Potassium bromate, a potent DNA oxidizing agent, exacerbates germline repeat expansion in a fragile X premutation mouse model

Human Mutation

Volumn 31, Issue 5, 2010, Pages 611-616

  Entezam, Ali ^a,b   Lokanga, Adihe Rachel ^a   Le, Wei ^c   Hoffman, Gloria ^c   Usdin, Karen ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c MORGAN STATE UNIVERSITY   (United States)

Author keywords

8 dihydro 8 oxo guanine (8 oxoG); DNA repair; FMR1; Fragile X syndrome; Oxidative damage; Repeat expansion disease; Triplet repeat instability

Indexed keywords

8 HYDROXYGUANINE; GENOMIC DNA; POTASSIUM BROMATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPOSURE; FEMALE; FRAGILE X SYNDROME; GENE DELETION; GENE FREQUENCY; GENE MUTATION; GENE PREMUTATION; GENOTOXICITY; GERM LINE; HETEROZYGOTE; HOMOZYGOTE; MALE; MOUSE; NONHUMAN; OOCYTE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROGENY; SOMATIC MUTATION; TRINUCLEOTIDE REPEAT; WILD TYPE;

ANIMALS; BROMATES; DEOXYGUANOSINE; DISEASE MODELS, ANIMAL; DNA DAMAGE; FLAP ENDONUCLEASES; FRAGILE X SYNDROME; HUMANS; MICE; MICE, KNOCKOUT; TANDEM REPEAT SEQUENCES; TRINUCLEOTIDE REPEAT EXPANSION;

ANIMALIA; MUS;

EID: 77951773059     PISSN: 10597794     EISSN: 10981004     Source Type: Journal    
DOI: 10.1002/humu.21237     Document Type: Article

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