Enhanced folate binding of cultured fibroblasts from Alzheimer's disease patients

Neuroscience Letters

Volumn 436, Issue 3, 2008, Pages 317-320

  Cazzaniga, Emanuela ^a   Bulbarelli, Alessandra ^a   Lonati, Elena ^a   Re, Francesca ^a   Galimberti, Gloria ^a   Gatti, Elena ^a   Pitto, Marina ^a   Ferrarese, Carlo ^a,b,c   Masserini, Massimo ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b SAN GERARDO HOSPITAL   (Italy)

^c SCIENTIFIC INSTITUTE   (Italy)

Author keywords

Alzheimer's disease; Fibroblasts; Folate; Folate carrier; Folate receptor

Indexed keywords

FOLIC ACID;

ALZHEIMER DISEASE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CARRIER PROTEINS; CELLS, CULTURED; FEMALE; FIBROBLASTS; FOLIC ACID; GENE EXPRESSION REGULATION; HUMANS; MALE; MENTAL STATUS SCHEDULE; RADIOACTIVITY; RECEPTORS, CELL SURFACE; RNA, MESSENGER;

EID: 43049117915     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.03.046     Document Type: Article

References (28)

1. Begni B., Brighina L., Sirtori E., Fumagalli L., Andreoni S., Beretta S., Oster T., Malaplate-Armand C., Isella V., Appollonio I., and Ferrarese C. Oxidative stress impairs glutamate uptake in fibroblasts from patients with Alzheimer's disease. Free Radic. Biol. Med. 37 (2004) 892-901
2. Brzezińska A., Wińska P., and Balińska M. Cellular aspects of folate and antifolate membrane transport. Acta Biochim. Pol. 47 (2000) 735-749
3. Clarke R., Smith A.D., Jobst K.A., Refsum H., Sutton L., and Ueland P.M. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol. 55 (1998) 1449-1455
4. D'Anci K.E., and Rosenberg I.H. Folate and brain function in the elderly. Curr. Opin. Clin. Nutr. Metab. Care 7 (2004) 659-664
5. Dhitavat S., Ortiz D., Rogers E., Rivera E., and Shea T.B. Folate, vitamin E, and acetyl-l-carnitine provide synergistic protection against oxidative stress resulting from exposure of human neuroblastoma cells to amyloid-beta. Brain Res. 1061 (2005) 114-117
6. Elnakat H., and Ratnam M. Distribution, functionality and gene regulation of folate receptor isofroms: implication in targeted therapy. Adv. Drug Deliv. Rev. 56 (2004) 1067-1084
7. Emiliani C., Urbanelli L., Racanicchi L., Orlacchio A., Pelicci G., Sorbi S., Bernardi G., and Orlacchio A. Up-regulation of glycohydrolases in Alzheimer's disease fibroblasts correlates with Ras activation. J. Biol. Chem. 278 (2003) 38453-38460
8. Ferrarese C., and Di Luca M. Biological markers in Alzheimer disease. Neurobiol. Aging 24 (2003) 191-193
9. Gasparini L., Racchi M., Binetti G., Trabucchi M., Solerte S.B., Alkon D., Etcheberrigaray R., Gibson G., Blass J., Paoletti R., and Govoni S. Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease. FASEB J. 12 (1998) 17-34
10. Govoni S., Bergamaschi S., Racchi M., Battaini F., Binetti G., Bianchetti A., and Trabucchi M. Cytosol protein kinase C downregulation in fibroblasts from Alzheimer's disease patients. Neurology 43 (1993) 2581-2586
11. Kamen B.A., Wang M.T., Streckfuss A.J., Peryea X., and Anderson R.G.W. Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles. J. Biol. Chem. 263 (1988) 13602-13609
12. Khan T.K., and Alkon D.L. An internally controlled peripheral biomarker for Alzheimer's disease: Erk1 and Erk2 responses to the inflammatory signal bradykinin. Proc. Natl. Acad. Sci. USA 103 (2006) 13203-13207
13. Kruman I.I., Kumaravel T.S., Lohani A., Pedersen W.A., Cutler R.G., Kruman Y., Haughey N., Lee J., Evans M., and Mattson M.P. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to Amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci. 22 (2002) 1752-1762
14. Lahiri D.K., Rogers J.T., Greig N.H., and Sambamurti K. Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents. Curr. Pharm. Des. 10 (2004) 3111-3119
15. Luchsinger J.A., and Mayeux R. Dietary factors and Alzheimer's disease. Lancet Neurol. 3 (2004) 579-587
16. Malaguarnera M., Ferri R., Bella R., Alagona G., Carnemolla A., and Pennini G. Homocysteine, vitamin B12 and folate in vascular dementia and in Alzheimer disease. Clin. Chem. Lab. Med. 42 (2004) 1032-1035
17. Pensalfini A., Cecchi C., Zampagni M., Becatti M., Favilli F., Paoli P., Catarzi S., Bagnoli S., Nacmias B., Sorbi S., and Liguri G. Protective effect of new S-acylglutathione derivatives against amyloid-induced oxidative stress. Free Radic. Biol. Med. 44 (2008) 1624-1636
18. Peterson G.L. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem. 83 (1977) 346-356
19. Peterson C., and Goldman J.E. Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors. Proc. Natl. Acad. Sci. USA 83 (1986) 2758-2762
20. Pitto M., Raimondo F., Zoia C., Brighina L., Ferrarese C., and Masserini M. Enhanced GM1 ganglioside catabolism in cultured fibroblasts from Alzheimer patients. Neurobiol. Aging 26 (2005) 833-838
21. Quadri P., Fragiacomo C., Pezzati R., Zanda E., Forloni G., Tettamanti M., and Lucca U. Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am. J. Clin. Nutr. 80 (2004) 114-122
22. Ravaglia G., Forti P., Maioli F., Martelli M., Servadei L., Brunetti N., Porcellini E., and Licastro F. Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am. J. Clin. Nutr. 82 (2005) 636-643
23. Ravaglia G., Forti P., Maioli F., Martelli M., Servadei L., Brunetti N., Pantieri G., and Mariani E. Conversion of mild cognitive impairment to dementia: predictive role of mild cognitive impairment subtypes and vascular risk factors. Dement. Geriatr. Cogn. Disord. 21 (2006) 51-58
24. Salazar M.D., and Ratnam M. Cancer Metastasis Rev. The folate receptor: what does it promise in tissue-targeted therapeutics? 26 (2007) 141-152
25. Sims N.R., Finegan J.M., and Blass J.P. Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease. Ann. Neurol. 21 (1987) 451-457
26. Vestling M., Cedazo-Minguez A., Adem A., Wiehager B., Racchi M., Lannfelt L., and Cowburn R.F. Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease cases. Biochim. Biophys. Acta 1453 (1999) 341-350
27. 12 and folate in relation to the development of Alzheimer's disease. Neurology 56 (2001) 1188-1194
28. Zoia C.P., Tagliabue E., Isella V., Begni B., Fumagalli L., Appollonio I., Racchi M., and Ferrarese C. Fibroblast glutamate transport in aging and in AD: correlations with disease severity. Neurobiol. Aging 26 (2005) 825-832