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Volumn 25, Issue 2, 2010, Pages 193-205

Preclinical evaluation of monoclonal antibody 14C5 for targeting pancreatic cancer

Author keywords

111 indium; 131 iodine; Monoclonal antibody; Pancreatic cancer; Radioimmunodetection

Indexed keywords

4 BENZYLISOTHIOCYANATE 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID IN 111; 4 ISOTHIOCYANATOBENZYL DIETHYLENETRIAMINEPENTAACETIC ACID IN 111; ALPHAVBETA5 INTEGRIN; INDIUM 111; IODINE 125; IODINE 131; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 14C5; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

EID: 77951946777     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/cbr.2009.0696     Document Type: Article
Times cited : (12)

References (63)
  • 1
    • 33847638137 scopus 로고    scopus 로고
    • Estimates of the cancer incidence and mortality in europe in 2006
    • Ferlay J, Autier P, Boniol M, et al. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007;18:581.
    • (2007) Ann. Oncol. , vol.18 , pp. 581
    • Ferlay, J.1    Autier, P.2    Boniol, M.3
  • 2
    • 1642588228 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Li D, Xie K, Wolff R, et al. Pancreatic cancer. Lancet 2004;363:1049.
    • (2004) Lancet , vol.363 , pp. 1049
    • Li, D.1    Xie, K.2    Wolff, R.3
  • 4
    • 33947410340 scopus 로고    scopus 로고
    • In vitro and in vivo comparison of dtpa-and dota-conjugated antiferritin monoclonal antibody for imaging and therapy of pancreatic cancer
    • Sabbah E, Kadouche J, Ellison D, et al. In vitro and in vivo comparison of DTPA-and DOTA-conjugated antiferritin monoclonal antibody for imaging and therapy of pancreatic cancer. Nucl Med Biol 2007;34:293.
    • (2007) Nucl Med. Biol. , vol.34 , pp. 293
    • Sabbah, E.1    Kadouche, J.2    Ellison, D.3
  • 5
    • 33748346243 scopus 로고    scopus 로고
    • Antitumor effect of trastuzumab for pancreatic cancer with high HER-2 expression and enhancement of effect by combined therapy with gemcitabine
    • Kimura K, Sawada T, Komatsu M, et al. Antitumor effect of trastuzumab for pancreatic cancer with high HER-2 expression and enhancement of effect by combined therapy with gemcitabine. Clin Cancer Res 2006;12:4925.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 4925
    • Kimura, K.1    Sawada, T.2    Komatsu, M.3
  • 6
    • 33746894777 scopus 로고    scopus 로고
    • Immunohistochemical study of the association between the progression of pancreatic ductal lesions and the expression of MUC1, MUC2, MUC5AC, and E-cadherin
    • Kigure S. Immunohistochemical study of the association between the progression of pancreatic ductal lesions and the expression of MUC1, MUC2, MUC5AC, and E-cadherin. Rinsho Byori 2006;54:447.
    • (2006) Rinsho Byori. , vol.54 , pp. 447
    • Kigure, S.1
  • 7
    • 0034975884 scopus 로고    scopus 로고
    • Localization of pancreatic cancer with radiolabelled monoclonal antibody PAM4
    • Gold DV, Cardillo T, Goldenberg DM, et al. Localization of pancreatic cancer with radiolabelled monoclonal antibody PAM4. Crit Rev Oncol Hematol 2001;39:147.
    • (2001) Crit. Rev. Oncol. Hematol. , vol.39 , pp. 147
    • Gold, D.V.1    Cardillo, T.2    Goldenberg, D.M.3
  • 8
    • 43249118924 scopus 로고    scopus 로고
    • Integrin alpha 6 beta 4 promotes migration, invasion through tiam1 upregulation, and subsequent rac activation
    • Cruz-Monserrate Z, O'Connor KL. Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent Rac activation. Neoplasia 2008;10:408.
    • (2008) Neoplasia , vol.10 , pp. 408
    • Cruz-Monserrate, Z.1    O'Connor, K.L.2
  • 9
    • 54349110130 scopus 로고    scopus 로고
    • Pancreatic cancer: From molecular signature to target therapy
    • Longo R, Cacciamani F, Naso G, et al. Pancreatic cancer: From molecular signature to target therapy. Crit Rev Oncol Hematol 2008;68:197.
    • (2008) Crit. Rev. Oncol. Hematol. , vol.68 , pp. 197
    • Longo, R.1    Cacciamani, F.2    Naso, G.3
  • 10
    • 33947326900 scopus 로고    scopus 로고
    • Biodistribution and planar gamma camera imaging of (123) I-and (131) I-labelled F (ab') (2) and fab fragments of monoclonal antibody 14C5 in nude mice bearing an A549 lung tumor
    • Burvenich I, Schoonooghe S, Blanckaert P, et al. Biodistribution and planar gamma camera imaging of (123) I-and (131) I-labelled F (ab') (2) and Fab fragments of monoclonal antibody 14C5 in nude mice bearing an A549 lung tumor. Nucl Med Biol 2007;34:257.
    • (2007) Nucl Med. Biol. , vol.34 , pp. 257
    • Burvenich, I.1    Schoonooghe, S.2    Blanckaert, P.3
  • 11
    • 0028239386 scopus 로고
    • A monoclonal antibody directed against a human cell membrane antigen prevents cell substrate adhesion and tumor invasion
    • De Potter CR, Schelfhout AM, De Smet FH, et al. A monoclonal antibody directed against a human cell membrane antigen prevents cell substrate adhesion and tumor invasion. Am J Pathol 1994;144:95.
    • (1994) Am. J. Pathol. , vol.144 , pp. 95
    • De Potter, C.R.1    Schelfhout, A.M.2    De Smet, F.H.3
  • 12
    • 0030992479 scopus 로고    scopus 로고
    • Generation of a monoclonal antibody directed against a human cell substrate adhesion molecule and the expression of the antigen in human tissues
    • Coene E, Schelfhout AM, De Ridder L, et al. Generation of a monoclonal antibody directed against a human cell substrate adhesion molecule and the expression of the antigen in human tissues. Hybridoma 1997;16:77.
    • (1997) Hybridoma , vol.16 , pp. 77
    • Coene, E.1    Schelfhout, A.M.2    De Ridder, L.3
  • 13
    • 27144452013 scopus 로고    scopus 로고
    • In vitro and in vivo targeting properties of iodine-123-or iodine-131-labelled monoclonal antibody 14C5 in a non-small cell lung cancer and colon carcinoma model
    • Burvenich I, Schoonooghe S, Cornelissen B, et al. In vitro and in vivo targeting properties of iodine-123-or iodine-131-labelled monoclonal antibody 14C5 in a non-small cell lung cancer and colon carcinoma model. Clin Cancer Res 2005;11:7288.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 7288
    • Burvenich, I.1    Schoonooghe, S.2    Cornelissen, B.3
  • 14
    • 3242689952 scopus 로고    scopus 로고
    • 123I-mAb 14C5: A new mAb for radioimmunodetection of tumor growth and metastasis in vivo
    • 123I-mAb 14C5: A new mAb for radioimmunodetection of tumor growth and metastasis in vivo. J Nucl Med 2004;45:1065.
    • (2004) J. Nucl. Med. , vol.45 , pp. 1065
    • Lahorte, C.M.1    Burvenich, I.2    Bacher, K.3
  • 16
    • 37349018272 scopus 로고    scopus 로고
    • The integrin-extracellular matrix axis in pancreatic cancer
    • Grzesiak JJ, Ho JC, Moossa AR, et al. The integrin-extracellular matrix axis in pancreatic cancer. Pancreas 2007;35:293.
    • (2007) Pancreas , vol.35 , pp. 293
    • Grzesiak, J.J.1    Ho, J.C.2    Moossa, A.R.3
  • 17
    • 34248141223 scopus 로고    scopus 로고
    • Tumor-stroma interactions in pancreatic ductal carcinoma
    • Mahadevan D, Von Hoff D. Tumor-stroma interactions in pancreatic ductal carcinoma. Mol Cancer Ther 2007;6:1186.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1186
    • Mahadevan, D.1    Hoff, D.V.2
  • 18
    • 63849290925 scopus 로고    scopus 로고
    • Fibrinogen induces cytokine and collagen production in pancreatic stellate cells
    • Masamune A, Kikuta K, Watanabe T, et al. Fibrinogen induces cytokine and collagen production in pancreatic stellate cells. Gut 2009;58:550.
    • (2009) Gut , vol.58 , pp. 550
    • Masamune, A.1    Kikuta, K.2    Watanabe, T.3
  • 19
    • 33845998896 scopus 로고    scopus 로고
    • The pancreatic stellate cell: A star on the rise in pancreatic diseases
    • Omary MB, Lugea A, Lowe AW, et al. The pancreatic stellate cell: A star on the rise in pancreatic diseases. J Clin Invest 2007;117:50.
    • (2007) J. Clin. Invest. , vol.117 , pp. 50
    • Omary, M.B.1    Lugea, A.2    Lowe, A.W.3
  • 20
    • 13644267274 scopus 로고    scopus 로고
    • Molecular regulation of pancreatic stellate cell function
    • Jaster R. Molecular regulation of pancreatic stellate cell function. Mol Cancer 2004;3:26.
    • (2004) Mol. Cancer , vol.3 , pp. 26
    • Jaster, R.1
  • 22
    • 17144404527 scopus 로고    scopus 로고
    • Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells
    • Bachem MG, Schunemann M, Ramadani M, et al. Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology 2005;128:907.
    • (2005) Gastroenterology , vol.128 , pp. 907
    • Bachem, M.G.1    Schunemann, M.2    Ramadani, M.3
  • 23
    • 0027377271 scopus 로고
    • Expression and distribution of VLA receptors in the pancreas: An immunohistochemical study
    • Rosendahl A, Neumann K, Chaloupka B, et al. Expression and distribution of VLA receptors in the pancreas: An immunohistochemical study. Pancreas 1993;8:711.
    • (1993) Pancreas , vol.8 , pp. 711
    • Rosendahl, A.1    Neumann, K.2    Chaloupka, B.3
  • 24
    • 19444363999 scopus 로고    scopus 로고
    • Immunohistochemical detection of the ß4 integrin subunit in pancreatic adenocarcinoma
    • Gleason B, Adley B, Sambasiva R, et al. Immunohistochemical detection of the ß4 integrin subunit in pancreatic adenocarcinoma. J Histochem Cytochem 2005;53:799.
    • (2005) J. Histochem Cytochem , vol.53 , pp. 799
    • Gleason, B.1    Adley, B.2    Sambasiva, R.3
  • 25
    • 0027368237 scopus 로고
    • Intracellular metabolism of indium-111-dtpa-labelled receptor targeted proteins
    • Duncan JR, Welch MJ. Intracellular metabolism of indium-111-DTPA-labelled receptor targeted proteins. J Nucl Med 1993;34:1728.
    • (1993) J. Nucl. Med. , vol.34 , pp. 1728
    • Duncan, J.R.1    Welch, M.J.2
  • 26
    • 40749130870 scopus 로고    scopus 로고
    • Preclinical radioimmunotargeting of folate receptor alpha using the monoclonal antibody conjugate dota-morab-003
    • Smith-Jones PM, Pandit-Taskar N, Cao W, et al. Preclinical radioimmunotargeting of folate receptor alpha using the monoclonal antibody conjugate DOTA-MORAb-003. Nucl Med Biol 2008;35:343.
    • (2008) Nucl Med. Biol. , vol.35 , pp. 343
    • Smith-Jones, P.M.1    Pandit-Taskar, N.2    Cao, W.3
  • 27
    • 0028198974 scopus 로고
    • The processing and fate of antibodies and their radiolabels bound to the surface of tumour cells in vitro: A comparison of nine radiolabels
    • Shih LB, Thorpe SR, Griffiths GL, et al. The processing and fate of antibodies and their radiolabels bound to the surface of tumour cells in vitro: A comparison of nine radiolabels. J Nucl Med 1994;35:899.
    • (1994) J. Nucl. Med. , vol.35 , pp. 899
    • Shih, L.B.1    Thorpe, S.R.2    Griffiths, G.L.3
  • 28
    • 0026552285 scopus 로고
    • The fate of antibodies bound to the surface of tumor cells in vitro
    • Kyriakos RJ, Shih LB, Ong GL, et al. The fate of antibodies bound to the surface of tumor cells in vitro. Cancer Res 1992;52:835.
    • (1992) Cancer Res. , vol.52 , pp. 835
    • Kyriakos, R.J.1    Shih, L.B.2    Ong, G.L.3
  • 29
    • 9244224115 scopus 로고    scopus 로고
    • Comparative metabolism and retention of iodine-125, yttrium-90, and indium-111 radioimmunoconjugates by cancer cells
    • Press OW, Shan D, Howell-Clark J, et al. Comparative metabolism and retention of iodine-125, yttrium-90, and indium-111 radioimmunoconjugates by cancer cells. Cancer Res 1996;56:2123.
    • (1996) Cancer Res. , vol.56 , pp. 2123
    • Press, O.W.1    Shan, D.2    Howell-Clark, J.3
  • 31
    • 0025083528 scopus 로고
    • Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers
    • Garin-Chesa P, Old LJ, Rettig WJ. Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers. Proc Natl Acad Sci USA 1990;87:7235.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7235
    • Garin-Chesa, P.1    Old, L.J.2    Rettig, W.J.3
  • 32
    • 0041335444 scopus 로고    scopus 로고
    • Generation of antiidiotype antibodies for application in clinical immunotherapy laboratory analysis
    • Liu A, Panousis C, Smyth FE, et al. Generation of antiidiotype antibodies for application in clinical immunotherapy laboratory analysis. Hybrid Hybridomics 2003;22:219.
    • (2003) Hybrid Hybridomics , vol.22 , pp. 219
    • Liu, A.1    Panousis, C.2    Smyth, F.E.3
  • 33
    • 33644827799 scopus 로고    scopus 로고
    • (89) zr as a pet surrogate radioisotope for scouting biodistribution of the therapeutic radiomet al.s (90) y and (177) lu in tumor-bearing nude mice after coupling to the internalizing antibody cetuximab
    • Perk LR, Visser GW, Vosjan MJ, et al. (89) Zr as a PET surrogate radioisotope for scouting biodistribution of the therapeutic radiomet al.s (90) Y and (177) Lu in tumor-bearing nude mice after coupling to the internalizing antibody cetuximab. J Nucl Med 2005;46:1898.
    • (2005) J. Nucl. Med. , vol.46 , pp. 1898
    • Perk, L.R.1    Visser, G.W.2    Vosjan, M.J.3
  • 34
    • 0021512252 scopus 로고
    • Conjugation of antibodies with bifunctional chelating agents: Isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of met al. Ions
    • Meares C, McCall M, Reardan D, et al. Conjugation of antibodies with bifunctional chelating agents: Isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of met al. ions. Anal Biochem 1984;142:68.
    • (1984) Anal Biochem. , vol.142 , pp. 68
    • Meares, C.1    McCall, M.2    Reardan, D.3
  • 35
    • 0021236693 scopus 로고
    • Determination of the immunoreactive fraction of radiolabelled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess
    • Lindmo T, Boven E, Cuttitta F, et al. Determination of the immunoreactive fraction of radiolabelled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess. J Immunol Methods 1984;72:77.
    • (1984) J. Immunol. Methods , vol.72 , pp. 77
    • Lindmo, T.1    Boven, E.2    Cuttitta, F.3
  • 37
    • 0037989982 scopus 로고    scopus 로고
    • A phase I doseescalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer
    • Scott AM, Wiseman G, Welt S, et al. A phase I doseescalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin Cancer Res 2003;9:1639.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1639
    • Scott, A.M.1    Wiseman, G.2    Welt, S.3
  • 38
    • 12144287320 scopus 로고    scopus 로고
    • A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer
    • Neoptolemos JP, Stocken DD, Friess H, et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 2004;350:1200.
    • (2004) N Engl. J. Med. , vol.350 , pp. 1200
    • Neoptolemos, J.P.1    Stocken, D.D.2    Friess, H.3
  • 41
    • 9344223986 scopus 로고    scopus 로고
    • Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library
    • Vaughan TJ, Williams AJ , Pritchard K, et al. Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library. Nat Biotechnol 1996;14:309.
    • (1996) Nat. Biotechnol. , vol.14 , pp. 309
    • Vaughan, T.J.1    Williams, A.J.2    Pritchard, K.3
  • 42
    • 49649089800 scopus 로고    scopus 로고
    • A novel bispecific, trivalent antibody construct for targeting pancreatic carcinoma
    • Gold DV, Goldenberg DM, Karacay H, et al. A novel bispecific, trivalent antibody construct for targeting pancreatic carcinoma. Cancer Res 2008;68:4819.
    • (2008) Cancer Res. , vol.68 , pp. 4819
    • Gold, D.V.1    Goldenberg, D.M.2    Karacay, H.3
  • 43
    • 0025241711 scopus 로고
    • Radiolocalization of human pancreatic tumors in athymic mice by monoclonal antibody du-pan 1
    • Worlock AJ, Zalutsky MR, Metzgar RS. Radiolocalization of human pancreatic tumors in athymic mice by monoclonal antibody DU-PAN 1. Cancer Res 1990;50:7246.
    • (1990) Cancer Res. , vol.50 , pp. 7246
    • Worlock, A.J.1    Zalutsky, M.R.2    Metzgar, R.S.3
  • 44
    • 33644863498 scopus 로고    scopus 로고
    • Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF
    • Liang WC, Wu X, Peale FV, et al. Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF. J Biol Chem 2006;281:951.
    • (2006) J. Biol. Chem. , vol.281 , pp. 951
    • Liang, W.C.1    Wu, X.2    Peale, F.V.3
  • 45
    • 0034282995 scopus 로고    scopus 로고
    • In vivo biodistribution of humanized anti-lewis y monoclonal antibody (HU3S193) in MCF-7 xenografted BALB/c nude mice
    • Clarke K, Lee FF, Brechbiel MW, et al. In vivo biodistribution of humanized anti-Lewis Y monoclonal antibody (hu3S193) in MCF-7 xenografted BALB/c nude mice. Cancer Res 2000;60:4804.
    • (2000) Cancer Res. , vol.60 , pp. 4804
    • Clarke, K.1    Lee, F.F.2    Brechbiel, M.W.3
  • 46
    • 0025234357 scopus 로고
    • Biodistribution and radiation dose estimates for yttrium-and iodine-labelled monoclonal antibody IgG and fragments in nude mice bearing human colonic tumour xenografts
    • Sharkey RM, Motta-Henessy C, Pawlyk D, et al. Biodistribution and radiation dose estimates for yttrium-and iodine-labelled monoclonal antibody IgG and fragments in nude mice bearing human colonic tumour xenografts. Cancer Res 1990;50:2330.
    • (1990) Cancer Res. , vol.50 , pp. 2330
    • Sharkey, R.M.1    Motta-Henessy, C.2    Pawlyk, D.3
  • 47
    • 0036023428 scopus 로고    scopus 로고
    • Antibody localization to b-cell lymphoma xenografts in immunodeficient mice: Importance of using residualizing radiolabels
    • Michel BR, Ochakovskaya R, Mattes MJ. Antibody localization to B-cell lymphoma xenografts in immunodeficient mice: Importance of using residualizing radiolabels. Clin Cancer Res 2002;8:2632.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2632
    • Michel, B.R.1    Ochakovskaya, R.2    Mattes, M.J.3
  • 48
    • 0344326255 scopus 로고    scopus 로고
    • High-linear energy transfer (LET) a versus low-LET b emitters in radioimmunotherapy of solid tumors: Therapeutic efficacy and dose-limiting toxicity of 213Bi-versus 90Y-labelled CO17-1A fab' fragments in a human colonic cancer model
    • Behr TM, Béhé M, Stabin MG, et al. High-linear energy transfer (LET) a versus low-LET b emitters in radioimmunotherapy of solid tumors: Therapeutic efficacy and dose-limiting toxicity of 213Bi-versus 90Y-labelled CO17-1A Fab' fragments in a human colonic cancer model. Cancer Res 1999;59:2635.
    • (1999) Cancer Res. , vol.59 , pp. 2635
    • Behr, T.M.1    Béhé, M.2    Stabin, M.G.3
  • 51
    • 0029053874 scopus 로고
    • Pharmacokinetics of chimeric l6 conjugated to indium-111-and yttrium-90-dota-peptide in tumour-bearing mice
    • DeNardo SJ, Motta-Henessy C, Pawlyk D, et al. Pharmacokinetics of chimeric L6 conjugated to indium-111-and yttrium-90-DOTA-peptide in tumour-bearing mice. J Nucl Med 1995;36:829.
    • (1995) J. Nucl. Med. , vol.36 , pp. 829
    • DeNardo, S.J.1    Motta-Henessy, C.2    Pawlyk, D.3
  • 53
    • 33749429154 scopus 로고    scopus 로고
    • 177Lu-DOTA-labelled a glycosylated monoclonal anti-L1-CAM antibody chCE7: Influence of the number of chelators on the in vitro and in vivo properties
    • 177Lu-DOTA-labelled a glycosylated monoclonal anti-L1-CAM antibody chCE7: Influence of the number of chelators on the in vitro and in vivo properties. Nucl Med Biol 2006;33:883.
    • (2006) Nucl Med. Biol. , vol.33 , pp. 883
    • Knogler, K.1    Grünberg, J.2    Novak-Hofer, I.3
  • 54
    • 27144544111 scopus 로고    scopus 로고
    • Pilot trial of unlabeled and indium-111-labeled anti-prostate-specific membrane antigen antibody J591 for castrate metastatic prostate cancer
    • Morris MJ, Divgi CR, Pandit-Taskar N, et al. Pilot trial of unlabeled and indium-111-labeled anti-prostate-specific membrane antigen antibody J591 for castrate metastatic prostate cancer. Clin Cancer Res 2005;11:7454.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 7454
    • Morris, M.J.1    Divgi, C.R.2    Pandit-Taskar, N.3
  • 57
    • 45749132692 scopus 로고    scopus 로고
    • Pharmacogenomics and pancreatic cancer treatment. Optimizing current therapy and individualizing future therapy
    • Kang SP, Saif MW. Pharmacogenomics and pancreatic cancer treatment. Optimizing current therapy and individualizing future therapy. Pancreas 2008;9:251.
    • (2008) Pancreas , vol.9 , pp. 251
    • Kang, S.P.1    Saif, M.W.2
  • 58
    • 1542405316 scopus 로고    scopus 로고
    • 90yttrium-DOTA-labelled PAM4 antibody radioimmunotherapy and gemcitabine radiosensitization for the treatment of a human pancreatic cancer xenograft
    • 90Yttrium- DOTA-labelled PAM4 antibody radioimmunotherapy and gemcitabine radiosensitization for the treatment of a human pancreatic cancer xenograft. Int J Cancer 2004;109:618.
    • (2004) Int. J. Cancer , vol.109 , pp. 618
    • Gold, D.V.1    Modrak, D.E.2    Schutsky, K.3
  • 59
    • 68949202319 scopus 로고    scopus 로고
    • The influence of Bz-DOTA and CHX-A"-DTPA on the biodistribution of ABD-fused anti-HER2 affibody molecules: Implications for (114m) in-mediated targeting therapy
    • Tolmachev V, Wållberg H, Andersson K, et al. The influence of Bz-DOTA and CHX-A"-DTPA on the biodistribution of ABD-fused anti-HER2 affibody molecules: Implications for (114m) In-mediated targeting therapy. Eur J Nucl Med Mol Imaging 2009;36:1460.
    • (2009) Eur. J. Nucl. Med. Mol. Imaging , vol.36 , pp. 1460
    • Tolmachev, V.1    Wållberg, H.2    Andersson, K.3
  • 60
    • 33748443549 scopus 로고    scopus 로고
    • Basic immunology of antibody targeted radiotherapy
    • Wong JYC. Basic immunology of antibody targeted radiotherapy. Int J Radiat Oncol 2006;66: S8.
    • (2006) Int. J. Radiat Oncol. , vol.66
    • Wong, J.Y.C.1
  • 61
    • 63549099316 scopus 로고    scopus 로고
    • Randomised phase I/II trial assessing the safety and efficacy of radiolabelled anticarcinoembryonic antigen i131 KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma
    • Sultana A, Shore S, Raraty MGT, et al. Randomised phase I/II trial assessing the safety and efficacy of radiolabelled anticarcinoembryonic antigen I131 KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma. BMC Cancer 2009;9:66.
    • (2009) BMC Cancer , vol.9 , pp. 66
    • Sultana, A.1    Shore, S.2    Raraty, M.G.T.3
  • 63
    • 34547786032 scopus 로고    scopus 로고
    • (111) in-labelled trastuzumab (herceptin) modified with nuclear localization sequences (NLS) : An auger electron-emitting radiotherapeutic agent for HER2/neu-amplified breast cancer
    • Constantini D, Chen P, Cai Z, et al. (111) In-labelled trastuzumab (Herceptin) modified with nuclear localization sequences (NLS) : An Auger electron-emitting radiotherapeutic agent for HER2/neu-amplified breast cancer. J Nucl Med 2007;48:1357.
    • (2007) J. Nucl. Med. , vol.48 , pp. 1357
    • Constantini, D.1    Chen, P.2    Cai, Z.3


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