Role of Arg301 in substrate orientation and catalysis in subsite 2 of d-alanine:d-alanine (d-lactate) ligase from Leuconostoc mesenteroides: A molecular docking study

Journal of Molecular Graphics and Modelling

Volumn 28, Issue 8, 2010, Pages 728-734

  Neuhaus, Francis C ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

AutoDock 4; d Alanine:d alanine (d lactate) ligase (ADP); d Lactate; Molecular docking; Vancomycin resistance

Indexed keywords

[CARBONYL; AUTODOCK; D-LACTATE; DUAL FUNCTION; H-BONDING; INHIBITOR DESIGN; INTRINSIC RESISTANCE; LEUCONOSTOC MESENTEROIDES; MOLECULAR DOCKING; SEQUENTIAL REACTION; SIDE CHAINS; SUBSTRATE ORIENTATION; TRANSITION STATE; VANCOMYCIN;

DOCKING; HYDROGEN BONDS; MOLECULAR MODELING; NUCLEOPHILES;

MOLECULAR ORIENTATION;

ARGININE; CARBONYL DERIVATIVE; DEPSIPEPTIDE; DEXTRO ALANINE; DEXTRO ALANINE DEXTRO ALANINE LIGASE; GUANIDINE DERIVATIVE; LACTIC ACID; LIGASE; LIGASE INHIBITOR; NUCLEOPHILE; VANCOMYCIN; WATER;

ANTIBIOTIC RESISTANCE; ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; ENZYME SUBSTRATE; HYDROGEN BOND; LEUCONOSTOC MESENTEROIDES; MOLECULAR DOCKING; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTON TRANSPORT;

ALANINE; ARGININE; BACTERIAL PROTEINS; CARBON-OXYGEN LIGASES; CATALYSIS; CATALYTIC DOMAIN; COMPUTER SIMULATION; DRUG RESISTANCE, BACTERIAL; LACTIC ACID; LEUCONOSTOC; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; VANCOMYCIN RESISTANCE;

LEUCONOSTOC MESENTEROIDES;

EID: 77951974714     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmgm.2010.01.010     Document Type: Article

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