A novel system for the production of high levels of functional human therapeutic proteins in stable cells with a Semliki Forest virus noncytopathic vector

New Biotechnology

Volumn 27, Issue 2, 2010, Pages 138-148

  Casales, Erkuden ^a   Aranda, Alejandro ^a   Quetglas, Jose I ^a   Ruiz Guillen, Marta ^a   Rodriguez Madoz, Juan R ^a   Prieto, Jesus ^a   Smerdou, Cristian ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOTROPHIN; CELL LINES; CONSTANT LEVEL; CYTOPATHIC EFFECT; FOOT-AND-MOUTH DISEASE VIRUS; HOST CELL PROTEIN; HUMAN THERAPEUTICS; IN-VITRO; INSULIN-LIKE GROWTH FACTOR-I; MAMMALIAN CELLS; MUTATION RATES; PROTEIN EXPRESSIONS; RECOMBINANT PROTEIN; SEMLIKI FOREST VIRUS; SEQUENCE CODING; STABLE CELL LINES; SUPERNATANTS; THERAPEUTIC GENES;

CELL CULTURE; CELLS; MAMMALS; RNA; VECTORS; VIRUSES;

PROTEINS;

ACYLTRANSFERASE; CARDIOTROPHIN 1; FMDV 2A AUTOPROTEASE; POLYPROTEIN; PUROMYCIN; RECOMBINANT PROTEIN; SOMATOMEDIN C; UNCLASSIFIED DRUG; VIRUS RNA; VIRUS VECTOR; CYTOKINE;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN BHK; CONTROLLED STUDY; GENE FUSION; GENETIC CODE; MOLECULAR CLONING; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA STABILITY; RNA VECTOR; SEMLIKI FOREST ALPHAVIRUS; SIGNAL TRANSDUCTION; SUPERNATANT; VIRAL GENE DELIVERY SYSTEM; ANIMAL; CELL LINE; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MOUSE; PROCEDURES; PROTEIN ENGINEERING;

ANIMALS; CELL LINE; CYTOKINES; GENETIC VECTORS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MICE; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SEMLIKI FOREST VIRUS; TRANSFECTION;

FOOT-AND-MOUTH DISEASE VIRUS; MAMMALIA; RABBIT FIBROMA VIRUS; SEMLIKI FOREST VIRUS;

EID: 77952237785     PISSN: 18716784     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbt.2010.02.005     Document Type: Article

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