Alpha-2B adrenergic receptor mediated hemodynamic profile of etomidate

Puerto Rico Health Sciences Journal

Volumn 29, Issue 2, 2010, Pages 91-95

  Creagh, Osmar ^a   Torres, Héctor ^b   Rodríguez, Normidaris ^a   Gatica, Sebastián Rodrigo ^a  

^a Resident Anesthesiology UPR MSC ^*  (Puerto Rico)

^b Faculty Department of Anesthesiology UPR MSC   (Puerto Rico)

Author keywords

Alpha 2B adrenergic receptor; Cardiovascular stability; Etomidate; Hemodynamia

Indexed keywords

ADRENERGIC RECEPTOR ALPHA 2B; ADRENERGIC RECEPTOR ALPHA-2B; ALPHA 2 ADRENERGIC RECEPTOR; ETOMIDATE;

DRUG EFFECT; HEMODYNAMICS; HUMAN; PHYSIOLOGY; REVIEW;

ETOMIDATE; HEMODYNAMICS; HUMANS; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 77952181341     PISSN: 07380658     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (46)

1. Barash PG, Cullen BF, Stoelting RK. Clinical Anesthesia, 5th Ed; Philadelphia; Lippincott Williams & Wilkins, 2006: p. 344-345.
2. Doenicke A. Etomidate, a new intravenous hypnotic. Acta Anaesthesiol Belg 1974;25:307-315.
3. Wolfson AB. Harwood-Nuss' Clinical Practice of Emergency Medicine, 4th Ed; Portland; Lippincott Williams & Wilins, 2005: p. 1150-1153.
4. Sarkar M. Hemodynamic Responses to Etomidate on Induction of Anesthesia in Pediatric Patients. Anesth Analg 2005;101:645-650.
5. Amidate (etomidate) [Package Insert]. North Chicago (IL): Abbott Laboratories; 1998.
6. White PF, Kan PB, Wagner RL, et al. Inhibition of adrenal steroidogenesis by the anesthetic etomidate. N Engl J Med 1984;310:1415, 1984.
7. Weng JT, Smith RA, Gooding JM, et al. Cardiovascular and pulmonary response following etomidate induction of anesthesia in patients with demonstrated cardiac disease. Anesth Analg 1979;50:40.
8. Pistis M, Peters JA, Lambert JJ, Belelli D. The interaction of general anaesthetics and neurosteroids with GABA(A) and glycine receptors. Neurochem Int 1999;34:447-455.
9. Knauer CS, Granja R, Moody EJ, et al. Distinct structural requirements for the direct and indirect actions of the anaesthetic etomidate at GABA(A) receptors. Toxicol Lett 1998;101:209-215.
10. Zeller A, Arras M, Lazaris A, Jurd R, Rudolph U. Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofol. FASEB J 2005;19:1677-1680.
11. White PF, Kan PB, Wagner RL, et al. Inhibition of adrenal steroidogenesis by the anesthetic etomidate. N Engl J Med 1984;310:1415.
12. White PF, Wagner RL. Etomidate inhibits adrenocortical function in surgical patients. Anesthesiology 1984;61:647.
13. Cuschieri J, Jurkovich GJ, Warner KJ, et al. Single-dose etomidate for rapid sequence intubation may impact outcome after severe injury. J Trauma 2009;67:45-50.
14. Weis S, Herr A, Gries A, et al. Etomidate and thiopental inhibit platelet function in patients undergoing infrainguinal vascular surgery. Acta Anaesthesiol Scand 2001;45:449-457.
15. Shirozu K. The Mechanisms of the Direct Action of Etomidate on Vascular Reactivity in Rat Mesenteric Resistance Arteries. Anesth Analg 2009;108:496-507.
16. Kessler P, Lischke V, Hecker M. Etomidate and Thiopental Inhibit the Release of Endothelium-derived Hyperpolarizing Factor in the Human Renal Artery. Anesthesiology 1996;84:1485-1486.
17. Maier-Rudolph W, von Beckerath N, Mehrke G, Gunther K, Goedel-Meinen Daut J. Hypoxic dilation of coronary arteries is mediated by ATPsensitive potassium channels. Science 1990;247:1341-1344.
18. Kawahito S, Kawano T, Nakamura A. Differential Effects of Etomidate and Midazolam on Vascular Adenosine Triphosphate-sensitive Potassium Channel. Anesthesiology 2007;106:515-522.
19. Scholz J, Suppe E, Schulte AM, Esch J, Tonner PH. L-nitroargininemethylester (L-NAME), a nitric oxide synthase inhibitor, increases the anesthetic potency of etomidate. Anasthesiol Intensivmed Notfallmed Schmerzther 1999;34:136-139.
20. Guo TZ, Davies MF, Kingery WS, Patterson AJ, Limbird LE, Maze M. Nitrous oxide produces antinociceptive response via alpha-2B and/or alpha-2C adrenoceptor subtypes in mice. Anesthesiology 1999;90:470-476.
21. Kingery WS, Davies MF, Agashe GS, Clark JD, Kobilka BK, Hashimoto T, Maze M, Sawamura S. Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of alpha-2B adrenoceptors. J Neurosci 2000;20:9242-9251.
22. Desai K, Hein L, Link RE. Cardiovascular regulation in mice lacking alpha 2-adrenergic receptor subtypes b and c. Science 1996;273:803-805.
23. Altman JD, Trendelenburg AU, MacMillan L, Bernstein D, Limbird L, Starke K, Kobilka BK, Hein L. Abnormal regulation of the sympathetic nervous system in alpha 2A-adrenergic receptor knockout mice. Mol Pharmacol 1999;56:154-161.
24. Philipp M, Tonner PH, Paris A. Activation of alpha-2B Adrenoceptors Mediates the Cardiovascular Effects of Etomidate. Anesthesiology 2003;99:889-895.
25. Mycek MJ, Harvey RA, Champe PC. Lippincott's Illustrated reviews: Pharmacology, Chapter 6, 2nd ed, Philadelphia, Unied States, Lippincott Williams and Wilkins, 2000: p. 57-59
26. Matsui H, Kobilka TS, Kobilka BK. Cloning, sequencing, and expression of the gene coding for the human platelet alpha-2-adrenergic receptor. Science 1987;238:650-656.
27. Kobilka TS, Yang-Feng TL, Regan JW, et al. Cloning and expression of a human kidney cDNA for an alpha-2 adrenergic receptor subtype. Proc Natl Acad Sci USA 1988;85:6301-6305.
28. Hein L. Alpha2-adrenoceptor subtypes-surprising insights from genetargeted mouse models. Auton Autacoid Pharmaco 2003;23:234-235.
29. MacMillan LB, Guo TZ, Lakhlani PP. Substitution of a mutant alpha-2A adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proc Natl Acad Sci USA 1997;94:9950-9955.
30. Hein L, Smith MS, MacMillan LB, et al. Central hypotensive effects of the alpha-2A adrenergic receptor subtype. Science 1996;273:801-803.
31. Eikenberg DC, Hieble JP, Bylund DB, et al. International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol Rev 1994;46:121-136.
32. Fontana DJ, Hedley LR, Hunter JC, et al. Assessment of the role of alpha- 2 adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. Br J Pharmacol 1997;122:1339-1344.
33. Altememi GF, Mandyam CD, Bawa-Khalfe T. The presence of β2 adrenoceptors sensitizes α2A-adrenoceptors to desensitization after chronic epinephrine treatment. BMC Pharmacology 2007;7:16.
34. Koulu M, Pesonen U, Heinonen P, et al. Identification of a three-amino acid deletion in the alpha-2B adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects. J Clin Endocrinol Metab 2006;84:2429-2433.
35. Baldwin CT, Schwartz F, Baima J, Burzstyn M, DeStefano AL, Gavras I, et al. Identification of a polymorphic glutamic acid stretch in the alpha-2Badrenergic receptor and lack of linkage with essential hypertension. Am J Hypertens 1999;12:853-857.
36. Matsunaga T, Nagasumi K, Naoko Suzuki, et al. Alpha 2B-Adrenergic Receptor Deletion Polymorphism Associates with Autonomic Nervous System Activity in Young Healthy Japanese. J Clin Endocrinol Metab 2003;88:1184-1187.
37. von Wowern F, Bengtsson K, Lindblad U, et al. A functional polymorphism in the alpha-2B adrenergic receptor gene, a positional candidate gene on chromosome 2, is associated with hypertension in Swedes. Am J Hypertens-Supp 2004;22:54.
38. Sallinen J, Haapalinna A,Scheinin M. Evaluation of the alpha 2C-adrenoceptor as a neuropsychiatric drug target studies in transgenic mouse models. Life Sci 2001;68:2277-2285.
39. Link RE, Haapalinna A, Sallinen J, et al. Genetic alteration of alpha 2Cadrenoceptor expression in mice: Influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtypenonselective alpha 2-adrenoceptor agonist. Mol Pharmacol 1997;51:36-46.
40. Stone LS, Kitto KF, Fairbanks CA, et al. Alpha 2C-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. J Pharmacol 2002;300:282-290.
41. Altman JD, Kobilka BK, Hein L. Two functionally distinct alpha 2-adrenergic receptors regulate sympathetic neurotransmission. Nature 1999;402:181-184.
42. Ward DS, Belleville JP, Maze M, Bloor BC. Effects of Intravenous Dexmedetomidine in Humans: II. Hemodynamic Changes. Anesthesiology 1992;77:1134-1142.
43. Ruffolo RR Jr, Nichols AJ, Stadel JM, Hieble JP, et al. Pharmacologic and Therapeutic Applications of alpha2-Adrenoceptor Subtypes. Annu. Rev. Pharmacol. Toxicol 1993;33:243-279.
44. Brown KM, Forbes SL, Small KM, et al. Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. J Biol Chem 2001;276:4917-4922.
45. Buzas B, Hipp H, Belfer I, et al. Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene. J Hum Genet 2005;50:12-20.
46. Large V. Alpha-2B adrenergic receptor and genetic variant. Clin Auton Res 2003;13:173-174.