Nebulized morphine for analgesia in an emergency setting

Journal of Opioid Management

Volumn 5, Issue 1, 2009, Pages 23-26

  Bounes, Vincent ^a   Ducassé, Jean Louis ^a   Bona, Annie Momo ^a   Battefort, Florent ^a   Houze Cerfon, Charles Henri ^a   Lauque, Dominique ^a  

^a Service d'Accueil des Urgences   (France)

Author keywords

Acute pain; Emergency medicine; Morphine; Nebulization; Opioids

Indexed keywords

MORPHINE; NARCOTIC ANALGESIC AGENT;

ABSENCE OF SIDE EFFECTS; ADULT; ANALGESIA; ARTICLE; CLINICAL ARTICLE; CLINICAL EVALUATION; CLINICAL PROTOCOL; DISEASE SEVERITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SAFETY; EMERGENCY CARE; EMERGENCY PATIENT; EMERGENCY TREATMENT; FEMALE; HUMAN; INCIDENCE; MALE; OUTCOME ASSESSMENT; PAIN; PAIN ASSESSMENT; RATING SCALE; SINGLE DRUG DOSE; TREATMENT OUTCOME; ACUTE DISEASE; EMERGENCY HEALTH SERVICE; INHALATIONAL DRUG ADMINISTRATION; NEBULIZER; PROSPECTIVE STUDY; TIME;

ACUTE DISEASE; ADMINISTRATION, INHALATION; ADULT; ANALGESICS, OPIOID; EMERGENCY MEDICAL SERVICES; FEMALE; HUMANS; MALE; MORPHINE; NEBULIZERS AND VAPORIZERS; PAIN; PROSPECTIVE STUDIES; TIME FACTORS;

EID: 64549158765     PISSN: 15517489     EISSN: None     Source Type: Journal    
DOI: 10.5055/jom.2009.0003     Document Type: Article

References (21)

1. Alliant L, Bourrier P, Brun-Ney D, et al.: Troisième conférence de consensus en médecine d'urgence de la Société francophone d'urgence médicale. Le traitement médicamenteux de la douleur de l'adulte dans un service d'accueil et d'urgence. Réan Urg. 1993; 2: 321-327.
2. Innés G, Murphy M, Nijssen-Jordan C, et al.: Procedural sedation and analgesia in the emergency department. Canadian consensus guidelines. J Emerg Med. 1998; 17: 145-156.
3. Adnet F, Alazia M, Ammirati C, et al.: Conférences d'experts. Modalités de la sedation et/ou de l'analgésie en situation extra- hospitalière. Ann Fr Anesth Reanim. 2000; 9: 56-62.
4. Krauss B, Green SM: Sedation and analgesia for procedures in children. N Engl J Med. 2000; 342: 938-945.
5. Ward KR, Yealy DM: Systemic analgesia and sedation in managing orthopedic emergencies. Emerg Med Clin North Am. 2000; 18: 141-166.
6. Masters NJ, Bennett MRD, Wedley JR: Nebulised morphine: A new delivery method for pain relief. Practitioner. 1985; 229: 649-653.
7. Keleş, SA, Toprak E, Demirel GC, et al.: Preliminary findings for preemptive analgesia with inhaled morphine: Efficacy in septoplasty and septorhinoplasty cases. Otolaryngol Head Neck Surg. 2006; 135: 85-89.
8. Thipphawong JB, Babul N, Morishige RJ, et al: Analgesic efficacy of inhaled morphine in patients after bunionectomy surgery. Anesthesiology. 2003; 99: 693-700. (Pubitemid 37051986)
9. Chrubasik S, Chrubasik J, Friedrich G, et al.: Postoperative treatment by means of a morphine aerosol: A multicenter study. In Chrubasik J, Cousins M, Martin E (eds.): Advances in Pain Therapy II. Heidelberg: Springer-Verlag, 1993: 151-167.
10. Chrubasik J, Wüst H, Friedrich G, et al.: Absorption and bioavailability of nebulized morphine. Br J Anaesth. 1988; 61: 228-230.
11. Zebraski SE, Kochenash SM, Rafa RB: Lung opioid receptors: Pharmacology and possible target for nebulized morphine in dyspnea. Life Sci. 2000; 66: 2221-2231.
12. Fulda GJ, Giberson F, Fagraeus L: A prospective randomized trial of nebulized morphine compared with patient-controlled analgesia morphine in the management of acute thoracic pain. J Trauma. 2005; 59: 383-388. (Pubitemid 41640000)
13. Dershwitz M, Walsh JL, Morishige RJ, et al.: Pharmacokinetics and pharmacodynamics of inhaled versus intravenous morphine in healthy volunteers. Anesthesiology. 2000; 93: 619-628. (Pubitemid 30703390)
14. Masood AR, Thomas SHL: Systemic absorption of nebulized morphine compared with oral morphine in healthy subjects. Br J Clin Pharmacol. 1996; 41: 250-252.
15. Kendrick DB, Strout TD: The minimum clinically significant difference in patient-assigned numeric scores for pain. Am J Emerg Med. 2005; 23: 828-832.
16. Bounes V, Charpentier S, Houze-Cerfon CH, et al.: Is there an ideal morphine dosing for pre-hospital treatment of severe acute pain: A randomized, double-blind comparison of two doses. Am J Emerg Med. 2008; 26: 148-154. (Pubitemid 351215788)
17. Silfvast T, Saarnivaara L: Comparison of alfentanil and morphine in the prehospital treatment of patient with acute ischaemic-type chest pain. Eur J Emerg Med. 2001; 8: 275-278.
18. Birnbaum A, Esses D, Bijur PE, et al.: Randomized double- blind placebo-controlled trial of two intravenous morphine dosages (0.10 mg/kg and 0.15 mg/kg) in emergency department patients with moderate to severe acute pain. Ann Emerg Med. 2007; 49: 445-453. (Pubitemid 46413416)
19. Farr SJ, Otulana BA: Pulmonary delivery of opioids as pain therapeutics. Adv Drug Deliv Rev. 2006; 58: 1076-1088.
20. Mather LE, Woodhouse A, Ward ME, et al.: Pulmonary administration of aerosolised fentanyl: Pharmacokinetic analysis of systemic delivery. Br J Clin Pharmacol. 1998; 46: 37-43. (Pubitemid 28308422)
21. McCaig LF, Burt CW: National Hospital Ambulatory Medical Care Survey: 2003 Emergency Department Summary: Advance Data from Vital and Health Statistics: No.358. Hyattsville, MD: National Center for Health Statistics, 2005.