An assessment of the safety, efficacy, and acceptability of intranasal fentanyl citrate in the management of cancer-related breakthrough pain: A pilot study

Journal of Pain and Symptom Management

Volumn 20, Issue 4, 2000, Pages 253-258

  Zeppetella, Giovambattista ^a  

^a ROYAL LONDON HOSPITAL   (United Kingdom)

Author keywords

Breakthrough pain; Cancer; Fentanyl citrate; Inhaled drugs

Indexed keywords

FENTANYL CITRATE; MORPHINE; OPIATE DERIVATIVE;

ADULT; AGED; ARTICLE; CANCER PAIN; CLINICAL ARTICLE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FRACTURE; HOSPICE; HUMAN; MALE; PAIN ASSESSMENT; PILOT STUDY; PRURITUS;

ADMINISTRATION, INTRANASAL; AGED; AGED, 80 AND OVER; ANALGESIA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; FEMALE; FENTANYL; HUMAN; MALE; MIDDLE AGE; MORPHINE; NEOPLASMS; PAIN MEASUREMENT; PAIN, INTRACTABLE; PILOT PROJECTS; SUPPORT, NON-U.S. GOV'T; TERMINALLY ILL; TREATMENT OUTCOME;

EID: 0033797308     PISSN: 08853924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0885-3924(00)00180-9     Document Type: Article

References (22)

1. Fine P.G., Busch M.A. Characterisation of breakthrough pain by hospice patients and their caregivers. J Pain Symptom Manage. 16:1998;179-183.
2. Wilton N.C.T., Leigh J., Rosen D., Pandit U. Intranasal midazolam premeditation in pre-school children. Anesth Analg. 67:1988;S260.
3. Aldrete J.A., Roman-de-Jesus J.C., Russell L.J., D'Cruz O. Intranasal ketamine as induction adjunct in children. Preliminary report Anesthesiology. 67:1987;A514.
4. Mahajan R.P., Vroger V.K., Sharma S.L., Singh H. Intranasal nitroglycerin and intraocular pressure during general anesthesia. Anesth Analg. 67:1988;631-636.
5. Striebel H.W., Koenigs D., Krämer J. Post-operative pain management by intranasal demand-adapted fentanyl titration. Anesthesiology. 77:1992;281-285.
6. Mathel L.E. Clinical pharmacokinetics studies of fentanyl and its newer derivatives. Clin Pharmacokinetics. 8:1983;422-446.
7. Striebel H.W., Krämer J., Luhmann I., Rohierse-Hohler I., Rieger A. Pharmakokinetische studie zu intranasalen gabe von fentanyl. Der Schmerz. 7:1993;122-125.
8. Striebel H.W., Pommerening J., Reiger A. Intranasal fentanyl titration for postoperative pain management in an unselected population. Anaesthesia. 48:1993;753-757.
9. Striebel H.W., Oelmann T., Spies C., Rieger A., Schwagmeier R. Patient-controlled intranasal analgesia. A method for non-invasive post-operative pain management Anesth Analg. 83:1996;548-551.
10. O'Neill G., Paech M., Wood F. Preliminary clinical use of a patient-controlled intranasal analgesia (PCINA) device. Anaesth Intens Care. 25:1997;408-412.
11. Portenoy R.K., Hagen N.A. Breakthrough pain. Definition, prevalence and characteristics Pain. 41:1990;273-281.
12. Dellemijn P.L.I., Vanneste J.A.L. Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain. Lancet. 349:1997;753-758.
13. Dellemijn P.L.I., van Duijn H., Vanneste J.A.L. Prolonged treatment with transdermal fentanyl in neuropathic pain. J Pain Symptom Manage. 16:1998;220-229.
14. Levy M.H. Pharmacologic treatment of cancer pain. N Engl J Med. 335:1996;1124-1132.
15. Morphine in cancer pain. Modes of administration Br Med J. 312:1996;823-826.
16. Kalso E., Vianio A. Morphine and oxycodone hydrochloride in the management of cancer pain. Clin Pharmacol Ther. 47:1990;639-646.
17. Portenoy R.K., Payne R., Coluzzi P., Raschko J.W., Lyss A., Busch M.A., Frigerio V., Ingham J., Loseth D.B., Nordbrock E., Rhiner M. Oral transmucosal fentanyl citrate (OTFC) for the treatment of breakthrough pain in cancer patients. A controlled dose titration study Pain. 79:1999;303-312.
18. Collins S.L., Faura C.C., Moore A., McQuay H.J. Peak plasma concentrations after oral morphine. A systematic review J Pain Symptom Manage. 16:1998;388-402.
19. Hardy J.G., Lee S.W., Wilson C.G. Intranasal drug delivery by spray and drops. J Pharm Pharmacol. 37:1985;294-297.
20. Hermens W.A.J.J., Schüsler-van Hees M.T.I.W., Merkus F.W.H.M. The in vitro effect of morphine, fentanyl and sufentanil on ciliary beat frequency of human nasal epithelial tissue. Acta Pharm Technol. 33:1987;88-90.
21. Vercauteren M., Boeckx E., Hanegreefs G., Noorduin H., Vanden Bussche G. Intranasal sufentanil for pre-operative sedation. Anaesthesia. 43:1988;270-273.
22. Helmers J.H.J.H., Noorduin H., Van Peer A., Van Leeuwen L., Zuurmond W.W.A. Comparison of intravenous and intranasal sufentanil absorption and sedation. Can J Anaesth. 36:1989;494-497.