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Volumn 8, Issue 1, 1998, Pages 106-116

An emerging link between cytoskeletal dynamics and cell adhesion molecules in growth cone guidance

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; CYTOSKELETON PROTEIN; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN; MYOSIN ADENOSINE TRIPHOSPHATASE;

EID: 0031967521     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(98)80014-7     Document Type: Article
Times cited : (144)

References (75)
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    • of outstanding interest. The strongest evidence to date for the signaling pathway discussed in [58]. Neurite outgrowth mediated by NCAM, L1 and N-cadherin was abolished in PC12 cells or primary neurons from transgenic mice expressing a kinase-deleted dominant-negative form of the FGF receptor. Addition of soluble NCAM- and L1-Fc chimera resulted in phosphorylation of the FGF receptor - a key step in receptor activation.
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    • of special interest. This in vitro study shows that all three Rho-related GTPases (Rho, Rac and Cdc42) are involved in dendritic growth and remodeling of cortical neurons, suggesting an important role of these regulatory proteins for the development of the cortex.
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