메뉴 건너뛰기




Volumn 110, Issue 2, 2010, Pages 321-332

Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells

Author keywords

Apoptosis; Cannabinoid; Gastric cancer; Invasion; Proliferation

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID 1 RECEPTOR; GELATINASE A; PROTEIN KINASE B; VASCULOTROPIN A;

EID: 77952063705     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22540     Document Type: Article
Times cited : (36)

References (49)
  • 2
    • 0028824336 scopus 로고
    • Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor 121
    • Asano M, Yukita A, Matsumoto T, Kondo S, Suzuki H. 1995. Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor 121. Cancer Res 55:5296-5301.
    • (1995) Cancer Res , vol.55 , pp. 5296-5301
    • Asano, M.1    Yukita, A.2    Matsumoto, T.3    Kondo, S.4    Suzuki, H.5
  • 6
    • 33746138649 scopus 로고    scopus 로고
    • Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
    • DOI 10.1158/0008-5472.CAN-06-0169
    • Carracedo A, Gironella M, Lorente M, Garcia S, Guzmán M, Velasco G, Iovanna JL. 2006a. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res 66:6748-6755. (Pubitemid 44085633)
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6748-6755
    • Carracedo, A.1    Gironella, M.2    Lorente, M.3    Garcia, S.4    Guzman, M.5    Velasco, G.6    Iovanna, J.L.7
  • 9
    • 27844598284 scopus 로고    scopus 로고
    • The Akt/PKB pathway: Molecular target for cancer drug discovery
    • DOI 10.1038/sj.onc.1209088, PII 1209088
    • Cheng JQ, Lindsley CW, Cheng GZ, Yang H, Nicosia SV. 2005. The Akt/PKB pathway: Molecular target for cancer drug discovery. Oncogene 24:7482-7492. (Pubitemid 41637988)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7482-7492
    • Cheng, J.Q.1    Lindsley, C.W.2    Cheng, G.Z.3    Yang, H.4    Nicosia, S.V.5
  • 10
    • 1842529993 scopus 로고    scopus 로고
    • Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1
    • DOI 10.1016/j.ygyno.2003.12.040, PII S0090825803009521
    • Contassot E, Tenan M, Schnuriger V, Pelte MF, Dietrich PY. 2004. Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1. Gynecol Oncol 93:182-188. (Pubitemid 38429568)
    • (2004) Gynecologic Oncology , vol.93 , Issue.1 , pp. 182-188
    • Contassot, E.1    Tenan, M.2    Schnuriger, V.3    Pelte, M.-F.4    Dietrich, P.-Y.5
  • 11
    • 4544275181 scopus 로고    scopus 로고
    • The endocannabinoid system and its therapeutic exploitation
    • DOI 10.1038/nrd1495
    • Di Marzo V, Bifulco M, De Petrocellis L. 2004. The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov 3:771-784. (Pubitemid 39242829)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.9 , pp. 771-784
    • Di Marzo, V.1    Bifulco, M.2    De Petrocellis, L.3
  • 12
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad M, Werb Z. 2002. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2:161-174. (Pubitemid 37328786)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.3 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 13
    • 32244449089 scopus 로고    scopus 로고
    • R(+)-methanandamide elicits a cyclooxygenase-2-dependent mitochondrial apoptosis signaling pathway in human neuroglioma cells
    • DOI 10.1007/s11095-005-8815-2
    • Eichele K, Weinzierl U, Ramer R, Brune K, Hinz B. 2006. R(+)-methanandamide elicits a cyclooxygenase-2-dependent mitochondrial apoptosis signaling pathway in human neuroglioma cells. Pharm Res 23:90-94. (Pubitemid 43214664)
    • (2006) Pharmaceutical Research , vol.23 , Issue.1 , pp. 90-94
    • Eichele, K.1    Weinzierl, U.2    Ramer, R.3    Brune, K.4    Hinz, B.5
  • 14
    • 4644226099 scopus 로고    scopus 로고
    • Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein
    • DOI 10.1016/j.cellsig.2004.05.011, PII S0898656804001007
    • Ellert-Miklaszewska A, Kaminska B, Konarska L. 2005. Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein. Cell Signal 17:25-37. (Pubitemid 39286777)
    • (2005) Cellular Signalling , vol.17 , Issue.1 , pp. 25-37
    • Ellert-Miklaszewska, A.1    Kaminska, B.2    Konarska, L.3
  • 17
    • 35348910284 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells
    • DOI 10.1002/ijc.22917
    • Greenhough A, Patsos HA, Williams AC, Paraskeva C. 2007. The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells. Int J Cancer 121:2172-2180. (Pubitemid 47585595)
    • (2007) International Journal of Cancer , vol.121 , Issue.10 , pp. 2172-2180
    • Greenhough, A.1    Patsos, H.A.2    Williams, A.C.3    Paraskeva, C.4
  • 19
    • 33751198532 scopus 로고    scopus 로고
    • Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win 55, 212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma
    • Gustafsson K, Christensson B, Sander B, Flygare J. 2006. Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win 55, 212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma. Mol Pharmacol 70:1612-1620.
    • (2006) Mol Pharmacol , vol.70 , pp. 1612-1620
    • Gustafsson, K.1    Christensson, B.2    Sander, B.3    Flygare, J.4
  • 20
    • 0142166330 scopus 로고    scopus 로고
    • Cannabinoids: Potential anticancer agents
    • Guzmán M. 2003. Cannabinoids: Potential anticancer agents. Nat Rev Cancer 3:745-755.
    • (2003) Nat Rev Cancer , vol.3 , pp. 745-755
    • Guzmán, M.1
  • 21
    • 11944262124 scopus 로고    scopus 로고
    • Cannabinoids and cancer: Causation, remediation, and palliation
    • Hall W, Christie M, Currow D. 2005. Cannabinoids and cancer: Causation, remediation, and palliation. Lancet Oncol 6:35-42.
    • (2005) Lancet Oncol , vol.6 , pp. 35-42
    • Hall, W.1    Christie, M.2    Currow, D.3
  • 22
    • 9444229367 scopus 로고    scopus 로고
    • Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells
    • DOI 10.1124/mol.104.002618
    • Hinz B, Ramer R, Eichele K, Weinzierl U, Brune K. 2004. Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells. Mol Pharmacol 66:1643-1651. (Pubitemid 39564792)
    • (2004) Molecular Pharmacology , vol.66 , Issue.6 , pp. 1643-1651
    • Hinz, B.1    Ramer, R.2    Eichele, K.3    Weinzierl, U.4    Brune, K.5
  • 24
    • 3242724820 scopus 로고    scopus 로고
    • Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes
    • Joseph J, Niggemann B, Zaenker KS, Entschladen F. 2004. Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes. Cancer Immunol Immunother 53:723-728. (Pubitemid 38962066)
    • (2004) Cancer Immunology, Immunotherapy , vol.53 , Issue.8 , pp. 723-728
    • Joseph, J.1    Niggemann, B.2    Zaenker, K.S.3    Entschladen, F.4
  • 25
    • 0031870765 scopus 로고    scopus 로고
    • Anti-tumor and anti-metastatic effects of human-vascular-endothelial- Growth-factor-neutralizing antibody on human colon and gastric carcinoma xenotransplanted orthotopically into nude mice
    • DOI 10.1002/(SICI)1097-0215(19980911)77:6<933::AID-IJC23>3.0.CO;2-0
    • Kanai T, Konno H, Tanaka T, Baba M, Matsumoto K, Nakamura S, Yukita A, Asano M, Suzuki H, Baba S. 1998. Anti-tumor and anti-metastatic effects of human-vascular-endothelial-growth-factor-neutralizing antibody on human colon and gastric carcinoma xenotransplanted orthotopically into nude mice. Int J Cancer 77:933-936. (Pubitemid 28378146)
    • (1998) International Journal of Cancer , vol.77 , Issue.6 , pp. 933-936
    • Kanai, T.1    Konno, H.2    Tanaka, T.3    Baba, M.4    Matsumoto, K.5    Nakamura, S.6    Yukita, A.7    Asano, M.8    Suzuki, H.9    Baba, S.10
  • 26
    • 0036292971 scopus 로고    scopus 로고
    • Circulating VEGF levels in the serum of gastric cancer patients: Correlation with pathological variables, patient survival, and tumor surgery
    • DOI 10.1097/00000658-200207000-00007
    • Karayiannakis AJ, Syrigos KN, Polychronidis A, Zbar A, Kouraklis G, Simopoulos C, Karatzas G. 2002. Circulating VEGF levels in the serum of gastric cancer patients: Correlation with pathological variables, patient survival, and tumor surgery. Ann Surg 236:37-42. (Pubitemid 34686448)
    • (2002) Annals of Surgery , vol.236 , Issue.1 , pp. 37-42
    • Karayiannakis, A.J.1    Syrigos, K.N.2    Polychronidis, A.3    Zbar, A.4    Kouraklis, G.5    Simopoulos, C.6    Karatzas, G.7
  • 27
    • 34147172414 scopus 로고    scopus 로고
    • VEGF-C and VEGF-A synergistically enhance lymph node metastasis of gastric cancer
    • DOI 10.1248/bpb.30.633
    • Kondo K, Kaneko T, Baba M, Konno H. 2007. VEGF-C and VEGF-A synergistically enhance lymph node metastasis of gastric cancer. Biol Pharm Bull 30:633-637. (Pubitemid 46570975)
    • (2007) Biological and Pharmaceutical Bulletin , vol.30 , Issue.4 , pp. 633-637
    • Kondo, K.1    Kaneko, T.2    Baba, M.3    Konno, H.4
  • 28
    • 46349091235 scopus 로고    scopus 로고
    • AM251 suppresses the viability of HepG2 cells through the AMPK (AMP-activated protein kinase)-JNK (c-Jun N-terminal kinase)-ATF3 (activating transcription factor 3) pathway
    • Lee YM, Uhm KO, Lee ES, Kwon J, Park SH, Kim HS. 2008. AM251 suppresses the viability of HepG2 cells through the AMPK (AMP-activated protein kinase)-JNK (c-Jun N-terminal kinase)-ATF3 (activating transcription factor 3) pathway. Biochem Biophys Res Commun 370:641-645.
    • (2008) Biochem Biophys Res Commun , vol.370 , pp. 641-645
    • Lee, Y.M.1    Uhm, K.O.2    Lee, E.S.3    Kwon, J.4    Park, S.H.5    Kim, H.S.6
  • 31
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • DOI 10.1038/346561a0
    • Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI. 1990. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561-564. (Pubitemid 20238806)
    • (1990) Nature , vol.346 , Issue.6284 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 32
    • 0035176717 scopus 로고    scopus 로고
    • Tumor progression: Defining the soil round the tumor seed
    • McCawley LJ, Matrisian LM. 2001. Tumor progression: Defining the soil round the tumor seed. Curr Biol 11:R25-27.
    • (2001) Curr Biol , vol.11
    • McCawley, L.J.1    Matrisian, L.M.2
  • 34
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • DOI 10.1038/365061a0
    • Munro S, Thomas KL, Abu-Shaar M. 1993. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365:61-65. (Pubitemid 23305569)
    • (1993) Nature , vol.365 , Issue.6441 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 36
    • 10844265493 scopus 로고    scopus 로고
    • 2-Arachidonoylglycerol: A novel inhibitor of androgen-independent prostate cancer cell invasion
    • DOI 10.1158/0008-5472.CAN-04-3136
    • Nithipatikom K, Endsley MP, Isbell MA, Falck JR, Iwamoto Y, Hillard CJ, Campbell WB. 2004. 2-arachidonoylglycerol: A novel inhibitor of androgenin-dependent prostate cancer cell invasion. Cancer Res 64:8826-8830. (Pubitemid 39665485)
    • (2004) Cancer Research , vol.64 , Issue.24 , pp. 8826-8830
    • Nithipatikom, K.1    Endsley, M.P.2    Isbell, M.A.3    Falck, J.R.4    Iwamoto, Y.5    Hillard, C.J.6    Campbell, W.B.7
  • 38
    • 0029882219 scopus 로고    scopus 로고
    • Enhanced production of matrix metalloproteinases and activation of matrix metalloproteinase 2 (gelatinase A) in human gastric carcinomas
    • DOI 10.1002/(SICI)1097-0215(19960220)69:1<9::AID-IJC3>3.0.CO;2-8
    • Nomura H, Fujimoto N, Seiki M, Mai M, Okada Y. 1996. Enhanced production of matrix metalloproteinases and activation of matrix metalloproteinase 2 (gelatinase A) in human gastric carcinomas. Int J Cancer 69:9-16. (Pubitemid 26083264)
    • (1996) International Journal of Cancer , vol.69 , Issue.1 , pp. 9-16
    • Nomura, H.1    Fujimoto, N.2    Seiki, M.3    Mai, M.4    Okada, Y.5
  • 40
    • 33644545381 scopus 로고    scopus 로고
    • Tumour microenvironment-opinion: Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy
    • Overall CM, Kleifeld O. 2006. Tumour microenvironment-opinion: Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer 6:227-239.
    • (2006) Nat Rev Cancer , vol.6 , pp. 227-239
    • Overall, C.M.1    Kleifeld, O.2
  • 41
    • 28144431771 scopus 로고    scopus 로고
    • The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: A possible role for cyclooxygenase 2
    • DOI 10.1136/gut.2005.073403
    • Patsos HA, Hicks DJ, Dobson RR, Greenhough A, Woodman N, Lane JD, Williams AC, Paraskeva C. 2005. The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: A possible role for cyclooxygenase 2. Gut 54:1741-1750. (Pubitemid 41697674)
    • (2005) Gut , vol.54 , Issue.12 , pp. 1741-1750
    • Patsos, H.A.1    Hicks, D.J.2    Dobson, R.R.H.3    Greenhough, A.4    Woodman, N.5    Lane, J.D.6    Williams, A.C.7    Paraskeva, C.8
  • 43
    • 32644441249 scopus 로고    scopus 로고
    • Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients - RIO-North America: A randomized controlled trial
    • DOI 10.1001/jama.295.7.761
    • Pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J. 2006. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: A randomized controlled trial. JAMA 295:761-775. (Pubitemid 43244304)
    • (2006) Journal of the American Medical Association , vol.295 , Issue.7 , pp. 761-775
    • Pi-Sunyer, F.X.1    Aronne, L.J.2    Heshmati, H.M.3    Devin, J.4    Rosenstock, J.5
  • 44
    • 0141594998 scopus 로고    scopus 로고
    • Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: Actions on signals involved in angiogenesis and metastasis
    • Portella G, Laezza C, Laccetti P, De Petrocellis L, Di Marzo V, Bifulco M. 2003. Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: Actions on signals involved in angiogenesis and metastasis. FASEB J 17:1771-1773.
    • (2003) FASEB J , vol.17 , pp. 1771-1773
    • Portella, G.1    Laezza, C.2    Laccetti, P.3    De Petrocellis, L.4    Di Marzo, V.5    Bifulco, M.6
  • 45
    • 38049185265 scopus 로고    scopus 로고
    • Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1
    • DOI 10.1093/jnci/djm268
    • Ramer R, Hinz B. 2008. Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1. J Natl Cancer Inst 100:59-69. (Pubitemid 351767340)
    • (2008) Journal of the National Cancer Institute , vol.100 , Issue.1 , pp. 59-69
    • Ramer, R.1    Hinz, B.2
  • 46
    • 24044459285 scopus 로고    scopus 로고
    • Matrix metalloproteinases and angiogenesis
    • Rundhaug JE. 2005. Matrix metalloproteinases and angiogenesis. J Cell Mol Med 9:267-285.
    • (2005) J Cell Mol Med , vol.9 , pp. 267-285
    • Rundhaug, J.E.1
  • 47
    • 0033055038 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor correlates with hematogenous recurrence in gastric carcinoma
    • DOI 10.1016/S0039-6060(99)70265-5
    • Saito H, Tsujitani S, Kondo A, Ikeguchi M, Maeta M, Kaibara N. 1999. Expression of vascular endothelial growth factor correlates with hematogenous recurrence in gastric carcinoma. Surgery 125:195-201. (Pubitemid 29076116) (Pubitemid 29076116)
    • (1999) Surgery , vol.125 , Issue.2 , pp. 195-201
    • Saito, H.1    Tsujitani, S.2    Kondo, A.3    Ikeguchi, M.4    Maeta, M.5    Kaibara, N.6
  • 48
    • 33845973763 scopus 로고    scopus 로고
    • 1 cell cycle arrest
    • DOI 10.1074/jbc.M603495200
    • Sarfaraz S, Afaq F, Adhami VM, Malik A, Mukhtar H. 2006. Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest. J Biol Chem 281:39480-39491. (Pubitemid 46041908)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.51 , pp. 39480-39491
    • Sarfaraz, S.1    Afaq, F.2    Adhami, V.M.3    Malik, A.4    Mukhtar, H.5
  • 49
    • 16444375370 scopus 로고    scopus 로고
    • Cannabinoid receptor as a novel target for the treatment of prostate cancer
    • DOI 10.1158/0008-5472.CAN-04-3410
    • Sarfaraz S, Afaq F, Adhami VM, Mukhtar H. 2005. Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res 65:1635-1641. (Pubitemid 40478586)
    • (2005) Cancer Research , vol.65 , Issue.5 , pp. 1635-1641
    • Sarfaraz, S.1    Afaq, F.2    Adhami, V.M.3    Mukhtar, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.