCER LOCALIZATION; CONTROLLED STUDY; DYSPLASIA; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUTH CARCINOMA; MOUTH MUCOSA; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; RNA SPLICING; SQUAMOUS CELL CARCINOMA;

BASEMENT MEMBRANE; CARCINOMA, SQUAMOUS CELL; DISEASE PROGRESSION; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HYPERPLASIA; LAMININ; MICROSCOPY, CONFOCAL; MOUTH MUCOSA; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; PROTEIN ISOFORMS; TENASCIN;

EID: 33845801252     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2006.00492.x     Document Type: Article

References (38)

1. Kosmehl H, Berndt A, Katenkamp D. Molecular variants of fibronectin and laminin: structure, physiological occurrence and histopathological aspects. Virchows Arch 1996; 42: 311-22.
2. Engbring JA, Kleinman HK. The basement membrane matrix in malignancy. J Pathol 2003; 200: 465-70.
3. Katayama M, Sekiguchi K. Laminin-5 in epithelial tumour invasion. J Mol Histol 2004; 35: 277-86.
4. Aumailley M, Bruckner-Tuderman L, Carter WG, et al. A simplified laminin nomenclature. Matrix Biol 2005; 24: 326-32.
5. Rousselle P, Lunstrum GP, Keene DR, Burgeson RE. Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. J Cell Biol 1991; 114: 567-76.
6. Masunaga T, Shimizu H, Ishiko A, et al. Localization of laminin-5 in the epidermal basement membrane. J Histochem Cytochem 1996; 44: 1223-30.
7. Meneguzzi G, Marinkovich MP, Aberdam D, Pisani A, Burgeson R, Ortonne JP. Kalinin is abnormally expressed in epithelial basement membranes of Herlitz's junctional epidermolysis bullosa patients. Exp Dermatol 1992; 1: 221-9.
8. Miyazaki K, Kikkawa Y, Nakamura A, Yasumitsu H, Umeda M. A large cell-adhesive scatter factor secreted by human gastric carcinoma cells. Proc Natl Acad Sci U S A 1993; 90: 11767-71.
9. Ryan MC, Tizard R, VanDevanter DR, Carter WG. Cloning of the LamA3 gene encoding the alpha 3 chain of the adhesive ligand epiligrin. Expression in wound repair. J Biol Chem 1994; 269: 22779-87.
10. Vailly J, Verrando P, Champliaud MF, et al. The 100-kDa chain of nicein/kalinin is a laminin B2 chain variant. Eur J Biochem 1994; 219: 209-18.
11. Pyke C, Rømer J, Kallunki P, et al. The γ2 chain of kalinin/laminin 5 is preferentially expressed in invading malignant cells in human cancers. Am J Pathol 1994; 145: 782-91.
12. Pyke C, Salo S, Ralfkiær E, Rømer J, Danø K, Tryggvason K. Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas. Cancer Res 1995; 55: 4132-9.
13. Kosmehl H, Berndt A, Strassburger S, et al. Distribution of laminin and fibronectin isoforms in oral mucosa and oral squamous cell carcinoma. Br J Cancer 1999; 81: 1071-9.
14. Haas KM, Berndt A, Stiller KJ, Hyckel P, Kosmehl H. A comparative quantitative analysis of laminin-5 in the basement membrane of normal, hyperplastic, and malignant oral mucosa by confocal immunofluorescence imaging. J Histochem Cytochem 2001; 49: 1261-8.
15. Mighell AJ, Thompson J, Hume WJ, Markham AF, Robinson PA. Human tenascin-C: identification of a novel type III repeat in oral cancer and of novel splice variants in normal, malignant and reactive oral mucosae. Int J Cancer 1997; 72: 236-40.
16. Borsi L, Carnemolla B, Nicolo G, Spina B, Tanara G, Zardi L. Expression of different tenascin isoforms in normal hyperplastic and neoplastic human breast tissues. Int J Cancer 1992; 52: 688-92.
17. Hindermann W, Berndt A, Borsi L, et al. Synthesis and protein distribution of the unspliced large tenascin-C isoform in oral squamous cell carcinoma. J Pathol 1999; 189: 475-80.
18. Bosman FT, Stamenkovic I. Functional structure and composition of the extracellular matrix. J Pathol 2003; 200: 423-8.
19. Ramos DM, Chen BL, Boylen K, et al. Stromal fibroblasts influence oral squamous-cell carcinoma cell interactions with tenascin-C. Int J Cancer 1997; 72: 369-76.
20. Berndt A, Borsi L, Hyckel P, Kosmehl H. Fibrillary co-deposition of laminin-5 and large unspliced tenascin-C in the invasive front of oral squamous cell carcinoma in vivo ad in vitro. J Cancer Res Clin Oncol 2001; 127: 286-92.
21. Franz M, Hansen T, Richter P, et al. Complex formation of the laminin-5 γ2 chain and large unspliced tenascin-C in oral squamous cell carcinoma in vitrop and in situ: implications for sequential modulation of extracellular matrix in the invasive tumor front. J Histochem Cell Biol 2006; 126: 125-31.
22. Carter RL, Burman JF, Barr L, Gusterson BA. Immunohistochemical localization of basement membrane type IV collagen in invasive and metastatic squamous carcinomas of the head and neck. J Pathol 1985; 147: 159-64.
23. Bryne M, Koppang HS, Lilleng R, Kjaerheim A. Malignancy grading of the deep invasive margins of oral squamous cell carcinoma has high prognostic value. J Pathol 1992; 166: 375-81.
24. Pindborg JJ, Reichart PA, Smith CJ, van der Wal I. Histological typing of cancer and precancer of the oral mucosa/World Health Organization. Berlin: Springer, 1997.
25. Mizushima H, Koshikawa N, Moriyama K, et al. Wide distribution of laminin-5 gamma 2 chain in basement membranes of various human tissues. Horm Res 1998; 50 (Suppl. 2): 7-14.
26. Balza E, Siri A, Ponassi M, et al. Production and characterization of monoclonal antibodies specific for different epitopes of human tenascin. FEBS Lett 1993; 332: 39-43.
27. Manders EMM, Verbeek FJ, Aten JA. Measurement of colocalization of objects in dual-colour confocal images. J Microsc 1992; 169: 375-82.
28. Tiitta O, Happonen RP, Virtanen I, Luomanen M. Distribution of tenascin in oral premalignant lesions and squamous cell carcinoma. J Oral Pathol Med 1994; 23: 446-50.
29. Ramos DM, Chen B, Regezi J, Zardi L, Pytela R. Tenascin-C matrix assembly in oral squamous cell carcinoma. Int J Cancer 1998; 75: 680-7.
30. De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol 2003; 200: 429-47.
31. Häkkinen L, Hildebrand HC, Berndt A, Kosmehl H, Larjava H. Immunolocalization of tenascin-C, α9 integrin subunit, and α6b4 integrin during wound healing in human oral mucosa. J Histochem Cytochem 2000; 48: 985-98.
32. Adams M, Jones JL, Walker RA, Pringle JH, Bell SC. Changes in tenascin-C isoform expression in invasive and preinvasive breast disease. Cancer Res 2002; 62: 3289-97.
33. Matsui C, Nelson CF, Hernandez GT, Herron GS, Bauer EA, Hoeffler WK. γ2 Chain of laminin-5 is recognized by monoclonal antibody GB3. J Invest Dermatol 1995; 105: 648-52.
34. Koshikawa N, Moriyama K, Takamura H, et al. Overexpression of laminin gamma 2 chain monomer in invading gastric carcinoma cells. Cancer Res 1999; 59: 5596-601.
35. Sordat I, Bosman FT, Dorta G, et al. Differential expression of laminin-5 subunits and integrin receptors in human colorectal neoplasia. J Pathol 1998; 185: 44-52.
36. Broll R, Meyer S, Neuber M, Bruch HP. Expression of tenascin in tumors of the esophageus, small intestine and colorectum. An immunohistchemical study. Gen Diagn Pathol 1995; 141: 111-9.
37. Murphy-Ullrich JE, Lightner VA, Aukhil I, Yan YZ, Erickson HP, Hook M. Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin. J Cell Biol 1991; 115: 1127-36.
38. Siri A, Knäuper V, Veirana N, Caocci F, Murphy G, Zardi L. Different susceptibility of small and large human tenascin-C isoforms to degradation by matrix metalloproteinases. J Biol Chem 1995; 270: 8650-4.