-
1
-
-
0027289115
-
Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII
-
Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y Kitamura N (1993) Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII. J Biol Chem 268, 10024 10028.
-
(1993)
J Biol Chem
, vol.268
, pp. 10024-10028
-
-
Miyazawa, K.1
Shimomura, T.2
Kitamura, A.3
Kondo, J.4
Morimoto, Y.5
Kitamura, N.6
-
2
-
-
67650472211
-
Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein
-
Kawaguchi M, Orikawa H, Baba T, Fukushima T Kataoka H (2009) Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein. FEBS J 276, 3481 3490.
-
(2009)
FEBS J
, vol.276
, pp. 3481-3490
-
-
Kawaguchi, M.1
Orikawa, H.2
Baba, T.3
Fukushima, T.4
Kataoka, H.5
-
3
-
-
77951719025
-
Hepatocyte growth factor activator (HGFA): Pathophysiological functions in vivo
-
Kataoka H Kawaguchi M (2010) Hepatocyte growth factor activator (HGFA): pathophysiological functions in vivo. FEBS J 277, 2230 2237.
-
(2010)
FEBS J
, vol.277
, pp. 2230-2237
-
-
Kataoka, H.1
Kawaguchi, M.2
-
4
-
-
13844296946
-
Conformational lability in serine protease active sites: Structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B
-
Shia S, Stamos J, Kirchhofer D, Fan B, Wu J, Corpuz RT, Santell L, Lazarus RA Eigenbrot C (2005) Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B. J Mol Biol 346, 1335 1349.
-
(2005)
J Mol Biol
, vol.346
, pp. 1335-1349
-
-
Shia, S.1
Stamos, J.2
Kirchhofer, D.3
Fan, B.4
Wu, J.5
Corpuz, R.T.6
Santell, L.7
Lazarus, R.A.8
Eigenbrot, C.9
-
5
-
-
0014405092
-
On the active site of proteases. 3. Mapping the active site of papain; Specific peptide inhibitors of papain
-
Schechter I Berger A (1968) On the active site of proteases. 3. Mapping the active site of papain; specific peptide inhibitors of papain. Biochem Biophys Res Commun 32, 898 902.
-
(1968)
Biochem Biophys Res Commun
, vol.32
, pp. 898-902
-
-
Schechter, I.1
Berger, A.2
-
6
-
-
0028914722
-
Structural basis of substrate specificity in the serine proteases
-
Perona JJ Craik CS (1995) Structural basis of substrate specificity in the serine proteases. Protein Sci 4, 337 360.
-
(1995)
Protein Sci
, vol.4
, pp. 337-360
-
-
Perona, J.J.1
Craik, C.S.2
-
7
-
-
38049174343
-
Structural insight into distinct mechanisms of protease inhibition by antibodies
-
Wu Y, Eigenbrot C, Liang WC, Stawicki S, Shia S, Fan B, Ganesan R, Lipari MT Kirchhofer D (2007) Structural insight into distinct mechanisms of protease inhibition by antibodies. Proc Natl Acad Sci USA 104, 19784 19789.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19784-19789
-
-
Wu, Y.1
Eigenbrot, C.2
Liang, W.C.3
Stawicki, S.4
Shia, S.5
Fan, B.6
Ganesan, R.7
Lipari, M.T.8
Kirchhofer, D.9
-
8
-
-
33947092515
-
Structural basis of the activation and action of trypsin
-
Huber R Bode W (1978) Structural basis of the activation and action of trypsin. Acc Chem Res 11, 114 122.
-
(1978)
Acc Chem Res
, vol.11
, pp. 114-122
-
-
Huber, R.1
Bode, W.2
-
9
-
-
71049189254
-
Unraveling the allosteric mechanism of serine protease inhibition by an antibody
-
Ganesan R, Eigenbrot C, Wu Y, Liang W-C, Shia S, Lipari MT Kirchhofer D (2009) Unraveling the allosteric mechanism of serine protease inhibition by an antibody. Structure 17, 1614 1624.
-
(2009)
Structure
, vol.17
, pp. 1614-1624
-
-
Ganesan, R.1
Eigenbrot, C.2
Wu, Y.3
Liang, W.-C.4
Shia, S.5
Lipari, M.T.6
Kirchhofer, D.7
-
11
-
-
0036385841
-
The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region
-
Marquardt U, Zettl F, Huber R, Bode W Sommerhoff C (2002) The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region. J Mol Biol 321, 491 502.
-
(2002)
J Mol Biol
, vol.321
, pp. 491-502
-
-
Marquardt, U.1
Zettl, F.2
Huber, R.3
Bode, W.4
Sommerhoff, C.5
-
12
-
-
0023192209
-
Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution
-
Fujinaga M James MN (1987) Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution. J Mol Biol 195, 373 396.
-
(1987)
J Mol Biol
, vol.195
, pp. 373-396
-
-
Fujinaga, M.1
James, M.N.2
-
13
-
-
2342659637
-
Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease
-
Wilken C, Kitzing K, Kurzbauer R, Ehrmann M Clausen T (2004) Crystal structure of the DegS stress sensor: how a PDZ domain recognizes misfolded protein and activates a protease. Cell 117, 483 494.
-
(2004)
Cell
, vol.117
, pp. 483-494
-
-
Wilken, C.1
Kitzing, K.2
Kurzbauer, R.3
Ehrmann, M.4
Clausen, T.5
-
14
-
-
0036382902
-
Crystal structure of a prostate kallikrein isolated from stallion seminal plasma: A homologue of human PSA
-
Carvalho AL, Sanz L, Barettino D, Romero A, Calvete JJ Romao MJ (2002) Crystal structure of a prostate kallikrein isolated from stallion seminal plasma: a homologue of human PSA. J Mol Biol 322, 325 337.
-
(2002)
J Mol Biol
, vol.322
, pp. 325-337
-
-
Carvalho, A.L.1
Sanz, L.2
Barettino, D.3
Romero, A.4
Calvete, J.J.5
Romao, M.J.6
-
15
-
-
58049218442
-
Structure of human prostasin, a target for the regulation of hypertension
-
Rickert KW, Kelley P, Byrne NJ, Diehl RE, Hall DL, Montalvo AM, Reid JC, Shipman JM, Thomas BW, Munshi SK et al. (2008) Structure of human prostasin, a target for the regulation of hypertension. J Biol Chem 283, 34864 34872.
-
(2008)
J Biol Chem
, vol.283
, pp. 34864-34872
-
-
Rickert, K.W.1
Kelley, P.2
Byrne, N.J.3
Diehl, R.E.4
Hall, D.L.5
Montalvo, A.M.6
Reid, J.C.7
Shipman, J.M.8
Thomas, B.W.9
Munshi, S.K.10
-
16
-
-
68849090838
-
Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations
-
Spraggon G, Hornsby M, Shipway A, Tully DC, Bursulaya B, Danahay H, Harris JL Lesley SA (2009) Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations. Protein Sci 18, 1081 1094.
-
(2009)
Protein Sci
, vol.18
, pp. 1081-1094
-
-
Spraggon, G.1
Hornsby, M.2
Shipway, A.3
Tully, D.C.4
Bursulaya, B.5
Danahay, H.6
Harris, J.L.7
Lesley, S.A.8
-
17
-
-
0037184613
-
The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features
-
Hink-Schauer C, Estebanez-Perpina E, Wilharm E, Fuentes-Prior P, Klinkert W, Bode W Jenne DE (2002) The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features. J Biol Chem 277, 50923 50933.
-
(2002)
J Biol Chem
, vol.277
, pp. 50923-50933
-
-
Hink-Schauer, C.1
Estebanez-Perpina, E.2
Wilharm, E.3
Fuentes-Prior, P.4
Klinkert, W.5
Bode, W.6
Jenne, D.E.7
-
18
-
-
28044444092
-
The structure of thrombin, a chameleon-like proteinase
-
Bode W (2005) The structure of thrombin, a chameleon-like proteinase. J Thromb Haemost 3, 2379 2388.
-
(2005)
J Thromb Haemost
, vol.3
, pp. 2379-2388
-
-
Bode, W.1
-
19
-
-
0010333946
-
Coagulation factor IXa: The relaxed conformation of Tyr99 blocks substrate binding
-
Hopfner KP, Lang A, Karcher A, Sichler K, Kopetzki E, Brandstetter H, Huber R, Bode W Engh RA (1999) Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding. Structure 7, 989 996.
-
(1999)
Structure
, vol.7
, pp. 989-996
-
-
Hopfner, K.P.1
Lang, A.2
Karcher, A.3
Sichler, K.4
Kopetzki, E.5
Brandstetter, H.6
Huber, R.7
Bode, W.8
Engh, R.A.9
-
20
-
-
0030959346
-
The thrombin E192Q-BPTI complex reveals gross structural rearrangements: Implications for the interaction with antithrombin and thrombomodulin
-
van de Locht A, Bode W, Huber R, Le Bonniec BF, Stone SR, Esmon CT Stubbs MT (1997) The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin. EMBO J 16, 2977 2984.
-
(1997)
EMBO J
, vol.16
, pp. 2977-2984
-
-
Van De Locht, A.1
Bode, W.2
Huber, R.3
Le Bonniec, B.F.4
Stone, S.R.5
Esmon, C.T.6
Stubbs, M.T.7
-
21
-
-
42449150052
-
Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex
-
Li W, Adams TE, Nangalia J, Esmon CT Huntington JA (2008) Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex. Proc Natl Acad Sci USA 105, 4661 4666.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 4661-4666
-
-
Li, W.1
Adams, T.E.2
Nangalia, J.3
Esmon, C.T.4
Huntington, J.A.5
-
22
-
-
34250749673
-
Protein C inhibitor directly and potently inhibits activated hepatocyte growth factor activator
-
Hayashi T, Nishioka J, Nakagawa N, Kamada H, Gabazza EC, Kobayashi T, Hattori A Suzuki K (2007) Protein C inhibitor directly and potently inhibits activated hepatocyte growth factor activator. J Thromb Haemost 5, 1477 1485.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 1477-1485
-
-
Hayashi, T.1
Nishioka, J.2
Nakagawa, N.3
Kamada, H.4
Gabazza, E.C.5
Kobayashi, T.6
Hattori, A.7
Suzuki, K.8
-
23
-
-
77951712406
-
Hepatocyte growth factor activator (HGFA): Its regulation by protein C inhibitor
-
Suzuki K (2010) Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor. FEBS J 277, 2223 2229.
-
(2010)
FEBS J
, vol.277
, pp. 2223-2229
-
-
Suzuki, K.1
-
24
-
-
0030894268
-
Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor
-
Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K et al. (1997) Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. J Biol Chem 272, 6370 6376.
-
(1997)
J Biol Chem
, vol.272
, pp. 6370-6376
-
-
Shimomura, T.1
Denda, K.2
Kitamura, A.3
Kawaguchi, T.4
Kito, M.5
Kondo, J.6
Kagaya, S.7
Qin, L.8
Takata, H.9
Miyazawa, K.10
-
25
-
-
1842713094
-
MANSC: A seven-cysteine-containing domain present in animal membrane and extracellular proteins
-
Guo J, Chen S, Huang C, Chen L, Studholme DJ, Zhao S Yu L (2004) MANSC: a seven-cysteine-containing domain present in animal membrane and extracellular proteins. Trends Biochem Sci 29, 172 174.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 172-174
-
-
Guo, J.1
Chen, S.2
Huang, C.3
Chen, L.4
Studholme, D.J.5
Zhao, S.6
Yu, L.7
-
26
-
-
0141815667
-
Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1
-
Kirchhofer D, Peek M, Li W, Stamos J, Eigenbrot C, Kadkhodayan S, Elliott JM, Corpuz RT, Lazarus RA Moran P (2003) Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1. J Biol Chem 278, 36341 36349.
-
(2003)
J Biol Chem
, vol.278
, pp. 36341-36349
-
-
Kirchhofer, D.1
Peek, M.2
Li, W.3
Stamos, J.4
Eigenbrot, C.5
Kadkhodayan, S.6
Elliott, J.M.7
Corpuz, R.T.8
Lazarus, R.A.9
Moran, P.10
-
27
-
-
33947164004
-
Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development
-
Szabo R, Molinolo A, List K Bugge TH (2007) Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development. Oncogene 26, 1546 1556.
-
(2007)
Oncogene
, vol.26
, pp. 1546-1556
-
-
Szabo, R.1
Molinolo, A.2
List, K.3
Bugge, T.H.4
-
28
-
-
33846917477
-
Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth
-
Fan B, Brennan J, Grant D, Peale F, Rangell L Kirchhofer D (2007) Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth. Dev Biol 303, 222 230.
-
(2007)
Dev Biol
, vol.303
, pp. 222-230
-
-
Fan, B.1
Brennan, J.2
Grant, D.3
Peale, F.4
Rangell, L.5
Kirchhofer, D.6
-
29
-
-
20744448360
-
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta
-
Tanaka H, Nagaike K, Takeda N, Itoh H, Kohama K, Fukushima T, Miyata S, Uchiyama S, Uchinokura S, Shimomura T et al. (2005) Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta. Mol Cell Biol 25, 5687 5698.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5687-5698
-
-
Tanaka, H.1
Nagaike, K.2
Takeda, N.3
Itoh, H.4
Kohama, K.5
Fukushima, T.6
Miyata, S.7
Uchiyama, S.8
Uchinokura, S.9
Shimomura, T.10
-
30
-
-
0037134489
-
Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1
-
Denda K, Shimomura T, Kawaguchi T, Miyazawa K Kitamura N (2002) Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1. J Biol Chem 277, 14053 14059.
-
(2002)
J Biol Chem
, vol.277
, pp. 14053-14059
-
-
Denda, K.1
Shimomura, T.2
Kawaguchi, T.3
Miyazawa, K.4
Kitamura, N.5
-
31
-
-
15544386767
-
Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2
-
Kirchhofer D, Peek M, Lipari MT, Billeci K, Fan B Moran P (2005) Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2. FEBS Lett 579, 1945 1950.
-
(2005)
FEBS Lett
, vol.579
, pp. 1945-1950
-
-
Kirchhofer, D.1
Peek, M.2
Lipari, M.T.3
Billeci, K.4
Fan, B.5
Moran, P.6
-
32
-
-
41449107352
-
Roles of functional and structural domains of hepatocyte growth factor activator inhibitor type 1 in the inhibition of matriptase
-
Kojima K, Tsuzuki S, Fushiki T Inouye K (2008) Roles of functional and structural domains of hepatocyte growth factor activator inhibitor type 1 in the inhibition of matriptase. J Biol Chem 283, 2478 2487.
-
(2008)
J Biol Chem
, vol.283
, pp. 2478-2487
-
-
Kojima, K.1
Tsuzuki, S.2
Fushiki, T.3
Inouye, K.4
-
33
-
-
27144432513
-
Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin
-
Fan B, Wu TD, Li W Kirchhofer D (2005) Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin. J Biol Chem 280, 34513 34520.
-
(2005)
J Biol Chem
, vol.280
, pp. 34513-34520
-
-
Fan, B.1
Wu, T.D.2
Li, W.3
Kirchhofer, D.4
-
34
-
-
0033603547
-
Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk
-
Lin CY, Anders J, Johnson M Dickson RB (1999) Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk. J Biol Chem 274, 18237 18242.
-
(1999)
J Biol Chem
, vol.274
, pp. 18237-18242
-
-
Lin, C.Y.1
Anders, J.2
Johnson, M.3
Dickson, R.B.4
-
35
-
-
67650500717
-
Structure of a serine protease poised to resynthesize a peptide bond
-
Zakharova E, Horvath MP Goldenberg DP (2009) Structure of a serine protease poised to resynthesize a peptide bond. Proc Natl Acad Sci USA 106, 11034 11039.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 11034-11039
-
-
Zakharova, E.1
Horvath, M.P.2
Goldenberg, D.P.3
-
36
-
-
0037127319
-
Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase
-
Friedrich R, Fuentes-Prior P, Ong E, Coombs G, Hunter M, Oehler R, Pierson D, Gonzalez R, Huber R, Bode W et al. (2002) Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. J Biol Chem 277, 2160 2168.
-
(2002)
J Biol Chem
, vol.277
, pp. 2160-2168
-
-
Friedrich, R.1
Fuentes-Prior, P.2
Ong, E.3
Coombs, G.4
Hunter, M.5
Oehler, R.6
Pierson, D.7
Gonzalez, R.8
Huber, R.9
Bode, W.10
-
37
-
-
12444316010
-
The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain
-
Somoza JR, Ho JD, Luong C, Ghate M, Sprengeler PA, Mortara K, Shrader WD, Sperandio D, Chan H, McGrath ME et al. (2003) The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain. Structure 11, 1123 1131.
-
(2003)
Structure
, vol.11
, pp. 1123-1131
-
-
Somoza, J.R.1
Ho, J.D.2
Luong, C.3
Ghate, M.4
Sprengeler, P.A.5
Mortara, K.6
Shrader, W.D.7
Sperandio, D.8
Chan, H.9
McGrath, M.E.10
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