Cardiotrophin-1 can protect cardiac myocytes from injury when added both prior to simulated ischaemia and at reoxygenation

Cardiovascular Research

Volumn 51, Issue 2, 2001, Pages 265-274

  Brar, Bhawanjit K ^a   Stephanou, Anastasis ^a   Liao, Zhihong ^a   O'Leary, Rhona M ^c   Pennica, Diane ^c   Yellon, Derek M ^b   Latchman, David S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

^c GENENTECH INC   (United States)

Author keywords

Apoptosis; Cardioplegia; Cell culture isolation; Cytokines; Hypoxia anoxia; Ischemia; Myocytes; Reperfusion

Indexed keywords

CARDIOTROPHIN 1; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; TRYPAN BLUE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; NEWBORN; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; REOXYGENATION; SIGNAL TRANSDUCTION;

ANIMALS; ANNEXIN A5; APOPTOSIS; CELLS, CULTURED; CYTOKINES; DNA-BINDING PROTEINS; ENZYME ACTIVATION; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 0034940330     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00294-2     Document Type: Article

References (34)

1. Expression cloning of cardiotrophin 1 a cytokine that induces cardiac myocyte hypertrophy
2. In vivo effects of cardiotrophin-1
3. Cardiotrophin-1: Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signalling complex
4. Cardiotrophin-1: A multifunctional cytokine that signals via LIF receptor gp130 Dependent pathways
5. Urocortin protects against ischemic and reperfusion injury via a MAP-kinase dependent pathway
6. Interleukin-6 family of cytokines and gp130
7. Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy
8. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91 related transcription factor involved in the gp130 mediated signalling pathway
9. Phosphorylation at threonine-235 by a ras-dependent mitogen activated protein kinase cascade is essential for transcription factor NF-IL6
10. Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level
11. Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival
12. Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen activated protein kinase dependent pathway
13. Cardiotrophin-1 induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli
14. Differentiation of rat myocytes in single cell cultures with and without proliferating non-myocardial cells
15. Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion
16. NADH measurements in adult rat myocytes during stimulated ischaemia
17. Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation
18. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo
19. Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers
20. Progression of myocardial necrosis during reperfusion of ischemic myocardium
21. An inhibitor of p38 mitogen activated protein kinase protects neonatal cardiac myocytes from ischemia
22. Force regulates smooth muscle actin in cardiac fibroblasts
23. The role of differential activation of P38-mitogen-activated protein kinase in preconditioned ventricular myocytes
24. Effect of intravenous adenosine on myocardial reperfusion injury in a model with low myocardial collateral blood flow
25. Adenosine attenuates reperfusion injury following regional myocardial ischaemia
26. Adenosine infusion during early reperfusion failed to limit myocardial infarct size in a collateral deficient species
27. Effect of adenosine therapy at reperfusion on myocardial infarct size in dogs
28. Urocortin protects against ischemic and reperfusion injury via a MAP-kinase dependent pathway
29. Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism
30. Post-ischemic apoptotic death of rat neonatal cardiomyocytes
31. Reperfusion injury induces apoptosis in rabbit cardiomyocytes
32. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family
33. Interleukin-6 activates heat shock protein 90β gene expression