Coenzyme Q10 prevents human lens epithelial cells from light-induced apoptotic cell death by reducing oxidative stress and stabilizing BAX/Bcl-2 ratio

Acta Ophthalmologica

Volumn 88, Issue 3, 2010, Pages

  Kernt, Marcus ^a   Hirneiss, Christoph ^a   Neubauer, Aljoscha S ^a   Ulbig, Michael W ^a   Kampik, Anselm ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Ageing; Antioxidants; Cataract; Coenzyme Q10; Cytoprotection

Indexed keywords

MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UBIDECARENONE;

APOPTOSIS; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IRRADIATION; LENS EPITHELIUM; LIGHT EXPOSURE; OXIDATIVE STRESS; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; WESTERN BLOTTING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; EPITHELIAL CELLS; HUMANS; LENS, CRYSTALLINE; LIGHT; MICROSCOPY, PHASE-CONTRAST; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UBIQUINONE; VITAMINS;

EID: 77951747045     PISSN: 1755375X     EISSN: 17553768     Source Type: Journal    
DOI: 10.1111/j.1755-3768.2010.01875.x     Document Type: Article

References (71)

1. Aaberg TM Jr., Flynn HW Jr., Schiffman J Newton J (1998 Nosocomial acute-onset postoperative endophthalmitis survey. A 10-year review of incidence and outcomes. Ophthalmology 105 : 1004 1010.
2. Andley UP, Walsh A, Kochevar IE Reddan JR (1990 Effect of ultraviolet-B radiation on protein synthesis in cultured lens epithelial cells. Curr Eye Res 9 : 1099 1106.
3. Andley UP, Rhim JS, Chylack LT Jr. Fleming TP (1994 Propagation and immortalization of human lens epithelial cells in culture. Invest Ophthalmol Vis Sci 35 : 3094 3102.
4. AREDS Report No. 5 (2001 Risk factors associated with age-related nuclear and cortical cataract: a case-control study in the Age-Related Eye Disease Study. Ophthalmology 108 : 1400 1408.
5. Balasubramanian D (2000 Ultraviolet radiation and cataract. J Ocul Pharmacol Ther 16 : 285 297.
6. Bassnett S (1992 Mitochondrial dynamics in differentiating fiber cells of the mammalian lens. Curr Eye Res 11 : 1227 1232.
7. Bassnett S Beebe DC (1992 Coincident loss of mitochondria and nuclei during lens fiber cell differentiation. Dev Dyn 194 : 85 93.
8. Beal MF Shults CW (2003 Effects of Coenzyme Q10 in Huntington's disease and early Parkinson's disease. Biofactors 18 : 153 161.
9. Bloemendal H (1977 The vertebrate eye lens. Science 197 : 127 138.
10. Bloemendal H, de Jong W, Jaenicke R, Lubsen NH, Slingsby C Tardieu A (2004 Ageing and vision: structure, stability and function of lens crystallins. Prog Biophys Mol Biol 86 : 407 485.
11. Canakci CF, Cicek Y Canakci V (2005 Reactive oxygen species and human inflammatory periodontal diseases. Biochemistry (Mosc) 70 : 619 628. (Pubitemid 41118160)
12. Choudhary S, Xiao T, Vergara LA, Srivastava S, Nees D, Piatigorsky J Ansari NH (2005 Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress. Invest Ophthalmol Vis Sci 46 : 259 267.
13. Congdon N, Vingerling JR, Klein BE et al. (2004 Prevalence of cataract and pseudophakia/aphakia among adults in the United States. Arch Ophthalmol 122 : 487 494. (Pubitemid 38456283)
14. Crane FL (2001 Biochemical functions of coenzyme Q10. J Am Coll Nutr 20 : 591 598.
15. Cruickshanks KJ, Klein BE Klein R (1992 Ultraviolet light exposure and lens opacities: the Beaver Dam Eye Study. Am J Public Health 82 : 1658 1662.
16. Dillon J, Spector A Nakanishi K (1976 Identification of beta carbolines isolated from fluorescent human lens proteins. Nature 259 : 422 423.
17. ESCRS Endophthalmitis Study Group (2007 Prophylaxis of postoperative endophthalmitis following cataract surgery: results of the ESCRS multicenter study and identification of risk factors. J Cataract Refract Surg 33 : 978 988.
18. Fernandez MM Afshari NA (2008 Nutrition and the prevention of cataracts. Curr Opin Ophthalmol 19 : 66 70.
19. Ferreira SM, Lerner SF, Brunzini R, Evelson PA Llesuy SF (2004 Oxidative stress markers in aqueous humor of glaucoma patients. Am J Ophthalmol 137 : 62 69.
20. Galpern WR Cudkowicz ME (2007 Coenzyme Q treatment of neurodegenerative diseases of aging. Mitochondrion 7 (Suppl. S146 S153.
21. Halliwell B Gutteridge JM (1990 Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 186 : 1 85.
22. Hara K, Yamashita S, Fujisawa A, Ishiwa S, Ogawa T Yamamoto Y (1999 Oxidative stress in newborn infants with and without asphyxia as measured by plasma antioxidants and free fatty acids. Biochem Biophys Res Commun 257 : 244 248.
23. van Heyningen R Linklater J (1975 The metabolism of the bovine lens in air and nitrogen. Exp Eye Res 20 : 393 396.
24. Hightower KR, Reddan JR, McCready JP Dziedzic DC (1994 Lens epithelium: a primary target of UVB irradiation. Exp Eye Res 59 : 557 564.
25. Hiller R, Sperduto RD Ederer F (1986 Epidemiologic associations with nuclear, cortical, and posterior subcapsular cataracts. Am J Epidemiol 124 : 916 925.
26. Hockenbery DM (1992 The bcl-2 oncogene and apoptosis. Semin Immunol 4 : 413 420.
27. Hockwin O (1971 Age changes of lens metabolism. Altern Entwickl Aging Dev 1 : 95 129.
28. Hollyfield JG, Bonilha VL, Rayborn ME et al. (2008 Oxidative damage-induced inflammation initiates age-related macular degeneration. Nat Med 14 : 194 198.
29. Huang L, Estrada R, Yappert MC Borchman D (2006 Oxidation-induced changes in human lens epithelial cells. 1. Phospholipids. Free Radic Biol Med 41 : 1425 1432.
30. Hull DS (1990 Oxygen free radicals and corneal endothelium. Trans Am Ophthalmol Soc 88 : 463 511.
31. Imagawa M, Naruse S, Tsuji S, Fujioka A Yamaguchi H (1992 Coenzyme Q10, iron, and vitamin B6 in genetically-confirmed Alzheimer's disease. Lancet 340 : 671.
32. Ishii N, Senoo-Matsuda N, Miyake K, Yasuda K, Ishii T, Hartman PS Furukawa S (2004 Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress. Mech Ageing Dev 125 : 41 46.
33. Javitt JC Taylor HR (1994 Cataract and latitude. Doc Ophthalmol 88 : 307 325.
34. Jose JG (1986 Posterior cataract induction by UV-B radiation in albino mice. Exp Eye Res 42 : 11 20.
35. Kanthan GL, Wang JJ, Rochtchina E, Tan AG, Lee A, Chia EM Mitchell P (2008 Ten-year incidence of age-related cataract and cataract surgery in an older Australian population. The Blue Mountains Eye Study. Ophthalmology 115 : 808 814. e801.
36. Kernt M, Neubauer AS, Liegl R, Eibl KH, Alge CS, Lackerbauer CA, Ulbig MW Kampik A (2009 Cytoprotective effects of a blue light-filtering intraocular lens on human retinal pigment epithelium by reducing phototoxic effects on vascular endothelial growth factor-alpha, Bax, and Bcl-2 expression. J Cataract Refract Surg 35 : 354 362.
37. Klein BE, Cruickshanks KJ Klein R (1994 Leisure time, sunlight exposure and cataracts. Doc Ophthalmol 88 : 295 305.
38. Krishna CM, Uppuluri S, Riesz P, Zigler JS Jr. Balasubramanian D (1991 A study of the photodynamic efficiencies of some eye lens constituents. Photochem Photobiol 54 : 51 58.
39. Lee EH, Wan XH, Song J, Kang JJ, Cho JW, Seo KY Lee JH (2002 Lens epithelial cell death and reduction of anti-apoptotic protein Bcl-2 in human anterior polar cataracts. Mol Vis 8 : 235 240.
40. Levin LA, Clark JA Johns LK (1996 Effect of lipid peroxidation inhibition on retinal ganglion cell death. Invest Ophthalmol Vis Sci 37 : 2744 2749.
41. Levine AJ (1997 p53, the cellular gatekeeper for growth and division. Cell 88 : 323 331.
42. Li WC Spector A (1996 Lens epithelial cell apoptosis is an early event in the development of UVB-induced cataract. Free Radic Biol Med 20 : 301 311.
43. Li WC, Kuszak JR, Dunn K et al. (1995 Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals. J Cell Biol 130 : 169 181.
44. Li L, Duker JS, Yoshida Y, Niki E, Rasmussen H, Russell RM Yeum KJ (2009 Oxidative stress and antioxidant status in older adults with early cataract. Eye (Lond) 23 : 1464 1468.
45. Long AC, Colitz CM Bomser JA (2004 Apoptotic and necrotic mechanisms of stress-induced human lens epithelial cell death. Exp Biol Med (Maywood) 229 : 1072 1080.
46. Lux-Neuwirth O Millar TJ (1990 Lipid soluble antioxidants preserve rabbit corneal cell function. Curr Eye Res 9 : 103 109.
47. McCarthy S, Somayajulu M, Sikorska M, Borowy-Borowski H Pandey S (2004 Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water-soluble Coenzyme Q10. Toxicol Appl Pharmacol 201 : 21 31.
48. McKinnon SJ, Lehman DM, Kerrigan-Baumrind LA et al. (2002 Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. Invest Ophthalmol Vis Sci 43 : 1077 1087.
49. McNulty R, Wang H, Mathias RT, Ortwerth BJ, Truscott RJ Bassnett S (2004 Regulation of tissue oxygen levels in the mammalian lens. J Physiol 559 : 883 898.
50. Mitchell P, Cumming RG, Attebo K Panchapakesan J (1997 Prevalence of cataract in Australia: the Blue Mountains eye study. Ophthalmology 104 : 581 588. (Pubitemid 27171978)
51. Miyashita T Reed JC (1995 Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80 : 293 299.
52. Miyashita T, Harigai M, Hanada M Reed JC (1994 Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res 54 : 3131 3135.
53. Mosmann T (1983 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65 : 55 63.
54. Nakajima Y, Inokuchi Y, Nishi M, Shimazawa M, Otsubo K Hara H (2008 Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo. Brain Res 1226 : 226 233.
55. Nickells RW Zack DJ (1996 Apoptosis in ocular disease: a molecular overview. Ophthalmic Genet 17 : 145 165.
56. Nishikawa T, Edelstein D, Du XL et al. (2000 Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404 : 787 790.
57. Ohira A, Ueda T, Ohishi K, Hiramitsu T, Akeo K Obara Y (2008 Oxidative stress in ocular disease. Nippon Ganka Gakkai Zasshi 112 : 22 29.
58. Papucci L, Schiavone N, Witort E et al. (2003 Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property. J Biol Chem 278 : 28220 28228.
59. Riaz Y, Mehta JS, Wormald R, Evans JR, Foster A, Ravilla T Snellingen T (2006 Surgical interventions for age-related cataract. Cochrane Database Syst Rev CD001323.
60. Sacca SC, Pascotto A, Camicione P, Capris P Izzotti A (2005 Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma. Arch Ophthalmol 123 : 458 463.
61. Sandhu JK, Pandey S, Ribecco-Lutkiewicz M, Monette R, Borowy-Borowski H, Walker PR Sikorska M (2003 Molecular mechanisms of glutamate neurotoxicity in mixed cultures of NT2-derived neurons and astrocytes: protective effects of coenzyme Q10. J Neurosci Res 72 : 691 703.
62. Shults CW (2003 Coenzyme Q10 in neurodegenerative diseases. Curr Med Chem 10 : 1917 1921.
63. Somayajulu M, McCarthy S, Hung M, Sikorska M, Borowy-Borowski H Pandey S (2005 Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiol Dis 18 : 618 627.
64. Spector A (1995 Oxidative stress-induced cataract: mechanism of action. FASEB J 9 : 1173 1182.
65. Spector A, Wang GM, Wang RR, Li WC Kleiman NJ (1995 A brief photochemically induced oxidative insult causes irreversible lens damage and cataract. II. Mechanism of action. Exp Eye Res 60 : 483 493.
66. Temple MD, Perrone GG Dawes IW (2005 Complex cellular responses to reactive oxygen species. Trends Cell Biol 15 : 319 326.
67. The Italian-American Cataract Study Group (1991 Risk factors for age-related cortical, nuclear, and posterior subcapsular cataracts. The Italian-American Cataract Study Group. Am J Epidemiol 133 : 541 553.
68. Wajda R, Zirkel J Schaffer T (2007 Increase of bioavailability of coenzyme Q(10) and vitamin E. J Med Food 10 : 731 734.
69. Watts GF, Playford DA, Croft KD, Ward NC, Mori TA Burke V (2002 Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. Diabetologia 45 : 420 426.
70. West SK Valmadrid CT (1995 Epidemiology of risk factors for age-related cataract. Surv Ophthalmol 39 : 323 334.
71. Williams DL (2008 Oxidative stress and the eye. Vet Clin North Am Small Anim Pract 38 : 179 192. vii.