Determinants for differential effects on D-Ala-D-lactate vs D-Ala-D-Ala formation by the VanA ligase from vancomycin-resistant enterococci

Biochemistry

Volumn 38, Issue 42, 1999, Pages 14006-14022

  Lessard, Ivan A D ^a,b   Healy, Vicki L ^a   Park, Il Seon ^a,c   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOEHRINGER INGELHEIM CANADA LTD   (Canada)

^c Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOSYNTHESIS; CATALYSIS; CATALYST SELECTIVITY; CELLS; CHEMICAL ACTIVATION; CHEMICAL BONDS; MUTAGENESIS;

DEPSIPEPTIDE LIGASE; LACTATE; PEPTIDOGLYCAN; VANCOMYCIN RESISTANT ENTEROCOCCI;

ENZYMES;

LIGASE; PEPTIDOGLYCAN; VANCOMYCIN;

AMINO ACID METABOLISM; AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MUTATION; ENZYME ACTIVITY; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATASES; ALANINE; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ARGININE; BACTERIAL PROTEINS; BASE SEQUENCE; CARBON-OXYGEN LIGASES; DIPEPTIDES; ENTEROCOCCUS; ENZYME ACTIVATION; HISTIDINE; HYDROGEN-ION CONCENTRATION; LACTIC ACID; LEUCONOSTOC; LIGANDS; LYSINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE SYNTHASES; STEREOISOMERISM; TEMPLATES, GENETIC; VANCOMYCIN; VANCOMYCIN RESISTANCE;

EID: 0345192358     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991384c     Document Type: Article

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