T cell Ig and mucin domain proteins and immunity

Journal of Immunology

Volumn 184, Issue 6, 2010, Pages 2743-2749

  Kane, Lawrence P ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; KIDNEY INJURY MOLECULE 1; CELL CYCLE PROTEIN; IMMUNOGLOBULIN; MEMBRANE PROTEIN; MUCIN; SIGNAL PEPTIDE; TIMELESS PROTEIN, HUMAN; TIMELESS PROTEIN, MOUSE;

BAGG ALBINO MOUSE; GLYCOSYLATION; IMMUNE RESPONSE; IMMUNITY; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; CELLULAR IMMUNITY; CLASSIFICATION; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ANIMALS; CELL CYCLE PROTEINS; HUMANS; IMMUNITY, CELLULAR; IMMUNOGLOBULINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MUCINS; PROTEIN STRUCTURE, TERTIARY; T-LYMPHOCYTES;

EID: 77951931902     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902937     Document Type: Review

References (52)

1. Chakravarti, S., C. A. Sabatos, S. Xiao, Z. Illes, E. K. Cha, R. A. Sobel, X. X. Zheng, T. B. Strom, and V. K. Kuchroo. 2005. Tim-2 regulates T helper type 2 responses and autoimmunity. J. Exp. Med. 202: 437-444.
2. Knickelbein, J. E., A. J. de Souza, R. Tosti, P. Narayan, and L. P. Kane. 2006. Cutting edge: inhibition of T cell activation by TIM-2. J. Immunol. 177: 4966-4970.
3. Rennert, P. D., T. Ichimura, I. D. Sizing, V. Bailly, Z. Li, R. Rennard, P. McCoon, L. Pablo, S. Miklasz, L. Tarilonte, and J. V. Bonventre. 2006. T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation. J. Immunol. 177: 4311-4321.
4. Santiago, C., A. Ballesteros, C. Tami, L. Martínez-Muñoz, G. G. Kaplan, and J. M. Casasnovas. 2007. Structures of T cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family. Immunity. 26: 299-310.
5. Cao, E., X. Zang, U. A. Ramagopal, A. Mukhopadhaya, A. Fedorov, E. Fedorov, W. D. Zencheck, J. W. Lary, J. L. Cole, H. Deng, et al. 2007. T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. Immunity. 26: 311-321.
6. Meyers, J. H., C. A. Sabatos, S. Chakravarti, and V. K. Kuchroo. 2005. The TIM gene family regulates autoimmune and allergic diseases. Trends Mol. Med. 11: 362-369.
7. Ichimura, T., J. V. Bonventre, V. Bailly, H. Wei, C. A. Hession, R. L. Cate, and M. Sanicola. 1998. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J. Biol. Chem. 273: 4135-4142.
8. Liangos, O., H. Tighiouart, M. C. Perianayagam, A. Kolyada, W. K. Han, R. Wald, J. V. Bonventre, and B. L. Jaber. 2009. Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass. Biomarkers 14: 423-431.
9. Feigelstock, D., P. Thompson, P. Mattoo, Y. Zhang, and G. G. Kaplan. 1998. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 72: 6621-6628. (Pubitemid 28323979)
10. Kaplan, G., A. Totsuka, P. Thompson, T. Akatsuka, Y. Moritsugu, and S. M. Feinstone. 1996. Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus. EMBO J. 15: 4282-4296. (Pubitemid 26278711)
11. McIntire, J. J., S. E. Umetsu, O. Akbari, M. Potter, V. K. Kuchroo, G. S. Barsh, G. J. Freeman, D. T. Umetsu, and R. H. DeKruyff. 2001. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat. Immunol. 2: 1109-1116.
12. Locksley, R. M., F. P. Heinzel, B. J. Holaday, S. S. Mutha, S. L. Reiner, and M. D. Sadick. 1991. Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection. Res. Immunol. 142: 28-32.
13. Corry, D. B., H. G. Folkesson, M. L. Warnock, D. J. Erle, M. A. Matthay, J. P. Wiener-Kronish, and R. M. Locksley. 1996. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183: 109-117.
14. Ansel, K. M., I. Djuretic, B. Tanasa, and A. Rao. 2006. Regulation of Th2 differentiation and Il4 locus accessibility. Annu. Rev. Immunol. 24: 607-656.
15. McIntire, J. J., S. E. Umetsu, C. Macaubas, E. G. Hoyte, C. Cinnioglu, L. L. Cavalli-Sforza, G. S. Barsh, J. F. Hallmayer, P. A. Underhill, N. J. Risch, et al. 2003. Immunology: hepatitis A virus link to atopic disease. Nature 425: 576.
16. Monney, L., C. A. Sabatos, J. L. Gaglia, A. Ryu, H. Waldner, T. Chernova, S. Manning, E. A. Greenfield, A. J. Coyle, R. A. Sobel, et al. 2002. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536-541.
17. de Souza, A. J., T. B. Oriss, K. J. O'malley, A. Ray, and L. P. Kane. 2005. T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation. Proc. Natl. Acad. Sci. USA 102: 17113-17118.
18. Meyers, J. H., S. Chakravarti, D. Schlesinger, Z. Illes, H. Waldner, S. E. Umetsu, J. Kenny, X. X. Zheng, D. T. Umetsu, R. H. DeKruyff, et al. 2005. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat. Immunol. 6: 455-464.
19. Umetsu, S. E., W. L. Lee, J. J. McIntire, L. Downey, B. Sanjanwala, O. Akbari, G. J. Berry, H. Nagumo, G. J. Freeman, D. T. Umetsu, and R. H. DeKruyff. 2005. TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat. Immunol. 6: 447-454.
20. Rodriguez-Manzanet, R., J. H. Meyers, S. Balasubramanian, J. Slavik, N. Kassam, V. Dardalhon, E. A. Greenfield, A. C. Anderson, R. A. Sobel, D. A. Hafler, et al. 2008. TIM-4 expressed on APCs induces T cell expansion and survival. J. Immunol. 180: 4706-4713.
21. Wilker, P. R., J. R. Sedy, V. Grigura, T. L. Murphy, and K. M. Murphy. 2007. Evidence for carbohydrate recognition and homotypic and heterotypic binding by the TIM family. Int. Immunol. 19: 763-773.
22. Mizui, M., T. Shikina, H. Arase, K. Suzuki, T. Yasui, P. D. Rennert, A. Kumanogoh, and H. Kikutani. 2008. Bimodal regulation of T cell-mediated immune responses by TIM-4. Int. Immunol. 20: 695-708.
23. Degauque, N., C. Mariat, J. Kenny, D. Zhang, W. Gao, M. D. Vu, S. Alexopoulos, M. Oukka, D. T. Umetsu, R. H. DeKruyff, et al. 2008. Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. J. Clin. Invest. 118: 735-741.
24. de Souza, A. J., J. S. Oak, R. Jordanhazy, R. H. DeKruyff, D. A. Fruman, and L. P. Kane. 2008. T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase. J. Immunol. 180: 6518-6526.
25. Binné, L. L., M. L. Scott, and P. D. Rennert. 2007. Human TIM-1 associates with the TCR complex and up-regulates T cell activation signals. J. Immunol. 178: 4342-4350.
26. Sizing, I. D., V. Bailly, P. McCoon, W. Chang, S. Rao, L. Pablo, R. Rennard, M. Walsh, Z. Li, M. Zafari, et al. 2007. Epitope-dependent effect of anti-murine TIM-1 monoclonal antibodies on T cell activity and lung immune responses. J. Immunol. 178: 2249-2261.
27. Xiao, S., N. Najafian, J. Reddy, M. Albin, C. Zhu, E. Jensen, J. Imitola, T. Korn, A. C. Anderson, Z. Zhang, et al. 2007. Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J. Exp. Med. 204: 1691-1702.
28. Ueno, T., A. Habicht, M. R. Clarkson, M. J. Albin, K. Yamaura, O. Boenisch, J. Popoola, Y. Wang, H. Yagita, H. Akiba, M. J. Ansari, J. Yang, L. A. Turka, D. M. Rothstein, R. F. Padera, N. Najafian, and M. H. Sayegh. 2008. The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin. Invest. 118: 742-751.
29. Yuan, X., M. J. Ansari, F. D'Addio, J. Paez-Cortez, I. Schmitt, M. Donnarumma, O. Boenisch, X. Zhao, J. Popoola, M. R. Clarkson, H. Yagita, H. Akiba, G. J. Freeman, J. Iacomini, L. A. Turka, L. H. Glimcher, and M. H. Sayegh. 2009. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc. Natl. Acad. Sci. USA. 106: 10,734-10,739.
30. Tami, C., E. Silberstein, M. Manangeeswaran, G. J. Freeman, S. E. Umetsu, R. H. DeKruyff, D. T. Umetsu, and G. G. Kaplan. 2007. Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J . Virol. 81: 3437-3446. (Pubitemid 46456652)
31. Sabatos, C. A., S. Chakravarti, E. Cha, A. Schubart, A. Sánchez-Fueyo, X. X. Zheng, A. J. Coyle, T. B. Strom, G. J. Freeman, and V. K. Kuchroo. 2003. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat. Immunol. 4: 1102-1110.
32. Sánchez-Fueyo, A., J. Tian, D. Picarella, C. Domenig, X. X. Zheng, C. A. Sabatos, N. Manlongat, O. Bender, T. Kamradt, V. K. Kuchroo, et al. 2003. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat. Immunol. 4: 1093-1101.
33. Kearley, J., S. J. McMillan, and C. M. Lloyd. 2007. Th2-driven, allergen-induced airway inflammation is reduced after treatment with anti-Tim-3 antibody in vivo. J. Exp. Med. 204: 1289-1294.
34. Sehrawat, S., A. Suryawanshi, M. Hirashima, and B. T. Rouse. 2009. Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators. J. Immunol. 182: 3191-3201.
35. Hastings, W. D., D. E. Anderson, N. Kassam, K. Koguchi, E. A. Greenfield, S. C. Kent, X. X. Zheng, T. B. Strom, D. A. Hafler, and V. K. Kuchroo. 2009. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur. J. Immunol. 39: 2492-2501.
36. Jones, R. B., L. C. Ndhlovu, J. D. Barbour, P. M. Sheth, A. R. Jha, B. R. Long, J. C. Wong, M. Satkunarajah, M. Schweneker, J. M. Chapman, et al. 2008. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J. Exp. Med. 205: 2763-2779.
37. Anderson, A. C., D. E. Anderson, L. Bregoli, W. D. Hastings, N. Kassam, C. Lei, R. Chandwaskar, J. Karman, E. W. Su, M. Hirashima, et al. 2007. Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science 318: 1141-1143.
38. Golden-Mason, L., B. E. Palmer, N. Kassam, L. Townshend-Bulson, S. Livingston, B. J. McMahon, N. Castelblanco, V. Kuchroo, D. R. Gretch, and H. R. Rosen. 2009. Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J. Virol. 83: 9122-9130.
39. Zhu, C., A. C. Anderson, A. Schubart, H. Xiong, J. Imitola, S. J. Khoury, X. X. Zheng, T. B. Strom, and V. K. Kuchroo. 2005. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat. Immunol. 6: 1245-1252.
40. Rabinovich, G. A., and M. A. Toscano. 2009. Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation. Nat. Rev. Immunol. 9: 338-352.
41. Seki, M., S. Oomizu, K. M. Sakata, A. Sakata, T. Arikawa, K. Watanabe, K. Ito, K. Takeshita, T. Niki, N. Saita, et al. 2008. Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin. Immunol. 127: 78-88.
42. Simmons, W. J., M. Koneru, M. Mohindru, R. Thomas, S. Cutro, P. Singh, R. H. Dekruyff, G. Inghirami, A. J. Coyle, B. S. Kim, and N. M. Ponzio. 2005. Tim-3+ T-bet+ tumor-specific Th1 cells colocalize with and inhibit development and growth of murine neoplasms. J. Immunol. 174: 1405-1415.
43. Geng, H., G. M. Zhang, D. Li, H. Zhang, Y. Yuan, H. G. Zhu, H. Xiao, L. F. Han, and Z. H. Feng. 2006. Soluble form of T cell Ig mucin 3 is an inhibitory molecule in T cell-mediated immune response. J. Immunol. 176: 1411-1420. (Pubitemid 43134283)
44. Nagahara, K., T. Arikawa, S. Oomizu, K. Kontani, A. Nobumoto, H. Tateno, K. Watanabe, T. Niki, S. Katoh, M. Miyake, et al. 2008. Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions. J. Immunol. 181: 7660-7669.
45. van de Weyer, P. S., M. Muehlfeit, C. Klose, J. V. Bonventre, G. Walz, and E. W. Kuehn. 2006. A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9. Biochem. Biophys. Res. Commun. 351: 571-576.
46. Wu, Y., N. Tibrewal, and R. B. Birge. 2006. Phosphatidylserine recognition by phagocytes: a view to a kill. Trends Cell Biol. 16: 189-197.
47. Miyanishi, M., K. Tada, M. Koike, Y. Uchiyama, T. Kitamura, and S. Nagata. 2007. Identification of Tim4 as a phosphatidylserine receptor. Nature 450: 435-439.
48. Kobayashi, N., P. Karisola, V. Peña-Cruz, D. M. Dorfman, M. Jinushi, S. E. Umetsu, M. J. Butte, H. Nagumo, I. Chernova, B. Zhu, et al. 2007. TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity 27: 927-940.
49. Santiago, C., A. Ballesteros, L. Martínez-Muñoz, M. Mellado, G. G. Kaplan, G. J. Freeman, and J. M. Casasnovas. 2007. Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds. Immunity 27: 941-951.
50. Nakayama, M., H. Akiba, K. Takeda, Y. Kojima, M. Hashiguchi, M. Azuma, H. Yagita, and K. Okumura. 2009. Tim-3 mediates phagocytosis of apoptotic cells and the cross-presentation. Blood 113: 3821-3830
51. Nakae, S., M. Iikura, H. Suto, H. Akiba, D. T. Umetsu, R. H. Dekruyff, H. Saito, and S. J. Galli. 2007. TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells. Blood 110: 2565-2568. (Pubitemid 47523180)
52. Suntharalingam, G., M. R. Perry, S. Ward, S. J. Brett, A. Castello-Cortes, M. D. Brunner, and N. Panoskaltsis. 2006. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N. Engl. J. Med. 355: 1018-1028.