Characterization of changes in global gene expression in the brain of neuron-specific enolase/human Tau23 transgenic mice in response to overexpression of Tau protein

International Journal of Molecular Medicine

Volumn 25, Issue 5, 2010, Pages 667-675

  Woo, Jong Min ^a,b   Park, So Jung ^a   Kang, Ho Il ^a   Kim, Byoung Guk ^a   Shim, Sun Bo ^a   Jee, Seung Wan ^a   Lee, Su Hae ^a   Sin, Ji Soon ^a   Bae, Chang Joon ^a   Jang, Mee Kyung ^a   Cho, Chunghee ^b   Hwang, Dae Youn ^c   Kim, Chuel Kyu ^a  

^a Korea FDA   (South Korea)

^b Gwangju Institute of Science and Technology (GIST)   (South Korea)

^c Pusan National University   (South Korea)

Author keywords

Alzheimer's disease; Microarray; Tau23 protein; Transgenic mice

Indexed keywords

BIOTIN; CHAPERONE; COMPLEMENTARY DNA; CYTOSKELETON PROTEIN; ENOLASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; OLIGONUCLEOTIDE; OXIDOREDUCTASE; TAU PROTEIN; TRANSCRIPTION FACTOR;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC TRAIT; GENETIC TRANSCRIPTION; HIPPOCAMPUS; HUMAN; MALE; MICROARRAY ANALYSIS; MOLECULAR MECHANICS; MOUSE; NERVE CELL; NEUROFIBRILLARY TANGLE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BRAIN; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHOPYRUVATE HYDRATASE; TAU PROTEINS;

EID: 77951725117     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000390     Document Type: Article

References (46)

1. Hebert LE, Scherr PA, Bienias JL, Bennett DA and Evans DA: Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 60: 1119-1122, 2003.
2. Citron M: Strategies for disease modification in Alzheimer's disease. Nat Rev Neurosci 5: 677-685, 2004.
3. Wang DS, Dickson DW and Malter JS: ß-Amyloid degradation and Alzheimer's Disease. J Biomed Biotech 2006: 58406, 2006.
4. Urbanc B, Cruz L, Buldyrev SV, Havlin S, Irizarry MC, Stanley HE and Hyman BT: Dynamics of plaque formation in Alzheimer's disease. J Biophys 76: 1330-1334, 1999. (Pubitemid 29262614)
5. Cruz L, Urbanc B, Buldyrev SV, Christie R, Gómez-Isla T, Havlin S, McNamara M, Stanley HE and Hyman BT: Aggregation and disaggregation of senile plaques in Alzheimer disease. Proc Natl Acad Sci USA 94: 7612-7616, 1997. (Pubitemid 27345364)
6. Mattson MP: Pathways towards and away from Alzheimer's disease. Nature 430: 631-639, 2000.
7. Evin G and Weidemann A: Biogenesis and metabolism of Alzheimer's disease A beta amyloid peptides. Peptide 23: 1285-1297, 2002. (Pubitemid 34786707)
8. Brion JP, Couck AM, Passareiro E and Flament-Durand J: Neurofibrillary tangles of Alzheimer's disease: an immuno-histochemical study. J Submicrosc Cytol 17: 89-96, 1985. (Pubitemid 15158027)
9. Utton MA, Vandecandelaere A, Wagner U, Reynolds CH, Gibb GM, Miller CC, Bayley PM and Anderton BH: Phosphorylation of tau by glycogen synthase kinase 3beta affects the ability of tau to promote microtubule self-assembly. Biochem J 323: 741-747, 1997. (Pubitemid 27202345)
10. Friedhoff P, von Bergen M, Mandelkow EM and Mandelkow E: Structure of tau protein and assembly into paired helical filaments. Biochim Biophys Acta 1502: 122-132, 2000. (Pubitemid 30433861)
11. Billingsley ML and Kincaid RL: Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration. Biochem J 323: 577-591, 1997.
12. Ahlijanian MK, Barrezueta NX, Williams RD, Jakowski A, Kowsz KP, McCarthy S, Coskran T, Carlo A, Seymour PA, Burkhardt JE, Nelson RB and McNeish JD: Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proc Natl Acad Sci USA 97: 2910-2915, 2000. (Pubitemid 30159271)
13. Leroy K, Yilmaz Z and Brion JP: Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration. Neuropathol Appl Neurobiol 33: 43-55, 2007. (Pubitemid 46090309)
14. Schindowski K, Belarbi K, Bretteville A, Ando K and Buée L: Neurogenesis and cell cycle-reactivated neuronal death during pathogenic tau aggregation. Genes Brain Behav 7 (suppl 1): 92-100, 2008.
15. Wagner U, Utton M, Gallo JM and Miller CC: Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation. J Cell Sci 109: 1537-1543, 1996. (Pubitemid 26190502)
16. Biernat J, Gustke N, Drewes G, Mandelkow EM and Mandelkow E: Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immuno-reactivity and microtubule binding. Neuron 11: 153-163, 1993. (Pubitemid 23222542)
17. Lu Q and Wood JG: Functional studies of Alzheimer's disease tau protein. J Neurosci 13: 508-515, 1993. (Pubitemid 23045135)
18. Trinczek B, Biernat J, Baumann K, Mandelkow EM and Mandelkow E: Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules. Mol Biol Cell 6: 1887-1902, 1995.
19. Lindwall G and Cole RD: Phosphorylation affects the ability of tau to promote microtubule assembly. J Biol Chem 259: 5301-5305, 1984. (Pubitemid 14140641)
20. Spires TL and Hyman BT: Transgenic models of Alzheimer's Disease: Learning from animals. NeuroRx 2: 423-437, 2005. (Pubitemid 41444876)
21. Hutton M, Lewis J, Dickson D, Yen SH and McGowan E: Analysis of tauopathies with transgenic mice. Trends Mol Med 7: 467-470, 2001.
22. Shim SB, Lim HJ, Chae KR, Kim CK, Hwang DY, Jee SW, Lee SH, Sin JS, Leem YH, Lee SH, Cho JS, Lee HH, Choi SY and Kim YK: Tau overexpression in transgenic mice induces glycogen synthase kinase 3beta and beta-catenin phosphorylation. Neuroscience 146: 730-740, 2007.
23. Benjamini Y and Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Statist Soc Ser B 57: 289-300, 1995.
24. Elnakat H and Ratnam M: Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy. Adv Drug Deliv Rev 56: 1067-1084, 2004. (Pubitemid 38496508)
25. Cazzaniga E, Bulbarelli A, Lonati E, Re F, Galimberti G, Gatti E, Pitto M, Ferrarese C and Masserini M: Enhanced folate binding of cultured fibroblasts from Alzheimer's disease patients. Neurosci Lett 436: 317-320, 2008.
26. Costa C, Tortosa R, Rodríguez A, Ferrer I, Torres JM, Bassols A and Pumarola M: Aquaporin 1 and aquaporin 4 overexpression in bovine spongiform encephalopathy in a transgenic murine model and in cattle field cases. Brain Res 1175: 96-106, 2007. (Pubitemid 47520609)
27. Nielsen S, Smith BL, Christensen EI and Agre P: Distribution of the aquaporin chip in secretory and resorptive epithelia and capillary endothelia. Proc Natl Acad Sci USA 90: 7275-7727, 1993.
28. Nagy G, Szekeres G, Kvell K, Berki T and Németh P: Development and characterisation of a monoclonal antibody family against aquaporin 1 (Aqp1) and aquaporin 4 (Aqp4). Pathol Oncol Res 8: 115-124, 2002. (Pubitemid 34988061)
29. Rodriguez A, Pérez-Gracia E, Espinosa JC, Pumarola M, Torres JM and Ferrer I: Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice. Acta Neuropathol 112: 573-585, 2006. (Pubitemid 44550681)
30. Pérez E, Barrachina M, Rodríguez A, Torrejón- Escribano B, Boada M, Hernández I, Sánchez M and Ferrer I: Aquaporin expression in the cerebral cortex is increased at early stages of Alzheimer disease. Brain Res 1128: 164-174, 2007. (Pubitemid 46048625)
31. Morita K, Furuse M, Fujimoto K and Tsukita S: Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci USA 96: 511-516, 1999. (Pubitemid 29061239)
32. Morita K, Sasaki H, Furuse M and Tsukita S: Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J Cell Biol 147: 185-194, 1999. (Pubitemid 30211806)
33. Lamas M, González-Mariscal L and Gutiérrez R: Presence of claudins mRNA in the brain. Selective modulation of expression by kindling epilepsy. Brain Res Mol Brain Res 104: 250-254, 2002.
34. Marco S and Skaper SD: Amyloid beta-peptide1-42 alters tight junction protein distribution and expression in brain microvessel endothelial cells. Neurosci Lett 401: 219-224, 2006. (Pubitemid 44250979)
35. Desai BS, Monahan AJ, Carvey PM and Hendey B: Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: implications for drug therapy. Cell Transplant 16: 285-299, 2007.
36. Liebner SM, Corada M, Bangsow T, Babbage J, Taddei A, Czupalla CJ, Reis M, Felici A, Wolburg H, Fruttiger M, Taketo MM, von Melchner H, Plate KH, Gerhardt H and Dejana E: Wnt/ß-catenin signaling controls development of the blood-brain barrier. J Cell Biol 183: 409-417, 2008.
37. Polakis P: Formation of the blood-brain barrier: Wnt signaling seals the deal. J Cell Biol 183: 371-373, 2008.
38. Zlokovic BV: The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57: 178-201, 2008.
39. Van der Laan S, Lachize SB, Vreugdenhil E, de Kloet ER and Meijer OC: Nuclear receptor coregulators differentially modulate induction and glucocorticoid receptor-mediated repression of the corticotropin-releasing hormone gene. Endocrinology 149: 725-732, 2008. (Pubitemid 351159322)
40. Jepsen K, Hermanson O, Onami TM, Gleiberman AS, Lunyak V, McEvilly RJ, Kurokawa R, Kumar V, Liu F, Seto E, Hedrick SM, Mandel G, Glass CK, Rose DW and Rosenfeld MG: Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell 102: 753-763, 2000.
41. Van der Laan S, Lachize SB, Schouten TG, Vreugdenhil E, de Kloet ER and Meijer OC: Neuroanatomical distribution and colocalisation of nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid receptors (SMRT) in rat brain. Brain Res 1059: 113-121, 2005. (Pubitemid 41457308)
42. Hoerndli FJ, Pelech S, Papassotiropoulos A and Götz J: Abeta treatment and P301L tau expression in an Alzheimer's disease tissue culture model act synergistically to promote aberrant cell cycle re-entry. Eur J Neurosci 26: 60-72, 2007. (Pubitemid 47035431)
43. Lagenaur C, Kunemund V, Fischer G, Fushiki S and Schachner M: Monoclonal M6 antibody interferes with neurite extension of cultured neurons. J Neurobiol 23: 71-88, 1992.
44. Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, Wenger SL, Yan Y, Lagenaur C and Narayanan V: Chromosomal mapping of the human M6 genes. Genomics 33: 532-536, 1996.
45. Alfonso J, Fernández ME, Cooper B, Flugge G and Frasch AC: The stress-regulated protein M6a is a key modulator for neurite outgrowth and filopodium/spine formation. Proc Natl Acad Sci USA 102: 17196-17201, 2005. (Pubitemid 41692706)
46. Xu PT, Li YJ, Qin XJ, Scherzer CR, Xu H, Schmechel DE, Hulette CM, Ervin J, Gullans SR, Haines J, Pericak-Vance MA and Gilbert JR: Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. Neurobiol Dis 21: 256-275, 2006. (Pubitemid 43099851)