Expression of a dominant-negative Rho-kinase promotes neurite outgrowth in a microenvironment mimicking injured central nervous system

Acta Pharmacologica Sinica

Volumn 31, Issue 5, 2010, Pages 531-539

  Yang, Ping ^a   Wen, Hui Zhong ^a   Zhang, Jin Hai ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Dorsal root ganglion neurons; Lentivirus; Nerve regeneration; Neurites; PC12 cells; Rho associated kinases; Signal transduction

Indexed keywords

DOMINANT NEGATIVE MUTANT RHO KINASE; GREEN FLUORESCENT PROTEIN; LAMININ; LENTIVIRUS VECTOR; MUTANT PROTEIN; MYELIN; MYOSIN SUBFRAGMENT 1; PHALLOIDIN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHODAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CELL DIFFERENTIATION; CELL MEMBRANE; CELL STRUCTURE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOSOL; DENSITY GRADIENT CENTRIFUGATION; DISSOCIATION; ENZYME ACTIVATION; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; GROWTH CONE; IMAGE ANALYSIS; IMMUNOBLOTTING; IN VITRO STUDY; MICROENVIRONMENT; NERVE CELL; NERVE FIBER GROWTH; NERVE INJURY; NEURITE; NONHUMAN; OSMOSIS; PERIKARYON; PLASMID; PROTEIN EXPRESSION; PROTEIN PURIFICATION; RAT; SIGNAL TRANSDUCTION; SPINAL CORD NERVE CELL; SPINAL GANGLION; STAINING; STRESS FIBER;

ANIMALS; CELL LINE; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CYTOSKELETON; GANGLIA, SPINAL; HUMANS; LENTIVIRUS; MICE; MUTATION; MYELIN SHEATH; NERVE REGENERATION; NEURITES; NEURONS; PROTEIN TRANSPORT; RATS; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; TRANSDUCTION, GENETIC;

EID: 77952068812     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.35     Document Type: Article

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