Structure-based design and synthesis of novel P2/P3 modified, non-peptidic β-secretase (BACE-1) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 6, 2010, Pages 1924-1927

  Hanessian, Stephen ^a   Shao, Zhihui ^a   Betschart, Claudia ^b   Rondeau, Jean Michel ^b   Neumann, Ulf ^b   Tintelnot Blomley, Marina ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Alzheimer's disease; Peptidomimetic; Protease inhibitor

Indexed keywords

AMINO ACID; BETA SECRETASE 1 INHIBITOR; BETA SECRETASE 2 INHIBITOR; BETA SECRETASE INHIBITOR; CATHEPSIN D; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; HYDROGEN; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; IC 50; STRUCTURE ACTIVITY RELATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; CRYSTALLIZATION; ENZYME INHIBITORS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

EID: 77649180798     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.139     Document Type: Article

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