Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF

Biochemical and Biophysical Research Communications

Volumn 290, Issue 1, 2002, Pages 475-481

  Kaibori, Masaki ^a   Inoue, Tomohisa ^a   Oda, Michio ^a   Kwon, A Hon ^a   Kamiyama, Yasuo ^a   Okumura, Tadayoshi ^a   Naka, Daiji ^b   Kawaguchi, Toshiya ^b   Kitamura, Naomi ^c   Miyazawa, Keiji ^c  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b MITSUBISHI CHEMICAL CORPORATION   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Hepatocyte growth factor (HGF); HGF precursor; HGF receptor c Met; HGF activator; Partial hepatectomy

Indexed keywords

CELL NUCLEUS ANTIGEN; METHIONINE; PROTEIN PRECURSOR; RECOMBINANT HEPATOCYTE GROWTH FACTOR ACTIVATOR; RECOMBINANT PROTEIN; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; LIVER CELL; LIVER LEVEL; LIVER REGENERATION; LIVER RESECTION; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0036289786     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6170     Document Type: Article

References (40)

1. Molecular cloning and expression of human hepatocyte growth factor
2. Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor
3. Proteolytic activation of hepatocyte growth factor in response to tissue injury
4. Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer
5. Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells
6. Emerging multipotent aspects of hepatocyte growth factor
7. Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
8. Activation of hepatocyte growth factor by the plasminogen activator uPA and tPA
9. Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII
10. Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XII a and hepatocyte growth factor activator
11. Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator
12. Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat
13. Induction of hepatocyte growth factor activator messenger RNA in the liver following tissue injury and acute inflammation
14. Activation of the zymogen of hepatocyte growth factor activator by thrombin
15. Roles of HGF as a pleiotropic factor in organ regeneration
16. Human hepatocyte growth factor in blood of patients with fulminant hepatic failure. I
17. Marked increase of HGF mRNA in non-parenchymal liver cells of rats treated with hepatotoxins
18. Primary structure of rat hepatocyte growth factor and induction of its mRNA during liver regeneration following hepatic injury
19. Serum hepatocyte growth factor levels in hepatectomized and nonhepatectomized surgical patients
20. Hepatocyte growth factor concentrations after liver resection
21. Changes in serum human hepatocyte growth factor levels after transcatheter arterial immobilization and partial hepatectomy
22. Elevation of hepatocyte growth factor levels in portal and hepatic veins immediately after hepatic resection in cirrhotic patients
23. Serum hepatocyte growth factor levels in liver diseases: Clinical implications
24. Evidence for the presence of an inactive precursor of human hepatocyte growth factor in plasma and sera of patients with liver diseases
25. u-PA and c-MET mRNA expression is co-ordinately enhanced while hepatocyte growth factor mRNA is down-regulated in human hepatocellular carcinoma
26. Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: An immunohistochemical study
27. Hepatocyte growth factor remains as an inactive single chain after partial hepatectomy or unilateral nephrectomy
28. Experimental pathology of the liver: Restoration of the liver of the white rat following partial removal
29. Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular micro-environment
30. An alternatively processed mRNA generated from human hepatocyte growth factor gene
31. Hepatocyte regeneration in acute fulminant and nonfulminant hepatitis: A study of proliferating cell nuclear antigen expression
32. Proliferating cell nuclear antigen (PCNA) expression in regenerating rat liver after partial hepatectomy
33. Functional identity of proliferating cell nuclear antigen and a DNA polymerase-δ auxiliary protein
34. Stimulation of liver regeneration and function after partial hepatectomy in cirrhotic rats by continuous infusion of recombinant human hepatocyte growth factor
35. Hepatocyte growth factor
36. Sulfated oligosaccharides promote hepatocyte growth factor association and govern its mitogenic activity
37. Internalization and degradation of hepatocyte growth factor in hepatocytes with down-regulation of the receptor/c-Met
38. Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor
39. Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor
40. Hepatocyte growth factor promotes migration of human hepatocellular carcinoma via phosphatidylinositol 3-kinase