The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 10, 2010, Pages 3177-3181

  Gangjee, Aleem ^a   Namjoshi, Ojas A ^a   Ihnat, Michael A ^b   Buchanan, Aaron ^b  

^a DUQUESNE UNIVERSITY   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Antitumor agents; Molecular modeling; Structure activity relationship; Tyrosine kinase inhibitors

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 ANILINOSUBSTITUTED PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; 6,7 DIMETHYL 2 PHENYLQUINOXALINE; ANGIOGENESIS INHIBITOR; CB 676475; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; IMATINIB; LAPATINIB; N (SUBSTITUTED PHENYL) 6 (2 PHENYLETHYL) 7H PYRROLO[2,3 D]PYRIMIDINE 2,4 DIAMINE DERIVATIVE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; SEMAXANIB; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL ASSAY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANGIOGENESIS INHIBITORS; CATALYTIC DOMAIN; CELL LINE, TUMOR; COMPUTER SIMULATION; HUMANS; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 77952108042     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.064     Document Type: Article

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