High dosage of Exendin-4 increased early insulin secretion in differentiated beta cells from mouse embryonic stem cells

Acta Pharmacologica Sinica

Volumn 31, Issue 5, 2010, Pages 570-577

  Li, Hua ^a,b   Lam, Amy ^a   Xu, Ai Min ^c   Sl Lam, Karen ^c   Kim Chung, Sookja ^a,c  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b DALIAN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Beta cells; Diabetes; Differentiation; Early insulin secretion; Embryonic stem cells; Exendin 4

Indexed keywords

ANTIPORTER; C PEPTIDE; EPAC 1 PROTEIN; EPAC 2 PROTEIN; EXENDIN 4; GENOMIC DNA; INSULIN; RNA; SULFONYLUREA RECEPTOR 1; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; IMMUNOFLUORESCENCE; IN VITRO STUDY; INSULIN RELEASE; MOUSE; NONHUMAN; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION;

ANIMALS; C-PEPTIDE; CELL DIFFERENTIATION; CELLS, CULTURED; EMBRYONIC STEM CELLS; GENE EXPRESSION PROFILING; GLUCOSE; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; MICE; PEPTIDES; PHENOTYPE; VENOMS;

EID: 77952014233     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.38     Document Type: Article

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