Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery

Annals of Pharmacotherapy

Volumn 42, Issue 10, 2008, Pages 1380-1387

  Foster, David ^a   Upton, Richard ^b   Christrup, Lona ^c   Popper, Lars ^d  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d Nycomed Pharma ^*  (Denmark)

Author keywords

Acute pain; Fentanyl; Intranasal administration; Pharmacokinetic dynamic modeling

Indexed keywords

FENTANYL;

ADULT; ANALGESIC ACTIVITY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; FEMALE; HUMAN; MALE; MOLAR TOOTH; PARAMETER; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; TIME TO MAXIMUM PLASMA CONCENTRATION; TOOTH EXTRACTION;

ADMINISTRATION, INTRANASAL; ANALGESICS, OPIOID; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FENTANYL; HALF-LIFE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MOLAR, THIRD; PAIN; PAIN MEASUREMENT; TIME FACTORS; TOOTH EXTRACTION;

EID: 52949120344     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1L168     Document Type: Article

References (25)

1. Dale O, Hjortkjaer R, Kharasch ED. Nasal administration of opioids for pain management in adults. Acta Anaesthesiol Scand 2002;46:759-70.
2. Zeppetella G. An assessment of the safety, efficacy, and acceptability of intranasal fentanyl citrate in the management of cancer-related breakthrough pain: a pilot study. J Pain Symptom Manage 2000;20:253-8.
3. Striebel HW, Krämer J, Luhmann I, Rohierse-Hohler I, Rieger A. Pharmakokinetische Studie zur intranasalen Gabe von Fentanyl. Der Schmerz 1993;7:122-5.
4. Lim S, Paech MJ, Sunderland VB, Robertson MJ, Banks SL, Rucklidge MWM. Pharmacokinetics of nasal fentanyl. J Pharm Pract Res 2003;33:59-63.
5. Christrup L, Foster D, Popper L, Troen T, Upton R. Pharmacokinetics, efficacy and tolerability of fentanyl following intranasal and intravenous administration in adults undergoing third-molar extraction: a randomized, double-blind, double-dummy, two-way, cross-over study. Clin Therapeut 2008;30:469-81.
6. Galinkin JL, Fazi LM, Cuy RM, et al. Use of intranasal fentanyl in children undergoing myringotomy and tube placement during halothane and sevoflurane anesthesia. Anesthesiology 2000;93:1378-83.
7. Streibel HW, Olmann T, Spies C, Brummer G. Patient-controlled intranasal analgesia (PCINA) for the management of postoperative pain: a pilot study. J Clin Anesth 1996;8:4-8.
8. Striebel HW, Olmann T, Spies C, Rieger A, Schwagmeier R. Patient-controlled intranasal analgesia: a method for noninvasive postoperative pain management. Anesth Analg 1996;83:548-51.
9. Toussaint S, Maidl J, Schwagmeier R, Striebel HW. Patient-controlled intranasal analgesia: effective alternative to intravenous PCA for postoperative pain relief. Can J Anaesth 2000;47:299-302.
10. Manjushree R, Lahiri A, Ghosh BR, Laha A, Handa K. Intranasal fentanyl provides adequate postoperative analgesia in pediatric patients. Can J Anaesth 2002;49:190-3.
11. Paech MJ, Lim CB, Banks SL, Rucklidge MW, Doherty DA. A new formulation of nasal fentanyl spray for postoperative analgesia: a pilot study. Anaesthesia 2003;58:740-4.
12. Wong P, Chadwick FD, Karovits J. Intranasal fentanyl for postoperative analgesia after elective Caesarean section. Anaesthesia 2003;58:818-9.
13. Borland ML, Jacobs I, Geelhoed G. Intranasal fentanyl reduces acute pain in children in the emergency department: a safety and efficacy study. Emeng Med (Fremantle) 2002;14:275-80.
14. Finn J, Wright J, Fong J, et al. A randomised crossover trial of patient controlled intranasal fentanyl and oral morphine for procedural wound care in adult patients with burns. Burns 2004;30:262-8.
15. Borland ML, Bergesio R, Pascoe EM, Turner S, Woodger S. Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind cross over study. Burns 2005;31:831-7.
16. Zeppetella G. Nebulized and intranasal fentanyl in the management of cancer-related breakthrough pain. Palliat Med 2000;14:57-8.
17. Scott JC, Ponganis KV, Stanski DR. EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil. Anesthesiology 1985;62:234-41.
18. Scott JC, Stanski DR. Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp Ther 1987;240:159-66.
19. Scott JC, Cooke JE, Stanski DR. Electroencephalographic quantitation of opioid effect: comparative pharmacodynamics of fentanyl and sufentanil. Anesthesiology 1991;74:34-42.
20. Lemmens HJ, Dyck JB, Shafer SL, Stanski DR. Pharmacokinetic- pharmacodynamic modeling in drug development: application to the investigational opioid trefentanil. Clin Pharmacol Ther 1994;56:261-71.
21. World Medical Association Declaration of Helsinki. Ethical principles for medical research involving human subjects. Helsinki 1964, amended in Tokyo 1975, Venice 1983, Hong Kong 1989, South Africa 1996, Edinburgh 2000, Washington 2002, Tokyo 2004.
22. Davison AC, Hinkley DV. Bootstrap methods and their application. Cambridge, UK: Cambridge University Press, 1997.
23. Anderson BJ, Holford NH, Woollard GA, Kanagasundaram S, Mahadevan M. Perioperative pharmacodynamics of acetaminophen analgesia in children. Anesthesiology 1999;90:411-21.
24. Stanski DR, Husdon RJ, Homer TD, Saidman LJ, Meathe E. Pharmacodynamic modeling of thiopental anesthesia. J Pharmacokinet Biopharm 1984;12:223-40.
25. Peng PW, Sandler AN. A review of the use of fentanyl analgesia in the management of acute pain in adults. Anesthesiology 1999;90:576-99.