Substrate-controlled and organocatalytic asymmetric synthesis of carbocyclic amino acid dipeptide mimetics

Journal of Organic Chemistry

Volumn 75, Issue 9, 2010, Pages 2861-2876

  Hanessian, Stephen ^a   Maji, Dilip K ^a   Govindan, Subramaniyan ^a   Matera, Riccardo ^a   Tintelnot Blomley, Marina ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC SYNTHESIS; DIPEPTIDE MIMETICS; ORGANOCATALYTIC; PEPTIDOMIMETICS;

AMINO ACIDS; ELECTRON TRANSITIONS; SYNTHESIS (CHEMICAL);

ORGANIC ACIDS;

3 (1 ACETAMIDO 2 METHYLPROPYL) N [6 (BUTYLAMINO) 3 HYDROXY 5 METHYL 6 OXO 1 PHENYLHEXAN 2 YL]CYCLOHEXANECARBOXAMIDE; 3 (1 ACETAMIDO 3 METHYLBUTYL) N [6 (BUTYLAMINO) 3 HYDROXY 5 METHYL 6 OXO 1 PHENYLHEXAN 2 YL]CYCLOHEXANECARBOXAMIDE; 3 (1 ACETAMIDOETHYL) N [6 (BUTYLAMINO) 3 HYDROXY 5 METHYL 6 OXO 1 PHENYLHEXAN 2 YL]CYCLOHEXANECARBOXAMIDE; 3 (1 ACETAMIDOPROPYL) NN[6 (BUTYLAMINO) 3 HYDROXY 5 METHYL 6 OXO 1 PHENYLHEXAN 2 YL]CYCLOHEXANECARBOXAMIDE; 3(1 ACETAMIDOBUTYL) N [6 (BUTYLAMINO) 3 HYDROXY 5 METHYL 6 OXO 1 PHENYLHEXAN 2 YL]CYCLOHEXANECARBOXAMIDE; BETA SECRETASE; BETA SECRETASE 1; BETA SECRETASE 2; BETA SECRETASE INHIBITOR; CARBOXYLIC ACID DERIVATIVE; CATHEPSIN; DIPEPTIDE; PEPTIDOMIMETIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; CATALYSIS; CONTROLLED STUDY; DIASTEREOISOMER; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; STEREOCHEMISTRY;

ACIDS, CARBOCYCLIC; AMINO ACIDS; BIOMIMETIC MATERIALS; CATALYSIS; DIPEPTIDES; MOLECULAR STRUCTURE;

EID: 77951836013     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo100017t     Document Type: Article

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