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Volumn 58, Issue 3, 2004, Pages 941-949

Rationale and clinical basis for combining gefitinib (IRESSA, ZD1839) with radiation therapy for solid tumors

Author keywords

EGFR; Gefitinib; IRESSA; Radiation; Tyrosine kinase inhibitor

Indexed keywords

AMINO ACIDS; CELLS; ENZYMES; IONIZING RADIATION; PATIENT TREATMENT; RADIOTHERAPY; TOXICITY; TUMORS;

EID: 1242293093     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2003.09.094     Document Type: Conference Paper
Times cited : (52)

References (51)
  • 1
    • 0035918847 scopus 로고    scopus 로고
    • Epidermal growth factor receptor signaling and response of cancer cells to ionizing radiation
    • Ethier S.P., Lawrence T.S. Epidermal growth factor receptor signaling and response of cancer cells to ionizing radiation. J Natl Cancer Inst. 93:2001;890-891.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 890-891
    • Ethier, S.P.1    Lawrence, T.S.2
  • 2
    • 0034788824 scopus 로고    scopus 로고
    • Radiation response modification following molecular inhibition of epidermal growth factor receptor signaling
    • Harari P.M., Huang S.-M. Radiation response modification following molecular inhibition of epidermal growth factor receptor signaling. Semin Radiat Oncol. 11:2001;281-289.
    • (2001) Semin Radiat Oncol , vol.11 , pp. 281-289
    • Harari, P.M.1    Huang, S.-M.2
  • 3
    • 0033757709 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy
    • Raymond E., Faivre S., Armand J.P. Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy. Drugs. 60:(Suppl. 1):2000;15-23.
    • (2000) Drugs , vol.60 , Issue.SUPPL. 1 , pp. 15-23
    • Raymond, E.1    Faivre, S.2    Armand, J.P.3
  • 4
    • 0034471959 scopus 로고    scopus 로고
    • Biological modifiers as potential radiosensitizers: Targeting the epidermal growth factor receptor family
    • Sartor C.I. Biological modifiers as potential radiosensitizers Targeting the epidermal growth factor receptor family . Semin Oncol. 27:(Suppl. 11):2000;15-20.
    • (2000) Semin Oncol , vol.27 , Issue.SUPPL. 11 , pp. 15-20
    • Sartor, C.I.1
  • 6
    • 0034992521 scopus 로고    scopus 로고
    • The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification
    • Prenzel N., Fischer O.M., Streit S., et al. The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocr Relat Cancer. 8:2001;11-31.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 11-31
    • Prenzel, N.1    Fischer, O.M.2    Streit, S.3
  • 7
    • 0032939325 scopus 로고    scopus 로고
    • Multiple positive and negative regulators of signaling by the EGF-receptor
    • Moghal N., Sternberg P.W. Multiple positive and negative regulators of signaling by the EGF-receptor. Curr Opin Cell Biol. 11:1999;190-196.
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 190-196
    • Moghal, N.1    Sternberg, P.W.2
  • 8
    • 0032915392 scopus 로고    scopus 로고
    • Epidermal growth factor receptors: Critical mediators of multiple receptor pathways
    • Hackel P.O., Zwick E., Prenzel N., et al. Epidermal growth factor receptors Critical mediators of multiple receptor pathways . Curr Opin Cell Biol. 11:1999;184-189.
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 184-189
    • Hackel, P.O.1    Zwick, E.2    Prenzel, N.3
  • 9
    • 0035479296 scopus 로고    scopus 로고
    • EGFR overexpression and radiation response in glioblastoma multiforme
    • Barker F.G. II, Simmons M.L., Chang S.M., et al. EGFR overexpression and radiation response in glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 51:2001;410-418.
    • (2001) Int J Radiat Oncol Biol Phys , vol.51 , pp. 410-418
    • Barker II, F.G.1    Simmons, M.L.2    Chang, S.M.3
  • 10
    • 0032719534 scopus 로고    scopus 로고
    • Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas
    • Akimoto T., Hunter N.R., Buchmiller L., et al. Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas. Clin Cancer Res. 5:1999;2884-2890.
    • (1999) Clin Cancer Res , vol.5 , pp. 2884-2890
    • Akimoto, T.1    Hunter, N.R.2    Buchmiller, L.3
  • 11
    • 0036462583 scopus 로고    scopus 로고
    • EGF receptor targeting in therapy-resistant human tumors
    • Schmidt M., Lichtner R.B. EGF receptor targeting in therapy-resistant human tumors. Drug Resist Update. 5:2002;11-18.
    • (2002) Drug Resist Update , vol.5 , pp. 11-18
    • Schmidt, M.1    Lichtner, R.B.2
  • 12
    • 0036005846 scopus 로고    scopus 로고
    • ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, alone and in combination with radiation and chemotherapy as a new therapeutic strategy in non-small cell lung cancer
    • Raben D., Helfrich B.A., Chan D., et al. ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, alone and in combination with radiation and chemotherapy as a new therapeutic strategy in non-small cell lung cancer. Semin Oncol. 29:(Suppl. 4):2002;37-46.
    • (2002) Semin Oncol , vol.29 , Issue.SUPPL. 4 , pp. 37-46
    • Raben, D.1    Helfrich, B.A.2    Chan, D.3
  • 13
    • 0033970141 scopus 로고    scopus 로고
    • Modulation of molecular targets to enhance radiation
    • Harari P.M., Huang S.-M. Modulation of molecular targets to enhance radiation. Clin Cancer Res. 6:2000;323-325.
    • (2000) Clin Cancer Res , vol.6 , pp. 323-325
    • Harari, P.M.1    Huang, S.-M.2
  • 14
    • 0036471754 scopus 로고    scopus 로고
    • Relationship between cyclin D1 expression and poor radioresponse of murine carcinomas
    • Milas L., Akimoto T., Hunter N.R., et al. Relationship between cyclin D1 expression and poor radioresponse of murine carcinomas. Int J Radiat Oncol Biol Phys. 52:2002;514-521.
    • (2002) Int J Radiat Oncol Biol Phys , vol.52 , pp. 514-521
    • Milas, L.1    Akimoto, T.2    Hunter, N.R.3
  • 15
    • 0036304685 scopus 로고    scopus 로고
    • Local recurrence in head and neck cancer: Relationship to radiation resistance and signal transduction
    • Gupta A.K., McKenna W.G., Weber C.N., et al. Local recurrence in head and neck cancer Relationship to radiation resistance and signal transduction . Clin Cancer Res. 8:2002;885-892.
    • (2002) Clin Cancer Res , vol.8 , pp. 885-892
    • Gupta, A.K.1    McKenna, W.G.2    Weber, C.N.3
  • 16
    • 0032815618 scopus 로고    scopus 로고
    • Radiation-induced release of transforming growth factor α activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death
    • Dent P., Reardon D.B., Park J.S., et al. Radiation-induced release of transforming growth factor α activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Mol Biol Cell. 10:1999;2493-2506.
    • (1999) Mol Biol Cell , vol.10 , pp. 2493-2506
    • Dent, P.1    Reardon, D.B.2    Park, J.S.3
  • 17
    • 0030772168 scopus 로고    scopus 로고
    • Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
    • Schmidt-Ullrich R.K., Mikkelsen R.B., Dent P., et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene. 15:1997;1191-1197.
    • (1997) Oncogene , vol.15 , pp. 1191-1197
    • Schmidt-Ullrich, R.K.1    Mikkelsen, R.B.2    Dent, P.3
  • 18
    • 0032575135 scopus 로고    scopus 로고
    • Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells
    • Carter S., Auer K.L., Reardon D.B., et al. Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells. Oncogene. 16:1998;2787-2796.
    • (1998) Oncogene , vol.16 , pp. 2787-2796
    • Carter, S.1    Auer, K.L.2    Reardon, D.B.3
  • 19
    • 0035918858 scopus 로고    scopus 로고
    • Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization
    • Lammering G., Hewit T.H., Hawkins W.T., et al. Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization. J Natl Cancer Inst. 93:2001;921-929.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 921-929
    • Lammering, G.1    Hewit, T.H.2    Hawkins, W.T.3
  • 20
    • 0033049978 scopus 로고    scopus 로고
    • The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells
    • Contessa J.N., Reardon D.B., Todd D., et al. The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells. Clin Cancer Res. 5:1999;405-411.
    • (1999) Clin Cancer Res , vol.5 , pp. 405-411
    • Contessa, J.N.1    Reardon, D.B.2    Todd, D.3
  • 21
    • 0034954124 scopus 로고    scopus 로고
    • The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy
    • Pedersen M.W., Meltorn M., Damstrup L., et al. The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy. Ann Oncol. 12:2001;745-760.
    • (2001) Ann Oncol , vol.12 , pp. 745-760
    • Pedersen, M.W.1    Meltorn, M.2    Damstrup, L.3
  • 22
    • 1242311473 scopus 로고    scopus 로고
    • EGFR and its mutant EGFRvIII as modulators of tumor cell radiosensitivity (Abstract)
    • Lammering G, Hewit TH, Contessa JN, et al. EGFR and its mutant EGFRvIII as modulators of tumor cell radiosensitivity (Abstract). Proc Am Soc Ther Radiol Oncol 2002;103.
    • (2002) Proc Am Soc Ther Radiol Oncol , vol.103
    • Lammering, G.1    Th, H.2    Contessa, J.N.3
  • 23
    • 0035254521 scopus 로고    scopus 로고
    • Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation
    • Harari P.M., Huang S.-M. Head and neck cancer as a clinical model for molecular targeting of therapy Combining EGFR blockade with radiation . Int J Radiat Oncol Biol Phys. 49:2001;427-433.
    • (2001) Int J Radiat Oncol Biol Phys , vol.49 , pp. 427-433
    • Harari, P.M.1    Huang, S.-M.2
  • 24
    • 0034084314 scopus 로고    scopus 로고
    • Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis
    • Huang S.-M., Harari P.M. Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis . Clin Cancer Res. 6:2000;2166-2174.
    • (2000) Clin Cancer Res , vol.6 , pp. 2166-2174
    • Huang, S.-M.1    Harari, P.M.2
  • 25
    • 0034068319 scopus 로고    scopus 로고
    • Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
    • Ciardiello F., Caputo R., Bianco R., et al. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res. 6:2000;2053-2063.
    • (2000) Clin Cancer Res , vol.6 , pp. 2053-2063
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3
  • 26
    • 0037109014 scopus 로고    scopus 로고
    • ZD1839 (Iressa): An orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy
    • Wakeling A.E., Guy S.P., Woodburn J.R., et al. ZD1839 (Iressa) An orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy . Cancer Res. 62:2002;5749-5754.
    • (2002) Cancer Res , vol.62 , pp. 5749-5754
    • Wakeling, A.E.1    Guy, S.P.2    Woodburn, J.R.3
  • 27
    • 0036139727 scopus 로고    scopus 로고
    • Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: Histopathologic and molecular consequences of receptor inhibition
    • Albanell J., Rojo F., Averbuch S., et al. Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients Histopathologic and molecular consequences of receptor inhibition . J Clin Oncol. 20:2002;110-124.
    • (2002) J Clin Oncol , vol.20 , pp. 110-124
    • Albanell, J.1    Rojo, F.2    Averbuch, S.3
  • 28
    • 0036681995 scopus 로고    scopus 로고
    • Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa)
    • Huang S.-M., Li J., Armstrong E.A., et al. Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa). Cancer Res. 62:2002;4300-4306.
    • (2002) Cancer Res , vol.62 , pp. 4300-4306
    • Huang, S.-M.1    Li, J.2    Armstrong, E.A.3
  • 29
    • 0036570203 scopus 로고    scopus 로고
    • ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase
    • Hirata A., Ogawa S., Kometani T., et al. ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase. Cancer Res. 62:2002;2554-2560.
    • (2002) Cancer Res , vol.62 , pp. 2554-2560
    • Hirata, A.1    Ogawa, S.2    Kometani, T.3
  • 30
    • 0036795061 scopus 로고    scopus 로고
    • Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa)
    • Bianco C., Tortora G., Bianco R., et al. Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa). Clin Cancer Res. 8:2002;3250-3258.
    • (2002) Clin Cancer Res , vol.8 , pp. 3250-3258
    • Bianco, C.1    Tortora, G.2    Bianco, R.3
  • 31
    • 1242311472 scopus 로고    scopus 로고
    • ZD1839 ('Iressa') an EGFR tyrosine kinase inhibitor radiosensitizes glioblastoma multiforme by inhibition of a cell survival pathway (Abstract)
    • Ambrad AA, Stea B, Martinez J, et al. ZD1839 ('Iressa') an EGFR tyrosine kinase inhibitor radiosensitizes glioblastoma multiforme by inhibition of a cell survival pathway (Abstract). Proc Am Soc Ther Radiol Oncol 2002;95.
    • (2002) Proc Am Soc Ther Radiol Oncol , vol.95
    • Ambrad, A.A.1    Stea, B.2    Martinez, J.3
  • 32
    • 85047696958 scopus 로고    scopus 로고
    • ZD1839 ('Iressa'), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model
    • Williams K.J., Telfer B.A., Stratford I.J., et al. ZD1839 ('Iressa'), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model. Br J Cancer. 86:2002;1157-1161.
    • (2002) Br J Cancer , vol.86 , pp. 1157-1161
    • Williams, K.J.1    Telfer, B.A.2    Stratford, I.J.3
  • 33
    • 0036842170 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types
    • Baselga J., Rischin D., Ranson M., et al. Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types. J Clin Oncol. 20:2002;4292-4302.
    • (2002) J Clin Oncol , vol.20 , pp. 4292-4302
    • Baselga, J.1    Rischin, D.2    Ranson, M.3
  • 34
    • 0036569870 scopus 로고    scopus 로고
    • ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: Results of a phase I trial
    • Ranson M., Hammond L.A., Ferry D., et al. ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors Results of a phase I trial . J Clin Oncol. 20:2002;2240-2250.
    • (2002) J Clin Oncol , vol.20 , pp. 2240-2250
    • Ranson, M.1    Hammond, L.A.2    Ferry, D.3
  • 35
    • 0037106377 scopus 로고    scopus 로고
    • Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: Results of a phase I trial
    • Herbst R.S., Maddox A.-M., Rothenberg M.L., et al. Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors Results of a phase I trial . J Clin Oncol. 20:2002;3815-3825.
    • (2002) J Clin Oncol , vol.20 , pp. 3815-3825
    • Herbst, R.S.1    Maddox, A.-M.2    Rothenberg, M.L.3
  • 36
    • 0036368423 scopus 로고    scopus 로고
    • ZD1839 (Iressa™) in non-small cell lung cancer
    • Herbst R.S., Kies M.S. ZD1839 (Iressa™) in non-small cell lung cancer. Oncologist. 7:(Suppl. 4):2002;9-15.
    • (2002) Oncologist , vol.7 , Issue.SUPPL. 4 , pp. 9-15
    • Herbst, R.S.1    Kies, M.S.2
  • 37
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
    • Fukuoka M., Yano S., Giaccone G., et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol. 21:2003;2237-2246.
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 38
    • 85030911096 scopus 로고    scopus 로고
    • A phase II trial of ZD1839 ('Iressa') in advanced non-small-cell lung cancer (NSCLC) patients who had failed platinum- and docetaxel-based regimens (IDEAL 2)
    • Kris M. A phase II trial of ZD1839 ('Iressa') in advanced non-small-cell lung cancer (NSCLC) patients who had failed platinum- and docetaxel-based regimens (IDEAL 2). Presented at: American Society of Clinical Oncology; May 18-21, 2002; Orlando, FL.
    • Presented At: American Society of Clinical Oncology; May 18-21, 2002; Orlando, FL
    • Kris, M.1
  • 39
    • 0001303063 scopus 로고    scopus 로고
    • A phase II trial of ZD1839 ('Iressa') in advanced non-small cell lung cancer (NSCLC) patients who had failed platinum- and docetaxel-based regimens (IDEAL 2)
    • Kris MG, Natale RB, Herbst RS, et al. A phase II trial of ZD1839 ('Iressa') in advanced non-small cell lung cancer (NSCLC) patients who had failed platinum- and docetaxel-based regimens (IDEAL 2). Proc Am Soc Clin Oncol 2002;21(1):292a.
    • (2002) Proc Am Soc Clin Oncol , vol.21 , Issue.1
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 40
    • 0035398021 scopus 로고    scopus 로고
    • Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer
    • Robert F., Ezekiel M.P., Spencer S.A., et al. Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer. J Clin Oncol. 19:2001;3234-3243.
    • (2001) J Clin Oncol , vol.19 , pp. 3234-3243
    • Robert, F.1    Ezekiel, M.P.2    Spencer, S.A.3
  • 41
    • 0037674062 scopus 로고    scopus 로고
    • Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Cohen E.E., Rosen F., Stadler W.M., et al. Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol. 21:2003;1980-1987.
    • (2003) J Clin Oncol , vol.21 , pp. 1980-1987
    • Cohen, E.E.1    Rosen, F.2    Stadler, W.M.3
  • 42
    • 0037010086 scopus 로고    scopus 로고
    • IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody for treatment of head and neck cancer
    • Herbst R.S., Hong W.K. IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody for treatment of head and neck cancer. Semin Oncol. 29:(Suppl. 14):2002;18-30.
    • (2002) Semin Oncol , vol.29 , Issue.SUPPL. 14 , pp. 18-30
    • Herbst, R.S.1    Hong, W.K.2
  • 43
    • 0011720039 scopus 로고    scopus 로고
    • A phase II study of Erbitux (IMC-C225), an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer (NSCLC)
    • Kim ES, Mauer AM, Fossella FV, et al. A phase II study of Erbitux (IMC-C225), an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2002;21:293a.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Kim, E.S.1    Mauer, A.M.2    Fossella, F.V.3
  • 44
    • 0036124415 scopus 로고    scopus 로고
    • Epidermal growth factor receptors as a target for cancer treatment: The emerging role of IMC-C225 in the treatment of lung and head and neck cancers
    • Herbst R.S., Langer C.J. Epidermal growth factor receptors as a target for cancer treatment The emerging role of IMC-C225 in the treatment of lung and head and neck cancers . Semin Oncol. 29:(Suppl. 4):2002;27-36.
    • (2002) Semin Oncol , vol.29 , Issue.SUPPL. 4 , pp. 27-36
    • Herbst, R.S.1    Langer, C.J.2
  • 45
    • 0035398631 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
    • Hidalgo M., Siu L.L., Nemunaitis J., et al. Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol. 19:2001;3267-3279.
    • (2001) J Clin Oncol , vol.19 , pp. 3267-3279
    • Hidalgo, M.1    Siu, L.L.2    Nemunaitis, J.3
  • 46
    • 0000329007 scopus 로고    scopus 로고
    • A phase II trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients (pts) with advanced, EGFR-expressing, non-small cell lung cancer (NSCLC)
    • Perez-Soler R, Chachoua A, Huberman M, et al. A phase II trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients (pts) with advanced, EGFR-expressing, non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2001;20(1):310a.
    • (2001) Proc Am Soc Clin Oncol , vol.20 , Issue.1
    • Perez-Soler, R.1    Chachoua, A.2    Huberman, M.3
  • 47
    • 0345636045 scopus 로고    scopus 로고
    • Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer
    • Oza A.M., Townsley C.A., Siu L.L., et al. Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol. 22:2003;196.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 196
    • Oza, A.M.1    Townsley, C.A.2    Siu, L.L.3
  • 48
    • 0042048800 scopus 로고    scopus 로고
    • Enhanced radiation response following HER1/EGFR blockade by erlotinib (Tarceva™, OSI-774) in human carcinoma cell lines
    • Chinnaiyan P., Huang S.-M., Armstrong E., et al. Enhanced radiation response following HER1/EGFR blockade by erlotinib (Tarceva™, OSI-774) in human carcinoma cell lines. Proc Am Assoc Cancer Res. 44:2003;867.
    • (2003) Proc Am Assoc Cancer Res , vol.44 , pp. 867
    • Chinnaiyan, P.1    Huang, S.-M.2    Armstrong, E.3
  • 49
    • 0034329308 scopus 로고    scopus 로고
    • Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers
    • Bonner JA, Raisch KP, Trummell HQ, et al. Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers. J Clin Oncol 2000;18(Suppl.):47s-53s.
    • (2000) J Clin Oncol , vol.18 , Issue.SUPPL.
    • Bonner, J.A.1    Kp, R.2    Trummell, H.Q.3
  • 50
    • 1242333987 scopus 로고    scopus 로고
    • For the University of Chicago Phase II Network. a phase I study of OSI-774 in combination with chemoradiation (CRT) for unresectable, locally advanced non-small cell lung cancer (NSCLC)
    • Mauer A, Haraf D, Hoffman PC, et al. for the University of Chicago Phase II Network. A phase I study of OSI-774 in combination with chemoradiation (CRT) for unresectable, locally advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2003;22:651.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 651
    • Mauer, A.1    Haraf, D.2    Hoffman, P.C.3
  • 51
    • 0242437303 scopus 로고    scopus 로고
    • Concurrent cetuximab, cisplatin, and concomitant boost radiation therapy (RT) for locoregionally advanced, squamous cell head and neck cancer (SCCHN): Preliminary evaluation of a new combined-modality paradigm
    • Pfister D.G., Aliff T.B., Kraus D.H., et al. Concurrent cetuximab, cisplatin, and concomitant boost radiation therapy (RT) for locoregionally advanced, squamous cell head and neck cancer (SCCHN) Preliminary evaluation of a new combined-modality paradigm . Proc Am Soc Clin Oncol. 22:2003;495.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 495
    • Pfister, D.G.1    Aliff, T.B.2    Kraus, D.H.3


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