메뉴 건너뛰기




Volumn 120, Issue 5, 2010, Pages 1441-1453

Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM); CARBENOXOLONE; CONNEXIN 43; DIAZOXIDE; GAP JUNCTION PROTEIN; POTASSIUM CHANNEL; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

EID: 77951850832     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI40927     Document Type: Article
Times cited : (74)

References (46)
  • 1
    • 0346059584 scopus 로고    scopus 로고
    • Primary and Secondary Signaling Pathways in Early Preconditioning That Converge on the Mitochondria to Produce Cardioprotection
    • DOI 10.1161/01.RES.0000108082.76667.F4
    • Murphy E. Primary and secondary signaling pathways in early preconditioning that converge on the mitochondria to produce cardioprotection. Circ Res. 2004;94(1):7-16. (Pubitemid 38064093)
    • (2004) Circulation Research , vol.94 , Issue.1 , pp. 7-16
    • Murphy, E.1
  • 2
    • 1842843647 scopus 로고    scopus 로고
    • Ischaemic preconditioning: Therapeutic implications for stroke?
    • DOI 10.1517/14728222.8.2.125
    • Pong K. Ischaemic preconditioning: therapeutic implications for stroke? Expert Opin Ther Targets. 2004;8(2):125-139. (Pubitemid 38489538)
    • (2004) Expert Opinion on Therapeutic Targets , vol.8 , Issue.2 , pp. 125-139
    • Pong, K.1
  • 3
    • 57149142506 scopus 로고    scopus 로고
    • Cardioprotection: Nitric oxide, protein kinases, and mitochondria
    • Heusch G, Boengler K, Schulz R. Cardioprotection: nitric oxide, protein kinases, and mitochondria. Circulation. 2008;118(19):1915-1919.
    • (2008) Circulation , vol.118 , Issue.19 , pp. 1915-1919
    • Heusch, G.1    Boengler, K.2    Schulz, R.3
  • 4
    • 0029130667 scopus 로고
    • Role of bradykinin in protection of ischemic preconditioning in rabbit hearts
    • Goto M, Liu Y, Yang XM, Ardell JL, Cohen MV, Downey JM. Role of bradykinin in protection of ischemic preconditioning in rabbit hearts. Circ Res. 1995;77(3):611-621.
    • (1995) Circ Res , vol.77 , Issue.3 , pp. 611-621
    • Goto, M.1    Liu, Y.2    Yang, X.M.3    Ardell, J.L.4    Cohen, M.V.5    Downey, J.M.6
  • 5
    • 33947388409 scopus 로고    scopus 로고
    • Mitochondrial ion channels
    • O'Rourke B. Mitochondrial ion channels. Annu Rev Physiol. 2007;69:19-49.
    • (2007) Annu Rev Physiol , vol.69 , pp. 19-49
    • O'Rourke, B.1
  • 6
    • 52449115978 scopus 로고    scopus 로고
    • Intramitochondrial signaling: Interactions among mitoKATP, PKCepsilon, ROS, and MPT
    • Costa AD, Garlid KD. Intramitochondrial signaling: interactions among mitoKATP, PKCepsilon, ROS, and MPT. Am J Physiol Heart Circ Physiol. 2008;295(2):H874-H882.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295 , Issue.2
    • Costa, A.D.1    Garlid, K.D.2
  • 7
    • 13044274187 scopus 로고    scopus 로고
    • Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation
    • Dorn GW II, et al. Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation. Proc Natl Acad Sci U S A. 1999;96(22):12798-12803.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.22 , pp. 12798-12803
    • Dorn II, G.W.1
  • 9
    • 25444512382 scopus 로고    scopus 로고
    • Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice
    • Heinzel FR, et al. Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice. Circ Res. 2005;97(6):583-586.
    • (2005) Circ Res , vol.97 , Issue.6 , pp. 583-586
    • Heinzel, F.R.1
  • 11
    • 0347635344 scopus 로고    scopus 로고
    • Role of connexin 43 in ischemic preconditioning does not involve intercellular communication through gap junctions
    • DOI 10.1016/j.yjmcc.2003.10.019
    • Li X, Heinzel FR, Boengler K, Schulz R, Heusch G. Role of connexin 43 in ischemic preconditioning does not involve intercellular communication through gap junctions. J Mol Cell Cardiol. 2004;36(1):161-163. (Pubitemid 38084801)
    • (2004) Journal of Molecular and Cellular Cardiology , vol.36 , Issue.1 , pp. 161-163
    • Li, X.1    Heinzel, F.R.2    Boengler, K.3    Schulz, R.4    Heusch, G.5
  • 12
    • 62249090215 scopus 로고    scopus 로고
    • Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria
    • Boengler K, et al. Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria. Basic Res Cardiol. 2009;104(2):141-147.
    • (2009) Basic Res Cardiol , vol.104 , Issue.2 , pp. 141-147
    • Boengler, K.1
  • 14
    • 0025913049 scopus 로고
    • + channel in the mitochondrial inner membrane
    • Inoue I, Nagase H, Kishi K, Higuti T. ATP-sensitive K+ channel in the mitochondrial inner membrane. Nature. 1991;352(6332):244-247. (Pubitemid 21912326)
    • (1991) Nature , vol.352 , Issue.6332 , pp. 244-247
    • Inoue, I.1    Nagase, H.2    Kishi, K.3    Higuti, T.4
  • 15
    • 0031573401 scopus 로고    scopus 로고
    • A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: Applications in detecting the activity of phagocyte NADPH oxidase and other oxidases
    • DOI 10.1006/abio.1997.2391
    • Zhou M, Diwu Z, Panchuk-Voloshina N, Haugland RP. A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases. Anal Biochem. 1997;253(2):162-168. (Pubitemid 27508167)
    • (1997) Analytical Biochemistry , vol.253 , Issue.2 , pp. 162-168
    • Zhou, M.1    Diwu, Z.2    Panchuk-Voloshina, N.3    Haugland, R.P.4
  • 16
    • 0035957635 scopus 로고    scopus 로고
    • Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism
    • Forbes RA, Steenbergen C, Murphy E. Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism. Circ Res. 2001;88(8):802-809. (Pubitemid 32429976)
    • (2001) Circulation Research , vol.88 , Issue.8 , pp. 802-809
    • Forbes, R.A.1    Steenbergen, C.2    Murphy, E.3
  • 17
    • 4444240180 scopus 로고    scopus 로고
    • A mitochondrial oscillator dependent on reactive oxygen species
    • DOI 10.1529/biophysj.104.041749
    • Cortassa S, Aon MA, Winslow RL, O'Rourke B. A mitochondrial oscillator dependent on reactive oxygen species. Biophys J. 2004;87(3):2060-2073. (Pubitemid 39167059)
    • (2004) Biophysical Journal , vol.87 , Issue.3 , pp. 2060-2073
    • Cortassa, S.1    Aon, M.A.2    Winslow, R.L.3    O'Rourke, B.4
  • 18
    • 67349133591 scopus 로고    scopus 로고
    • Ambivalent effects of diazoxide on mitochondrial ROS production at respiratory chain complexes I and III
    • Drose S, Hanley PJ, Brandt U. Ambivalent effects of diazoxide on mitochondrial ROS production at respiratory chain complexes I and III. Biochim Biophys Acta. 2009;1790(6):558-565.
    • (2009) Biochim Biophys Acta , vol.1790 , Issue.6 , pp. 558-565
    • Drose, S.1    Hanley, P.J.2    Brandt, U.3
  • 19
    • 0037531231 scopus 로고    scopus 로고
    • Functional hemichannels in astrocytes: A novel mechanism of glutamate release
    • Ye ZC, Wyeth MS, Baltan-Tekkok S, Ransom BR. Functional hemichannels in astrocytes: a novel mechanism of glutamate release. J Neurosci. 2003;23(9):3588-3596. (Pubitemid 36958466)
    • (2003) Journal of Neuroscience , vol.23 , Issue.9 , pp. 3588-3596
    • Ye, Z.-C.1    Wyeth, M.S.2    Baltan-Tekkok, S.3    Ransom, B.R.4
  • 20
    • 0030765777 scopus 로고    scopus 로고
    • Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries
    • Chaytor AT, Evans WH, Griffith TM. Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J Physiol. 1997;503(Pt 1):99-110.
    • (1997) J Physiol , vol.503 , Issue.PART 1 , pp. 99-110
    • Chaytor, A.T.1    Evans, W.H.2    Griffith, T.M.3
  • 22
    • 11244310899 scopus 로고    scopus 로고
    • Cardioprotection by epsilon-protein kinase C activation from ischemia: Continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide
    • DOI 10.1161/01.CIR.0000151614.22282.F1
    • Inagaki K, Begley R, Ikeno F, Mochly-Rosen D. Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide. Circulation. 2005;111(1):44-50. (Pubitemid 40070842)
    • (2005) Circulation , vol.111 , Issue.1 , pp. 44-50
    • Inagaki, K.1    Begley, R.2    Ikeno, F.3    Mochly-Rosen, D.4
  • 23
    • 0033621884 scopus 로고    scopus 로고
    • The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation
    • Doble BW, Ping P, Kardami E. The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation. Circ Res. 2000;86(3):293-301. (Pubitemid 30108823)
    • (2000) Circulation Research , vol.86 , Issue.3 , pp. 293-301
    • Doble, B.W.1    Ping, P.2    Kardami, E.3
  • 24
    • 0037040343 scopus 로고    scopus 로고
    • Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: Enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection
    • Baines CP, et al. Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection. Circ Res. 2002;90(4):390-397.
    • (2002) Circ Res , vol.90 , Issue.4 , pp. 390-397
    • Baines, C.P.1
  • 25
    • 0017740356 scopus 로고
    • Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle
    • Palmer JW, Tandler B, Hoppel CL. Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle. J Biol Chem. 1977;252(23):8731-8739. (Pubitemid 8243644)
    • (1977) Journal of Biological Chemistry , vol.252 , Issue.23 , pp. 8731-8739
    • Palmer, J.W.1    Tandler, B.2    Hoppel, C.L.3
  • 26
    • 33749670149 scopus 로고    scopus 로고
    • Mitochondrial PKCepsilon and mitochondrial ATP-sensitive K+ channel copurify and coreconstitute to form a functioning signaling module in proteoliposomes
    • DOI 10.1161/01.RES.0000245106.80628.d3, PII 0000301220061013000014
    • Jaburek M, Costa AD, Burton JR, Costa CL, Garlid KD. Mitochondrial PKC epsilon and mitochondrial ATP-sensitive K+ channel copurify and coreconstitute to form a functioning signaling module in proteoliposomes. Circ Res. 2006;99(8):878-883. (Pubitemid 44556387)
    • (2006) Circulation Research , vol.99 , Issue.8 , pp. 878-883
    • Jaburek, M.1    Costa, A.D.T.2    Burton, J.R.3    Costa, C.L.4    Garlid, K.D.5
  • 27
    • 33749684852 scopus 로고    scopus 로고
    • Signaling mechanisms in ischemic preconditioning: Interaction of PKCepsilon and mitoKATP in the inner membrane of mitochondria
    • DOI 10.1161/01.RES.0000247029.31997.a4, PII 0000301220061013000005
    • Ardehali H. Signaling mechanisms in ischemic preconditioning: interaction of PKCepsilon and MitoK(ATP) in the inner membrane of mitochondria. Circ Res. 2006;99(8):798-800. (Pubitemid 44556378)
    • (2006) Circulation Research , vol.99 , Issue.8 , pp. 798-800
    • Ardehali, H.1
  • 28
    • 0037382614 scopus 로고    scopus 로고
    • Beyond the gap: Functions of unpaired connexon channels
    • Goodenough DA, Paul DL. Beyond the gap: functions of unpaired connexon channels. Nat Rev Mol Cell Biol. 2003;4(4):285-294.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , Issue.4 , pp. 285-294
    • Goodenough, D.A.1    Paul, D.L.2
  • 29
    • 20444420130 scopus 로고    scopus 로고
    • Gap junction- and hemichannel-independent actions of connexins
    • DOI 10.1016/j.bbamem.2004.10.001, PII S0005273604002470
    • Jiang JX, Gu S. Gap junction- and hemichannel-independent actions of connexins. Biochim Biophys Acta. 2005;1711(2):208-214. (Pubitemid 40799295)
    • (2005) Biochimica et Biophysica Acta - Biomembranes , vol.1711 , Issue.2 SPEC. ISS , pp. 208-214
    • Jiang, J.X.1    Gu, S.2
  • 30
    • 0025219686 scopus 로고
    • ATP directly affects junctional conductance between paired ventricular myocytes isolated from guinea pig heart
    • Sugiura H, Toyama J, Tsuboi N, Kamiya K, Kodama I. ATP directly affects junctional conductance between paired ventricular myocytes isolated from guinea pig heart. Circ Res. 1990;66(4):1095-1102. (Pubitemid 20126440)
    • (1990) Circulation Research , vol.66 , Issue.4 , pp. 1095-1102
    • Sugiura, H.1    Toyama, J.2    Tsuboi, N.3    Kamiya, K.4    Kodama, I.5
  • 32
    • 0035920268 scopus 로고    scopus 로고
    • The cytoplasm: No longer a well-mixed bag
    • Weiss JN, Korge P. The cytoplasm: no longer a well-mixed bag. Circ Res. 2001;89(2):108-110.
    • (2001) Circ Res , vol.89 , Issue.2 , pp. 108-110
    • Weiss, J.N.1    Korge, P.2
  • 33
    • 0028938152 scopus 로고
    • Localization of protein kinases by anchoring proteins: A theme in signal transduction
    • Mochly-Rosen D. Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science. 1995;268(5208):247-251.
    • (1995) Science , vol.268 , Issue.5208 , pp. 247-251
    • Mochly-Rosen, D.1
  • 36
    • 34247216741 scopus 로고    scopus 로고
    • Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2'(3')-O-(N-methylanthraniloyl)-guanosine 5́-[gamma-thio] triphosphate
    • DOI 10.1124/jpet.106.118422
    • Rottlaender D, Matthes J, Vatner SF, Seifert R, Herzig S. Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2'(3')-O- (Nmethylanthraniloyl)-guanosine 5́-[gammathio] triphosphate. J Pharmacol Exp Ther. 2007;321(2):608-615. (Pubitemid 46624491)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.321 , Issue.2 , pp. 608-615
    • Rottlaender, D.1    Matthes, J.2    Vatner, S.F.3    Seifert, R.4    Herzig, S.5
  • 37
    • 66549102938 scopus 로고    scopus 로고
    • Two distinct human voltage-gated Ca2+-channels regulate cardiac mitochondrial Ca2+-uptake
    • Michels G, et al. Two distinct human voltage-gated Ca2+-channels regulate cardiac mitochondrial Ca2+-uptake. Circulation. 2009;119(18):2435-2443.
    • (2009) Circulation , vol.119 , Issue.18 , pp. 2435-2443
    • Michels, G.1
  • 38
    • 0036826892 scopus 로고    scopus 로고
    • + channels in the cardiac inner mitochondrial membrane
    • DOI 10.1126/science.1074360
    • Xu W, et al. Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane. Science. 2002;298(5595):1029-1033. (Pubitemid 35247311)
    • (2002) Science , vol.298 , Issue.5595 , pp. 1029-1033
    • Xu, W.1    Liu, Y.2    Wang, S.3    McDonald, T.4    Van Eyk, J.E.5    Sidor, A.6    O'Rourke, B.7
  • 39
    • 1642540210 scopus 로고    scopus 로고
    • The mitochondrial calcium uniporter is a highly selective ion channel
    • DOI 10.1038/nature02246
    • Kirichok Y, Krapivinsky G, Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. Nature. 2004;427(6972):360-364. (Pubitemid 38133664)
    • (2004) Nature , vol.427 , Issue.6972 , pp. 360-364
    • Kirichok, Y.1    Krapivinsky, G.2    Clapham, D.E.3
  • 41
    • 29544435052 scopus 로고    scopus 로고
    • Angiotensin II-induced changes of calcium sparks and ionic currents in human atrial myocytes: Potential role for early remodeling in atrial fibrillation
    • DOI 10.1016/j.ceca.2005.10.008, PII S0143416005002046
    • Gassanov N, Brandt MC, Michels G, Lindner M, Er F, Hoppe UC. Angiotensin II-induced changes of calcium sparks and ionic currents in human atrial myocytes: potential role for early remodeling in atrial fibrillation. Cell Calcium. 2006;39(2):175-186. (Pubitemid 43013849)
    • (2006) Cell Calcium , vol.39 , Issue.2 , pp. 175-186
    • Gassanov, N.1    Brandt, M.C.2    Michels, G.3    Lindner, M.4    Er, F.5    Hoppe, U.C.6
  • 42
    • 0142058955 scopus 로고    scopus 로고
    • K1 in a dominant-negative fashion
    • DOI 10.1016/S0008-6363(03)00434-6
    • Lange PS, Er F, Gassanov N, Hoppe UC. Andersen mutations of KCNJ2 suppress the native inward rectifier current I(K1) in a dominant-negative fashion. Cardiovasc Res. 2003;59(2):321-327. (Pubitemid 37272026)
    • (2003) Cardiovascular Research , vol.59 , Issue.2 , pp. 321-327
    • Lange, P.S.1    Er, F.2    Gassanov, N.3    Hoppe, U.C.4
  • 44
    • 13444310644 scopus 로고    scopus 로고
    • Single-channel properties support a potential contribution of HCN channels and if to cardiac arrhythmias
    • Michels G, Er F, Khan IF, Südkamp M, Herzig S, Hoppe UC. Single-channel properties support a potential contribution of HCN channels and If to cardiac arrhythmias. Circulation. 2005;111(4):399-404.
    • (2005) Circulation , vol.111 , Issue.4 , pp. 399-404
    • Michels, G.1    Er, F.2    Khan, I.F.3    Südkamp, M.4    Herzig, S.5    Hoppe, U.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.