메뉴 건너뛰기




Volumn 10, Issue 5, 2010, Pages 757-773

Recent development in therapeutics for breakthrough pain

Author keywords

Breakthrough; Incident pain; Intranasal; Oral; Pain; Pharmacokinetic; Spinal; Sublingual

Indexed keywords

ALFENTANIL; BUPRENORPHINE; DIAMORPHINE; FENTANYL; HYDROCODONE; HYDROMORPHONE; KETAMINE; LEVOBUPIVACAINE; LEVORPHANOL; LOCAL ANESTHETIC AGENT; METHADONE; MORPHINE; NALOXONE; OPIATE; OXYCODONE; PLACEBO; RADIOISOTOPE; SUFENTANIL; TRAMADOL;

EID: 77951845975     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/ern.10.41     Document Type: Review
Times cited : (16)

References (140)
  • 1
    • 2542487952 scopus 로고    scopus 로고
    • Diffcult pain problems: An integrated approach
    • Doyle D, Hanks G, Cherny N, Calman K (Eds). Oxford University Press, Oxford, UK
    • rd Edition. Doyle D, Hanks G, Cherny N, Calman K (Eds). Oxford University Press, Oxford, UK 438-458 (2004).
    • (2004) rd Edition , pp. 438-458
    • Portenoy, R.K.1    Forbes, K.2    Lussier, D.3
  • 2
    • 61849093095 scopus 로고    scopus 로고
    • The management of cancer-related breakthrough pain: Recommendations of a task group of the science committee of the association for palliative medicine of great britain and ireland
    • •• One of the best manuscripts on the subject of breakthrough pain (BTP)
    • Davies AN, Dickman A, Reid C et al. The management of cancer-related breakthrough pain: recommendations of a task group of the Science Committee of the Association for Palliative Medicine of Great Britain and Ireland. Eur. J. Pain 13, 331-338 (2009). •• One of the best manuscripts on the subject of breakthrough pain (BTP).
    • (2009) Eur. J. Pain , vol.13 , pp. 331-338
    • Davies, A.N.1    Dickman, A.2    Reid, C.3
  • 4
    • 0031759360 scopus 로고    scopus 로고
    • Dose-titration, multicenter study of oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients using transdermal fentanyl for persistent pain
    • Christie JM, Simmonds M, Patt R et al. Dose-titration, multicenter study of oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients using transdermal fentanyl for persistent pain. J. Clin. Oncol. 16 (10), 3238-3245 (1998). (Pubitemid 28481617)
    • (1998) Journal of Clinical Oncology , vol.16 , Issue.10 , pp. 3238-3245
    • Christie, J.M.1    Simmonds, M.2    Patt, R.3    Coluzzi, P.4    Busch, M.A.5    Nordbrock, E.6    Portenoy, R.K.7
  • 5
    • 0036468726 scopus 로고    scopus 로고
    • Episodic (breakthrough) pain: Consensus conference of an expert working group of the European Association for Palliative Care
    • DOI 10.1002/cncr.10249
    • Mercadante S, Radbruch L, Caraceni N et al. Episodic (breakthrough) pain. Consensus Conference of an Expert Working Group of the European Association for Palliative Care. Cancer 94, 832-839 (2002). • Important consensus guideline, even though high-grade evidence for managing BTP was not available at the time of publication. (Pubitemid 34132314)
    • (2002) Cancer , vol.94 , Issue.3 , pp. 832-839
    • Mercadante, S.1    Radbruch, L.2    Caraceni, A.3    Cherny, N.4    Kaasa, S.5    Nauck, F.6    Ripamonti, C.7    De Conno, F.8
  • 6
    • 42649098261 scopus 로고    scopus 로고
    • The importance of a word: How to translate 'breakthrough'
    • Goncalves JJ. The importance of a word: how to translate 'breakthrough'. Palliat. Med. 22 (2), 195 (2008).
    • (2008) Palliat. Med. , vol.22 , Issue.2 , pp. 195
    • Goncalves, J.J.1
  • 7
    • 43049104583 scopus 로고    scopus 로고
    • Opioids for cancer breakthrough pain: A pilot study reporting patient assessment of time to meaningful pain relief
    • Zeppetella G. Opioids for cancer breakthrough pain: a pilot study reporting patient assessment of time to meaningful pain relief. J. Pain Symptom Manage. 35 (5), 563-567 (2008).
    • (2008) J. Pain Symptom Manage. , vol.35 , Issue.5 , pp. 563-567
    • Zeppetella, G.1
  • 8
    • 0032899247 scopus 로고    scopus 로고
    • Breakthrough pain: Characteristics and impact in patients with cancer pain
    • DOI 10.1016/S0304-3959(99)00006-8, PII S0304395999000068
    • Portenoy RK, Payne D, Jacobsen P. Breakthrough pain: characteristics and impact in patients with cancer pain. Pain 81, 129-134 (1999). • Russ Portenoy is responsible for placing BTP on the radar screen of clinicians. This is an excellent study on BTP characteristics. (Pubitemid 29199908)
    • (1999) Pain , vol.81 , Issue.1-2 , pp. 129-134
    • Portenoy, R.K.1    Payne, D.2    Jacobsen, P.3
  • 9
    • 0033797308 scopus 로고    scopus 로고
    • An assessment of the safety, effcacy, and acceptability of intranasal fentanyl citrate in the management of cancer-related breakthrough pain: A pilot study
    • Zeppetella G. An assessment of the safety, effcacy, and acceptability of intranasal fentanyl citrate in the management of cancer-related breakthrough pain: a pilot study. J. Pain Symptom Manage. 20 (4), 253-258 (2000).
    • (2000) J. Pain Symptom Manage. , vol.20 , Issue.4 , pp. 253-258
    • Zeppetella, G.1
  • 10
    • 2942637938 scopus 로고    scopus 로고
    • Breakthrough pain characteristics and syndromes in patients with cancer pain an international survey
    • • This international survey highlights the problem with nomenclature
    • Caraceni A, Martini C, Zecca E et al. Breakthrough pain characteristics and syndromes in patients with cancer pain. An international survey. Palliat. Med. 18, 177-183 (2004). • This international survey highlights the problem with nomenclature.
    • (2004) Palliat. Med. , vol.18 , pp. 177-183
    • Caraceni, A.1    Martini, C.2    Zecca, E.3
  • 11
    • 65349096207 scopus 로고    scopus 로고
    • Cancer and breakthrough pains impact on a diverse population
    • Montague L, Green CC. Cancer and breakthrough pains impact on a diverse population. Pain Med. 10 (3), 549-561 (2009).
    • (2009) Pain Med. , vol.10 , Issue.3 , pp. 549-561
    • Montague, L.1    Green, C.C.2
  • 12
    • 0029021038 scopus 로고
    • A prospective multicenter assessment of the edmonton staging system for cancer pain
    • Bruera E, Schoeller T, Wenk R et al. A prospective multicenter assessment of the Edmonton staging system for cancer pain. J. Pain Symptom Manage. 10 (5), 348-355 (1995).
    • (1995) J. Pain Symptom Manage. , vol.10 , Issue.5 , pp. 348-355
    • Bruera, E.1    Schoeller, T.2    Wenk, R.3
  • 13
    • 0036176288 scopus 로고    scopus 로고
    • A survey of pain-related hospitalizations, emergency department visits, and physician offce visits reported by cancer patients with and without history or breakthrough
    • Fortner BV, Okon TA, Portenoy RR. A survey of pain-related hospitalizations, emergency department visits, and physician offce visits reported by cancer patients with and without history or breakthrough. J. Pain 3 (1), 38-44 (2002).
    • (2002) J. Pain , vol.3 , Issue.1 , pp. 38-44
    • Fortner, B.V.1    Okon, T.A.2    Portenoy, R.R.3
  • 14
    • 40849092551 scopus 로고    scopus 로고
    • An observational study of oncology patients' utilization of breakthrough pain medication
    • Davies AN, Vriens J, Kennett A et al. An observational study of oncology patients' utilization of breakthrough pain medication. J. Pain Symptom Manage. 35 (4), 406-411 (2008).
    • (2008) J. Pain Symptom Manage. , vol.35 , Issue.4 , pp. 406-411
    • Davies, A.N.1    Vriens, J.2    Kennett, A.3
  • 15
    • 0025336568 scopus 로고
    • Breakthrough pain: Defnition, prevalence and characteristics
    • • Portenoy's original paper on BTP
    • Portenoy RK, Hagen NN. Breakthrough pain: defnition, prevalence and characteristics. Pain 45 (1), 273-281 (1990). • Portenoy's original paper on BTP.
    • (1990) Pain , vol.45 , Issue.1 , pp. 273-281
    • Portenoy, R.K.1    Hagen, N.N.2
  • 16
    • 39549101768 scopus 로고    scopus 로고
    • Intravenous morphine for breakthrough (episodic) pain in an acute palliative care unit: A confrmatory study
    • Mercadante S, Intravaia G, Villari P et al. Intravenous morphine for breakthrough (episodic) pain in an acute palliative care unit: a confrmatory study. J. Pain Symptom Manage. 35 (3), 307-313 (2008).
    • (2008) J. Pain Symptom Manage. , vol.35 , Issue.3 , pp. 307-313
    • Mercadante, S.1    Intravaia, G.2    Villari, P.3
  • 17
    • 33750322229 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study of fentanyl buccal tablet for breakthrough pain in opioid-treated patients with cancer
    • DOI 10.1097/01.ajp.0000210932.27945.4a, PII 0000250820061100000009
    • Portenoy RK, Taylor D, Messina J et al. A randomized, placebo-controlled study of fentanyl buccal tablet for breakthrough pain in opioid-treated patients with cancer. Clin. J. Pain 22, 805-811 (2006). (Pubitemid 44627444)
    • (2006) Clinical Journal of Pain , vol.22 , Issue.9 , pp. 805-811
    • Portenoy, R.K.1    Taylor, D.2    Messina, J.3    Tremmel, L.4
  • 19
    • 0032522607 scopus 로고    scopus 로고
    • Oral transmucosal fentanyl citrate: Randomized, double-blinded, placebo- controlled trial for treatment of breakthrough pain in cancer patients
    • Farrar JT, Clearly J, Rauck R et al. Oral transmucosal fentanyl citrate: randomized, double-blinded, placebo-controlled trials for treatment of breakthrough pain in cancer patients. J. Natl Cancer Inst. 90 (8), 611-616 (1998). (Pubitemid 28204805)
    • (1998) Journal of the National Cancer Institute , vol.90 , Issue.8 , pp. 611-616
    • Farrar, J.T.1    Cleary, J.2    Rauck, R.3    Busch, M.4    Nordbrock, E.5
  • 20
    • 38549181857 scopus 로고    scopus 로고
    • Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: Immpact recommendations
    • •• Important manuscript for anyone reading the pain literature
    • Dworkin RH, Turk DC, Wyrwich KW et al. Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations. J. Pain 9 (2), 105-121 (2008). •• Important manuscript for anyone reading the pain literature.
    • (2008) J. Pain , vol.9 , Issue.2 , pp. 105-121
    • Dworkin, R.H.1    Turk, D.C.2    Wyrwich, K.W.3
  • 21
    • 0037406025 scopus 로고    scopus 로고
    • Clinically important changes in acute pain outcome measures: A validation study
    • Farrar JT, Berlin JA, Strom BB. Clinically important changes in acute pain outcome measures: a validation study. J. Pain Symptom Manage. 25 (5), 406-411 (2003).
    • (2003) J. Pain Symptom Manage. , vol.25 , Issue.5 , pp. 406-411
    • Farrar, J.T.1    Berlin, J.A.2    Strom, B.B.3
  • 22
    • 38349144052 scopus 로고    scopus 로고
    • The alberta breakthrough pain assessment tool for cancer patients: A validation study using a delphi process and patient think-aloud interview
    • Hagen NA, Stiles C, Nekolaichuk C et al. The Alberta breakthrough pain assessment tool for cancer patients: a validation study using a Delphi process and patient think-aloud interview. J. Pain Symptom Manage. 35 (2), 136-152 (2008).
    • (2008) J. Pain Symptom Manage. , vol.35 , Issue.2 , pp. 136-152
    • Hagen, N.A.1    Stiles, C.2    Nekolaichuk, C.3
  • 23
    • 67650333512 scopus 로고    scopus 로고
    • Impact and management of breakthrough pain in cancer
    • • Nice review on the features and treatment of BTP
    • Zeppetella G. Impact and management of breakthrough pain in cancer. Curr. Opin. Support. Palliat. Care 3, 1-6 (2009). • Nice review on the features and treatment of BTP.
    • (2009) Curr. Opin. Support. Palliat. Care , vol.3 , pp. 1-6
    • Zeppetella, G.1
  • 24
    • 7044247398 scopus 로고    scopus 로고
    • Optimization of opioid therapy for preventing incident pain associated with bone metastases
    • DOI 10.1016/j.jpainsymman.2004.02.024, PII S0885392404003392
    • Mercadante S, Villari P, Ferrera P et al. Optimization of opioid therapy for preventing incident pain associated with bone metastases. J. Pain Symptom Manage. 28 (5), 505-510 (2004). (Pubitemid 39422489)
    • (2004) Journal of Pain and Symptom Management , vol.28 , Issue.5 , pp. 505-510
    • Mercadante, S.1    Villari, P.2    Ferrera, P.3    Casuccio, A.4
  • 25
    • 0034327030 scopus 로고    scopus 로고
    • Nccn practice guidelines for cancer pain
    • Benedetti N, Brock C, Cleeland C et al. NCCN practice guidelines for cancer pain. Oncology 14 (11A), 135-150 (2000).
    • (2000) Oncology , vol.14 , Issue.11 A , pp. 135-150
    • Benedetti, N.1    Brock, C.2    Cleeland, C.3
  • 28
    • 56549092721 scopus 로고    scopus 로고
    • Control of pain in adults with cancer: Summary of sign guidelines
    • Cormie PH, Nairn M, Welsh J. Control of pain in adults with cancer: summary of SIGN guidelines. Br. Med. J. 337, 1106-1112 (2008).
    • (2008) Br. Med. J. , vol.337 , pp. 1106-1112
    • Cormie, P.H.1    Nairn, M.2    Welsh, J.3
  • 29
    • 36348967160 scopus 로고    scopus 로고
    • Effervescent morphine results in faster relief of breakthrough pain in patients compared to immediate release morphine sulfate tablet
    • DOI 10.1111/j.1533-2500.2007.00157.x
    • Freye E, Levy JV, Braun D. Effervescent morphine results in faster relief of breakthrough pain in patients compared to immediate release morphine sulfate tablet. Pain Practice 7 (4), 324-331 (2007). (Pubitemid 350142301)
    • (2007) Pain Practice , vol.7 , Issue.4 , pp. 324-331
    • Freye, E.1    Levy, J.V.2    Braun, D.3
  • 30
    • 41049094950 scopus 로고    scopus 로고
    • Early pharmacokinetics of nasal fentanyl: Is there a signifcant arteriovenous difference?
    • • Illustrates the potential problems of interpreting venous pharmacokinetics
    • Moksnes K, Fredheim OM, Klepstad P et al. Early pharmacokinetics of nasal fentanyl: is there a signifcant arteriovenous difference? Eur. J. Clin. Pharmacol. 64 (5), 497-502 (2008). • Illustrates the potential problems of interpreting venous pharmacokinetics.
    • (2008) Eur. J. Clin. Pharmacol , vol.64 , Issue.5 , pp. 497-502
    • Moksnes, K.1    Fredheim, O.M.2    Klepstad, P.3
  • 32
    • 0022523086 scopus 로고
    • A comparative study of the effcacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer
    • Gourlay GK, Cherry DA, Cousins MM. A comparative study of the effcacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer. Pain 25 (3), 297-312 (1986).
    • (1986) Pain , vol.25 , Issue.3 , pp. 297-312
    • Gourlay, G.K.1    Cherry, D.A.2    Cousins, M.M.3
  • 33
    • 0024077857 scopus 로고
    • Sublingual absorption of selected opioid analgesics
    • • Defnitive original study on sublingual opioids
    • Weinberg DS, Inturrisi CE, Reidenberg B et al. Sublingual absorption of selected opioid analgesics. Clin. Pharmacol. Ther. 44 (3), 335-342 (1988). • Defnitive original study on sublingual opioids.
    • (1988) Clin. Pharmacol. Ther , vol.44 , Issue.3 , pp. 335-342
    • Weinberg, D.S.1    Inturrisi, C.E.2    Reidenberg, B.3
  • 34
    • 0023092375 scopus 로고
    • Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain
    • Inturrisi CE, Colburn WA, Kaiko RF et al. Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain. Clin. Pharmacol. Ther. 41 (4), 392-401 (1987). (Pubitemid 17058923)
    • (1987) Clinical Pharmacology and Therapeutics , vol.41 , Issue.4 , pp. 392-401
    • Inturrisi, C.E.1    Colburn, W.A.2    Kaiko, R.F.3
  • 35
    • 0036881593 scopus 로고    scopus 로고
    • Disposition of nasal, intravenous, and oral methadone in healthy volunteers
    • DOI 10.1067/mcp.2002.128386
    • Dale O, Hoffer C, Sheffels P et al. Disposition of nasal, intravenous, and oral methadone in healthy volunteers. Clin. Pharmacol. Ther. 72, 536-545 (2002). • Defnitive paper on nasal opioids. (Pubitemid 36237725)
    • (2002) Clinical Pharmacology and Therapeutics , vol.72 , Issue.5 , pp. 536-545
    • Dale, O.1    Hoffer, C.2    Sheffels, P.3    Kharasch, E.D.4
  • 36
    • 10344222128 scopus 로고    scopus 로고
    • Characterization of the early pharmacodynamic profile of oral methadone for cancer-related breakthrough pain: A pilot study
    • DOI 10.1016/j.jpainsymman.2004.03.003, PII S0885392404003938
    • Fisher K, Stiles C, Hagen NA et al. Characterization of the early pharmacodynamic profle of oral methadone for cancer-related breakthrough pain: a pilot study. J. Pain Symptom Manage. 28 (6), 619-625 (2004). (Pubitemid 39626108)
    • (2004) Journal of Pain and Symptom Management , vol.28 , Issue.6 , pp. 619-625
    • Fisher, K.1    Stiles, C.2    Hagen, N.A.3
  • 37
    • 34248341294 scopus 로고    scopus 로고
    • Sublingual methadone for the management of cancer-related breakthrough pain: A pilot study
    • DOI 10.1089/jpm.2006.0163
    • Hagen NA, Fisher K, Stiles C. Sublingual methadone for the management of cancer-related breakthrough pain: a pilot study. J. Palliat. Med. 10 (2), 331-337 (2007). (Pubitemid 46740205)
    • (2007) Journal of Palliative Medicine , vol.10 , Issue.2 , pp. 331-337
    • Hagen, N.A.1    Fisher, K.2    Stiles, C.3
  • 39
    • 34248329090 scopus 로고    scopus 로고
    • Rational use of sublingual opioids in palliative medicine
    • •• Important summary on sublingual opioids
    • Reisfeld GM, Wilson GG. Rational use of sublingual opioids in palliative medicine. J. Palliat. Med. 10 (2), 465-475 (2007). •• Important summary on sublingual opioids.
    • (2007) J. Palliat. Med. , vol.10 , Issue.2 , pp. 465-475
    • Reisfeld, G.M.1    Wilson, G.G.2
  • 40
    • 0032167534 scopus 로고    scopus 로고
    • Sublingual morphine: Effcacy reviewed
    • Coluzzi PP. Sublingual morphine: effcacy reviewed. J. Pain Symptom Manage. 16, 184-192 (1998).
    • (1998) J. Pain Symptom Manage. , vol.16 , pp. 184-192
    • Coluzzi, P.P.1
  • 41
    • 33846916463 scopus 로고    scopus 로고
    • A titration strategy is needed to manage breakthrough cancer pain effectively: Observations from data pooled from three clinical trials
    • DOI 10.1089/jpm.2006.0151
    • Hagen NA, Fisher K, Victorino C et al. A titration strategy is needed to manage breakthrough cancer pain effectively: observations from data pooled from three clinical trials. J. Palliat. Med. 10 (1), 47-55 (2007). (Pubitemid 46238952)
    • (2007) Journal of Palliative Medicine , vol.10 , Issue.1 , pp. 47-55
    • Hagen, N.A.1    Fisher, K.2    Victorino, C.3    Farrar, J.T.4
  • 42
    • 0020327223 scopus 로고
    • Control of chronic pain in very advanced cancer patients with morphine hydrochloride administered by oral, rectal and sublingual route. Clinical report and preliminary results on morphine pharmacokinetics
    • DOI 10.1016/S0031-6989(82)80107-0
    • Pannutti F, Rossi AP, Iafelice G et al. Control of chronic pain in very advanced cancer patients with morphine hydrochloride administered by oral, rectal and sublingual route. Clinical report and preliminary results on morphine pharmacokinetics. Pharmacol. Res. Commun. 14 (4), 369-380 (1982). (Pubitemid 12007174)
    • (1982) Pharmacological Research Communications , vol.14 , Issue.4 , pp. 369-380
    • Pannuti, F.1    Rossi, A.P.2    Iafelice, G.3
  • 43
    • 77951769699 scopus 로고
    • Advances in pain research and therapy
    • NY, USA
    • McQuay HL, Foley KK. Advances in Pain Research and Therapy. Raven Press, NY, USA 407-412 (1986).
    • (1986) Raven Press , pp. 407-412
    • McQuay, H.L.1    Foley, K.K.2
  • 44
    • 0025190756 scopus 로고
    • Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine-6-glucuronide
    • Osborne R, Joel S, Trew D et al. Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide. Clin. Pharmacol. Ther. 47 (1), 12-19 (1990). (Pubitemid 20041204)
    • (1990) Clinical Pharmacology and Therapeutics , vol.47 , Issue.1 , pp. 12-19
    • Osborne, R.1    Joel, S.2    Trew, D.3    Slevin, M.4
  • 45
    • 0027351317 scopus 로고
    • Comparative morphine pharmacokinetics following sublingual, intramuscular, and oral administration in patients with cancer
    • Davis T, Miser AW, Loprinzi CL et al. Comparative morphine pharmacokinetics following sublingual, intramuscular, and oral administration in patients with cancer. Hospice J. 9 (1), 85-91 (1993).
    • (1993) Hospice J. , vol.9 , Issue.1 , pp. 85-91
    • Davis, T.1    Miser, A.W.2    Loprinzi, C.L.3
  • 46
    • 0030458664 scopus 로고    scopus 로고
    • A pharmacokinetic study of sublingual aerosolized morphine in healthy volunteers
    • Watson NW, Taylor KM, Joel SP et al. A pharmacokinetic study of sublingual aerosolized morphine in healthy volunteers. J. Pharm. Pharmacol. 48 (12), 1256-1259 (1996).
    • (1996) J. Pharm. Pharmacol , vol.48 , Issue.12 , pp. 1256-1259
    • Watson, N.W.1    Taylor, K.M.2    Joel, S.P.3
  • 47
    • 84920231000 scopus 로고
    • Buccal morphine - A new route for analgesia?
    • Bell MD, Murray GR, Mishra P et al. Buccal morphine - a new route for analgesia. Lancet 12 (1), 71-73 (1985). (Pubitemid 15189821)
    • (1985) Lancet , vol.1 , Issue.8420 , pp. 71-73
    • Bell, M.D.D.1    Murray, G.R.2    Mishra, P.3
  • 49
    • 0030425324 scopus 로고    scopus 로고
    • Buprenorphine, morphine and naloxone effects during ascending morphine maintenance in humans
    • Schuh KJ, Walsh SL, Bigelow GE et al. Buprenorphine, morphine and naloxone effects during ascending morphine maintenance in humans. J. Pharmacol. Exp. Ther. 278 (2), 836-846 (1996).
    • (1996) J. Pharmacol. Exp. Ther , vol.278 , Issue.2 , pp. 836-846
    • Schuh, K.J.1    Walsh, S.L.2    Bigelow, G.E.3
  • 50
    • 0018423239 scopus 로고
    • A trial of sublingual buprenorphine in cancer pain
    • Robbie DD. A trial of sublingual buprenorphine in cancer pain. Br. J. Clin. Pharmacol. 7 (Suppl. 3), S315-S317 (1979).
    • (1979) Br. J. Clin. Pharmacol , vol.7 , Issue.SUPPL. 3
    • Robbie, D.D.1
  • 53
    • 38549096021 scopus 로고    scopus 로고
    • Buprenorphine: New tricks with an old molecule for pain management
    • Heit HA, Gourlay DD. Buprenorphine: new tricks with an old molecule for pain management. Clin. J. Pain 24 (2), 93-97 (2008).
    • (2008) Clin. J. Pain , vol.24 , Issue.2 , pp. 93-97
    • Heit, H.A.1    Gourlay, D.D.2
  • 54
    • 33645037365 scopus 로고    scopus 로고
    • Effect of pH on sublingual absorption of oxycodone hydrochloride
    • Al-Ghananeem AM, Malkawi AH, Crooks PP. Effect of pH on sublingual absorption of oxycodone hydrochloride. AAPS PharmSciTech 7 (1), E1-E5 (2006).
    • (2006) AAPS PharmSciTech , vol.7 , Issue.1
    • Al-Ghananeem, A.M.1    Malkawi, A.H.2    Crooks, P.P.3
  • 56
    • 3242682244 scopus 로고    scopus 로고
    • Pharmacokinetics of oxycodone after intravenous, buccal, intramuscular and gastric administration in children
    • DOI 10.2165/00003088-200443090-00004
    • Kokki H, Rasanen I, Reinikainen M et al. Pharmacokinetics of oxycodone after intravenous, buccal, intramuscular and gastric administration in children. Clin. Pharmacokinet. 43 (9), 613-622 (2004). (Pubitemid 38951803)
    • (2004) Clinical Pharmacokinetics , vol.43 , Issue.9 , pp. 613-622
    • Kokki, H.1    Rasanen, I.2    Reinikainen, M.3    Suhonen, P.4    Vanamo, K.5    Ojanpera, I.6
  • 57
    • 68149181408 scopus 로고    scopus 로고
    • Dynamics of breakthrough pain vs pharmacokinetics of oral morphine: Implications for management
    • • Nice summary of the problems with using oral morphine for BTP
    • Zeppetella G. Dynamics of breakthrough pain vs pharmacokinetics of oral morphine: implications for management. Eur. J. Cancer Care (Engl.) 18, 331-337 (2009). • Nice summary of the problems with using oral morphine for BTP.
    • (2009) Eur. J. Cancer Care (Engl.) , vol.18 , pp. 331-337
    • Zeppetella, G.1
  • 58
    • 0034897679 scopus 로고    scopus 로고
    • Oral transmucosal fentanyl and sufentanil for incident pain [1]
    • DOI 10.1016/S0885-3924(01)00321-9, PII S0885392401003219
    • Gardner-Nix J. Oral transmucosal fentanyl and sufentanil for incident pain. J. Pain Symptom Manage. 22 (2), 627-629 (2001). • First paper on the extemporaneous use of parenteral preparations. (Pubitemid 32725801)
    • (2001) Journal of Pain and Symptom Management , vol.22 , Issue.2 , pp. 627-630
    • Gardner-Nix, J.1
  • 59
    • 0035000136 scopus 로고    scopus 로고
    • Prevalence and characteristics of breakthrough pain in patients with non-malignant terminal disease admitted to a hospice
    • DOI 10.1191/026921601678576220
    • Zeppetella G, O'Doherty CA, Collins S. Prevalence and characteristics of breakthrough pain in patients with non-malignant terminal disease admitted to a hospice. Palliat. Med. 15, 243-246 (2001). (Pubitemid 32479462)
    • (2001) Palliative Medicine , vol.15 , Issue.3 , pp. 243-246
    • Zeppetella, G.1    O'doherty, C.A.2    Collins, S.3
  • 60
    • 28444445630 scopus 로고    scopus 로고
    • ®) dosing guidelines
    • • Important review on the use of sublingual fentanyl
    • ®) dosing guidelines. Pain Med. 6 (4), 305-314 (2005). • Important review on the use of sublingual fentanyl.
    • (2005) Pain med , vol.6 , Issue.4 , pp. 305-314
    • Aronoff, G.M.1    Brennan, M.J.2    Pritchard, D.D.3
  • 61
    • 0042121265 scopus 로고    scopus 로고
    • A pharmacokinetic study to compare two simultaneous 400 μg doses with a single 800 μg dose of oral transmucosal fentanyl citrate
    • DOI 10.1016/S0885-3924(03)00241-0
    • Lee M, Kern SE, Kisicki JC et al. A pharmacokinetic study to compare two simultaneous 400 microg doses with a single 800 microg dose of oral transmucosal fentanyl citrate. J. Pain Symptom Manage. 26 (2), 743-747 (2003). (Pubitemid 36952350)
    • (2003) Journal of Pain and Symptom Management , vol.26 , Issue.2 , pp. 743-747
    • Lee, M.1    Kern, S.E.2    Kisicki, J.C.3    Egan, T.D.4
  • 62
    • 33645518854 scopus 로고    scopus 로고
    • Opioids for the management of breakthrough (episodic) pain in cancer patients
    • Zeppetella G, Ribeiro MM. Opioids for the management of breakthrough (episodic) pain in cancer patients. Cochrane Database Syst. Rev. 25 (1), CF004311 (2006).
    • (2006) Cochrane Database Syst. Rev. , vol.25 , Issue.1
    • Zeppetella, G.1    Ribeiro, M.M.2
  • 63
    • 34250339548 scopus 로고    scopus 로고
    • Transmucosal fentanyl vs intravenous morphine in doses proportional to basal opioid regimen for episodic-breakthrough pain
    • DOI 10.1038/sj.bjc.6603811, PII 6603811
    • Mercandante S, Villari P, Ferrera P et al. Transmucosal fentanyl vs intravenous morphine in doses proportional to basal opioid regimen for episodic-breakthrough pain. Br. J. Cancer 96, 1828-1833 (2007). • Important study comparing parenteral morphine with transmucosal fentanyl. (Pubitemid 46912022)
    • (2007) British Journal of Cancer , vol.96 , Issue.12 , pp. 1828-1833
    • Mercadante, S.1    Villari, P.2    Ferrera, P.3    Casuccio, A.4    Mangione, S.5    Intravaia, G.6
  • 65
    • 13444274550 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: A new approach to treatment of incident pain
    • DOI 10.1111/j.1365-2125.2004.02264.x
    • Lennernas B, Hedner R, Holmberg M et al. Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain. Br. J. Clin. Pharmacol. 59 (2), 249-253 (2004). (Pubitemid 40208864)
    • (2005) British Journal of Clinical Pharmacology , vol.59 , Issue.2 , pp. 249-253
    • Lennernas, B.1    Hedner, T.2    Holmberg, M.3    Bredenberg, S.4    Nystrom, C.5    Lennernas, H.6
  • 66
    • 33846115564 scopus 로고    scopus 로고
    • Fentanyl buccal tablet: In breakthrough pain in opioid-tolerant patients with cancer
    • Blick SKA, Wagstaff AJ. Fentanyl buccal tablet in breakthrough pain in opioidtolerant patients with cancer. Drugs 66 (18), 2387-2393 (2006). (Pubitemid 46072453)
    • (2006) Drugs , vol.66 , Issue.18 , pp. 2387-2393
    • Blick, S.K.A.1    Wagstaff, A.J.2
  • 67
    • 37249044167 scopus 로고    scopus 로고
    • Bioequivalence following buccal and sublingual placement of fentanyl buccal tablet 400 μg in healthy subjects
    • Darwish M, Kirby M, Jiang JG et al. Bio equivalence following buccal and sublingual placement of fentanyl buccal tablet 400 microg in healthy subjects. Clin. Drug Investig. 28 (1), 1-7 (2008). (Pubitemid 350274395)
    • (2008) Clinical Drug Investigation , vol.28 , Issue.1 , pp. 1-7
    • Darwish, M.1    Kirby, M.2    Jiang, J.G.3    Tracewell, W.4    Robertson Jr., P.5
  • 68
    • 33746849278 scopus 로고    scopus 로고
    • Relative bioavailability of the fentanyl effervescent buccal tablet (FEBT) 1080 pg versus Oral transmucosal fentanyl citrate 1600 pg and dose proportionality of FEBT 270 to 1300 μg: A single-dose, randomized, open-label, three-period study in healthy adult volunteers
    • DOI 10.1016/j.clinthera.2006.05.016, PII S0149291806001275
    • Darwish M, Tempero K, Kirby M et al. Relative bioavailability of the fentanyl effervescent buccal tablet pg versus oral transmucosal fentanyl citrate 1, 600 pg and dose FEBT 270-1, 300 μg: a single-dose, randomized, open-period study in healthy adult volunteers. Clin. Ther. 28 (5), 715-724 (2006). (Pubitemid 44173055)
    • (2006) Clinical Therapeutics , vol.28 , Issue.5 , pp. 715-724
    • Darwish, M.1    Tempero, K.2    Kirby, M.3    Thompson, J.4
  • 69
    • 34548077818 scopus 로고    scopus 로고
    • Absorption of fentanyl from fentanyl buccal tablet in cancer patients with or without oral mucositis: A pilot study
    • DOI 10.2165/00044011-200727090-00002
    • Darwish M, Kirby M, Robertson P et al. Absorption of fentanyl from fentanyl buccal tablet in cancer patients with or without oral mucositis: a pilot study. Clin. Drug Investig. 27 (9), 605-611 (2007). (Pubitemid 47295719)
    • (2007) Clinical Drug Investigation , vol.27 , Issue.9 , pp. 605-611
    • Darwish, M.1    Kirby, M.2    Robertson, P.3    Tracewell, W.4    Jiang, J.G.5
  • 70
    • 34948821962 scopus 로고    scopus 로고
    • Fentanyl buccal tablet for relief of breakthrough pain in opioid-tolerant patients with cancer-related chronic pain
    • Slatkin NE, Xie F, Messina J et al. Fentanyl buccal tablet for relief of breakthrough pain in opioid-tolerant patients with cancer-related chronic pain. J. Support. Oncol. 5 (7), 327-334 (2007). (Pubitemid 350055013)
    • (2007) Journal of Supportive Oncology , vol.5 , Issue.7 , pp. 327-334
    • Slatkin, N.E.1    Xie, F.2    Messina, J.3    Segal, T.J.4
  • 71
    • 33746559173 scopus 로고    scopus 로고
    • Prevalence and Characteristics of Breakthrough Pain in Opioid-Treated Patients With Chronic Noncancer Pain
    • DOI 10.1016/j.jpain.2006.02.003, PII S1526590006005451
    • Portenoy RK, Bennett DS, Rauck R et al. Prevalence characteristics of breakthrough pain in opioid-treated patients with chronic cancer pain. J. Pain 7 (8), 583-591 (2006). (Pubitemid 44137488)
    • (2006) Journal of Pain , vol.7 , Issue.8 , pp. 583-591
    • Portenoy, R.K.1    Bennett, D.S.2    Rauck, R.3    Simon, S.4    Taylor, D.5    Brennan, M.6    Shoemaker, S.7
  • 72
    • 34347328100 scopus 로고    scopus 로고
    • Fentanyl buccal tablet for the relief of breakthrough pain in opioid-tolerant adult patients with chronic neuropathic pain: a multicenter, randomized, double-blind, placebo-controlled study
    • DOI 10.1016/j.clinthera.2007.04.007, PII S0149291807001075
    • Simpson DM, Messina J, Xie F et al. Fentanyl buccal tablet for the relief of breakthrough pain in opioid-tolerant adult patients with chronic neuropathic pain: a multicenter, randomized, double-blind, placebo-controlled study. Clin. Ther. 29 (4), 588-601 (2007). (Pubitemid 47016640)
    • (2007) Clinical Therapeutics , vol.29 , Issue.4 , pp. 588-601
    • Simpson, D.M.1    Messina, J.2    Xie, F.3    Hale, M.4
  • 73
    • 0027175857 scopus 로고
    • Severe episodic pain: Management with sublingual sufentanil
    • Kunz KM, Theisen JA, Schroeder MM. Severe episodic pain: management with sublingual sufentanil. J. Pain Symptom Manage. 8 (4), 189-190 (1993).
    • (1993) J. Pain Symptom Manage. , vol.8 , Issue.4 , pp. 189-190
    • Kunz, K.M.1    Theisen, J.A.2    Schroeder, M.M.3
  • 74
    • 65249096630 scopus 로고    scopus 로고
    • Development of a sublingual/oral formulation of ketamine for use in neuropathic pain
    • Chong C, Schug SA, Page-Sharp M et al. Development of a sublingual/oral formulation of ketamine for use in neuropathic pain. Clin. Drug Invest. 29 (5), 317-324 (2009).
    • (2009) Clin. Drug Invest. , vol.29 , Issue.5 , pp. 317-324
    • Chong, C.1    Schug, S.A.2    Page-Sharp, M.3
  • 75
    • 18444363020 scopus 로고    scopus 로고
    • Nasal administration of opioids for pain management in adults
    • DOI 10.1034/j.1399-6576.2002.460702.x
    • Dale O, Hjortkjaer R, Kharasch EE. Nasal administration of opioids for pain management in adults. Acta Anesthesiol Scand. 48, 759-770 (2002). (Pubitemid 34803193)
    • (2002) Acta Anaesthesiologica Scandinavica , vol.46 , Issue.7 , pp. 759-770
    • Dale, O.1    Hjortkjaer, R.2    Kharasch, E.D.3
  • 76
    • 28344436049 scopus 로고    scopus 로고
    • Alternative treatments of breakthrough pain in patients receiving spinal analgesics for cancer pain
    • DOI 10.1016/j.jpainsymman.2005.04.014, PII S0885392405004975
    • Mercadante S, Arcuri E, Ferrera P et al. Alternative treatments of breakthrough pain in patients receiving spinal analgesics for cancer pain. J. Pain Symptom Manage. 30 (5), 485-491 (2005). (Pubitemid 41718968)
    • (2005) Journal of Pain and Symptom Management , vol.30 , Issue.5 , pp. 485-491
    • Mercadante, S.1    Arcuri, E.2    Ferrera, P.3    Villari, P.4    Mangione, S.5
  • 77
    • 55149091591 scopus 로고    scopus 로고
    • From nose to brain: Understanding transport capacity and transport rate of drugs
    • Wu H, Hu K, Jiang H. From nose to brain: understanding transport capacity and transport rate of drugs. Expert Opin. Drug Deliv. 5 (10), 1159-1168 (2008).
    • (2008) Expert Opin. Drug Deliv , vol.5 , Issue.10 , pp. 1159-1168
    • Wu, H.1    Hu, K.2    Jiang, H.3
  • 78
    • 0030861849 scopus 로고    scopus 로고
    • Preliminary clinical use of a patient-controlled intranasal analgesia (PCINA) device
    • O'Neil G, Paech N, Wood F. Preliminary clinical use of a patient-control led intranasal analgesia (PCINA) device. Anaesth. Intensive Care 25 (4), 408-412 (1997). (Pubitemid 27389204)
    • (1997) Anaesthesia and Intensive Care , vol.25 , Issue.4 , pp. 408-412
    • O'Neil, G.1    Paech, M.2    Wood, F.3
  • 79
    • 38949134457 scopus 로고    scopus 로고
    • The clinical applications of intranasal opioids
    • DOI 10.2174/156720108783330989
    • Shelley K, Paech MM. The clinical applications of intranasal opioids. Curr. Drug Deliv. 5, 55-58 (2008). • Nice review on the subject of nasal opioids. (Pubitemid 351225634)
    • (2008) Current Drug Delivery , vol.5 , Issue.1 , pp. 55-58
    • Shelley, K.1    Paech, M.J.2
  • 80
    • 42249103294 scopus 로고    scopus 로고
    • Recent patents review on intranasal administration for CNS drug delivery
    • DOI 10.2174/187221108783331429
    • Jogani V, Jinturkar K, Vyas T, Misra A. Recent patents review on intranasal administration for CNS drug delivery Recent Pat. Drug Deliv. Formul. 2, 25-40 (2008). • Exhaustive review on nasal opioids. (Pubitemid 351546432)
    • (2008) Recent Patents on Drug Delivery and Formulation , vol.2 , Issue.1 , pp. 25-40
    • Jogani, V.1    Jinturkar, K.2    Vyas, T.K.3    Misra, A.4
  • 81
    • 0344737799 scopus 로고    scopus 로고
    • Initial pharmacokinetic, safety and efficacy evaluation of nasal morphine gluconate for breakthrough pain in cancer patients
    • DOI 10.1016/S0304-3959(03)00318-X
    • Fitzgibbon D, Morgan D, Dockter D et al. Initial pharmacokinetic, safety and effcacy evaluation of nasal morphine gluconate for breakthrough pain in cancer patients. Pain 106, 309-315 (2003). (Pubitemid 37505878)
    • (2003) Pain , vol.106 , Issue.3 , pp. 309-315
    • Fitzgibbon, D.1    Morgan, D.2    Dockter, D.3    Barry, C.4    Kharasch, E.D.5
  • 83
    • 38949167532 scopus 로고    scopus 로고
    • Analgesic effcacy and safety of morphinechitosan nasal solution in patients with moderate to severe pain following orthopedic surgery
    • Stoker DG, Reber KR, Waltzman LS et al. Analgesic effcacy and safety of morphinechitosan nasal solution in patients with moderate to severe pain following orthopedic surgery. Pain Med. 9 (1), 3-12 (2008).
    • (2008) Pain Med. , vol.9 , Issue.1 , pp. 3-12
    • Stoker, D.G.1    Reber, K.R.2    Waltzman, L.S.3
  • 84
    • 58149295881 scopus 로고    scopus 로고
    • The analgesic effcacy and safety of a novel intranasal morphine formulation (morphine plus chitosan), immediate release oral morphine, intravenous morphine, and placebo in a postsurgical dental pain model
    • Christensen KS, Cohen AE, Mermelstein FH et al. The analgesic effcacy and safety of a novel intranasal morphine formulation (morphine plus chitosan), immediate release oral morphine, intravenous morphine, and placebo in a postsurgical dental pain model. Pain Med. 107 (6), 2018-2024 (2008).
    • (2008) Pain Med. , vol.107 , Issue.6 , pp. 2018-2024
    • Christensen, K.S.1    Cohen, A.E.2    Mermelstein, F.H.3
  • 85
    • 0036881593 scopus 로고    scopus 로고
    • Disposition of nasal, intravenous, and oral methadone in healthy volunteers
    • DOI 10.1067/mcp.2002.128386
    • Dale O, Hoffer C, Sheffels P et al. Disposition of nasal, intravenous, and oral methadone in healthy volunteers. Clin. Pharmacol. Ther. 72 (5), 536-545 (2002). (Pubitemid 36237725)
    • (2002) Clinical Pharmacology and Therapeutics , vol.72 , Issue.5 , pp. 536-545
    • Dale, O.1    Hoffer, C.2    Sheffels, P.3    Kharasch, E.D.4
  • 86
    • 0038383783 scopus 로고    scopus 로고
    • Intranasal diamorphine as an alternative to intramuscular morphine: Pharmacokinetic and pharmacodynamic aspects
    • Kendall JM, Latter VV. Intranasal diamorphine as an alternative to intramuscular morphine: pharmacokinetic and pharmacodynamic aspects. Clin. Pharmacokinet. 42 (6), 501-513 (2003).
    • (2003) Clin. Pharmacokinet , vol.42 , Issue.6 , pp. 501-513
    • Kendall, J.M.1    Latter, V.V.2
  • 87
    • 0024237802 scopus 로고
    • Pharmacokinetics and bioavailability of hydromorphone: Effect of various routes of administration
    • DOI 10.1023/A:1015959912021
    • Chang SF, Moore L, Chien YY. Pharmacokinetics and bioavailability of hydromorphone: effect of various routes of administration. Pharm. Res. 5 (11), 718-721 (1988). (Pubitemid 19019674)
    • (1988) Pharmaceutical Research , vol.5 , Issue.11 , pp. 718-721
    • Chang, S.-F.1    Moore, L.2    Chien, Y.W.3
  • 88
    • 0037974435 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of single-dose intranasal hydromorphone hydrochloride in healthy volunteers
    • Coda BA, Rudy AC, Archer SM et al. Pharmacokinetics and bioavailability of single-dose intranasal hydromorphone hydrochloride in healthy volunteers. Anesth. Analg. 97, 117-123 (2003). (Pubitemid 36736548)
    • (2003) Anesthesia and Analgesia , vol.97 , Issue.1 , pp. 117-123
    • Coda, B.A.1    Rudy, A.C.2    Archer, S.M.3    Wermeling, D.P.4
  • 90
    • 49749131556 scopus 로고    scopus 로고
    • Pharmacokinetics of tramadol in rat plasma and cerebrospinal fuid after intranasal administration
    • Zhao Y, Tao T, Wu J et al. Pharmacokinetics of tramadol in rat plasma and cerebrospinal fuid after intranasal administration. J. Pharm. Pharmacol. 60 (9), 1149-1154 (2008).
    • (2008) J. Pharm. Pharmacol , vol.60 , Issue.9 , pp. 1149-1154
    • Zhao, Y.1    Tao, T.2    Wu, J.3
  • 91
    • 52949120344 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery
    • Foster D, Upton R, Christrup L et al. Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery. Ann. Pharmacother. 42 (10), 1380-1387 (2008).
    • (2008) Ann. Pharmacother , vol.42 , Issue.10 , pp. 1380-1387
    • Foster, D.1    Upton, R.2    Christrup, L.3
  • 92
    • 41649083735 scopus 로고    scopus 로고
    • Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: A randomized, double-blind, double-dummy, two-way, crossover study
    • DOI 10.1016/j.clinthera.2008.03.001, PII S0149291808001021
    • Christrup LL, Foster D, Popper LD et al. Pharmacokinetics, effcacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: a randomized, double-blind, doubledummy, two-way, crossover study. Clin. Ther. 30 (3), 469-481 (2008). (Pubitemid 351483922)
    • (2008) Clinical Therapeutics , vol.30 , Issue.3 , pp. 469-481
    • Christrup, L.L.1    Foster, D.2    Popper, L.D.3    Troen, T.4    Upton, R.5
  • 93
    • 1842785725 scopus 로고    scopus 로고
    • A randomised crossover trial of patient controlled intranasal fentanyl and oral morphine for procedural wound care in adult patients with burns
    • DOI 10.1016/j.burns.2003.10.017, PII S0305417903003279
    • Finn J, Wright J, Fong J et al. A randomised crossover trial of patient controlled intranasal for morphine for procedural wound care in adult patients with burns. Burns 30 (3), 262-268 (2004). (Pubitemid 38479907)
    • (2004) Burns , vol.30 , Issue.3 , pp. 262-268
    • Finn, J.1    Wright, J.2    Fong, J.3    Mackenzie, E.4    Wood, F.5    Leslie, G.6    Gelavis, A.7
  • 94
    • 0029843916 scopus 로고    scopus 로고
    • Patient-controlled intranasal analgesia: A method for noninvasive postoperative pain management
    • Striebel HW, Oelmann T, Spies C et al. Patient-controlled intranasal analgesia: a method for noninvasive postoperative pain management. Anesth. Analg. 548-551 (1996). (Pubitemid 26296364)
    • (1996) Anesthesia and Analgesia , vol.83 , Issue.3 , pp. 548-551
    • Striebel, H.W.1    Oelmann, T.2    Spies, C.3    Rieger, A.4    Schwagmeier, R.5
  • 95
    • 0030861849 scopus 로고    scopus 로고
    • Preliminary clinical use of a patient-controlled intranasal analgesia (PCINA) device
    • O'Neil G, Paech M, Wood F. Preliminary clinical use of a patient-controlled intranasal analgesia (PCINA) device. Anaesth. Intens. Care 25, 408-412 (1997). (Pubitemid 27389204)
    • (1997) Anaesthesia and Intensive Care , vol.25 , Issue.4 , pp. 408-412
    • O'Neil, G.1    Paech, M.2    Wood, F.3
  • 96
    • 0033759857 scopus 로고    scopus 로고
    • Patient-controlled intranasal analgesia: Effective alternative to intravenous pca for postoperative pain relief
    • Toussaint S, Maidl J, Schwagmeier MD et al. Patient-controlled intranasal analgesia: effective alternative to intravenous PCA for postoperative pain relief. Can. J. Anesth. 47 (4), 299-302 (2000).
    • (2000) Can. J. Anesth. , vol.47 , Issue.4 , pp. 299-302
    • Toussaint, S.1    Maidl, J.2    Schwagmeier, M.D.3
  • 97
    • 67649229310 scopus 로고    scopus 로고
    • Pecsys: In situ gelling system for optimised nasal drug delivery
    • Watts P, Smith A. PecSys: in situ gelling system for optimised nasal drug delivery. Expert Opin. Drug Deliv. 6 (5), 543-552 (2009).
    • (2009) Expert Opin. Drug Deliv , vol.6 , Issue.5 , pp. 543-552
    • Watts, P.1    Smith, A.2
  • 98
    • 84881275665 scopus 로고    scopus 로고
    • Fentanyl pectin nasal spray (FPNS) with pecsys (r): Effcacy, tolerability, and onset of action in the treatment of breakthrough cancer pain (btcp)
    • San Diego, CA, USA, 7-9 May
    • th Annual Scientifc Meeting. San Diego, CA, USA, 7-9 May 2009.
    • (2009) th Annual Scientifc Meeting
    • Wallace, M.1    Taylor, D.2    Rauck, R.3
  • 102
    • 0024468996 scopus 로고
    • Intranasal opiates: Old route for new drugs
    • Ralley FF. Intranasal opiates: old route for new drugs. Can. J. Anaesth. 36 (5), 491-493 (1989).
    • (1989) Can. J. Anaesth , vol.36 , Issue.5 , pp. 491-493
    • Ralley, F.F.1
  • 104
    • 32544443456 scopus 로고    scopus 로고
    • Intranasal sufentanil is effective for postoperative analgesia in adults
    • Mathieu N, Cnuddle N, Engelman E et al. Intranasal sufentanil is effective for postoperative analgesia in adults. Can. J. Anaesth. 53 (1), 60-66 (2006). (Pubitemid 43230993)
    • (2006) Canadian Journal of Anesthesia , vol.53 , Issue.1 , pp. 60-66
    • Mathieu, N.1    Cnudde, N.2    Engelman, E.3    Barvais, L.4
  • 105
    • 58549109020 scopus 로고    scopus 로고
    • Intranasal sufentanil for cancer-associated breakthrough pain
    • Good P, Jackson K, Brumley D et al. Intranasal sufentanil for cancer-associated breakthrough pain. Palliat. Med. 23, 54-58 (2009).
    • (2009) Palliat. Med. , vol.23 , pp. 54-58
    • Good, P.1    Jackson, K.2    Brumley, D.3
  • 106
    • 0028961792 scopus 로고
    • Pharmacokinetics of intranasal alfentanil
    • Schwagmeier R, Boerger N, Meissner W et al. Pharmacokinetics of intranasal alfentanil. J. Clin. Anesth. 7 (2), 109-113 (1995).
    • (1995) J. Clin. Anesth. , vol.7 , Issue.2 , pp. 109-113
    • Schwagmeier, R.1    Boerger, N.2    Meissner, W.3
  • 107
    • 0036445509 scopus 로고    scopus 로고
    • Ketamine as an analgesic: Parenteral, oral, rectal, subcutaneous, transdermal and intranasal administration
    • Kroenenberg RR. Ketamine as an analgesic: parenteral, oral, rectal, subcutaneous, transdermal and intranasal administration. J. Pain Palliat. Care Pharmacother. 16 (3), 27-35 (2002).
    • (2002) J. Pain Palliat. Care Pharmacother , vol.16 , Issue.3 , pp. 27-35
    • Kroenenberg, R.R.1
  • 109
    • 11144261753 scopus 로고    scopus 로고
    • S-ketamine and s-norketamine plasma concentrations after nasal and i.v. administration in anesthesized children
    • Weber F, Wulf J, Gruber M et al. S-ketamine and s-norketamine plasma concentrations after nasal and i.v. administration in anesthesized children. Paediatr. Anaesth. 14 (12), 983-988 (2004).
    • (2004) Paediatr. Anaesth , vol.14 , Issue.12 , pp. 983-988
    • Weber, F.1    Wulf, J.2    Gruber, M.3
  • 110
    • 10744219957 scopus 로고    scopus 로고
    • Safety and effcacy of intranasal ketamine for the treatment of pain in patients with chronic pain: A randomized, double-blind controlled, crossover study
    • Carr DB, Goudas LC, Denman WT et al. Safety and effcacy of intranasal ketamine for the treatment of pain in patients with chronic pain: a randomized, double-blind controlled, crossover study. Pain 108 (1-2), 17-27 (2004).
    • (2004) Pain , vol.108 , Issue.1-2 , pp. 17-27
    • Carr, D.B.1    Goudas, L.C.2    Denman, W.T.3
  • 111
    • 3843153055 scopus 로고    scopus 로고
    • Safety and effcacy of intranasal ketamine in a mixed population with chronic pain
    • Carr DB, Goudas LC, Denman WT et al. Safety and effcacy of intranasal ketamine in a mixed population with chronic pain. Pain 110 (3), 762-764 (2004).
    • (2004) Pain , vol.110 , Issue.3 , pp. 762-764
    • Carr, D.B.1    Goudas, L.C.2    Denman, W.T.3
  • 112
    • 64149090138 scopus 로고    scopus 로고
    • Anosmia - A potential complication of intranasal ketamine
    • Mayell A, Natusch D. Anosmia - a potential complication of intranasal ketamine. Anaesthesia 64 (4), 457-458 (2009).
    • (2009) Anaesthesia , vol.64 , Issue.4 , pp. 457-458
    • Mayell, A.1    Natusch, D.2
  • 114
    • 1642619135 scopus 로고    scopus 로고
    • Safety and effectiveness of intravenous morphine for episodic (breakthrough) pain using a fixed ratio with the oral daily morphine dose
    • DOI 10.1016/j.jpainsymman.2003.09.006, PII S0885392404000041
    • Mercadante S, Villari P, Ferrera P et al. Safety and effectiveness of intravenous morphine for episodic (breakthrough) pain using a fxed ratio with the oral daily morphine dose. J. Pain Symptom Manage. 27 (4), 352-359 (2004). (Pubitemid 38410903)
    • (2004) Journal of Pain and Symptom Management , vol.27 , Issue.4 , pp. 352-359
    • Mercadante, S.1    Villari, P.2    Ferrera, P.3    Bianchi, M.4    Casuccio, A.5
  • 115
    • 39549101768 scopus 로고    scopus 로고
    • Intravenous morphine for breakthrough (episodic-) pain in an acute palliative care unit: A confrmatory study
    • Mercadante S, Intravaia G, Villari P et al. Intravenous morphine for breakthrough (episodic-) pain in an acute palliative care unit: a confrmatory study. J. Pain Symptom Manage. 35 (3), 307-313 (2008).
    • (2008) J. Pain Symptom Manage. , vol.35 , Issue.3 , pp. 307-313
    • Mercadante, S.1    Intravaia, G.2    Villari, P.3
  • 116
    • 33746498600 scopus 로고    scopus 로고
    • Safety and effectiveness of intravenous morphine for episodic breakthrough pain in patients receiving transdermal buprenorphine
    • DOI 10.1016/j.jpainsymman.2006.01.013, PII S0885392406002764
    • Mercadante S, Villari P, Ferrara P et al. Safety and effectiveness of intravenous morphine for episodic breakthrough pain in patient receiving transdermal buprenorphine. J. Pain Symptom Manage. 32 (2), 175-179 (2006). (Pubitemid 44131646)
    • (2006) Journal of Pain and Symptom Management , vol.32 , Issue.2 , pp. 175-179
    • Mercadante, S.1    Villari, P.2    Ferrera, P.3    Porzio, G.4    Aielli, F.5    Verna, L.6    Casuccio, A.7
  • 117
    • 33645471469 scopus 로고    scopus 로고
    • Systematic delivery of drugs to humans via inhalation
    • Gonda I. Systematic delivery of drugs to humans via inhalation. J. Aerosol Med. 19 (1), 47-53 (2006).
    • (2006) J. Aerosol Med. , vol.19 , Issue.1 , pp. 47-53
    • Gonda, I.1
  • 118
    • 0023759264 scopus 로고
    • Absorption and bioavailabilty of nebulized morphine
    • Chrubasik J, Wust H, Friedrich G et al. Absorption and bioavailabilty of nebulized morphine. Br. J. Anaesth. 61 (2), 228-230 (1988).
    • (1988) Br. J. Anaesth , vol.61 , Issue.2 , pp. 228-230
    • Chrubasik, J.1    Wust, H.2    Friedrich, G.3
  • 119
    • 0029936582 scopus 로고    scopus 로고
    • Systematic absorption of nebulized morphine compared with oral morphine in healthy subjects
    • Masood AR, Thomas SS. Systematic absorption of nebulized morphine compared with oral morphine in healthy subjects. Br. J. Clin. Pharmacol. 41 (3), 250-252 (1996).
    • (1996) Br. J. Clin. Pharmacol , vol.41 , Issue.3 , pp. 250-252
    • Masood, A.R.1    Thomas, S.S.2
  • 122
    • 0033822179 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of inhaled versus intravenous morphine in healthy volunteers
    • Dershwitz M, Walsh JL, Morishige RJ et al. Pharmacokinetics and pharmacodynamics of inhaled versus intravenous morphine in healthy volunteers. Anesthesiology 93 (3), 619-628 (2000).
    • (2000) Anesthesiology , vol.93 , Issue.3 , pp. 619-628
    • Dershwitz, M.1    Walsh, J.L.2    Morishige, R.J.3
  • 125
    • 0001639507 scopus 로고    scopus 로고
    • Bolus delivery of morphine solutions with the aerx pain management system (PMS)
    • Gonda I, Fiore ET, Johansson K et al. Bolus delivery of morphine solutions with the AERx pain management system (PMS). J. Aerosol Med. 12, 114 (1999).
    • (1999) J. Aerosol Med. , vol.12 , pp. 114
    • Gonda, I.1    Fiore, E.T.2    Johansson, K.3
  • 126
    • 0026076489 scopus 로고
    • Inhaled nebulised fentanyl for postoperative analgesia
    • Higgins MJ, Asbury AJ, Brodie MM. Inhaled nebulised fentanyl for postoperative analgesia. Anaesthesia 46 (11), 973-976 (1991).
    • (1991) Anaesthesia , vol.46 , Issue.11 , pp. 973-976
    • Higgins, M.J.1    Asbury, A.J.2    Brodie, M.M.3
  • 127
    • 0025338462 scopus 로고
    • Inhaled fentanyl as a method of analgesia
    • Worsley MH, MacLeod AD, Brodie MJ et al. Inhaled fentanyl as a method of analgesia. Anaesthesia 45 (6), 449-451 (1990).
    • (1990) Anaesthesia , vol.45 , Issue.6 , pp. 449-451
    • Worsley, M.H.1    MacLeod, A.D.2    Brodie, M.J.3
  • 131
    • 33750690664 scopus 로고    scopus 로고
    • Pulmonary delivery of opioids as pain therapeutics
    • Farr SJ, Otulana BB. Pulmonary delivery of opioids as pain therapeutics. Adv. Drug Deliv. Rev. 58, 1076-1088 (2006).
    • (2006) Adv. Drug Deliv. Rev , vol.58 , pp. 1076-1088
    • Farr, S.J.1    Otulana, B.B.2
  • 132
    • 64549158765 scopus 로고    scopus 로고
    • Nebulized morphine for analgesia in an emergency setting
    • Bounes V, Ducasse JL, Bona AM et al. Nebulized morphine for analgesia in an emergency setting. J. Opioid Manage. 6 (1), 23-26 (2009).
    • (2009) J. Opioid Manage , vol.6 , Issue.1 , pp. 23-26
    • Bounes, V.1    Ducasse, J.L.2    Bona, A.M.3
  • 134
    • 62949156819 scopus 로고    scopus 로고
    • Intravenous fubiprofen axetil can increase analgesic effect in refractory cancer pain
    • Wu, H, Chen Z, Sun G et al. Intravenous fubiprofen axetil can increase analgesic effect in refractory cancer pain. J. Exp. Clin. Res. 28 (33), 1-4 (2009).
    • (2009) J. Exp. Clin. Res. , vol.28 , Issue.33 , pp. 1-4
    • Wu, H.1    Chen, Z.2    Sun, G.3
  • 135
    • 0037385039 scopus 로고    scopus 로고
    • Burst ketamine to reverse opioid tolerance in cancer pain [3]
    • DOI 10.1016/S0885-3924(03)00047-2, PII S0885392403000472
    • Mercadante S, Villari P, Ferrera P et al. Burst ketamine in reserve opioid tolerance in cancer pain. J. Pain Symptom Manage. 25 (4), 302-304 (2003). (Pubitemid 36411784)
    • (2003) Journal of Pain and Symptom Management , vol.25 , Issue.4 , pp. 302-305
    • Mercadante, S.1    Villari, P.2    Ferrera, P.3
  • 136
    • 28344436049 scopus 로고    scopus 로고
    • Alternative treatments of breakthrough pain in patients receiving spinal analgesics for cancer pain
    • DOI 10.1016/j.jpainsymman.2005.04.014, PII S0885392405004975
    • Mercadante S, Arcuri E, Ferrera P et al. Alternative treatments of breakthrough pain in patients receiving spinal analgesics for cancer pain. J. Pain Symptom Manage. 30 (5), 485-491 (2005). (Pubitemid 41718968)
    • (2005) Journal of Pain and Symptom Management , vol.30 , Issue.5 , pp. 485-491
    • Mercadante, S.1    Arcuri, E.2    Ferrera, P.3    Villari, P.4    Mangione, S.5
  • 137
    • 0029131082 scopus 로고
    • Suprascapular nerve block by catheter for breakthrough shoulder cancer pain
    • Mercadante S, Sapio M, Villari P. Suprascapular nerve block by catheter for breakthrough shoulder cancer pain. Reg. Anesth. 20 (4), 343-346 (1995).
    • (1995) Reg. Anesth. , vol.20 , Issue.4 , pp. 343-346
    • Mercadante, S.1    Sapio, M.2    Villari, P.3
  • 138
    • 61349185102 scopus 로고    scopus 로고
    • An evaluation of half-body irradiation in the treatment of widespread, painful metastatic bone disease
    • Miszczyk L, Tukiendorf A, Gaborek A et al. An evaluation of half-body irradiation in the treatment of widespread, painful metastatic bone disease. Tumori 94 (6), 813-821 (2008).
    • (2008) Tumori , vol.94 , Issue.6 , pp. 813-821
    • Miszczyk, L.1    Tukiendorf, A.2    Gaborek, A.3
  • 139
    • 62349121784 scopus 로고    scopus 로고
    • Effcacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE) : A randomised controlled trial
    • Wardlaw D, Cummings SR, Meirhaeghe JV et al. Effcacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE) : a randomised controlled trial. Lancet 373, 1016-1024 (2009).
    • (2009) Lancet , vol.373 , pp. 1016-1024
    • Wardlaw, D.1    Cummings, S.R.2    Meirhaeghe, J.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.